The prognostic value of plasma sTREM-1 in predicting 28-day mortality in sepsis: a systematic review_Chinese Journal of Evidence-Based Medicine

Authors：

LU Yingying , ZHU Dandan , XU Shuang , CHEN Xue ,  YU Jian

Department of Intensive Care Unit, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, P.R.China;

Corresponding author：

YU Jian, Email: yujian0427@163.com

Keywords：

Sepsis; Plasma soluble triggering receptor expressed on myeloid cells-1; 28-day mortality; Systematic review; Meta-analysis

DOI：

10.7507/1672-2531.201903075

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Objectives To systematically review the prognostic value of plasma soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) level in predicting 28-day mortality in sepsis.Methods PubMed, The Cochrane Library, EMbase, Web of Science, CBM, CNKI, VIP and WanFang Data databases were electronically searched to collect studies about the prognostic value of plasma sTREM-1 in early 28-day mortality in sepsis from inception to April 16^th, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using Stata 14.0 software.Results A total of 13 studies involving 1 115 patients were included. The results of meta-analysis showed that the sensitivity and specificity were 79% and 77%, respectively. The positive likelihood ratio and the negative likelihood ratio were 3.4 and 0.28, respectively. The diagnostic ratio was 12. The overall area under the summary receiver operator characteristic (SROC) curve was 0.80.Conclusions Current evidence shows that plasma sTREM-1, as a single index, may play a prognostic role in the early 28-day mortality of sepsis in patients. Due to limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusion.

Citation： LU Yingying, ZHU Dandan, XU Shuang, CHEN Xue, YU Jian. The prognostic value of plasma sTREM-1 in predicting 28-day mortality in sepsis: a systematic review. Chinese Journal of Evidence-Based Medicine, 2019, 19(9): 1044-1050. doi: 10.7507/1672-2531.201903075 Copy

