SG13S89 polymorphism in<i>ALOX5AP</i> and risk of ischemic stroke in Chinese population: a meta-analysis _Chinese Journal of Evidence-Based Medicine

Authors：

DAI Huixu , HE Qiao ,  SHI Jingpu

Department of Clinical Epidemiology, The First Affiliated Hospital, China Medical University, Shenyang, 110001, P.R.China;

Corresponding author：

SHI Jingpu, Email: sjp562013@126.com

Keywords：

ALOX5AP; Polymorphism; Ischemic stroke; Meta-analysis

DOI：

10.7507/1672-2531.201612005

Video：

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Objective To systematically review the association between SG13S89 polymorphism inALOX5AP gene and ischemic stroke in Chinese population. Methods Web of Science, PubMed, CNKI, CBM, EMbase and WanFang Data databases were searched to collect studies about the association between SG13S89 polymorphism inALOX5AP gene and ischemic stroke from inception to October 2016. Two researchers independently screened literature, extracted data and evaluated the risk of bias of included studies. The meta-analysis was performed by STATA 12.0. Results A total of 11 case-control studies were included. The results of meta-analysis showed that SG13S89 polymorphism inALOX5AP gene was associated with the risk of ischemic stroke in Chinese (Avs. G: OR=1.192, 95%CI 1.029 to 1.381,P=0.019; AA+AGvs. GG: OR=1.20, 95%CI 1.029 to 1.400,P=0.020; AGvs. GG: OR=1.195, 95%CI 1.022 to 1.397,P=0.025). Conclusion SG13S89 polymorphism inALOX5AP gene may be related to ischemic stroke for Chinese, A allele may be a risk factor.

Citation： DAI Huixu, HE Qiao, SHI Jingpu. SG13S89 polymorphism inALOX5AP and risk of ischemic stroke in Chinese population: a meta-analysis . Chinese Journal of Evidence-Based Medicine, 2017, 17(4): 389-394. doi: 10.7507/1672-2531.201612005 Copy

1.	Wu XM, Zhu B, Fu LY,et al. Prevalence, incidence, and mortality of stroke in the chinese island populations: a systematic review. PLoS One, 2013, 8(11): e78629.
2.	黎炳护, 张莉莉, 尹延伟, 等. 白细胞介素-6 基因 174G-C 多态性与缺血性脑卒中风险相关性的 Meta 分析. 中国循证医学杂志, 2012, 12(5): 563-569.
3.	吴敌, 王拥军. 卒中二级预防中落实证据的阻碍因素和改进措施. 中国卒中杂志, 2006, 1(8): 563-567.
4.	李海先, 吴海容, 李健业, 等. ALOX5AP 基因多态性及肥胖与缺血性脑卒中相关性. 青岛大学医学院学报, 2013, 49(4): 319-322.
5.	Helgadottir A, Manolescu A, Thorleifsson G,et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet, 2004. 36(3): 233-239.
6.	Shen CD, Zhang WL, Sun K,et al. Interaction of genetic risk factors confers higher risk for thrombotic stroke in male Chinese: a multicenter case-control study. Ann Hum Genet, 2007, 71(5): 620-629.
7.	Yang Y, Zhang D, Feng N,et al., Increased intake of vegetables, but not fruit, reduces risk for hepatocellular carcinoma: a meta-analysis. Gastroenterology, 2014, 147(5): 1031-1042.
8.	邵敏洁, 易兴阳, 池丽芬. 浙江南部地区人群 5-脂氧合酶激活蛋白和磷酸二酯酶 4D 基因突变与缺血性脑卒中的研究. 中华老年心脑血管病杂志, 2013, 15(6): 592-595.
9.	王剑南, 杨兆宁, 隋强. 5-脂氧合酶激活蛋白及磷酸二酯酶 4D 基因多态性与脑梗死易患性的分子流行病学研究. 蚌埠医学院学报, 2015, 40(10): 1338-1340.
10.	徐佳亮. ALOX5AP 基因和 IL-1A 基因多态性与缺血性卒中的相关性. 沈阳: 中国医科大学, 2009.
11.	姚倩倩, 周畅, 刘丽君, 等. ALOX5AP 基因多态性与动脉粥样硬化性脑梗死相关性. 青岛大学医学院学报, 2013, 49(6): 471-475.
12.	高志嵩, 杜秦川. 缺血性脑卒中 ALOX5AP 基因 SG13S114T/A 和 SG13S89G/A 多态性研究. 宁夏医学杂志, 2008, 30(5): 388-390.
13.	廖断修, 易兴阳, 张标, 等. ALOX5AP 和 CYP3A5 基因多态性与缺血性卒中后血栓事件的相关性. 西部医学, 2016, 28(6): 823-828.
14.	冯学问, 吴伟林, 陈春友, 等. 5-脂氧合酶激活蛋白基因多态性与脑梗死易患性的临床研究. 中国医师杂志, 2016, 18(2): 212-215.
15.	高卓, 田国萍. 沈阳地区汉族人群脑梗死患者 ALOX5AP 基因 SNP 分析. 中风与神经疾病杂志, 2010, 27(11): 1022-1026.
16.	Zhang WL, Yang XM, Shi J,et al. Polymorphism of SG13S114T/A in the ALOX5AP Gene and the Risk for Stroke in a Large Chinese Cohort. Acta Genetica Sinica, 2006, 33(8): 678-684.
17.	Yang DZ, He Y, Li MY,et al. A novel risk haplotype of ALOX5AP gene is associated with ischemic stroke in Chinese Han population. J Mol Neurosci, 2014, 53(3): 493-499.
18.	Qu ZY, Su F, Zhu YL,et al. A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population. Int J Clin Exp Med, 2015, 8(11): 21343-21350.
19.	中华医学会神经病学分会脑血管病学组缺血性脑卒中二级预防指南组. 中国缺血性脑卒中和短暂性脑缺血发作的二级预防指南 2010. 中华神经内科杂志, 2010, 43(2): 134-160.
20.	邓淑敏, 何志义. 参与花生四烯酸代谢的酶单核苷酸多态性与脑卒中相关性研究进展. 中国神经免疫学和神经病学杂志, 2011, 18(5): 365-367.
21.	徐佳亮, 蔺慕会, 陈晓虹, 等. 中国人群 ALOX5AP 基因 SG13S114A/T 多态性与缺血性卒中相关性的 Meta 分析. 中风与神经疾病杂志, 2010, 27(9): 811-814.
22.	张伟丽, 陈宇, 惠汝太, 等. 缺血性卒中的遗传机制进展. 中国卒中杂志, 2010, 5(12): 988-995.

