Genetic loci in the NF-<i>κ</i>B pathway and lung cancer susceptibility: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

GUAN Haijian ¹ , SUN Gaofeng ² ,  XIE Huifang ¹

1. School of Public Health, Xinjiang Medical University, Urumqi, 830011, P.R.China;
2. Disease Control and Prevention Center of Urumqi, Urumqi, 830000, P.R.China;

Corresponding author：

XIE Huifang, Email: xhfworld@sina.com

Keywords：

NFKB1 gene; NFKBIA gene; Lung cancer; Meta-analysis; Systematic review; Case-control study

DOI：

10.7507/1672-2531.201904095

Video：

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Objectives To systematically review the correlation between NFKB1 gene, NFKBIA gene and lung cancer susceptibility.Methods Web of Science, PubMed, VIP, CNKI and WanFang Data databases were electronically searched to collect case-control studies on the correlation between NFKB1 gene rs4648127, rs28362491 polymorphisms and NFKBIA gene rs696 polymorphism and lung cancer susceptibility from inception to November, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies; then, meta-analysis was performed by using Stata 12.0 software.Results A total of 7 case-control studies were included. The results of meta-analysis showed that: no correlation was found between rs4648127 and lung cancer susceptibility (C vs. T: OR=1.065, 95%CI 0.323 to 3.512, P=0.918). A positive correlation was found in hospital population between rs28362491 (D vs. I: OR=1.290, 95%CI 1.117 to 1.489, P=0.001; DD vs. II: OR=1.707, 95%CI 1.273 to 2.289, P<0.001; DD vs. ID+II: OR=1.409, 95%CI 1.100 to 1.806, P=0.008) and lung cancer. Rs696 polymorphism (A vs. G: OR=1.215, 95%CI 1.105 to 1.336, P<0.001; AA vs. GG: OR=1.438, 95%CI 1.194 to 1.731, P<0.001; GG vs. AG+AA: OR=1.566, 95%CI 1.341 to 1.829, P<0.001) was correlated with lung cancer susceptibility.Conclusions Current evidence shows that NFKB1 gene rs4648127 may not be associated with lung cancer. The rs28362491 pdymorphism of NFKB1 gene in hospital population and rs696 pdymorphism of NFKBIA gene may be positively correlated with lung cancer susceptibility. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above conclusions.

Citation： GUAN Haijian, SUN Gaofeng, XIE Huifang. Genetic loci in the NF-κB pathway and lung cancer susceptibility: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2019, 19(12): 1430-1435. doi: 10.7507/1672-2531.201904095 Copy

