The association between long non-coding RNA overexpression and poor prognostic of gastric cancer: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LONG Bo , ZHAN Hao , DU Hengrui , WANG Zhenjiang , GUO Lingyun ,  JIAO Zuoyi

First Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, 730030, P.R.China;

Corresponding author：

JIAO Zuoyi, Email: jiaozx@lzu.edu.com

Keywords：

Long non-coding RNA; Overexpression; Gastric cancer; Association; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.201706081

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectivesTo systematically review the association between the expression level of LncRNA and clinicopathological features and prognostic value of gastric cancer.MethodsWe searched PubMed, EMbase, The Cochrane Library, Web of Science, CNKI, VIP, WanFang Data and CBM databases to collect studies on the association between LncRNA overexpression and prognosis for gastric cancer from inception to April 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using Stata 12.0 software.ResultsA total of 21 case-control studies were included. The results of meta-analysis showed that: LncRNA overexpression patients had poor TNM stage (OR=0.29, 95%CI 0.24 to 0.35, P<0.001), deeper tumor invasion (OR=0.24, 95%CI 0.12 to 0.49,P<0.001), shorter overall survival (OS) (HR=2.52, 95%CI 2.07 to 3.06,P<0.001) and disease-free survival (DFS) (HR=2.31, 95%CI 1.75 to 3.05,P<0.001).ConclusionsLncRNA overexpression is a poor prognosis risk factor for gastric cancer patients. Due to limited quantity and quality of the included studies, more high quality studies are needed to verify above conclusions.

Citation： LONG Bo, ZHAN Hao, DU Hengrui, WANG Zhenjiang, GUO Lingyun, JIAO Zuoyi. The association between long non-coding RNA overexpression and poor prognostic of gastric cancer: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2018, 18(3): 286-293. doi: 10.7507/1672-2531.201706081 Copy

