LIU Lu 1,2 , WEI Lili 3,4 , LIU Donghai 1,2 , WANG Jiabin 2,5 , WANG Yanxia 2 , MAO Baohong 2 , HU Yaguang 2 , QIU Jie 2,5 , YANG Kehu 3,4,5
  • 1. Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou 730000, P.R.China;
  • 2. Gansu Provincial Maternity and Child-care Hospital, Lanzhou 730050, P.R.China;
  • 3. Evidence-based Medicine Center of Lanzhou University, Lanzhou 730000, P.R.China;
  • 4. Key Laboratory of Evidence-Based Medicine and Clinical Transformation in Gansu Province, Lanzhou 730000, P.R.China;
  • 5. School of Public Health, Lanzhou University, Lanzhou 730000, P.R.China;
LIU Donghai, Email: ldhai2005@163.com; YANG Kehu, Email: kehuyang2006@126.com
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Objectives To systematically review the correlation between maternal serum selenium levels during pregnancy and premature birth.Methods Databases including PubMed, The Cochrane Library, EMbase, Web of Science, CNKI and CBM were searched to collect studies on correlation between maternal serum selenium levels during pregnancy with preterm birth in the offspring from inception to January, 2020. Two reviewers independently screened literature, extracted data and evaluated risk of bias of the included literature. Then, meta-analysis was conducted by using RevMan 5.3 software.Results A total of 12 studies involving 2 484 patients were included. The results of meta-analysis showed that compared with control group, the preterm group had lower serum selenium levels in pregnant females (SMD=−0.89, 95%CI −1.56 to −0.22, P=0.01). The results of the subgroup analysis showed that heterogeneity among subjects was still large when grouped accorcding to the continent to which a country belongs, the time of blood sample collection and test method in pregnant females.Conclusions Low maternal serum selenium levels during pregnancy may increase the risk of preterm birth. Due to the limitation of the quantity and quality of the included studies, the above conclusions are required to be verified by more high quality studies.

Citation: LIU Lu, WEI Lili, LIU Donghai, WANG Jiabin, WANG Yanxia, MAO Baohong, HU Yaguang, QIU Jie, YANG Kehu. The correlation between serum selenium levels in pregnant females and preterm birth: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2020, 20(9): 1045-1051. doi: 10.7507/1672-2531.201909079 Copy

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