Genetic polymorphism in ALDH2 and risk of Chinese people with ischemic stroke: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

DAI Huixu , HE Qiao ,  SHI Jingpu

Department of Clinical Epidemiology, the First Affiliated Hospital, China Medical University, Shenyang, 110001, P.R.China;

Corresponding author：

SHI Jingpu, Email: sjp562013@126.com

Keywords：

ALDH2; Polymorphism; Ischemic stroke; Meta-analysis

DOI：

10.7507/1672-2531.201611024

Video：

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Objective To systematically review the association between ALDH2 polymorphism and ischemic stroke. Methods Web of Science, PubMed, CNKI, CBM and WanFang data were searched to collect case-control studies about the association between ALDH2 polymorphism and ischemic stroke from the inception to October 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed by using Stata 12.0 software. Results A total of seven case-control studies were included. The results of meta-analysis showed that the A allele and AA genotype in ALDH2 was associated with the risk of ischemic stroke (Avs. G: OR=1.430, 95%CI 1.006 to 2.033,P=0.046; AAvs. AG+GG: OR=1.734, 95%CI 1.267 to 2.373,P=0.001; AAvs. GG: OR=1.757, 95%CI 1.274 to 2.424,P=0.001). Conclusion ALDH2 gene polymorphism may related to ischemic stroke for Chinese and A allele of ALDH2 may be the risk factors.

Citation： DAI Huixu, HE Qiao, SHI Jingpu. Genetic polymorphism in ALDH2 and risk of Chinese people with ischemic stroke: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(1): 72-77. doi: 10.7507/1672-2531.201611024 Copy

1.	Wu X, Zhu B, Fu L, et al. Prevalence, incidence, and mortality of stroke in the chinese island populations: a systematic review. PLoS One, 2013, 8(11): e78629.
2.	Goldstein LB, Adams R, Alberts MJ, et al. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Stroke, 2006, 37(6): 1583-1633.
3.	黎炳护, 张莉莉, 尹延伟, 等. 白细胞介素-6基因 174G-C 多态性与缺血性脑卒中风险相关性的 Meta 分析. 中国循证医学杂志, 2012, 12(5): 563-569.
4.	吴敌, 王拥军. 卒中二级预防中落实证据的阻碍因素和改进措施. 中国卒中杂志, 2006(8): 563-567.
5.	Teramoto T, Sasaki J, Ueshima H, et al. Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese. J Atheroscler Thromb, 2007, 14(2): 45-50.
6.	Chen YC, Peng GS, Tsao TP, et al. Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet Genomics, 2009, 19(8): 588-599.
7.	潘强强, 高琴, 王洪巨. 乙醛脱氢酶2与心血管疾病研究进展. 中国老年学杂志, 2013, 33: 1962-1964.
8.	孙华林. 乙醛脱氢酶 2 基因多态性与脑梗死患者颈动脉粥样硬化斑块形成的相关性. 山东大学学报(医学版), 2012, 50(7): 65-68.
9.	Takagi S, Iwai N, Yamauchi R, et al. Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Hypertens Res, 2002, 25(5): 677-681.
10.	Nagasawa H, Wada M, Arawaka S, et al. A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study. Eur J Neurol, 2007, 14(4): 428-434.
11.	Macgregor S, Lind PA, Bucholz KK, et al. Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. Hum Mol Genet, 2009, 18(3): 580-593.
12.	王耕银, 陈乃耀, 徐应军. 乙醛脱氢酶2基因多态性与脑梗死相关性研究. 中国煤炭工业医学杂志, 2014, 17(1): 29-31.
13.	徐筱婧. ALDH2 基因单核苷酸多态性与脑梗死的关联分析. 遵义: 遵义医学院, 2012.
14.	张春媛, 戴艳萍, 李军, 等. 黑龙江省汉族乙醛脱氢酶2基因多态性与急性脑梗死相关性的研究. 中国校医, 2014, 28(5): 334-335.
15.	周青. ALDH2 基因多态性与脑卒中易感性的关系. 泰安: 泰山医学院, 2014.
16.	Sung YF, Lu CC, Lee JT, et al. Homozygous ALDH2*2 Is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men. Stroke, 2016, 47(9): 2174-2179.
17.	Li QY, Zhao NM, Ma JJ, et al. ALDH2*2 Allele is a Negative Risk Factor for Cerebral Infarction in Chinese Women. Biochem Genet, 2015, 53(9-10): 260-267.
18.	陈娟. 4-羟基壬烯醛在疾病发生机制方面的研究进展. 国际呼吸杂志, 2006, 11: 821-824.
19.	李梦, 陈阳美. 缺血性脑卒中患者颈动脉粥样硬化斑块危险因素的分析. 中国循证医学杂志, 2006, 6(5): 385-389.

