• Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;
YING Binwu, Email: binwuying@126.com
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Objective  To investigate HCV genotypes in HCV patients in West China Hospital of Sichuan University, and to analyze the major genotypes and clinical characteristics. Methods  From March 2011 to September 2016, 4 520 HCV patients who were successfully genotyped HCV genotypes were enrolled in West China Hospital of Sichuan University. The genotypes distributions and the characteristics of laboratory characteristics of liver function, the viral loading were all analyzed. In addition, the genotypes in HCC patients, liver cirrhosis, HBC/HCV co-infection were also analyzed. Results  HCV genotypes of HCV patients were divided into five genotypes of 1, 2, 3, 4, 6 and 23 subtypes, including predominant genotypes/subtypes 1b, 1*, 3b, 2a, 3a and 6a, accounting for 66.42%, 8.01%, 6.57%, 4.54%, 4.29%, and 3.41%, respectively. Subtype 1b was the predominant subtype for both sex. In male patients, the levels of ALT were highest in 6a subtype, while in female, the levels of ALT were highest in 3a subtype. For the 94 liver cirrhosis patients, 42 patients were 1b subtypes; as for the 6 HCC patients, 1b and 3b subtypes were the only detected. Conclusion  HCV genotypes/subtypes of HCV patients in West China Hospital of Sichuan University have unique characteristics of distribution, while the predominant genotype/subtypes are 1b,1*, 3b, 2a, 3a, 6a.

Citation: WANG Xuemei, ZHOU Juan, YE Yuanxin, YANG Lian, ZHOU Yi, LU Xiaojun, YING Binwu. The investigation of genotypes of HCV and clinical characteristics in HCV patients in West China Hospital of Sichuan University. Chinese Journal of Evidence-Based Medicine, 2017, 17(5): 511-516. doi: 10.7507/1672-2531.201611041 Copy

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