Level of evidence and reporting standard in N-of-1 trial_Chinese Journal of Evidence-Based Medicine

Authors：

LI Jiang ^1# , ZHAI Jingbo ^2# , SHANG Hongcai ³ , YANG Kehu ^4,5 , TIAN Jinhui ^4,5 ,  CHEN Jing ² ,  DAI Min ¹

1. Program Office for Cancer Screening in Urban China, National Cancer Center/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, P.R.China;
2. Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, P.R.China;
3. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, P.R.China;
4. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, P.R.China;
5. Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province, Lanzhou University, Lanzhou, 730000, P.R.China;

Corresponding author：

CHEN Jing, Email: cjshcsyc@126.com; DAI Min, Email: daimin2002@hotmail.com

Keywords：

N-of-1 trial; Level of evidence; Quality assessment

DOI：

10.7507/1672-2531.201701074

Video：

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The study appeared the comparison between CONSORT and CENT, and promoted the combination with GRADE and N-of-1 trial. Our objective is to further develop the method of N-of-1 trial and to widely use it in clinical researches of some diseases.

Citation： LI Jiang, ZHAI Jingbo, SHANG Hongcai, YANG Kehu, TIAN Jinhui, CHEN Jing, DAI Min. Level of evidence and reporting standard in N-of-1 trial. Chinese Journal of Evidence-Based Medicine, 2017, 17(5): 612-615. doi: 10.7507/1672-2531.201701074 Copy

1.	Guyatt GH, Meade MO, Jaeschke RZ, et al. Practitioners of evidence based care: not all clinicians need to appraise evidence from scratchbut all need some skills. BMJ, 2000, 320(7240): 954-955.
2.	Guyatt GH, Haynes B, Jaeschke RZ, et al. The philosophy of evidence-based medicine. In users’ guides to the medical literature. Chicago: AMA Press, 2002.
3.	No authors listed. Canadian task force on the periodic health examination: the periodic health examination. CMAJ, 1979, 121(19): 1193-1254.
4.	Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ, 2004, 328(7454): 1490-1494.
5.	Schünemann HJ, Oxman AD, Brozek J, et al. Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ, 2008, 336(7653): 1106-1110.
6.	Moher D, Hopewell S, Schulz KF, et al. Consolidated Standards of Reporting Trials Group. CONSORT 2010 Explanation and Elaboration: Updated guidelines for reporting parallel group randomized trials. J Clin Epidemiol, 2010, 63(8): e1-37.
7.	Vohra S, Shamseer L, Sampson M, et al. CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. BMJ, 2015, 350: h1738.
8.	张燕舞, 蒋朱明, 王杨, 等. 与转化医学有关的临床研究质量及研究报告质量的评价工具. 中华临床营养杂志, 2011, 19(1): 1-6.

1. Guyatt GH, Meade MO, Jaeschke RZ, et al. Practitioners of evidence based care: not all clinicians need to appraise evidence from scratchbut all need some skills. BMJ, 2000, 320(7240): 954-955.
2. Guyatt GH, Haynes B, Jaeschke RZ, et al. The philosophy of evidence-based medicine. In users’ guides to the medical literature. Chicago: AMA Press, 2002.
3. No authors listed. Canadian task force on the periodic health examination: the periodic health examination. CMAJ, 1979, 121(19): 1193-1254.
4. Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ, 2004, 328(7454): 1490-1494.
5. Schünemann HJ, Oxman AD, Brozek J, et al. Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ, 2008, 336(7653): 1106-1110.
6. Moher D, Hopewell S, Schulz KF, et al. Consolidated Standards of Reporting Trials Group. CONSORT 2010 Explanation and Elaboration: Updated guidelines for reporting parallel group randomized trials. J Clin Epidemiol, 2010, 63(8): e1-37.
7. Vohra S, Shamseer L, Sampson M, et al. CONSORT extension for reporting N-of-1 trials (CENT) 2015 Statement. BMJ, 2015, 350: h1738.
8. 张燕舞, 蒋朱明, 王杨, 等. 与转化医学有关的临床研究质量及研究报告质量的评价工具. 中华临床营养杂志, 2011, 19(1): 1-6.

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