1. Wu X, Zhu B, Fu L, et al. Prevalence, incidence, and mortality of stroke in the chinese island populations: a systematic review. PLoS One, 2013, 8(11): e78629.
2. Goldstein LB, Adams R, Alberts MJ, et al. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Stroke, 2006, 37(6): 1583-1633.
3. 黎炳护, 张莉莉, 尹延伟, 等. 白细胞介素-6基因 174G-C 多态性与缺血性脑卒中风险相关性的 Meta 分析. 中国循证医学杂志, 2012, 12(5): 563-569.
4. 吴敌, 王拥军. 卒中二级预防中落实证据的阻碍因素和改进措施. 中国卒中杂志, 2006(8): 563-567.
5. Teramoto T, Sasaki J, Ueshima H, et al. Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese. J Atheroscler Thromb, 2007, 14(2): 45-50.
6. Chen YC, Peng GS, Tsao TP, et al. Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. Pharmacogenet Genomics, 2009, 19(8): 588-599.
7. 潘强强, 高琴, 王洪巨. 乙醛脱氢酶2与心血管疾病研究进展. 中国老年学杂志, 2013, 33: 1962-1964.
8. 孙华林. 乙醛脱氢酶 2 基因多态性与脑梗死患者颈动脉粥样硬化斑块形成的相关性. 山东大学学报(医学版), 2012, 50(7): 65-68.
9. Takagi S, Iwai N, Yamauchi R, et al. Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Hypertens Res, 2002, 25(5): 677-681.
10. Nagasawa H, Wada M, Arawaka S, et al. A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study. Eur J Neurol, 2007, 14(4): 428-434.
11. Macgregor S, Lind PA, Bucholz KK, et al. Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. Hum Mol Genet, 2009, 18(3): 580-593.
12. 王耕银, 陈乃耀, 徐应军. 乙醛脱氢酶2基因多态性与脑梗死相关性研究. 中国煤炭工业医学杂志, 2014, 17(1): 29-31.
13. 徐筱婧. ALDH2 基因单核苷酸多态性与脑梗死的关联分析. 遵义: 遵义医学院, 2012.
14. 张春媛, 戴艳萍, 李军, 等. 黑龙江省汉族乙醛脱氢酶2基因多态性与急性脑梗死相关性的研究. 中国校医, 2014, 28(5): 334-335.
15. 周青. ALDH2 基因多态性与脑卒中易感性的关系. 泰安: 泰山医学院, 2014.
16. Sung YF, Lu CC, Lee JT, et al. Homozygous ALDH2*2 Is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men. Stroke, 2016, 47(9): 2174-2179.
17. Li QY, Zhao NM, Ma JJ, et al. ALDH2*2 Allele is a Negative Risk Factor for Cerebral Infarction in Chinese Women. Biochem Genet, 2015, 53(9-10): 260-267.
18. 陈娟. 4-羟基壬烯醛在疾病发生机制方面的研究进展. 国际呼吸杂志, 2006, 11: 821-824.
19. 李梦, 陈阳美. 缺血性脑卒中患者颈动脉粥样硬化斑块危险因素的分析. 中国循证医学杂志, 2006, 6(5): 385-389.

Chinese Journal of Evidence-Based Medicine

Genetic polymorphism in ALDH2 and risk of Chinese people with ischemic stroke: a meta-analysis

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