• 1. Henan University People's Hospital, Zhengzhou 450003, P.R.China;
  • 2. Department of Endocrinology, Henan Provincial People’s Hospital, Zhengzhou 450003, P.R.China;
  • 3. Jinzhou Medical University, Jinzhou 121000, P.R.China;
WANG Yanfang, Email: yfwang612@126.com
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Objectives To systematically review the efficacy of Bailing capsule for autoimmune antibodies in Hashimoto thyroiditis (HT).Methods PubMed, EMbase, The Cochrane Library, CBM, WanFang Data and CNKI databases were electronically searched to collect the randomized controlled trials (RCTs) on Bailing capsule in treatment of HT from inception to January 2019. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software.Results A total of 7 RCTs involving 428 patients were included. The results of meta-analysis showed that the changes of TGAb and TPOAb in Bailing capsule combined with Euthyrox group were higher than that in control group (MD=−228.91, 95%CI −398.61 to −59.20, P=0.008; MD=−158.19, 95%CI −222.44 to −93.94, P<0.000 01); the changes of TGAb and TPOAb in Bailing capsule combined with Iodine modification diet group were higher than that in control group(MD=−499.27, 95%CI −540.39 to −458.15, P<0.000 01; MD=−407.37, 95%CI −448.60 to −366.14, P<0.000 01).Conclusions Current evidence shows that Bailing capsule combined with other therapies can decrease the levels of TGAb and TPOAb in HT patients. Due to limited quality and quantity of the included studies, more high-quality studies are required to verify the above conclusion.

Citation: LIU Yangqing, WANG Yanfang, GUO Lijun. Efficacy of Bailing capsule for autoimmune antibodies in Hashimoto thyroiditis: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2020, 20(4): 453-457. doi: 10.7507/1672-2531.201904064 Copy

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