1.	Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA, 2016, 315(8): 801-810.
2.	Fleischmann C, Scherag A, Adhikari NK, et al. Assessment of global incidence and mortality of hospital-treated sepsis, current estimates and limitations. Am J Respir Crit Care Med, 2016, 193(3): 259-272.
3.	Kibe S, Adams K, Barlow G. Diagnostic and prognostic biomarkers of sepsis in critical care. J Antimicrob Chemother, 2011, 66(Suppl 2): i33-i40.
4.	Sandquist M, Wong HR. Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment. Expert Rev Clin Immunol, 2014, 10(10): 1349-1356.
5.	Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature, 2001, 410(6832): 1103-1107.
6.	Ye W, Hu Y, Zhang R, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in lower respiratory tract infections: a meta-analysis. Respirology, 2014, 19(4): 501-507.
7.	Liu Y, Hou JH, Li Q, et al. Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis. Springerplus, 2016, 5(1): 2091.
8.	Wu Y, Wang F, Fan X, et al. Accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients: a systematic review and meta-analysis (Provisional abstract). Crit Care, 2012, 16(6): R229.
9.	Summah H, Tao LL, Zhu YG, et al. Pleural fluid soluble triggering receptor expressed on myeloid cells-1 as a marker of bacterial infection: a meta-analysis. BMC Infect Dis, 2011, 11: 280.
10.	Jiyong J, Tiancha H, Wei C, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med, 2009, 35(4): 587-595.
11.	Zhang J, She D, Feng D, et al. Dynamic changes of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) reflect sepsis severity and can predict prognosis: a prospective study. BMC Infect Dis, 2011, 11: 53.
12.	Ravetti CG, Moura AD, Vieira ÉL, et al. sTREM-1 predicts intensive care unit and 28-day mortality in cancer patients with severe sepsis and septic shock. J Crit Care, 2015, 30(2): 440.
13.	Su L, Liu D, Chai W, et al. Role of sTREM-1 in predicting mortality of infection: a systematic review and meta-analysis. BMJ Open, 2016, 6(5): e010314.
14.	Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med, 2011, 155(8): 529-536.
15.	Gibot S, Cravoisy A, Kolopp-Sarda MN, et al. Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis. Crit Care Med, 2005, 33(4): 792-796.
16.	Latour-Pérez J, Alcalá-López A, García-García MA, et al. Prognostic value of the sTREM-1 plasma values in patients with sepsis: a cohort study. Med Intensiva, 2010, 34(4): 231-236.
17.	孙洁, 宋诗铎, 赵华杰. 脓毒症患者血清可溶性髓系细胞表达的触发受体-1水平及与预后的关系. 中国危重病急救医学, 2011, 23(5): 305-308.
18.	Su L, Liu C, Li C, et al. Dynamic changes in serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and its gene polymorphisms are associated with sepsis prognosis. Inflammation, 2012, 35(6): 1833-1843.
19.	Li L, Zhu Z, Chen J, et al. Diagnostic value of soluble triggering receptor expressed on myeloid cells-1 in critically-ill, postoperative patients with suspected sepsis. Am J Med Sci, 2013, 345(3): 178-184.
20.	Li Z, Wang H, Liu J, et al. Serum soluble triggering receptor expressed on myeloid cells-1 and procalcitonin can reflect sepsis severity and predict prognosis: a prospective cohort study. Mediators Inflamm, 2014, 2014: 641039.
21.	Charles PE, Noel R, Massin F, et al. Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis. BMC Infect Dis, 2016, 16(1): 559.
22.	Li Z, Zhang E, Hu Y, et al. High serum sTREM-1 correlates with myocardial dysfunction and predicts prognosis in septic patients. Am J Med Sci, 2016, 351(6): 555-562.
23.	潘定康, 陈怿, 段鹏凯, 等. 血清可溶性髓样细胞触发受体-1对重症脓毒症患者预后判断价值. 第三军医大学学报, 2016, 38(8): 845-849.
24.	Jedynak M, Siemiatkowski A, Mroczko B, et al. Soluble TREM-1 serum level can early predict mortality of patients with sepsis, severe sepsis and septic shock. Arch Immunol Ther Exp (Warsz), 2018, 66(4): 299-306.
25.	刘雪燕, 吴伟元, 江意春, 等. 血清sTREM-1对脓毒症诊断及预后评估中的价值研究. 中国急救医学, 2017, 37(12): 1091-1095.
26.	毛云, 盛孝燕, 朱红阳, 等. 血清降钙素原和可溶性髓样细胞触发受体-1及可溶性CD_(14)亚型水平联合预测脓毒症患者28 d病死率的价值研究. 中国全科医学, 2017, 20(36): 4494-4500.
27.	杨俊杰, 黄芸菲, 吴宏成. 可溶性髓细胞触发受体-1对伴肺部渗出脓毒症患者的临床价值. 中国急救医学, 2014, (11): 970-976.
28.	Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest, 1992, 101(6): 1644-1655.
29.	Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med, 2003, 31(4): 1250-1256.

