Traditional Chinese medicine paste in the treatment of chronic obstructive pulmonary disease in stable stage: a systematic review of randomized controlled trials_Chinese Journal of Evidence-Based Medicine

Authors：

ZENG Yan , YAN Min , YI Qinyu , WU Lihua , WANG Shengjun ,  JIANG Hongli , MAO Bing

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China;

Corresponding author：

Keywords：

Chronic obstructive pulmonary disease; Traditional Chinese medicine paste; Systematic review; Meta-analysis; Randomized controlled trials

DOI：

10.7507/1672-2531.201606067

Video：

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Objective To evaluate the efficacy and safety of traditional Chinese medicine(TCM) paste in treating chronic obstructive pulmonary disease (COPD) in stable stage. Methods We electronically searched databases including PubMed, EMbase, The Cochrane Library (Issue 12, 2016), VIP, WanFang Data, CNKI and CBM to collect randomized controlled trials (RCTs) regarding TCM paste in combination with conventional Western therapy versus Western therapy alone in treating stable COPD from inception to December 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. The meta-analysis was conducted by RevMan 5.3 software. Results A total of 9 RCTs involving 605 Chinese patients were included. The results of meta-analysis showed that: when compared with conventional Western medicine alone, TCM paste combined with the conventional Western medicine significantly improved clinical effective rate (RR=1.20, 95% CI 1.10 to 1.31,P<0.000 1), decreased SGRQ score (MD=–4.53, 95% CI –5.41 to –3.65,P<0.000 01) and CAT score (MD=–2.45, 95% CI –3.38 to –1.51,P<0.000 01), increased FEV₁% (MD=3.80, 95% CI 0.40 to 7.20,P=0.03), and reduced the frequency of acute exacerbation (P<0.05). No serious adverse reaction occurred in both groups. Conclusion The current evidence shows that combination of TCM paste and conventional Western medicine may improve clinical effective rate, quality of life, increase FEV₁%, and reduce the frequency of acute exacerbation in patients with stable COPD. Due to the limited quality and quantity of included studies, the above results are needed to verify by more studies.

Citation： ZENG Yan, YAN Min, YI Qinyu, WU Lihua, WANG Shengjun, JIANG Hongli, MAO Bing. Traditional Chinese medicine paste in the treatment of chronic obstructive pulmonary disease in stable stage: a systematic review of randomized controlled trials. Chinese Journal of Evidence-Based Medicine, 2017, 17(3): 340-346. doi: 10.7507/1672-2531.201606067 Copy

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14.	邱念念, 刘良丽, 刘亿淑. 养肺保元膏对慢性阻塞性肺疾病稳定期患者血清白介素–2 及白介素–10 的影响. 中国中医急症, 2015, 24(2): 255-257.
15.	王振伟, 杨佩兰, 沈丽. 百部养肺煎膏治疗慢性阻塞性肺疾病疗效及机制. 吉林中医药, 2014, 34(9): 899-902.
16.	赵建军, 秦建平, 唐书福. 补肺化浊膏方对慢性阻塞性肺疾病稳定期的临床观察. 中国实验方剂学杂志, 2014, 20(7): 216-219.
17.	王浩, 张念志, 纪娟. 从脾论治慢阻肺的概述. 光明中医, 2015, 30(11): 2476-2479.
18.	Resch KL, Ernst E. Research methodologies in complementary medicine: making sure it works. In: Ernst E, edited. Complementary Medicine: An Objective Appraisal. Oxford, Butterworth, 1996.
19.	Gordon HG, Andrew DO, Victor M, et al. Grade 指南证据质量评价—发表偏倚. 中国循证医学杂志, 2011, 11(12): 1430-1434.
20.	王玉光, 周平安. 肾不纳气证新绎. 中国中医基础医学杂志, 2004, 10(5): 27.

1. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组慢性阻塞性肺疾病诊治指南(2013 年修订版). 中华结核和呼吸杂志, 2013, 36(4): 255-264.
2. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease 2017. Available at: .
3. 中华中医药学会内科分会肺系疾病专业委员会. 慢性阻塞性肺疾病中医诊疗指南 2011 版. 中医杂志, 2012, 53(1): 80-84.
4. 杨欣莹. 慢性阻塞性肺疾病稳定期的中医药治疗研究进展. 中医药学报, 2015, 43(5): 115-117.
5. 何绿苑, 臧敏, 陈秀华. 冬令膏方对慢性阻塞性肺疾病生活质量和近期预后的影响. 山东中医药大学学报, 2015, 39(6): 533-535.
6. 中华医学会呼吸病学分会慢性阻塞性肺疾病学组. 慢性阻塞性肺疾病诊治指南(2007 年修订版). 中华内科杂志, 2007, 30(3): 254-261.
7. 郑筱萸. 中药新药临床研究指导原则. 中国医药科技出版社, 2002: 53-66.
8. Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1.0). Available at: .
9. 姜明华, 王延辉, 李泱. 益肾敛肺膏治疗慢性阻塞性肺疾病临床分析. 实用中医药杂志, 2015, 31(2): 86-87.
10. 张丽, 赵辉, 季辉. 膏方治疗慢性阻塞性肺病稳定期肺肾两虚型的临床观察. 四川中医, 2013, 31(6): 106-107.
11. 朱理芬, 边永君, 郑菲. 补肺益肾膏对慢性阻塞性肺疾病稳定期患者生活质量影响的评价研究. 中国中医药信息杂志, 2009, 16(12): 13-14.
12. 王唯益, 刘建博, 雷源. 肺康膏方调治慢性阻塞性肺疾病稳定期肺脾两虚证的临床疗效观察. 新中医, 2013, 45(11): 43-45.
13. 王振伟, 杨佩兰, 沈丽. 百部养肺煎膏治疗 COPD 稳定期患者的临床研究. 西部中医药, 2015, 28(5): 56-59.
14. 邱念念, 刘良丽, 刘亿淑. 养肺保元膏对慢性阻塞性肺疾病稳定期患者血清白介素–2 及白介素–10 的影响. 中国中医急症, 2015, 24(2): 255-257.
15. 王振伟, 杨佩兰, 沈丽. 百部养肺煎膏治疗慢性阻塞性肺疾病疗效及机制. 吉林中医药, 2014, 34(9): 899-902.
16. 赵建军, 秦建平, 唐书福. 补肺化浊膏方对慢性阻塞性肺疾病稳定期的临床观察. 中国实验方剂学杂志, 2014, 20(7): 216-219.
17. 王浩, 张念志, 纪娟. 从脾论治慢阻肺的概述. 光明中医, 2015, 30(11): 2476-2479.
18. Resch KL, Ernst E. Research methodologies in complementary medicine: making sure it works. In: Ernst E, edited. Complementary Medicine: An Objective Appraisal. Oxford, Butterworth, 1996.
19. Gordon HG, Andrew DO, Victor M, et al. Grade 指南证据质量评价—发表偏倚. 中国循证医学杂志, 2011, 11(12): 1430-1434.
20. 王玉光, 周平安. 肾不纳气证新绎. 中国中医基础医学杂志, 2004, 10(5): 27.

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Traditional Chinese medicine paste in the treatment of chronic obstructive pulmonary disease in stable stage: a systematic review of randomized controlled trials

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