1.	Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin, 2017, 67(1): 7-30.
2.	Niccolai E, Taddei A, Prisco D, et al. Gastric cancer and the epoch of immunotherapy approaches. World J Gastroenterol, 2015, 21(19): 5778-5793.
3.	Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol, 2010, 17(6): 1471-1474.
4.	Marano L, Boccardi V, Braccio B, et al. Comparison of the 6th and 7th editions of the AJCC/UICC TNM staging system for gastric cancer focusing on the "N" parameter-related survival: the monoinstitutional NodUs Italian study. World J Surg Oncol, 2015, 13: 215.
5.	Zhu X, Tian X, Yu C, et al. A long non-coding RNA signature to improve prognosis prediction of gastric cancer. Mol Cancer, 2016, 15(1): 60.
6.	Li PF, Chen SC, Xia T, et al. Non-coding RNAs and gastric cancer. World J Gastroenterol, 2014, 20(18): 5411-5419.
7.	ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature, 2012, 489(7414): 57-74.
8.	Hombach S, Kretz M. Non-coding RNAs: classification, biology and functioning. Adv Exp Med Biol, 2016, 937: 3-17.
9.	Suhail A, Imad M, Tamar S, et al. Possible physiological role of H19 RNA. Mol Carcinogenesis, 2002, 35(2): 63-74.
10.	Michalik KM, You X, Manavski Y, et al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ Res, 2014, 114(9): 1389-1397.
11.	Yang C, Li Z, Li Y, et al. Long non-coding RNA NEAT1 overexpression is associated with poor prognosis in cancer patients: a systematic review and meta-analysis. Oncotarget, 2017, 8(2): 2672-2680.
12.	Jiang C, Li X, Zhao H, et al. Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis. Mol Cancer, 2016, 15(1): 62.
13.	曾明曦, 朱林林, 康长明. 胃癌组织中 LncRNA RP11-513G11.1 的表达及其临床意义. 肿瘤, 2017, (2): 171-176.
14.	Zuo ZK, Gong Y, Chen XH, et al. TGF beta 1-Induced LncRNA UCA1 upregulation promotes gastric cancer invasion and migration. DNA Cell Biol, 2017, 36(2): 159-167.
15.	Liu JN, Shangguan YM. Long non-coding RNA CARLo-5 upregulation associates with poor prognosis in patients suffering gastric cancer. Eur Rev Med Pharmacol Sci, 2017, 21(3): 530-534.
16.	Zou JH, Li CY, Bao J, et al. High expression of long noncoding RNA Sox2ot is associated with the aggressive progression and poor outcome of gastric cancer. Eur Rev Med Pharmacol Sci, 2016, 20(21): 4482-4486.
17.	Zhang Y, Yang R, Lian J, et al. LncRNA Sox2ot overexpression serves as a poor prognostic biomarker in gastric cancer. Am J Transl Res, 2016, 8(11): 5035-5043.
18.	Zhang JJ, Chen JT, Yao KH, et al. Up-regulated expression of long non-coding RNA ZFAS1 associates with aggressive tumor progression and poor prognosis in gastric cancer patients. Int J Clin Exp Pathol, 2016, 9(2): 2059-2063.
19.	Yuan CL, Li H, Zhu L, et al. Aberrant expression of long noncoding RNA PVT1 and its diagnostic and prognostic significance in patients with gastric cancer. Neoplasma, 2016, 63(3): 442-449.
20.	Wang YQ, Zhang QY, Weng WW, et al. Upregulation of the non-coding RNA OTUB1-isoform 2 contributes to gastric cancer cell proliferation and invasion and predicts poor gastric cancer prognosis. Int J Biol Sci, 2016, 12(5): 545-557.
21.	Ma P, Xu T, Huang M, et al. Increased expression of LncRNA PANDAR predicts a poor prognosis in gastric cancer. Biomed Pharmacother, 2016, 78: 172-176.
22.	Jin C, Shi W, Wang F, et al. Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer. Oncotarget, 2016, 7(32): 51763-51772.
23.	Chen SX, Yin JF, Lin BC, et al. Upregulated expression of long noncoding RNA SNHG15 promotes cell proliferation and invasion through regulates MMP2/MMP9 in patients with GC. Tumor Biol, 2016, 37(5): 6801-6812.
24.	Chen JS, Wang YF, Zhang XQ, et al. H19 serves as a diagnostic biomarker and up-regulation of H19 expression contributes to poor prognosis in patients with gastric cancer. Neoplasma, 2016, 63(2): 223-230.
25.	Yang H, Liu Z, Yuan C, et al. Elevated JMJD1A is a novel predictor for prognosis and a potential therapeutic target for gastric cancer. Int J Clin Exp Pathol, 2015, 8(9): 11092-11099.
26.	Wang CY, Hua L, Yao KH, et al. Long non-coding RNA CCAT2 is up-regulated in gastric cancer and associated with poor prognosis. Int J Clin Exp Pathol, 2015, 8(1): 779-785.
27.	Saito T, Kurashige J, Nambara S, et al. A Long Non-coding RNA activated by transforming growth factor-β is an independent prognostic marker of gastric cancer. Ann Surg Oncol, 2015, 22: 915-922.
28.	Peng W, Wu G, Fan H, et al. Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer. Tumor Biol, 2015, 36(9): 6751-6758.
29.	Li L, Zhang L, Zhang Y, et al. Increased expression of LncRNA BANCR is associated with clinical progression and poor prognosis in gastric cancer. Biomed Pharmacother, 2015, 72: 109-112.
30.	Hu Y, Pan J, Wang Y, et al. Long noncoding RNA linc-UBC1 is negative prognostic factor and exhibits tumor pro-oncogenic activity in gastric cancer. Int J Clin Exp Pathol, 2015, 8(1): 594-600.
31.	Chen WM, Huang MD, Kong R, et al. Antisense long noncoding RNA HIF1A-AS2 is upregulated in gastric cancer and associated with poor prognosis. Dig Dis Sci, 2015, 60(6): 1655-1662.
32.	Zhang EB, Han L, Yin DD, et al. c-Myc-induced, long, noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer. Med Oncol, 2014, 31(5): 914.
33.	Liu XH, Sun M, Nie FQ, et al. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer, 2014, 13(1): 92.
34.	周支瑞, 张天嵩, 李博, 等. 生存曲线中 Meta 分析适宜数据的提取与转换. 中国循证心血管医学杂志, 2014, 3(6): 243-247.
35.	Hayden JA, CôTé P, Bombardier C. Evaluation of the quality of prognosis studies in systematic reviews. Ann Intern Med, 2006, 144(6): 427-437.
36.	Ioannidis JPA, Trikalinos TA. The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey. CMAJ, 2007, 176(8): 1091-1096.
37.	张天嵩, 钟文昭. 非参数剪补法在 Stata 中的实现. 循证医学, 2009, 9(4): 240-242.
38.	Wang J, Sun J, Wang J, et al. Long noncoding RNAs in gastric cancer: functions and clinical applications. Onco Targets Ther, 2016, 9(Issue 1): 681.
39.	UA Ø, Shiekhattar R. Long non-coding RNAs and enhancers. Curr Opin Genet Dev, 2011, 21(2): 194-198.
40.	Shao Y, Ye M, Jiang X, et al. Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer. Cancer, 2014, 120(21): 3320.
41.	Arita T, Ichikawa D, Konishi H, et al. Circulating long non-coding RNAs in plasma of patients with gastric cancer. Anticancer Res, 2013, 33(8): 3185-3193.
42.	Yang F, Bi J, Xue X, et al. Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells. FEBS J, 2012, 279(17): 3159-3165.
43.	Liu X, Sun M, Nie F, et al. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer, 2014, 13(1): 92.
44.	Zhao Y, Guo Q, Chen J, et al. Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer: A clinical and in vitro investigation. Oncol Rep, 2014, 31(1): 358-364.

1. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin, 2017, 67(1): 7-30.
2. Niccolai E, Taddei A, Prisco D, et al. Gastric cancer and the epoch of immunotherapy approaches. World J Gastroenterol, 2015, 21(19): 5778-5793.
3. Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol, 2010, 17(6): 1471-1474.
4. Marano L, Boccardi V, Braccio B, et al. Comparison of the 6th and 7th editions of the AJCC/UICC TNM staging system for gastric cancer focusing on the "N" parameter-related survival: the monoinstitutional NodUs Italian study. World J Surg Oncol, 2015, 13: 215.
5. Zhu X, Tian X, Yu C, et al. A long non-coding RNA signature to improve prognosis prediction of gastric cancer. Mol Cancer, 2016, 15(1): 60.
6. Li PF, Chen SC, Xia T, et al. Non-coding RNAs and gastric cancer. World J Gastroenterol, 2014, 20(18): 5411-5419.
7. ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature, 2012, 489(7414): 57-74.
8. Hombach S, Kretz M. Non-coding RNAs: classification, biology and functioning. Adv Exp Med Biol, 2016, 937: 3-17.
9. Suhail A, Imad M, Tamar S, et al. Possible physiological role of H19 RNA. Mol Carcinogenesis, 2002, 35(2): 63-74.
10. Michalik KM, You X, Manavski Y, et al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ Res, 2014, 114(9): 1389-1397.
11. Yang C, Li Z, Li Y, et al. Long non-coding RNA NEAT1 overexpression is associated with poor prognosis in cancer patients: a systematic review and meta-analysis. Oncotarget, 2017, 8(2): 2672-2680.
12. Jiang C, Li X, Zhao H, et al. Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis. Mol Cancer, 2016, 15(1): 62.
13. 曾明曦, 朱林林, 康长明. 胃癌组织中 LncRNA RP11-513G11.1 的表达及其临床意义. 肿瘤, 2017, (2): 171-176.
14. Zuo ZK, Gong Y, Chen XH, et al. TGF beta 1-Induced LncRNA UCA1 upregulation promotes gastric cancer invasion and migration. DNA Cell Biol, 2017, 36(2): 159-167.
15. Liu JN, Shangguan YM. Long non-coding RNA CARLo-5 upregulation associates with poor prognosis in patients suffering gastric cancer. Eur Rev Med Pharmacol Sci, 2017, 21(3): 530-534.
16. Zou JH, Li CY, Bao J, et al. High expression of long noncoding RNA Sox2ot is associated with the aggressive progression and poor outcome of gastric cancer. Eur Rev Med Pharmacol Sci, 2016, 20(21): 4482-4486.
17. Zhang Y, Yang R, Lian J, et al. LncRNA Sox2ot overexpression serves as a poor prognostic biomarker in gastric cancer. Am J Transl Res, 2016, 8(11): 5035-5043.
18. Zhang JJ, Chen JT, Yao KH, et al. Up-regulated expression of long non-coding RNA ZFAS1 associates with aggressive tumor progression and poor prognosis in gastric cancer patients. Int J Clin Exp Pathol, 2016, 9(2): 2059-2063.
19. Yuan CL, Li H, Zhu L, et al. Aberrant expression of long noncoding RNA PVT1 and its diagnostic and prognostic significance in patients with gastric cancer. Neoplasma, 2016, 63(3): 442-449.
20. Wang YQ, Zhang QY, Weng WW, et al. Upregulation of the non-coding RNA OTUB1-isoform 2 contributes to gastric cancer cell proliferation and invasion and predicts poor gastric cancer prognosis. Int J Biol Sci, 2016, 12(5): 545-557.
21. Ma P, Xu T, Huang M, et al. Increased expression of LncRNA PANDAR predicts a poor prognosis in gastric cancer. Biomed Pharmacother, 2016, 78: 172-176.
22. Jin C, Shi W, Wang F, et al. Long non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancer. Oncotarget, 2016, 7(32): 51763-51772.
23. Chen SX, Yin JF, Lin BC, et al. Upregulated expression of long noncoding RNA SNHG15 promotes cell proliferation and invasion through regulates MMP2/MMP9 in patients with GC. Tumor Biol, 2016, 37(5): 6801-6812.
