Prevalence and disease burden of knee osteoarthritis in China: a systematic review_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Bin ¹ ^# , XING Dan ² ^# , DONG Shengjie ³ , TIE Ruxiu ⁴ , ZHANG Zhiqiang ¹ ,  LIN Jianhao ² ,  WEI Xiaochun ¹

1. Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, P.R.China;
2. Arthritis Clinic & Research Center, Peking University People’s Hospital, Peking University, Beijing, 100044, P.R.China;
3. Department of Orthopaedics, Yantaishan Hospital, Yantai, 264025, P.R.China;
4. Department of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan, 030001, P.R.China;

Corresponding author：

LIN Jianhao, Email: linjianhao@pkuph.edu.cn; WEI Xiaochun, Email: weixiaochun11@126.com

Keywords：

Knee osteoarthritis; Prevalence; Quality of life; Disease burden; Cross-sectional study; Systematic review

DOI：

10.7507/1672-2531.201712031

Video：

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ObjectivesTo systematically review the prevalence and disease burden of knee osteoarthritis (KOA) in China.MethodsPubMed, EMbase, CNKI, WanFang Data and VIP databases were searched to collect cross-sectional studies about the prevalence and disease burden of KOA in China from January 1^st 1995 to August 31^st 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then meta-analysis was performed by using R statistical software.ResultsA total of thirty-three studies were included. The results of meta-analysis showed the prevalance rate of KOA was 18% (95%CI 14% to 22%), and it was higher in women (19%, 95%CI 16% to 23%) than in men (11%, 95%CI 9% to 13%) (P<0.05). The prevalence rates of KOA in different regions were as follows: 11% (95%CI 8% to 14%) in north, 17% (95%CI 15% to 20%) in north-east, 21% (95%CI 13% to 32%) in east, 21% (95%CI 13% to 33%) in north-west, 22% (95%CI 6% to 57%) in south-west, and 18% (95%CI 13% to 23%) in south-central, respectively.ConclusionsThe prevalence of KOA in China is high, and the disease burden is heavy. Due to the quantity and quality of included studies, more high-quality studies are required to verify the above conclusions in future.

Citation： WANG Bin, XING Dan, DONG Shengjie, TIE Ruxiu, ZHANG Zhiqiang, LIN Jianhao, WEI Xiaochun. Prevalence and disease burden of knee osteoarthritis in China: a systematic review. Chinese Journal of Evidence-Based Medicine, 2018, 18(2): 134-142. doi: 10.7507/1672-2531.201712031 Copy

