The association between levels of serum leptin and hepatitis C virus: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

ZHANG Qiongyuan ¹ , XU Xuan ² , LUO Mei ² , ZUO Guowei ³ ,  XUE Jianjiang ¹ ,  QIU Jingfu ²

1. Department of Clinical Laboratory, the University Town Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, P.R. China;
2. School of Public Health and Management, Chongqing Medical University, Chongqing, 400016, P.R. China;
3. School of LabMed, Chongqing Medical University, Chongqing, 400016, P.R. China;

Corresponding author：

XUE Jianjiang, Email: jianjiangxue@126.com; QIU Jingfu, Email: jfqiu@126.com

Keywords：

Serum leptin; Hepatitis C; Systematic review; Meta-analysis; Case-control study

DOI：

10.7507/1672-2531.201709036

Video：

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ObjectivesTo systematically review the association between serum leptin level and hepatitis C virus.MethodPubMed, EMbase, Web of Science, CNKI, CBM, VIP and WanFang Data databases were electronically searched to collect case-control studies on the association between serum leptin level and hepatitis C virus from 2007 to July, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed by using RevMan 5.3 software.ResultsA total of 11 studies including 1 115 patients were included. The results of meta-analysis showed the serum leptin level was higher in hepatitis C patients than in healthy people (SMD=0.68, 95%CI 0.44 to 0.91, P<0.000 01). The results of subgroup analysis showed that, in hepatitis C patients whose serum leptin levels detected by RIA and European population, serum leptin levels were higher. Women had higher serum leptin levels than men in hepatitis C virus patients (P<0.000 01).ConclusionThe serum leptin level is associated with hepatitis C virus and the serum leptin levels of women are higher than those in men. Due to limited quantity and quality of the included studies, more high quality studies are required to verify above conclusions.

Citation： ZHANG Qiongyuan, XU Xuan, LUO Mei, ZUO Guowei, XUE Jianjiang, QIU Jingfu. The association between levels of serum leptin and hepatitis C virus: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2018, 18(4): 359-364. doi: 10.7507/1672-2531.201709036 Copy