1. Singer M, Deutschman CS, Seymour CW, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA, 2016, 315(8): 801-810.
2. Fleischmann C, Scherag A, Adhikari NK, et al. Assessment of global incidence and mortality of hospital-treated sepsis, current estimates and limitations. Am J Respir Crit Care Med, 2016, 193(3): 259-272.
3. Kibe S, Adams K, Barlow G. Diagnostic and prognostic biomarkers of sepsis in critical care. J Antimicrob Chemother, 2011, 66(Suppl 2): i33-i40.
4. Sandquist M, Wong HR. Biomarkers of sepsis and their potential value in diagnosis, prognosis and treatment. Expert Rev Clin Immunol, 2014, 10(10): 1349-1356.
5. Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature, 2001, 410(6832): 1103-1107.
6. Ye W, Hu Y, Zhang R, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in lower respiratory tract infections: a meta-analysis. Respirology, 2014, 19(4): 501-507.
7. Liu Y, Hou JH, Li Q, et al. Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis. Springerplus, 2016, 5(1): 2091.
8. Wu Y, Wang F, Fan X, et al. Accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients: a systematic review and meta-analysis (Provisional abstract). Crit Care, 2012, 16(6): R229.
9. Summah H, Tao LL, Zhu YG, et al. Pleural fluid soluble triggering receptor expressed on myeloid cells-1 as a marker of bacterial infection: a meta-analysis. BMC Infect Dis, 2011, 11: 280.
10. Jiyong J, Tiancha H, Wei C, et al. Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis. Intensive Care Med, 2009, 35(4): 587-595.
11. Zhang J, She D, Feng D, et al. Dynamic changes of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) reflect sepsis severity and can predict prognosis: a prospective study. BMC Infect Dis, 2011, 11: 53.
12. Ravetti CG, Moura AD, Vieira ÉL, et al. sTREM-1 predicts intensive care unit and 28-day mortality in cancer patients with severe sepsis and septic shock. J Crit Care, 2015, 30(2): 440.
13. Su L, Liu D, Chai W, et al. Role of sTREM-1 in predicting mortality of infection: a systematic review and meta-analysis. BMJ Open, 2016, 6(5): e010314.
14. Whiting PF, Rutjes AW, Westwood ME, et al. QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med, 2011, 155(8): 529-536.
15. Gibot S, Cravoisy A, Kolopp-Sarda MN, et al. Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsis. Crit Care Med, 2005, 33(4): 792-796.
16. Latour-Pérez J, Alcalá-López A, García-García MA, et al. Prognostic value of the sTREM-1 plasma values in patients with sepsis: a cohort study. Med Intensiva, 2010, 34(4): 231-236.
17. 孙洁, 宋诗铎, 赵华杰. 脓毒症患者血清可溶性髓系细胞表达的触发受体-1水平及与预后的关系. 中国危重病急救医学, 2011, 23(5): 305-308.
18. Su L, Liu C, Li C, et al. Dynamic changes in serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and its gene polymorphisms are associated with sepsis prognosis. Inflammation, 2012, 35(6): 1833-1843.
19. Li L, Zhu Z, Chen J, et al. Diagnostic value of soluble triggering receptor expressed on myeloid cells-1 in critically-ill, postoperative patients with suspected sepsis. Am J Med Sci, 2013, 345(3): 178-184.
20. Li Z, Wang H, Liu J, et al. Serum soluble triggering receptor expressed on myeloid cells-1 and procalcitonin can reflect sepsis severity and predict prognosis: a prospective cohort study. Mediators Inflamm, 2014, 2014: 641039.
21. Charles PE, Noel R, Massin F, et al. Significance of soluble triggering receptor expressed on myeloid cells-1 elevation in patients admitted to the intensive care unit with sepsis. BMC Infect Dis, 2016, 16(1): 559.
22. Li Z, Zhang E, Hu Y, et al. High serum sTREM-1 correlates with myocardial dysfunction and predicts prognosis in septic patients. Am J Med Sci, 2016, 351(6): 555-562.
23. 潘定康, 陈怿, 段鹏凯, 等. 血清可溶性髓样细胞触发受体-1对重症脓毒症患者预后判断价值. 第三军医大学学报, 2016, 38(8): 845-849.
24. Jedynak M, Siemiatkowski A, Mroczko B, et al. Soluble TREM-1 serum level can early predict mortality of patients with sepsis, severe sepsis and septic shock. Arch Immunol Ther Exp (Warsz), 2018, 66(4): 299-306.
25. 刘雪燕, 吴伟元, 江意春, 等. 血清sTREM-1对脓毒症诊断及预后评估中的价值研究. 中国急救医学, 2017, 37(12): 1091-1095.
26. 毛云, 盛孝燕, 朱红阳, 等. 血清降钙素原和可溶性髓样细胞触发受体-1及可溶性CD_(14)亚型水平联合预测脓毒症患者28 d病死率的价值研究. 中国全科医学, 2017, 20(36): 4494-4500.
27. 杨俊杰, 黄芸菲, 吴宏成. 可溶性髓细胞触发受体-1对伴肺部渗出脓毒症患者的临床价值. 中国急救医学, 2014, (11): 970-976.
28. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest, 1992, 101(6): 1644-1655.
29. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med, 2003, 31(4): 1250-1256.

Chinese Journal of Evidence-Based Medicine

The prognostic value of plasma sTREM-1 in predicting 28-day mortality in sepsis: a systematic review

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