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1. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ, 2003, 81(9): 646-656.
2. Hunter DJ, Schofield D, Callander E. The individual and socioeconomic impact of osteoarthritis. Nat Rev Rheumatol, 2014, 10(7): 437-441.
3. 曾小峰, 朱松林, 谭爱春, 等. 我国类风湿关节炎疾病负担和生存质量研究的系统评价. 中国循证医学杂志, 2013, 13(3): 300-307.
4. 周波, 陈欣, 时景璞, 等. 率的 Meta 分析及软件实现. 中国循证医学杂志, 2014, 14(8): 1009-1016.
5. 张乃峥, 施全胜, 张雪哲, 等. 膝骨关节炎的流行病学调查. 中华内科杂志, 1995, 15(2): 84-87.
6. Zhang Y, Xu L, Nevitt MC, et al. Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: the beijing osteoarthritis study. Arthritis Rheum, 2001, 44(9): 2065-2071.
7. 顾斌, 朱秀龙, 张美花, 等. 上海市郊区老年人膝关节骨关节炎现患调查. 中国全科医学, 2011, 34(29): 3374-3376.
8. 顾明士, 杨军, 金哲峰, 等. 社区中老年人膝骨关节炎发病趋势的分析. 中医药临床杂志, 2005, 3(5): 246-247.
9. Du H, Chen S, Bao C, et al. Prevalence and risk factors of knee osteoarthritis in Huang-Pu District, Shanghai, China. Rheumatol Int, 2005, 25(8): 585-590.
10. 臧长海, 曾庆馀, 李小峰, 等. 太原市膝骨关节炎的流行病学研究. 中华内科杂志, 2006, 45(7): 533-536.
11. 张建新, 王和鸣, 吴超英, 等. 泉州市中老年人退行性膝骨关节炎的流行病学调查. 中国中医骨伤科杂志, 2007, 15(2): 4-5.
12. 李宁华, 张耀南, 张毅, 等. 国内六大行政区域六城市中老年人群膝关节骨性关节炎患病危险因素比较. 中国组织工程研究与临床康复, 2007, 11(39): 7758-7760.
13. 王伟, 王坤正, 党小谦, 等. 中老年膝骨关节炎发病的相关因素. 中国临床康复, 2006, 10(44): 15-18.
14. 李立强. 上海市中心城区老年人膝关节骨关节炎流行病学调查. 黑龙江医药, 2007, 20(4): 347-348.
15. 荣杰生, 陶天遵, 陶树清, 等. 高寒地区城市汉族人群膝骨关节炎情况调查. 中国骨质疏松杂志, 2007, 13(10): 723-726.
16. 颜贻站, 曾云记, 谢作完, 等. 农村 50 岁以上 5 016 人退行性膝关节病流行病学调查. 浙江中西医结合杂志, 2007, 17(7): 422, 456.
17. 高靖宇, 景建刚, 赵小明, 等. 山西阳泉农村地区膝骨关节炎流行病学调查. 山西医药杂志, 2008, 37(7): 621-623.
18. 王永斌, 宋志红, 阮玉琦, 等. 上海市奉贤区农村中老年人骨关节炎流行病学调查. 中国全科医学, 2008, 11(5A): 785-788.
19. Kang X, Fransen M, Zhang Y, et al. The high prevalence of knee osteoarthritis in a rural Chinese population: the wuchuan osteoarthritis study. Arthritis Rheum, 2009, 61(5): 641-647.
20. 杨静, 孙官军, 裴福兴, 等. 四川省部分地区汉族中老年人骨关节炎的流行病学研究. 中国骨与关节损伤杂志, 2010, 25(8): 693-696.
21. 苏阳, 朱志刚, 蔡裕兴, 等. 广州地区中老年人症状性膝关节骨关节炎流行病学的调查研究. 中华关节外科杂志(电子版), 2010, 4(4): 438-444.
22. 曾勤, 蔡立民, 朱玉霞, 等. 东莞市社区居民症状性膝关节骨性关节炎患病情况调查. 新中医, 2011, 43(8): 70-71.
23. Jiang L, Rong J, Zhang Q, et al. Prevalence and associated factors of knee osteoarthritis in a community-based population in Heilongjiang, Northeast China. Rheumatol Int, 2012, 32(5): 1189-1195.
24. 仇立春, 冒四平. 兵团四师昭苏垦区中老年膝关节骨性关节炎现状普查及影响因素分析. 兵团医学, 2013, 38(4): 7-8.
25. 王蕾, 卢慧茹, 王健, 等. 天津市老年人膝关节骨关节炎流行病学调查. 中华老年医学杂志, 2012, 31(5): 438-440.
26. 黄洪容. 我国社区中老年人膝骨关节炎的发病趋势分析. 当代医学, 2012, 18(12): 59-60.
27. 孙红, 田文, 廖伟华, 等. 社区居民膝关节骨性关节炎流行病学调查分析. 海南医学, 2013, 7(3): 1064-1066.
28. 唐江龙. 迪庆高原民族地区农村中老年人膝骨性关节炎的流行病学调查. 中国当代医药, 2013, 20(17): 159-160, 163.
29. 马东华, 刘敏, 黄庭山, 等. 湖南省桑植县膝关节骨性关节炎发病原因的流行病学调查. 医学临床研究, 2014, 31(4): 722-724.
30. 李玉飞. 湖南省中老年膝骨关节炎的流行病学调查研究. 武汉: 中南大学, 2013.
31. 王新军, 刘俊昌, 木合塔尔·阿尤甫, 等. 新疆北疆牧区不同民族居民膝骨性关节炎患病现状调查. 中国公共卫生, 2015, 31(7): 853-855.
32. Tang X, Wang S, Zhan S, et al. The prevalence of symptomatic knee osteoarthritis in China: results from the China health and retirement longitudinal study. Arthritis Rheum, 2016, 68(3): 648-653.
33. Liu Y, Zhang H, Liang N, et al. Prevalence and associated factors of knee osteoarthritis in a rural Chinese adult population: an epidemiological survey. BMC Public Health, 2015, 16(1): 2782-2786.
34. Zhang JF, Song LH, Wei JN, et al. Prevalence of and risk factors for the occurrence of symptomatic osteoarthritis in rural regions of Shanxi Province, China. Int J Rheum Dis, 2016, 19(8): 781-789.
35. 安丙辰. 膝关节骨关节炎运动疗法相关研究. 上海: 上海交通大学, 2008.
36. Pang J, Cao YL, Zheng YX, et al. Influence of pain severity on health-related quality of life in Chinese knee osteoarthritis patients. Int J Clin Exp Med, 2015, 8(3): 4472-4479.
37. 史方. 上海市关节炎疾病负担评价. 上海: 复旦大学, 2004.
38. Woo J, Lau E, Lee P, et al. Impact of osteoarthritis on quality of life in a Hong Kong Chinese population. J Rheumatol, 2004, 31(12): 2433-2438.
39. 李宁秀, 刘朝杰, 李俊, 等. 四川省城乡居民 SF-36 评价参考值. 华西医科大学学报, 2001, 32(1): 43-47.
40. Weinstein SL. 2000–2010: the bone and joint decade. J Bone Joint Surg Am, 2000, 82(1): 1-3.
41. Felson DT, Niu J, Guermazi A, et al. Defining radiographic incidence and progression of knee osteoarthritis: suggested modifications of the Kellgren and Lawrence scale. Ann Rheum Dis, 2011, 70(11): 1884-1886.
42. Felson DT, Goggins J, Niu J, et al. Hunter DJ. The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum, 2004, 50(12): 3904-3909.
43. Felson DT, Niu J, Gross KD, et al. Valgus malalignment is a risk factor for lateral knee osteoarthritis incidence and progression: Findings from the multicenter osteoarthritis study and the osteoarthritis initiative. Arthritis Rheum, 2013, 65(2): 355-362.
44. 蓝常贡. 百色地区膝骨关节炎病因探讨. 南宁: 广西医科大学, 2007.
45. 孙国梁, 吕发明. 膝关节骨性关节炎危险因素的病例对照研究. 新疆中医药, 2008, 26(3): 44-45.
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Chinese Journal of Evidence-Based Medicine

Prevalence and disease burden of knee osteoarthritis in China: a systematic review

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