1.	Choo QL, Kuo G, Weiner AJ, et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science, 1989, 244(4902): 359-362.
2.	Hepatitis C Council of NSW. Hepatitis C: fact sheet. N S W Public Health Bull, 2000, 11(4): 63-64.
3.	Fassio E. Hepatitis C and hepatocellular carcinoma. Ann Hepatol, 2010, 9(Suppl): 119-122.
4.	Lavanchy D. Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect, 2011, 17(2): 107-115.
5.	Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature, 1998, 395(6704): 763-770.
6.	Mantzoros CS, Magkos F, Brinkoetter M, et al. Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab, 2011, 301(4): E567-584.
7.	Kelesidis T, Kelesidis I, Chou S, et al. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med, 2010, 152(2): 93-100.
8.	Kukla M, Mazur W, Buldak RJ, et al. Potential role of leptin, adiponectin and three novel adipokines-visfatin, chemerin and vaspin-in chronic hepatitis. Mol Med, 2011, 17(11-12): 1397-1410.
9.	Ding X, Saxena NK, Lin S, et al. The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Pathol, 2005, 166(6): 1655-1669.
10.	Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
11.	Abdel-Razik A, Mousa N, Abdel-Aziz M, et al. Elevated serum alpha-fetoprotein levels in patients with chronic hepatitis C virus genotype 4: not the end of the story. Eur J Gastroenterol Hepatol, 2016, 28(3): 313-322.
12.	Anty R, Marjoux S, Bekri S, et al. Plasma carnitine is associated with fatigue in chronic hepatitis C but not in the irritable bowel syndrome. Aliment Pharmacol Ther, 2011, 33(8): 961-968.
13.	El-Gindy EM, Ali-Eldin FA, Meguid MA. Serum leptin level and its association with fatigue in patients with chronic hepatitis C virus infection. Arab J Gastroenterol, 2012, 13(2): 54-57.
14.	Gonzalez-Reimers E, Lopez-Prieto J, Quintero-Platt G, et al. Adipokines, cytokines and body fat stores in hepatitis C virus liver steatosis. World J Hepatol, 2016, 8(1): 74-82.
15.	Khattab MA, Eslam M, Aly MM, et al. Association of serum adipocytokines with insulin resistance and liver injury in patients with chronic hepatitis C genotype 4. J Clin Gastroenterol, 2012, 46(10): 871-879.
16.	Tiftikci A, Atug O, Yilmaz Y, et al. Serum levels of adipokines in patients with chronic HCV infection: relationship with steatosis and fibrosis. Arch Med Res, 2009, 40(4): 294-298.
17.	付小国, 蒋文姣, 秦加巍, 等. 血清瘦素水平、白细胞介素 6 和 ALT 联合检测在丙型肝炎患者中临床意义. 临床与检验, 2009, 30(7): 703-704.
18.	卢莺燕, 王伟, 周林福, 等. 血清瘦素水平在评估慢性病毒性肝炎肝纤维化程度中的意义. 浙江医学, 2013, 35(12): 1150-1152.
19.	孙树红, 兰翠霞, 孙冰梅, 等. 病毒性肝炎及脂肪肝患者血清瘦素的测定. 标记免疫分析与临床, 2007, 14(2): 65-67, 75.
20.	宋皆金, 周国平. 慢性丙型肝炎患者血清 leptin 含量与 HA、PⅢP 水平的相关分析. 放射免疫学杂志, 2008, 21(3): 217-219.
21.	张仙森, 方年, 张欣. 血清瘦素水平和外周血 B 细胞及 T 细胞亚群水平与丙型肝炎致肝功能损害的相关性. 临床医学, 2008, 28(3): 114-115.
22.	Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol, 2005, 115(5): 911-919, 920.
23.	Hajri T, Gharib M, Kaul S, et al. Association between adipokines and critical illness outcomes. J Trauma Acute Care Surg, 2017, 83(3): 507-519.
24.	Cao D, Cai C, Ye M, et al. Differential metabonomic profiles of primary hepatocellular carcinoma tumors from alcoholic liver disease, HBV-infected, and HCV-infected cirrhotic patients. Oncotarget, 2017, 8(32): 53313-53325.
25.	Chang ML, Hsu CM, Tseng JH, et al. Plasminogen activator inhibitor-1 is independently associated with non-alcoholic fatty liver disease whereas leptin and adiponectin vary between genders. J Gastroenterol Hepatol, 2015, 30(2): 329-336.
26.	Jackson AS, Stanforth PR, Gagnon J, et al. The effect of sex, age and race on estimating percentage body fat from body mass index: the heritage family study. Int J Obes Relat Metab Disord, 2002, 26(6): 789-796.
27.	Mabry-Hernandez I, Blackmer S. Screening for hepatitis C virus infection in adults. Am Fam Physician, 2014, 90(6): 405-406.
28.	Jiang S, Song K, Feng S, et al. Association between serum leptin levels and peritoneal dialysis: a meta-analysis. Exp Ther Med, 2015, 10(1): 300-308.

