Efficacy and safety of Yangyinqingfei decoction in the treatment of chronic cough and chronic obstructive pulmonary disease: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LIU Yanfei ¹ ,  LIU Yue ² , CHENG Long ³ ,  WANG Hui ⁴

1. Beijing University of Chinese Medicine, Beijing, 100029, P.R.China;
2. Cardiovascular Diseases Centre, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, 100091, P.R.China;
3. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, P.R.China;
4. Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, P.R.China;

Corresponding author：

LIU Yue, Email: liuyue@188.com; WANG Hui, Email: wanghui9890@163.com

Keywords：

Yangyinqingfei decoction; Chronic cough; Chronic obstructive pulmonary disease; Meta-analysis; Randomized controlled trial

DOI：

10.7507/1672-2531.201701015

Video：

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ObjectiveTo systematically review the efficacy and safety of Yangyinqingfei decoction for chronic cough and chronic obstructive pulmonary disease (COPD) patients.MethodsWe electronically searched databases including PubMed, Web of Science, CBM, CNKI, VIP and WanFang Data for randomized controlled trials (RCTs) of Yangyinqingfei decoction for chronic cough and COPD patients from inception to August 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, RevMan 5.3 software was used for meta-analysis.ResultsTwenty-four RCTs involving 2 268 patients with COPD and chronic cough were included. The results of meta-analysis showed that compared with the control group, Yangyinqingfei decoction combined with the conventional medicine could significantly improve clinical effective rate (RR=1.21, 95%CI 1.16 to 1.27, P<0.000 01) and lung function (SMD=0.76, 95%CI 0.59 to 0.94, P<0.000 01) in patients with COPD. Yangyinqingfei decoction combined with the conventional medicine group was superior to the control group (RR=1.41, 95%CI 1.22 to 1.64, P<0.000 01) in clinical efficacy for adults patients with chronic cough. In terms of safety, seven cases occurred adverse reactions in the Yangyinqingfei decoction group, while 13 were found in the control group, the types and degree of adverse reactions in both groups were almost the same.ConclusionThe combination of Yangyinqingfei plus conventional medicine may significantly improve the clinical efficacy for chronic cough and COPD with reliable safety. However, due to the limited quality and quantity of included studies, the above conclusions are needed to verify by more high quality studies.

Citation： LIU Yanfei, LIU Yue, CHENG Long, WANG Hui. Efficacy and safety of Yangyinqingfei decoction in the treatment of chronic cough and chronic obstructive pulmonary disease: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2017, 17(6): 698-704. doi: 10.7507/1672-2531.201701015 Copy