1.	郑荣寿, 顾秀瑛, 李雪婷, 等. 2000-2014 年中国肿瘤登记地区癌症发病趋势及年龄变化分析. 中华预防医学杂志, 2018, 52(6): 593-600.
2.	中国国家癌症中心. 2018 年全国癌症报告. Available at: http://www.sohu.com/a/226139022_100120288.
3.	陈秋生, 田文娴, 董润, 等. NF-κB, VEGF 及 ICAM-1 在非小细胞肺癌中的表达及意义. 临床肺科杂志, 2018, 23(4): 587-590.
4.	Saxon JA, Yu H, Polosukhin VV, et al. p52 expression enhances lung cancer progression. Sci Rep, 2018, 8(1): 6078.
5.	翟建霞, 董润. TLR4 与 NF-κB 在非小细胞肺癌组织中的表达和临床意义分析. 甘肃医药, 2018, 37(5): 405-407.
6.	杨雷, 邓进, 邓志红. NF-κB 及其基因多态性与炎症及肿瘤关系的研究进展. 贵州医药, 2016, 40(10): 1098-1100.
7.	Xia L, Tan S, Zhou Y, et al. Role of the NFκB-signaling pathway in cancer. Onco Targets Ther, 2018, 11: 2063-2073.
8.	Yamamoto Y, Kiyohara C, Suetsugu-Ogata S, et al. Biological interaction of cigarette smoking on the association between genetic polymorphisms involved in infla mmation and the risk of lung cancer: a case-control study in Japan. Oncol Lett, 2017, 13(5): 3873.
9.	Wang Y, Chen L, Pan L, et al. The association between NFKB1-94ins/del ATTG polymorphism and non-small cell lung cancer risk in a Chinese Han population. Int J Clin Exp Med, 2015, 8(5): 8153-8157.
10.	Zhang JW, Chen QS, Zhai JX, et al. Polymorphisms in NF-κB pathway genes & their association with risk of lung cancer in the Chinese population. Pak J Med Sci, 2015, 31(6): 1411-1416.
11.	黄冬生. NFκB1 和 IκBα 基因遗传变异与慢性阻塞性肺疾病和肺癌易感性研究. 广州: 广州医学院, 2012.
12.	Zhang M, Huang J, Tan X, et al. Common polymorphisms in the NFKBIA gene and cancer susceptibility: a meta-analysis. Med Sci Monit, 2015, 21: 3186-3196.
13.	Stang A. Critical evaluation of the Newcastle-Ottawa Scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
14.	汤金星. CHRNB4 基因和 NFKB1 基因位点的单核苷酸多态性与中国人群肺癌易感性关系的研究. 苏州: 苏州大学, 2015.
15.	Shiels MS, Engels EA, Jianxin S, et al. Genetic variation in innate immunity and inflame mation pathways associated with lung cancer risk. Cancer, 2013, 119(9): 1761.
16.	Oltulu YM, Coskunpinar E, Ozkan G, et al. Investigation of NF-κB1 and NF-κBIA gene polymorphism in non-small cell lung cancer. Biomed Res Int, 2014, 2014: 530381.
17.	曲世宁. NF-κB1 基因启动子-94del/ins ATTG 与肺癌风险相关性研究. 北京: 中国协和医科大学, 2004.
18.	赵旭, 王晓寒, 广东, 等. NF-κB 对肺癌细胞生长、细胞周期及肿瘤坏死因子-α 分泌的影响. 中国老年学杂志, 2018, 38(17): 4223-4226.
19.	Fu W, Zhuo ZJ, Chen YC, et al. NFKB1-94insertion/deletion ATTG polymorphism and cancer risk: Evidence from 50 case-control studies. Oncotarget, 2017, 8(6): 9806-9822.
20.	姜一弘, 张丹, 张天择, 等. 核因子 κB(NF-κB)信号通路在炎症与肿瘤中作用的研究进展. 细胞与分子免疫学杂志, 2018, 34(12): 1130-1135.
21.	杨晓晓, 黄虹婷, 刘满华, 等. NF-κB 参与调控细胞凋亡. 上海交通大学学报(医学版), 2017, 37(10): 1446-1452.
22.	Szymura SJ, Zaemes JP, Allison DF, et al. NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer. Cell Commun Signal, 2019, 17(1): 24.
23.	Rahnamoun H, Lu H, Duttke SH, et al. Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling. Nat Commun, 2017, 8(1): 754.
24.	He F, Xiao RD, Lin T, et al. Dietary patterns, BCMO1 polymorphisms, and primary lung cancer risk in a Han Chinese population: a case-control study in Southeast China. BMC Cancer, 2018, 18(1): 445.

