SHAO Minmin 1 , HU Jiangwen 1 , XIANG Songjie 2 , CHEN Chaowei 1 , XIONG Guofeng 1 , WU Aimin 3 , CHEN Bobei 2
  • 1. Department of Otorhinolaryngology, Affiliated Dingli Hospital of Wenzhou Medical University and Wenzhou Central Hospital, Wenzhou, 325000, P.R.China;
  • 2. Department of Otorhinolaryngology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, P.R.China;
  • 3. Clinical Research Center, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, P.R.China;
CHEN Bobei, Email: wzbobei@126.com
Idiopathic sudden sensorineural hearing loss; Total cholesterol; Prognosis factor; Prospective cohort study
10.7507/1672-2531.201708030
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Objectives  To investigate the correlation between blood total cholesterol (TC) and prognosis of idiopathic sudden sensorineural hearing loss (ISSNHL) and to provide references for clinical treatment and prognosis assessment. Methods  We included 232 ISSNHL patients with total deafness in Wenzhou Central Hospital from June 2015 to March 2017 using a prospective cohort design. Recording information including age, gender, hypertension, diabetes mellitus, vertigo, level of blood total cholesterol (TC), level of triglyceride (TG), level of low-density lipoprotein (LDL-C) and LDL/HDL ratio (LDL-C/HDL-C) were collected. Correlation between the prognosis of ISSNHL and blood total cholesterol were analyzed by univariable and multivariable logistic regression analysis. Results  The clinical effective rate of patients with TC ranging from 5.2 mmol/L to 6.2 mmol/L was higher than that of patients with TC lower than 5.2 mmol/L (univariable: RR=6.49, 95%CI 3.16 to 13.30, P<0.001; multivariable-adjusted covariates: RR=6.15, 95%CI 2.66 to 14.3,P<0.001) with significant difference. No significant difference was found between patients with TC lower than 5.2 mmol/L and patients with TC higher than 6.2 mmol/L (univariable: RR=1.02, 95%CI 0.52 to 2.00,P=0.960; multivariable-adjusted covariates: RR=1.61, 95%CI 0.55 to 4.73, P=0.386). Gender-specific analysis showed for both male and female groups, the effective rates of patients with TC ranging from 5.2 mmol/L to 6.2 mmol/L were significantly higher than those of patients with TC lower than 5.2 mmol/L. There was no significant difference between patients with TC lower than 5.2 mmol/L and patients with TC higher than 6.2 mmol/L (P>0.05) in either male group or female group. Conclusion  The current study suggests that patients with levels of TC ranging from 5.2 mmol/L to 6.2 mmol/L predicts the best prognosis.

Citation： SHAO Minmin, HU Jiangwen, XIANG Songjie, CHEN Chaowei, XIONG Guofeng, WU Aimin, CHEN Bobei. Correlation between serum total cholesterol and prognosis of idiopathic sudden sensorineural hearing loss: a prospective cohort study. Chinese Journal of Evidence-Based Medicine, 2018, 18(1): 8-12. doi: 10.7507/1672-2531.201708030 Copy

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