1.	Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease (updated 2016). Available at: http://goldcopd.org/global-strategy-diagnosis-management-prevention-copd-2016.
2.	中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南 (2015). 中华结核和呼吸杂志, 2016, 39(5): 323-354.
3.	Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1.0). Available at: http://www. cochranehandbook.org.
4.	杜万朋. 养阴清肺汤联合头孢呋辛钠治疗慢性阻塞性肺气肿 60 例临床观察. 中国民族民间医药, 2015, 24(14): 51-52.
5.	王宁德, 李莉. 养阴清肺汤联合西药治疗老年慢性肺气肿临床疗效. 陕西中医, 2015, 36(7): 827-828.
6.	孔令魁. 养阴清肺汤在老年慢性阻塞性肺气肿治疗中的疗效分析. 临床心身疾病杂志, 2015, 21(z1): 256.
7.	高轶峰, 崔红, 刘宾娜. 养阴清肺汤治疗老年慢性阻塞性肺气肿. 中国实验方剂学杂志, 2011, 17(4): 204-205.
8.	谭国柱. 养阴清肺汤治疗老年慢性阻塞性肺气肿的临床观察. 中医临床研究, 2014, 6(23): 73-74.
9.	朱文平. 养阴清肺汤治疗老年慢性阻塞性肺气肿的临床观察. 大家健康(学术版), 2014, 8(4): 54.
10.	谢小芹, 元文峰, 邹萍. 养阴清肺汤治疗老年慢性阻塞性肺气肿的临床观察. 医学信息, 2013, 6(29): 134.
11.	兰映天. 养阴清肺汤治疗老年慢性阻塞性肺气肿的临床观察. 现代养生, 2012, 7(16): 71-73.
12.	谢杏爱. 养阴清肺汤治疗老年慢性阻塞性肺气肿疗效分析. 按摩与康复医学, 2014, 5(1): 126-127.
13.	张定学, 张著勋. 养阴清肺汤治疗老年慢性阻塞性肺气肿疗效观察. 现代中西医结合杂志, 2014, 23(13): 1447-1448.
14.	何龙. 养阴清肺汤治疗慢性阻塞性肺气肿的临床疗效观察. 中国医药指南, 2016, 14(12): 8-9.
15.	宁静, 程永华. 养阴清肺汤治疗痰热郁肺型老年 COPD 的临床观察. 中医临床研究, 2015, 7(31): 78-80.
16.	盖莹. 中西医结合治疗慢性阻塞性肺气肿临床效果分析. 中国中医药咨讯, 2012, 4(1): 214.
17.	王建华, 李梅娟. 中西医结合治疗慢性阻塞性肺气肿 30 例临床观察. 国际医药卫生导报, 2010, 16(5): 572-573.
18.	倪敏. 养阴清肺汤联合糖皮质激素治疗老年慢性阻塞性肺气肿临床观察. 新中医, 2015, 47(1): 70-71.
19.	董日. 养阴清肺汤治疗老年慢性阻塞性肺气肿 44 例. 江西中医药, 2014, 45(383): 33-34.
20.	岳团华. 养阴清肺汤治疗老年慢性阻塞性肺气肿临床疗效观察. 亚太传统医药, 2014, 10(20): 117-118.
21.	周明. 养阴清肺汤治疗老年慢性阻塞性肺气肿的疗效观察. 现代诊断与治疗, 2013, 24(15): 3420-3421.
22.	郑远方. 中西结合治疗慢性阻塞性肺气肿 128 例临床疗效研究. 中外医疗, 2012, 31(19): 113.
23.	於志娟. 养阴清肺汤加减治疗小儿上气道咳嗽综合征 75 例疗效观察. 内蒙古中医药, 2010, 29(22): 10.
24.	唐洁芬, 余培煌. 养阴清肺汤联合孟鲁司特治疗小儿支原体感染肺炎后慢性咳嗽临床观察. 四川中医, 2016, 34(8): 72-75.
25.	安立, 李林. 养阴清肺汤联合西药治疗慢性咽炎随机平行对照研究. 实用中医内科杂志, 2016, 30(3): 61-63.
26.	赵秀贞. 用养阴清肺汤治疗慢性咽炎的远期疗效与安全性分析. 当代医药论丛, 2014, 34(8): 14-16.
27.	穆传军, 李振山, 孙兆勋. 养阴清肺口服液治疗慢性咽炎 80 例疗效观察. 山东中医杂志, 2006, 25(2): 91-92.

1. Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease (updated 2016). Available at: http://goldcopd.org/global-strategy-diagnosis-management-prevention-copd-2016.
2. 中华医学会呼吸病学分会哮喘学组. 咳嗽的诊断与治疗指南 (2015). 中华结核和呼吸杂志, 2016, 39(5): 323-354.
3. Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions (Version 5.1.0). Available at: http://www. cochranehandbook.org.
4. 杜万朋. 养阴清肺汤联合头孢呋辛钠治疗慢性阻塞性肺气肿 60 例临床观察. 中国民族民间医药, 2015, 24(14): 51-52.
5. 王宁德, 李莉. 养阴清肺汤联合西药治疗老年慢性肺气肿临床疗效. 陕西中医, 2015, 36(7): 827-828.
6. 孔令魁. 养阴清肺汤在老年慢性阻塞性肺气肿治疗中的疗效分析. 临床心身疾病杂志, 2015, 21(z1): 256.
7. 高轶峰, 崔红, 刘宾娜. 养阴清肺汤治疗老年慢性阻塞性肺气肿. 中国实验方剂学杂志, 2011, 17(4): 204-205.
8. 谭国柱. 养阴清肺汤治疗老年慢性阻塞性肺气肿的临床观察. 中医临床研究, 2014, 6(23): 73-74.
9. 朱文平. 养阴清肺汤治疗老年慢性阻塞性肺气肿的临床观察. 大家健康(学术版), 2014, 8(4): 54.
10. 谢小芹, 元文峰, 邹萍. 养阴清肺汤治疗老年慢性阻塞性肺气肿的临床观察. 医学信息, 2013, 6(29): 134.
11. 兰映天. 养阴清肺汤治疗老年慢性阻塞性肺气肿的临床观察. 现代养生, 2012, 7(16): 71-73.
12. 谢杏爱. 养阴清肺汤治疗老年慢性阻塞性肺气肿疗效分析. 按摩与康复医学, 2014, 5(1): 126-127.
13. 张定学, 张著勋. 养阴清肺汤治疗老年慢性阻塞性肺气肿疗效观察. 现代中西医结合杂志, 2014, 23(13): 1447-1448.
14. 何龙. 养阴清肺汤治疗慢性阻塞性肺气肿的临床疗效观察. 中国医药指南, 2016, 14(12): 8-9.
15. 宁静, 程永华. 养阴清肺汤治疗痰热郁肺型老年 COPD 的临床观察. 中医临床研究, 2015, 7(31): 78-80.
16. 盖莹. 中西医结合治疗慢性阻塞性肺气肿临床效果分析. 中国中医药咨讯, 2012, 4(1): 214.
17. 王建华, 李梅娟. 中西医结合治疗慢性阻塞性肺气肿 30 例临床观察. 国际医药卫生导报, 2010, 16(5): 572-573.
18. 倪敏. 养阴清肺汤联合糖皮质激素治疗老年慢性阻塞性肺气肿临床观察. 新中医, 2015, 47(1): 70-71.
19. 董日. 养阴清肺汤治疗老年慢性阻塞性肺气肿 44 例. 江西中医药, 2014, 45(383): 33-34.
20. 岳团华. 养阴清肺汤治疗老年慢性阻塞性肺气肿临床疗效观察. 亚太传统医药, 2014, 10(20): 117-118.
21. 周明. 养阴清肺汤治疗老年慢性阻塞性肺气肿的疗效观察. 现代诊断与治疗, 2013, 24(15): 3420-3421.
22. 郑远方. 中西结合治疗慢性阻塞性肺气肿 128 例临床疗效研究. 中外医疗, 2012, 31(19): 113.
23. 於志娟. 养阴清肺汤加减治疗小儿上气道咳嗽综合征 75 例疗效观察. 内蒙古中医药, 2010, 29(22): 10.
24. 唐洁芬, 余培煌. 养阴清肺汤联合孟鲁司特治疗小儿支原体感染肺炎后慢性咳嗽临床观察. 四川中医, 2016, 34(8): 72-75.
25. 安立, 李林. 养阴清肺汤联合西药治疗慢性咽炎随机平行对照研究. 实用中医内科杂志, 2016, 30(3): 61-63.
26. 赵秀贞. 用养阴清肺汤治疗慢性咽炎的远期疗效与安全性分析. 当代医药论丛, 2014, 34(8): 14-16.
27. 穆传军, 李振山, 孙兆勋. 养阴清肺口服液治疗慢性咽炎 80 例疗效观察. 山东中医杂志, 2006, 25(2): 91-92.

Chinese Journal of Evidence-Based Medicine

Efficacy and safety of Yangyinqingfei decoction in the treatment of chronic cough and chronic obstructive pulmonary disease: a meta-analysis

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