24. Chen JS, Wang YF, Zhang XQ, et al. H19 serves as a diagnostic biomarker and up-regulation of H19 expression contributes to poor prognosis in patients with gastric cancer. Neoplasma, 2016, 63(2): 223-230.
25. Yang H, Liu Z, Yuan C, et al. Elevated JMJD1A is a novel predictor for prognosis and a potential therapeutic target for gastric cancer. Int J Clin Exp Pathol, 2015, 8(9): 11092-11099.
26. Wang CY, Hua L, Yao KH, et al. Long non-coding RNA CCAT2 is up-regulated in gastric cancer and associated with poor prognosis. Int J Clin Exp Pathol, 2015, 8(1): 779-785.
27. Saito T, Kurashige J, Nambara S, et al. A Long Non-coding RNA activated by transforming growth factor-β is an independent prognostic marker of gastric cancer. Ann Surg Oncol, 2015, 22: 915-922.
28. Peng W, Wu G, Fan H, et al. Long noncoding RNA SPRY4-IT1 predicts poor patient prognosis and promotes tumorigenesis in gastric cancer. Tumor Biol, 2015, 36(9): 6751-6758.
29. Li L, Zhang L, Zhang Y, et al. Increased expression of LncRNA BANCR is associated with clinical progression and poor prognosis in gastric cancer. Biomed Pharmacother, 2015, 72: 109-112.
30. Hu Y, Pan J, Wang Y, et al. Long noncoding RNA linc-UBC1 is negative prognostic factor and exhibits tumor pro-oncogenic activity in gastric cancer. Int J Clin Exp Pathol, 2015, 8(1): 594-600.
31. Chen WM, Huang MD, Kong R, et al. Antisense long noncoding RNA HIF1A-AS2 is upregulated in gastric cancer and associated with poor prognosis. Dig Dis Sci, 2015, 60(6): 1655-1662.
32. Zhang EB, Han L, Yin DD, et al. c-Myc-induced, long, noncoding H19 affects cell proliferation and predicts a poor prognosis in patients with gastric cancer. Med Oncol, 2014, 31(5): 914.
33. Liu XH, Sun M, Nie FQ, et al. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer, 2014, 13(1): 92.
34. 周支瑞, 张天嵩, 李博, 等. 生存曲线中 Meta 分析适宜数据的提取与转换. 中国循证心血管医学杂志, 2014, 3(6): 243-247.
35. Hayden JA, CôTé P, Bombardier C. Evaluation of the quality of prognosis studies in systematic reviews. Ann Intern Med, 2006, 144(6): 427-437.
36. Ioannidis JPA, Trikalinos TA. The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey. CMAJ, 2007, 176(8): 1091-1096.
37. 张天嵩, 钟文昭. 非参数剪补法在 Stata 中的实现. 循证医学, 2009, 9(4): 240-242.
38. Wang J, Sun J, Wang J, et al. Long noncoding RNAs in gastric cancer: functions and clinical applications. Onco Targets Ther, 2016, 9(Issue 1): 681.
39. UA Ø, Shiekhattar R. Long non-coding RNAs and enhancers. Curr Opin Genet Dev, 2011, 21(2): 194-198.
40. Shao Y, Ye M, Jiang X, et al. Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer. Cancer, 2014, 120(21): 3320.
41. Arita T, Ichikawa D, Konishi H, et al. Circulating long non-coding RNAs in plasma of patients with gastric cancer. Anticancer Res, 2013, 33(8): 3185-3193.
42. Yang F, Bi J, Xue X, et al. Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells. FEBS J, 2012, 279(17): 3159-3165.
43. Liu X, Sun M, Nie F, et al. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer, 2014, 13(1): 92.
44. Zhao Y, Guo Q, Chen J, et al. Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer: A clinical and in vitro investigation. Oncol Rep, 2014, 31(1): 358-364.

Previous Article
Prevalence rate of gestational diabetes mellitus in China: a meta-analysis
Next Article
The participation of pharmacists in clinical pathways: a systematic review

Chinese Journal of Evidence-Based Medicine

The association between long non-coding RNA overexpression and poor prognostic of gastric cancer: a meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content