Brief introduction of Bayesian N-of-1 trials_Chinese Journal of Evidence-Based Medicine

Authors：

ZHAI Jingbo ¹ , LI Jiang ² , SHANG Hongcai ³ , WANG Hui ¹ ,  DAI Min ² ,  CHEN Jing ¹

1. Traditional Chinese Medicine of Tianjin University, Tianjin, 300193, P.R.China;
2. Program Office for Cancer Screening in Urban China, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, P.R.China;
3. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, P.R.China;

Corresponding author：

DAI Min, Email: daimin2002@hotmail.com; CHEN Jing, Email: cjshcsyc@126.com

Keywords：

N-of-1 trial; Bayesian

DOI：

10.7507/1672-2531.201701079

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Bayesian N-of-1 trials is increasingly popular in recent years. This study introduced the principle, statistical requirements, application status, advantages and disadvantages of Bayesian N-of-1 trials. Although the application of Bayesian N-of-1 trials is still limited in small scale and some problems remain to be solved, but it can provide more posterior information, and it can be the most important type of N-of 1 trial in future.

Citation： ZHAI Jingbo, LI Jiang, SHANG Hongcai, WANG Hui, DAI Min, CHEN Jing. Brief introduction of Bayesian N-of-1 trials. Chinese Journal of Evidence-Based Medicine, 2017, 17(7): 848-851. doi: 10.7507/1672-2531.201701079 Copy

1.	Zucker DR, Ruthazer R, Schmid CH. Individual (N-of-1) trials can be combined to give population comparative treatment effect estimates: methodologic considerations. J Clin Epidemiol, 2010, 63(12): 1312-1323.
2.	Sung L, Tomlinson GA, Greenberg ML, et al. Serial controlled N-of-1 trials of topical vitamin E as prophylaxis for chemotherapy-induced oral mucositis in paediatric patients. Eur J Cancer, 2007, 43(8): 1269-1275.
3.	朱丽叶. 分层模型与贝叶斯方法. 广州: 暨南大学, 2012.
4.	Zucker DR, Schmid CH, Mcintosh MW, et al. Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. J Clin Epidemiol, 1997, 50(4): 401-410.
5.	Nathan PC, Tomlinson G, Dupuis LL, et al. A pilot study of ondansetron plus metopimazine vs. ondansetron monotherapy in children receiving highly emetogenic chemotherapy: a Bayesian randomized serial N-of-1 trials design. Support Care Cancer, 2006, 14(3): 268-276.
6.	Zucker DR, Ruthazer R, Schmid CH, et al. Lessons learned combining N-of-1 trials to assess fibromyalgia therapies. J Rheumatol, 2006, 33(10): 2069-2077.
7.	Huber AM, Tomlinson GA, Koren G, et al. Amitriptyline to relieve pain in juvenile idiopathic arthritis: a pilot study using Bayesian metaanalysis of multiple N-of-1 clinical trials. J Rheumatol, 2007, 34(5): 1125-1132.
8.	Coxeter PD, Schluter PJ, Eastwood HL, et al. Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-1 trials. Complement Ther Med, 2003, 11(4): 215-222.
9.	Lunn DJ, Thomas A, Best N, et al. WinBUGS-A bayesian modelling framework: concepts, structure, and extensibility. Stat Comput, 2000, 10(4): 325-337.
10.	Nikles CJ, McKinlay L, Mitchell GK, et al. Aggregated n-of-1 trials of central nervous system stimulants versus placebo for paediatric traumatic brain injury-a pilot study. Trials, 2014, 15: 54.
11.	Willke RJ, Zheng Z, Subedi P, et al. From concepts, theory, and evidence of heterogeneity of treatment effects to methodological approaches: a primer. BMC Med Res Methodol, 2012,(12): 185.
12.	Gabler NB, Duan N, Liao D, et al. Dealing with heterogeneity of treatment effects: is the literature up to the challenge? Trials, 2009, 10: 43.
13.	Nikles J, Mitchell GK, Schluter P, et al. Aggregating single patient (n-of-1) trials in populations where recruitment and retention was difficult: the case of palliative care. J Clin Epidemiol, 2011, 64(5): 471-480.
14.	Zhai JB, Cao HB, Ren M, et al. Reporting of core items in hierarchical Bayesian analysis for aggregating N-of-1 trials to estimate population treatment effects is suboptimal. J Clin Epidemiol, 2016, 76: 99-107.

1. Zucker DR, Ruthazer R, Schmid CH. Individual (N-of-1) trials can be combined to give population comparative treatment effect estimates: methodologic considerations. J Clin Epidemiol, 2010, 63(12): 1312-1323.
2. Sung L, Tomlinson GA, Greenberg ML, et al. Serial controlled N-of-1 trials of topical vitamin E as prophylaxis for chemotherapy-induced oral mucositis in paediatric patients. Eur J Cancer, 2007, 43(8): 1269-1275.
3. 朱丽叶. 分层模型与贝叶斯方法. 广州: 暨南大学, 2012.
4. Zucker DR, Schmid CH, Mcintosh MW, et al. Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. J Clin Epidemiol, 1997, 50(4): 401-410.
5. Nathan PC, Tomlinson G, Dupuis LL, et al. A pilot study of ondansetron plus metopimazine vs. ondansetron monotherapy in children receiving highly emetogenic chemotherapy: a Bayesian randomized serial N-of-1 trials design. Support Care Cancer, 2006, 14(3): 268-276.
6. Zucker DR, Ruthazer R, Schmid CH, et al. Lessons learned combining N-of-1 trials to assess fibromyalgia therapies. J Rheumatol, 2006, 33(10): 2069-2077.
7. Huber AM, Tomlinson GA, Koren G, et al. Amitriptyline to relieve pain in juvenile idiopathic arthritis: a pilot study using Bayesian metaanalysis of multiple N-of-1 clinical trials. J Rheumatol, 2007, 34(5): 1125-1132.
8. Coxeter PD, Schluter PJ, Eastwood HL, et al. Valerian does not appear to reduce symptoms for patients with chronic insomnia in general practice using a series of randomised n-of-1 trials. Complement Ther Med, 2003, 11(4): 215-222.
9. Lunn DJ, Thomas A, Best N, et al. WinBUGS-A bayesian modelling framework: concepts, structure, and extensibility. Stat Comput, 2000, 10(4): 325-337.
10. Nikles CJ, McKinlay L, Mitchell GK, et al. Aggregated n-of-1 trials of central nervous system stimulants versus placebo for paediatric traumatic brain injury-a pilot study. Trials, 2014, 15: 54.
11. Willke RJ, Zheng Z, Subedi P, et al. From concepts, theory, and evidence of heterogeneity of treatment effects to methodological approaches: a primer. BMC Med Res Methodol, 2012,(12): 185.
12. Gabler NB, Duan N, Liao D, et al. Dealing with heterogeneity of treatment effects: is the literature up to the challenge? Trials, 2009, 10: 43.
13. Nikles J, Mitchell GK, Schluter P, et al. Aggregating single patient (n-of-1) trials in populations where recruitment and retention was difficult: the case of palliative care. J Clin Epidemiol, 2011, 64(5): 471-480.
14. Zhai JB, Cao HB, Ren M, et al. Reporting of core items in hierarchical Bayesian analysis for aggregating N-of-1 trials to estimate population treatment effects is suboptimal. J Clin Epidemiol, 2016, 76: 99-107.

Chinese Journal of Evidence-Based Medicine

Brief introduction of Bayesian N-of-1 trials

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content