1. 郑荣寿, 顾秀瑛, 李雪婷, 等. 2000-2014 年中国肿瘤登记地区癌症发病趋势及年龄变化分析. 中华预防医学杂志, 2018, 52(6): 593-600.
2. 中国国家癌症中心. 2018 年全国癌症报告. Available at: http://www.sohu.com/a/226139022_100120288.
3. 陈秋生, 田文娴, 董润, 等. NF-κB, VEGF 及 ICAM-1 在非小细胞肺癌中的表达及意义. 临床肺科杂志, 2018, 23(4): 587-590.
4. Saxon JA, Yu H, Polosukhin VV, et al. p52 expression enhances lung cancer progression. Sci Rep, 2018, 8(1): 6078.
5. 翟建霞, 董润. TLR4 与 NF-κB 在非小细胞肺癌组织中的表达和临床意义分析. 甘肃医药, 2018, 37(5): 405-407.
6. 杨雷, 邓进, 邓志红. NF-κB 及其基因多态性与炎症及肿瘤关系的研究进展. 贵州医药, 2016, 40(10): 1098-1100.
7. Xia L, Tan S, Zhou Y, et al. Role of the NFκB-signaling pathway in cancer. Onco Targets Ther, 2018, 11: 2063-2073.
8. Yamamoto Y, Kiyohara C, Suetsugu-Ogata S, et al. Biological interaction of cigarette smoking on the association between genetic polymorphisms involved in infla mmation and the risk of lung cancer: a case-control study in Japan. Oncol Lett, 2017, 13(5): 3873.
9. Wang Y, Chen L, Pan L, et al. The association between NFKB1-94ins/del ATTG polymorphism and non-small cell lung cancer risk in a Chinese Han population. Int J Clin Exp Med, 2015, 8(5): 8153-8157.
10. Zhang JW, Chen QS, Zhai JX, et al. Polymorphisms in NF-κB pathway genes & their association with risk of lung cancer in the Chinese population. Pak J Med Sci, 2015, 31(6): 1411-1416.
11. 黄冬生. NFκB1 和 IκBα 基因遗传变异与慢性阻塞性肺疾病和肺癌易感性研究. 广州: 广州医学院, 2012.
12. Zhang M, Huang J, Tan X, et al. Common polymorphisms in the NFKBIA gene and cancer susceptibility: a meta-analysis. Med Sci Monit, 2015, 21: 3186-3196.
13. Stang A. Critical evaluation of the Newcastle-Ottawa Scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol, 2010, 25(9): 603-605.
14. 汤金星. CHRNB4 基因和 NFKB1 基因位点的单核苷酸多态性与中国人群肺癌易感性关系的研究. 苏州: 苏州大学, 2015.
15. Shiels MS, Engels EA, Jianxin S, et al. Genetic variation in innate immunity and inflame mation pathways associated with lung cancer risk. Cancer, 2013, 119(9): 1761.
16. Oltulu YM, Coskunpinar E, Ozkan G, et al. Investigation of NF-κB1 and NF-κBIA gene polymorphism in non-small cell lung cancer. Biomed Res Int, 2014, 2014: 530381.
17. 曲世宁. NF-κB1 基因启动子-94del/ins ATTG 与肺癌风险相关性研究. 北京: 中国协和医科大学, 2004.
18. 赵旭, 王晓寒, 广东, 等. NF-κB 对肺癌细胞生长、细胞周期及肿瘤坏死因子-α 分泌的影响. 中国老年学杂志, 2018, 38(17): 4223-4226.
19. Fu W, Zhuo ZJ, Chen YC, et al. NFKB1-94insertion/deletion ATTG polymorphism and cancer risk: Evidence from 50 case-control studies. Oncotarget, 2017, 8(6): 9806-9822.
20. 姜一弘, 张丹, 张天择, 等. 核因子 κB(NF-κB)信号通路在炎症与肿瘤中作用的研究进展. 细胞与分子免疫学杂志, 2018, 34(12): 1130-1135.
21. 杨晓晓, 黄虹婷, 刘满华, 等. NF-κB 参与调控细胞凋亡. 上海交通大学学报(医学版), 2017, 37(10): 1446-1452.
22. Szymura SJ, Zaemes JP, Allison DF, et al. NF-κB upregulates glutamine-fructose-6-phosphate transaminase 2 to promote migration in non-small cell lung cancer. Cell Commun Signal, 2019, 17(1): 24.
23. Rahnamoun H, Lu H, Duttke SH, et al. Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling. Nat Commun, 2017, 8(1): 754.
24. He F, Xiao RD, Lin T, et al. Dietary patterns, BCMO1 polymorphisms, and primary lung cancer risk in a Han Chinese population: a case-control study in Southeast China. BMC Cancer, 2018, 18(1): 445.

Chinese Journal of Evidence-Based Medicine

Genetic loci in the NF-κB pathway and lung cancer susceptibility: a meta-analysis

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