Efficacy and safety of oral polyethylene glycol versus sodium phosphate solution in capsule endoscopy: a systematic review_Chinese Journal of Evidence-Based Medicine

Authors：

TANG Ying ¹ , GE Long ² ,  ZHANG Zhigang ³ , ZHANG Caiyun ³ , TIAN Jinhui ²

1. The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, P.R.China;
2. Evidence-based Medicine Center, Lanzhou University, Lanzhou, 730000, P.R.China;
3. The First Hospital, Lanzhou University, Lanzhou, 730000, P.R.China;

Corresponding author：

ZHANG Zhigang, Email: zzg3444@163.com

Keywords：

Polyethylene glycol solution; Sodium phosphate solution; Capsule endoscopy; Systematic review; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.201611042

Video：

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Objective To systematically review the efficacy and safety of polyethylene glycol and sodium phosphate in bowel preparation of capsule endoscopy. Methods We searched CNKI, CBM, WanFang Data, PubMed, EMbase, and The Cochrane Library (Issue 6, 2016) up to June 2016, to collect randomized controlled trials (RCTs) about polyethylene glycol and sodium phosphate in bowel preparation of capsule endoscopy. Two reviewers independently screened literatures, extracted data and assessed the risk of bias of included studies, and then meta-analysis was performed by using RevMan 5.0 software. Results A total of six RCTs involving 531 patients were included. The results of meta-analysis showed that: compared with the sodium phosphate solution group, the polyethylene glycol solution group had poor intestinal cleansing effect (OR=0.43, 95%CI 0.21 to 0.88,P=0.02), higher incidence of adverse reaction (OR=3.20, 95%CI 1.13 to 9.06,P=0.03); but shorter gastric retention time (OR=–11.61, 95%CI –13.71 to –9.51,P<0.000 01) and residence time in the small intestine (OR=–4.17, 95%CI –7.74 to –0.60,P=0.02). Conclusion The efficacy of oral polyethylene glycol is poor in cleaning effect and adverse reaction than sodium phosphate solution, but better in the digestive tract residence time for capsule endoscopy. Due to the limited quality and quantity of included studies, the above conclusion is still needed to be proved by more high-quality studies.

Citation： TANG Ying, GE Long, ZHANG Zhigang, ZHANG Caiyun, TIAN Jinhui. Efficacy and safety of oral polyethylene glycol versus sodium phosphate solution in capsule endoscopy: a systematic review. Chinese Journal of Evidence-Based Medicine, 2017, 17(1): 52-57. doi: 10.7507/1672-2531.201611042 Copy

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11.	Wi J, Moon E, Choi M,et al. Bowel preparation for capsule endoscopy: a prospective randomized multicenter study. Gut and Liver, 2009, 3(3): 180-185.
12.	李运红, 徐肇敏, 卢晓云, 等. 胶囊内镜检查前肠道准备方法的临床研究. 生物医学工程与临床, 2006, 10(6): 372-374.
13.	张爱芳, 杨志杰, 缪学勤. 胶囊内镜检查前应用复方聚乙二醇电解质散行肠道清洁的临床价值. 黑龙江医药, 2013, 6(26): 1065-1066.
14.	丁列敏. 复方聚乙二醇电解质散在老年肠道准备中的观察及护理. 海峡药学, 2010, 22(7): 203-204.
15.	王新丹, 王华芬. 聚乙二醇电解质溶液在结肠镜检查前肠道准备中的应用与护理. 护士进修杂志, 2006, 3(3): 212-214．.
16.	李丽君, 申晓静. 聚乙二醇电解质散 (和爽) 在肠道准备中的应用与护理体会. 中国实用医药, 2007, 6(18): 111-112．.
17.	李耀东, 王一平, 潘涛, 等. 磷酸钠法与聚乙二醇电解质液法在结肠镜检前肠道准备中应用效果的系统评价. 中国循证医学杂志, 2005, 5(7): 555-561.
18.	王宁. 聚乙二醇与磷酸钠盐清洁肠道安全性和有效性的 Meta 分析. 医学综述, 2015, 21(15): 2823-2827.
19.	Viazis N, Sgouros S, Papaxoinis K,et al. Bowel preparation increases the diagnostic yield of capsule endoscopy: a prospective, randomized, controlled study. Gastrointestinal Endoscopy, 2004, 4(60): 534-539.