1. Wu XM, Zhu B, Fu LY,et al. Prevalence, incidence, and mortality of stroke in the chinese island populations: a systematic review. PLoS One, 2013, 8(11): e78629.
2. 黎炳护, 张莉莉, 尹延伟, 等. 白细胞介素-6 基因 174G-C 多态性与缺血性脑卒中风险相关性的 Meta 分析. 中国循证医学杂志, 2012, 12(5): 563-569.
3. 吴敌, 王拥军. 卒中二级预防中落实证据的阻碍因素和改进措施. 中国卒中杂志, 2006, 1(8): 563-567.
4. 李海先, 吴海容, 李健业, 等. ALOX5AP 基因多态性及肥胖与缺血性脑卒中相关性. 青岛大学医学院学报, 2013, 49(4): 319-322.
5. Helgadottir A, Manolescu A, Thorleifsson G,et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet, 2004. 36(3): 233-239.
6. Shen CD, Zhang WL, Sun K,et al. Interaction of genetic risk factors confers higher risk for thrombotic stroke in male Chinese: a multicenter case-control study. Ann Hum Genet, 2007, 71(5): 620-629.
7. Yang Y, Zhang D, Feng N,et al., Increased intake of vegetables, but not fruit, reduces risk for hepatocellular carcinoma: a meta-analysis. Gastroenterology, 2014, 147(5): 1031-1042.
8. 邵敏洁, 易兴阳, 池丽芬. 浙江南部地区人群 5-脂氧合酶激活蛋白和磷酸二酯酶 4D 基因突变与缺血性脑卒中的研究. 中华老年心脑血管病杂志, 2013, 15(6): 592-595.
9. 王剑南, 杨兆宁, 隋强. 5-脂氧合酶激活蛋白及磷酸二酯酶 4D 基因多态性与脑梗死易患性的分子流行病学研究. 蚌埠医学院学报, 2015, 40(10): 1338-1340.
10. 徐佳亮. ALOX5AP 基因和 IL-1A 基因多态性与缺血性卒中的相关性. 沈阳: 中国医科大学, 2009.
11. 姚倩倩, 周畅, 刘丽君, 等. ALOX5AP 基因多态性与动脉粥样硬化性脑梗死相关性. 青岛大学医学院学报, 2013, 49(6): 471-475.
12. 高志嵩, 杜秦川. 缺血性脑卒中 ALOX5AP 基因 SG13S114T/A 和 SG13S89G/A 多态性研究. 宁夏医学杂志, 2008, 30(5): 388-390.
13. 廖断修, 易兴阳, 张标, 等. ALOX5AP 和 CYP3A5 基因多态性与缺血性卒中后血栓事件的相关性. 西部医学, 2016, 28(6): 823-828.
14. 冯学问, 吴伟林, 陈春友, 等. 5-脂氧合酶激活蛋白基因多态性与脑梗死易患性的临床研究. 中国医师杂志, 2016, 18(2): 212-215.
15. 高卓, 田国萍. 沈阳地区汉族人群脑梗死患者 ALOX5AP 基因 SNP 分析. 中风与神经疾病杂志, 2010, 27(11): 1022-1026.
16. Zhang WL, Yang XM, Shi J,et al. Polymorphism of SG13S114T/A in the ALOX5AP Gene and the Risk for Stroke in a Large Chinese Cohort. Acta Genetica Sinica, 2006, 33(8): 678-684.
17. Yang DZ, He Y, Li MY,et al. A novel risk haplotype of ALOX5AP gene is associated with ischemic stroke in Chinese Han population. J Mol Neurosci, 2014, 53(3): 493-499.
18. Qu ZY, Su F, Zhu YL,et al. A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population. Int J Clin Exp Med, 2015, 8(11): 21343-21350.
19. 中华医学会神经病学分会脑血管病学组缺血性脑卒中二级预防指南组. 中国缺血性脑卒中和短暂性脑缺血发作的二级预防指南 2010. 中华神经内科杂志, 2010, 43(2): 134-160.
20. 邓淑敏, 何志义. 参与花生四烯酸代谢的酶单核苷酸多态性与脑卒中相关性研究进展. 中国神经免疫学和神经病学杂志, 2011, 18(5): 365-367.
21. 徐佳亮, 蔺慕会, 陈晓虹, 等. 中国人群 ALOX5AP 基因 SG13S114A/T 多态性与缺血性卒中相关性的 Meta 分析. 中风与神经疾病杂志, 2010, 27(9): 811-814.
22. 张伟丽, 陈宇, 惠汝太, 等. 缺血性卒中的遗传机制进展. 中国卒中杂志, 2010, 5(12): 988-995.

Chinese Journal of Evidence-Based Medicine

SG13S89 polymorphism inALOX5AP and risk of ischemic stroke in Chinese population: a meta-analysis

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