Relationship between vitamin D level and the incidence of metabolic syndrome in adults in Chengdu city: a prospective cohort study_Chinese Journal of Evidence-Based Medicine

Authors：

GAO Yun ¹ , RAN Xingwu ¹ , REN Yan ¹ , CHEN Tao ¹ , ZHENG Tianpeng ² , ZHONG Li ³ ,  TIAN Haoming ¹

1. Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, 610041, P.R.China;
2. Department of Endocrinology and Metabolism, Affiliated Hospital of Guilin Medical University, Guilin, 541001, P.R.China;
3. Department of Endocrinology and Metabolism, First People’s Hospital of Longquanyi District, Chengdu, 610100, P.R.China;

Corresponding author：

TIAN Haoming, Email: hmtian999@126.comc

Keywords：

25-hydroxyvitamin D; Metabolic syndrome; Insulin resistance; Prospective cohort study

DOI：

10.7507/1672-2531.201703140

Video：

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Objective To explore the association between 25-hydroxyvitamin D (25OHD) level and risk of the onset of metabolic syndrome (MS) in people in Chengdu. Methods In total, 474 participants were selected randomly by cluster sampling from one urban district and two rural villages in Longquanyi district of Chengdu. The data of sociodemographic information, lifestyle and family history were collected by questionnaires. Binary logistic regression was performed to assess the relationship between baseline 25OHD level and incident of MS, while multiple linear regression was conducted to analyze the relationship between baseline 25OHD level and insulin resistance. Results Four hundred seventy-four people were enrolled in the cohort study, 39 of them developed MS, with the incidences of 20.8 events per 1 000 person years. Among women, low 25OHD status was significantly associated with the risk of developing MS (OR=4.29, 95%CI 1.05 to 29.50, P=0.044) after adjustment for multiple potential confounders. In a multiple linear regression analysis, low 25OHD level of baseline was independently associated with the increased HOMA-IR over a 4-year period among Chengdu individuals (P<0.05) and was independently related to the decreased ISIcomp over a 4-year period in female (P<0.05). Conclusions The current prospective study suggests that low 25OHD level may contribute to increase insulin resistance in Chengdu population. Furthermore, low 25OHD level may increase the risk of MS among women in Chengdu.

Citation： GAO Yun, RAN Xingwu, REN Yan, CHEN Tao, ZHENG Tianpeng, ZHONG Li, TIAN Haoming. Relationship between vitamin D level and the incidence of metabolic syndrome in adults in Chengdu city: a prospective cohort study. Chinese Journal of Evidence-Based Medicine, 2017, 17(10): 1121-1126. doi: 10.7507/1672-2531.201703140 Copy

1.	Boucher B. Vitamin D, obesity, and risk of diabetes. Lancet Diabetes Endocrinol, 2014, 2(5): 361-362.
2.	Sypniewska G, Pollak J, Strozecki P, et al. 25-hydroxyvitamin D, biomarkers of endothelial dysfunction and subclinical organ damage in adults with hypertension. Am J Hypertens, 2014, 27(1): 114-121.
3.	Lu L, Yu Z, Pan A, et al. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care, 2009, 32(7): 1278-1283.
4.	Yin X, Yan L, Lu Y, et al. Correction of hypovitaminosis D does not improve the metabolic syndrome risk profile in a Chinese population: a randomized controlled trial for 1 year. Asia Pac J ClinNutr, 2016, 25(1): 71-717.
5.	中华医学会糖尿病学分会代谢综合征研究协作组. 中华医学会糖尿病学分会关于代谢综合征的建议. 中华糖尿病杂志, 2004, 12(3): 156-1610.
6.	Lu Y, Liu M, Pei Y, et al. Low levels of serum 25-hydroxyvitamin D and risk of metabolic syndrome in China. Int J Clin Exp Med, 2015, 8(8): 13790-13796.
7.	Pham TM, Ekwaru JP, Setayeshgar S, et al. The effect of changing serum 25-hydroxyvitamin d concentrations on metabolic syndrome: a longitudinal analysis of participants of a preventive health program. Nutrients, 2015, 7(9): 7271-7284.
8.	Wood AD, Secombes KR, Thies F, et al. Vitamin D3 supplementation has no effect on conventional cardiovascular risk factors: a parallel-group, double-blind, placebo-controlled RCT. J Clin Endocrinol Metab, 2012, 97(10): 3557-3568.
9.	唐毅, 杨靖, 曹洪义, 等. 成都地区不同年龄城乡妇女维生素D和骨代谢指标及骨密度的状况分析. 中国骨质疏松杂志, 2016, 22(6): 756-7600.
10.	Maki KC, Fulgoni VL 3rd, Keast DR, et al. Vitamin D intake and status are associated with lower prevalence of metabolic syndrome in U.S. adults: National Health and Nutrition Examination Surveys 2003-2006. Metab Syndr Relat Disord, 2012, 10(5): 363-372.
11.	Ju SY, Jeong HS, Kim DH. Blood vitamin D status and metabolic syndrome in the general adult population: a dose-response meta-analysis. J Clin Endocrinol Metab, 2014, 99(3): 1053-1063.
12.	Parker J, Hashmi O, Dutton D, et al. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas, 2010, 65(3): 225-236.
13.	Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care, 2004, 27(12): 2813-2818.
14.	Harris SS, Pittas AG, Palermo NJ. A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans. Diabetes Obes Metab, 2012, 14(9): 789-794.
15.	Mccarty MF, Thomas CA. PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight. Med Hypotheses, 2003, 61(5-6): 535-542.