1. 楼杰. 胶囊内镜检查前不同肠道准备方法的效果比较. 现代实用医学, 2012, 24(2): 182-183.
2. 杨建民, 郑卫华, 张骏, 等. 国产 OMOM 胶囊内镜对小肠疾病的诊断价值. 中华消化杂志, 2006, 26(10): 697-698.
3. Loftus EVJr. Capsule endoscopy for Crohn’s disease: ready for prime time. Clin Gastroenterol Hepatol, 2004, 2(1): 14-16.
4. 徐青丽, 黄春美, 郑雪芬, 等. OMOM 胶囊内镜检查前肠道准备的临床研究. 护士进修杂志, 2014, 29(6): 575-576.
5. Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.0.0. London: The Cochrane Collaboration, 2008. Available at: http://handbook.cochrane.org/.
6. 杨晓强, 赵亚刚, 孙大勇. 两种清肠剂在胶囊内镜检查中应用的对比研究. 中国内镜杂志, 2009, 15(10): 1043-1046.
7. 陈涛, 刘辉. 3 种方法在胶囊内镜肠道准备中的清洁效果比较. 现代临床护理, 2012, 11(5): 50-51.
8. Pons Beltrán V, González Suárez B, González Asanza C,et al. Evaluation of different bowel preparations for small bowel capsule endoscopy: a prospective, randomized, controlled study. Dig Dis Sci, 2011, 56(10): 2900-2905.
9. 邓源, 江雪. 不同肠道准备方法对胶囊内镜检查图像的影响. 中国医院用药评价与分析, 2010, 10(10): 931-932.
10. 罗文基, 黄丽娟, 陈鸿江. 胶囊内镜检查术前老年人肠道清洁准备方法研究. 中国实用医药, 2012, 7(8): 116-118.
11. Wi J, Moon E, Choi M,et al. Bowel preparation for capsule endoscopy: a prospective randomized multicenter study. Gut and Liver, 2009, 3(3): 180-185.
12. 李运红, 徐肇敏, 卢晓云, 等. 胶囊内镜检查前肠道准备方法的临床研究. 生物医学工程与临床, 2006, 10(6): 372-374.
13. 张爱芳, 杨志杰, 缪学勤. 胶囊内镜检查前应用复方聚乙二醇电解质散行肠道清洁的临床价值. 黑龙江医药, 2013, 6(26): 1065-1066.
14. 丁列敏. 复方聚乙二醇电解质散在老年肠道准备中的观察及护理. 海峡药学, 2010, 22(7): 203-204.
15. 王新丹, 王华芬. 聚乙二醇电解质溶液在结肠镜检查前肠道准备中的应用与护理. 护士进修杂志, 2006, 3(3): 212-214．.
16. 李丽君, 申晓静. 聚乙二醇电解质散 (和爽) 在肠道准备中的应用与护理体会. 中国实用医药, 2007, 6(18): 111-112．.
17. 李耀东, 王一平, 潘涛, 等. 磷酸钠法与聚乙二醇电解质液法在结肠镜检前肠道准备中应用效果的系统评价. 中国循证医学杂志, 2005, 5(7): 555-561.
18. 王宁. 聚乙二醇与磷酸钠盐清洁肠道安全性和有效性的 Meta 分析. 医学综述, 2015, 21(15): 2823-2827.
19. Viazis N, Sgouros S, Papaxoinis K,et al. Bowel preparation increases the diagnostic yield of capsule endoscopy: a prospective, randomized, controlled study. Gastrointestinal Endoscopy, 2004, 4(60): 534-539.

Chinese Journal of Evidence-Based Medicine

Efficacy and safety of oral polyethylene glycol versus sodium phosphate solution in capsule endoscopy: a systematic review

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