The distribution and drug-resistance of <i>pseudomonas aeruginosa</i> in Fuwai Hospital of Chinese Academy of Medical Sciences from 2013 to 2016 _Chinese Journal of Evidence-Based Medicine

Authors：

CHENG Jun ¹ , GENG Jie ¹ , LI Feng ¹ , ZHANG Siming ¹ , GAO Xiaojing ¹ , ZHANG Yanbo ² ,  WANG Feiyan ¹

1. Clinical Laboratory Center, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, 100037, P.R.China;
2. ICU of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, 100037, P.R.China;

Corresponding author：

WANG Feiyan, Email: wang_feiyanfw@sina.com

Keywords：

Cardiovascular disease; Pseudomonas aeruginosa; Drug-resistance; Antibiotics

DOI：

10.7507/1672-2531.201712006

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objectives To retrospectively analyze the isolation rate and drug-resistance of pseudomonas aeruginosa in Fuwai Hospital of Chinese Academy of Medical Sciences from 2013 to 2016. Methods The specimens were collected and cultured. If the isolated bacteria were from the same part of the same patient, the first isolated strains were only counted. The isolated pathogens were identified and the drug-resistance were analyzed. Results A total of 1 404 pseudomonas aeruginosa were isolated. The majority of them were from postoperative recovery room of surgery department (62.1%) and ICU of internal medicine (22.3%). The specimen source were mainly from respiratory tract (75.7%), followed by blood (10.0%) and venous catheter (5.5%). The resistance rate of piperacillin and piperacillin/sulbactam to pseudomonas aeruginosa was 0.6% to 10.4%. The resistance rate of ceftazidime and cefepime was 0.3% to 11.7%. The resistance rate of imipenem and meropenem was 7.6% to 20.1%. The resistance rate of amikacin, gentamicin, and tobramycin was 0.3% to 3.2%. The resistance rate of ciprofloxacin and levofloxacin was 0.6% to 5.2%. Conclusions The isolates of pseudomonas aeruginosa are mainly from postoperative recovery room of surgery department and ICU of internal medicine . Imipenem and meropenem are not the best choices for pseudomonas aeruginosa infection. It has great value to combine piperacillin, piperacillin/sulbactam, ceftazidime and cefepime with aminoglycoside or quinolone antibiotics for the treatment of pseudomonas aeruginosa infection which will reduce drug resistance.

Citation： CHENG Jun, GENG Jie, LI Feng, ZHANG Siming, GAO Xiaojing, ZHANG Yanbo, WANG Feiyan. The distribution and drug-resistance of pseudomonas aeruginosa in Fuwai Hospital of Chinese Academy of Medical Sciences from 2013 to 2016 . Chinese Journal of Evidence-Based Medicine, 2018, 18(5): 450-453. doi: 10.7507/1672-2531.201712006 Copy

1.	Mocanu V, Buth KJ, Johnston LB, et al. Importance of continued quality improvement efforts in monitoring hospital-acquired infection rates: a cardiac surgery experience. Ann Thorac Surg, 2015, 99(6): 2061-2069.
2.	Tago S, Hirai Y, Ainoda Y, et al. Gram-negative rod bacteremia after cardiovascular surgery: Clinical features and prognostic factors. J Microbiol Immunol Infect, 2017, 50(3): 333-338.
3.	Sonmezer MC, Ertem G, Erdinc FS, et al. Evaluation of Risk Factors for Antibiotic Resistance in Patients with Nosocomial Infections Caused by Pseudomonas aeruginosa. Can J Infect Dis Med Microbiol, 2016, 2016: 1321487.
4.	中华医学会呼吸病学分会感染学组. 铜绿假单胞菌下呼吸道感染诊治专家共识. 中华结核和呼吸杂志, 2014, 37(1): 9-15.
5.	汪复, 朱德妹, 胡付品, 等. 2012 年中国 CHINET 细菌耐药性监测. 中国感染与化疗杂志, 2013, 13(5): 321-330.
6.	胡付品, 朱德妹, 汪复, 等. 2013 年中国 CHINET 细菌耐药性监测. 中国感染与化疗杂志, 2014, 14(5): 365-374.
7.	胡付品, 朱德妹, 汪复, 等. 2014 年 CHINET 中国细菌耐药性监测. 中国感染与化疗杂志, 2015, 15(5): 401-410.
8.	生伟, 池一凡, 侯文明, 等. 心脏直视术后呼吸机相关性肺炎的临床分析. 中华心血管病杂志, 2012, 40(10): 825-829.
9.	王昌明, 王晨, 何宗广, 等. 铜绿假单胞菌致呼吸机相关性肺炎的临床分析. 中华医院感染学杂志, 2011, 21(2): 376-378.
10.	韩江, 章可谓, 葛丹枫. 医院感染呼吸机相关肺炎及致病菌调查. 中国消毒学杂志, 2012, 29(1): 69-70.
11.	胡晓红, 邓敏, 史嘉玮. 心血管外科 ICU66 例心脏移植患者医院感染发病率. 中国感染控制杂志, 2016, 15(8): 552-555.

1. Mocanu V, Buth KJ, Johnston LB, et al. Importance of continued quality improvement efforts in monitoring hospital-acquired infection rates: a cardiac surgery experience. Ann Thorac Surg, 2015, 99(6): 2061-2069.
2. Tago S, Hirai Y, Ainoda Y, et al. Gram-negative rod bacteremia after cardiovascular surgery: Clinical features and prognostic factors. J Microbiol Immunol Infect, 2017, 50(3): 333-338.
3. Sonmezer MC, Ertem G, Erdinc FS, et al. Evaluation of Risk Factors for Antibiotic Resistance in Patients with Nosocomial Infections Caused by Pseudomonas aeruginosa. Can J Infect Dis Med Microbiol, 2016, 2016: 1321487.
4. 中华医学会呼吸病学分会感染学组. 铜绿假单胞菌下呼吸道感染诊治专家共识. 中华结核和呼吸杂志, 2014, 37(1): 9-15.
5. 汪复, 朱德妹, 胡付品, 等. 2012 年中国 CHINET 细菌耐药性监测. 中国感染与化疗杂志, 2013, 13(5): 321-330.
6. 胡付品, 朱德妹, 汪复, 等. 2013 年中国 CHINET 细菌耐药性监测. 中国感染与化疗杂志, 2014, 14(5): 365-374.
7. 胡付品, 朱德妹, 汪复, 等. 2014 年 CHINET 中国细菌耐药性监测. 中国感染与化疗杂志, 2015, 15(5): 401-410.
8. 生伟, 池一凡, 侯文明, 等. 心脏直视术后呼吸机相关性肺炎的临床分析. 中华心血管病杂志, 2012, 40(10): 825-829.
9. 王昌明, 王晨, 何宗广, 等. 铜绿假单胞菌致呼吸机相关性肺炎的临床分析. 中华医院感染学杂志, 2011, 21(2): 376-378.
10. 韩江, 章可谓, 葛丹枫. 医院感染呼吸机相关肺炎及致病菌调查. 中国消毒学杂志, 2012, 29(1): 69-70.
11. 胡晓红, 邓敏, 史嘉玮. 心血管外科 ICU66 例心脏移植患者医院感染发病率. 中国感染控制杂志, 2016, 15(8): 552-555.

Chinese Journal of Evidence-Based Medicine

The distribution and drug-resistance of pseudomonas aeruginosa in Fuwai Hospital of Chinese Academy of Medical Sciences from 2013 to 2016

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content