1. Boucher B. Vitamin D, obesity, and risk of diabetes. Lancet Diabetes Endocrinol, 2014, 2(5): 361-362.
2. Sypniewska G, Pollak J, Strozecki P, et al. 25-hydroxyvitamin D, biomarkers of endothelial dysfunction and subclinical organ damage in adults with hypertension. Am J Hypertens, 2014, 27(1): 114-121.
3. Lu L, Yu Z, Pan A, et al. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care, 2009, 32(7): 1278-1283.
4. Yin X, Yan L, Lu Y, et al. Correction of hypovitaminosis D does not improve the metabolic syndrome risk profile in a Chinese population: a randomized controlled trial for 1 year. Asia Pac J ClinNutr, 2016, 25(1): 71-717.
5. 中华医学会糖尿病学分会代谢综合征研究协作组. 中华医学会糖尿病学分会关于代谢综合征的建议. 中华糖尿病杂志, 2004, 12(3): 156-1610.
6. Lu Y, Liu M, Pei Y, et al. Low levels of serum 25-hydroxyvitamin D and risk of metabolic syndrome in China. Int J Clin Exp Med, 2015, 8(8): 13790-13796.
7. Pham TM, Ekwaru JP, Setayeshgar S, et al. The effect of changing serum 25-hydroxyvitamin d concentrations on metabolic syndrome: a longitudinal analysis of participants of a preventive health program. Nutrients, 2015, 7(9): 7271-7284.
8. Wood AD, Secombes KR, Thies F, et al. Vitamin D3 supplementation has no effect on conventional cardiovascular risk factors: a parallel-group, double-blind, placebo-controlled RCT. J Clin Endocrinol Metab, 2012, 97(10): 3557-3568.
9. 唐毅, 杨靖, 曹洪义, 等. 成都地区不同年龄城乡妇女维生素D和骨代谢指标及骨密度的状况分析. 中国骨质疏松杂志, 2016, 22(6): 756-7600.
10. Maki KC, Fulgoni VL 3rd, Keast DR, et al. Vitamin D intake and status are associated with lower prevalence of metabolic syndrome in U.S. adults: National Health and Nutrition Examination Surveys 2003-2006. Metab Syndr Relat Disord, 2012, 10(5): 363-372.
11. Ju SY, Jeong HS, Kim DH. Blood vitamin D status and metabolic syndrome in the general adult population: a dose-response meta-analysis. J Clin Endocrinol Metab, 2014, 99(3): 1053-1063.
12. Parker J, Hashmi O, Dutton D, et al. Levels of vitamin D and cardiometabolic disorders: systematic review and meta-analysis. Maturitas, 2010, 65(3): 225-236.
13. Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care, 2004, 27(12): 2813-2818.
14. Harris SS, Pittas AG, Palermo NJ. A randomized, placebo-controlled trial of vitamin D supplementation to improve glycaemia in overweight and obese African Americans. Diabetes Obes Metab, 2012, 14(9): 789-794.
15. Mccarty MF, Thomas CA. PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight. Med Hypotheses, 2003, 61(5-6): 535-542.

Chinese Journal of Evidence-Based Medicine

Relationship between vitamin D level and the incidence of metabolic syndrome in adults in Chengdu city: a prospective cohort study

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