1. Choo QL, Kuo G, Weiner AJ, et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science, 1989, 244(4902): 359-362.
2. Hepatitis C Council of NSW. Hepatitis C: fact sheet. N S W Public Health Bull, 2000, 11(4): 63-64.
3. Fassio E. Hepatitis C and hepatocellular carcinoma. Ann Hepatol, 2010, 9(Suppl): 119-122.
4. Lavanchy D. Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect, 2011, 17(2): 107-115.
5. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature, 1998, 395(6704): 763-770.
6. Mantzoros CS, Magkos F, Brinkoetter M, et al. Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab, 2011, 301(4): E567-584.
7. Kelesidis T, Kelesidis I, Chou S, et al. Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med, 2010, 152(2): 93-100.
8. Kukla M, Mazur W, Buldak RJ, et al. Potential role of leptin, adiponectin and three novel adipokines-visfatin, chemerin and vaspin-in chronic hepatitis. Mol Med, 2011, 17(11-12): 1397-1410.
9. Ding X, Saxena NK, Lin S, et al. The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Pathol, 2005, 166(6): 1655-1669.
10. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
11. Abdel-Razik A, Mousa N, Abdel-Aziz M, et al. Elevated serum alpha-fetoprotein levels in patients with chronic hepatitis C virus genotype 4: not the end of the story. Eur J Gastroenterol Hepatol, 2016, 28(3): 313-322.
12. Anty R, Marjoux S, Bekri S, et al. Plasma carnitine is associated with fatigue in chronic hepatitis C but not in the irritable bowel syndrome. Aliment Pharmacol Ther, 2011, 33(8): 961-968.
13. El-Gindy EM, Ali-Eldin FA, Meguid MA. Serum leptin level and its association with fatigue in patients with chronic hepatitis C virus infection. Arab J Gastroenterol, 2012, 13(2): 54-57.
14. Gonzalez-Reimers E, Lopez-Prieto J, Quintero-Platt G, et al. Adipokines, cytokines and body fat stores in hepatitis C virus liver steatosis. World J Hepatol, 2016, 8(1): 74-82.
15. Khattab MA, Eslam M, Aly MM, et al. Association of serum adipocytokines with insulin resistance and liver injury in patients with chronic hepatitis C genotype 4. J Clin Gastroenterol, 2012, 46(10): 871-879.
16. Tiftikci A, Atug O, Yilmaz Y, et al. Serum levels of adipokines in patients with chronic HCV infection: relationship with steatosis and fibrosis. Arch Med Res, 2009, 40(4): 294-298.
17. 付小国, 蒋文姣, 秦加巍, 等. 血清瘦素水平、白细胞介素 6 和 ALT 联合检测在丙型肝炎患者中临床意义. 临床与检验, 2009, 30(7): 703-704.
18. 卢莺燕, 王伟, 周林福, 等. 血清瘦素水平在评估慢性病毒性肝炎肝纤维化程度中的意义. 浙江医学, 2013, 35(12): 1150-1152.
19. 孙树红, 兰翠霞, 孙冰梅, 等. 病毒性肝炎及脂肪肝患者血清瘦素的测定. 标记免疫分析与临床, 2007, 14(2): 65-67, 75.
20. 宋皆金, 周国平. 慢性丙型肝炎患者血清 leptin 含量与 HA、PⅢP 水平的相关分析. 放射免疫学杂志, 2008, 21(3): 217-219.
21. 张仙森, 方年, 张欣. 血清瘦素水平和外周血 B 细胞及 T 细胞亚群水平与丙型肝炎致肝功能损害的相关性. 临床医学, 2008, 28(3): 114-115.
22. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol, 2005, 115(5): 911-919, 920.
23. Hajri T, Gharib M, Kaul S, et al. Association between adipokines and critical illness outcomes. J Trauma Acute Care Surg, 2017, 83(3): 507-519.
24. Cao D, Cai C, Ye M, et al. Differential metabonomic profiles of primary hepatocellular carcinoma tumors from alcoholic liver disease, HBV-infected, and HCV-infected cirrhotic patients. Oncotarget, 2017, 8(32): 53313-53325.
25. Chang ML, Hsu CM, Tseng JH, et al. Plasminogen activator inhibitor-1 is independently associated with non-alcoholic fatty liver disease whereas leptin and adiponectin vary between genders. J Gastroenterol Hepatol, 2015, 30(2): 329-336.
26. Jackson AS, Stanforth PR, Gagnon J, et al. The effect of sex, age and race on estimating percentage body fat from body mass index: the heritage family study. Int J Obes Relat Metab Disord, 2002, 26(6): 789-796.
27. Mabry-Hernandez I, Blackmer S. Screening for hepatitis C virus infection in adults. Am Fam Physician, 2014, 90(6): 405-406.
28. Jiang S, Song K, Feng S, et al. Association between serum leptin levels and peritoneal dialysis: a meta-analysis. Exp Ther Med, 2015, 10(1): 300-308.

Chinese Journal of Evidence-Based Medicine

The association between levels of serum leptin and hepatitis C virus: a meta-analysis

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