Knowledge, attitude and practice of hepatitis E among the residents of Anlu City_Chinese Journal of Evidence-Based Medicine

Authors：

ZHOU Sheng ^1,2 ,  ZHANG Zhijiang ¹ , YUAN Zhanpeng ¹ , WAN Qin ³ , ZHANG Xuefeng ³

1. Department of Preventive Medicine, School of Health Sciences, Wuhan University, Wuhan 430071, P.R.China;
2. Hannan District Center for Disease Control and Prevention, Wuhan 430090, P.R.China;
3. Anlu Center for Disease Control and Prevention, Xiaogan 432600, P.R.China;

Corresponding author：

ZHANG Zhijiang, Email: zhang22968@163.com

Keywords：

Hepatitis E; Awareness rate; Knowledge, attitude, practice (KAP); Influencing factors

DOI：

10.7507/1672-2531.202003010

Video：

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Objectives To investigate the knowledge, attitude and practice (KAP) of hepatitis E among Anlu residents and to identify the influencing factors.Methods A stratified random sampling method was used and 1 840 Anlu residents were recruited between March 2019 and September 2019. Chi-square test and multivariate logistic regression model were used to analyze the influencing factors by SPSS 22.0 software.Results The overall awareness rate of residents was 36.32%. There were statistically significant differences in age, occupation category and education (P<0.05). Qualification rate of awareness increased with age until age 40, but not with age after 40. Individuals occupationally exposed to swines (swine breeders, sales staff, slaughterers) had the lowest rates. Education level was positively associated with the qualification rate of awareness. The overall positive attitude rate was 53.89%. The overall healthy behavior rate was 82.95%.Conclusions The overall knowledge and awareness of hepatitis E among Anlu residents is low, especially individuals who have been occupationally exposed to swines. Health education and promotion programs are necessary.

Citation： ZHOU Sheng, ZHANG Zhijiang, YUAN Zhanpeng, WAN Qin, ZHANG Xuefeng. Knowledge, attitude and practice of hepatitis E among the residents of Anlu City. Chinese Journal of Evidence-Based Medicine, 2020, 20(8): 923-929. doi: 10.7507/1672-2531.202003010 Copy

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2.	Simanavicius M, Juskaite K, Verbickaite A, et al. Detection of rat hepatitis E virus, but not human pathogenic hepatitis E virus genotype 1-4 infections in wild rats from Lithuania. Vet Microbiol, 2018, 221: 129-133.
3.	Wang L, Liu L, Wang L. An overview: Rabbit hepatitis E virus (HEV) and rabbit providing an animal model for HEV study. Rev Med Virol, 2018, 28(1): 10.
4.	Gerber PF, Hossain MF, Reynolds P, et al. Propagation of an avirulent turkey hemorrhagic enteritis virus isolate in chickens. Avian Dis, 2018, 62(1): 6-13.
5.	World Health Organization. Hepatitis E. Available from: https://www.who.int/news-room/fact-sheets/detail/hepatitis-e.
6.	黄晓丽. 被忽视的肝炎—戊型肝炎. 肝博士, 2019, (3): 43-44.
7.	Dagnew M, Belachew A, Tiruneh M, et al. Hepatitis E virus infection among pregnant women in Africa: systematic review and meta-analysis. BMC Infect Dis, 2019, 19(1): 519.
8.	Nimgaonkar I, Ding Q, Schwartz RE, et al. Hepatitis E virus: advances and challenges. Nat Rev Gastroenterol Hepatol, 2018, 15(2): 96-110.
9.	陈雪飞. 慢性乙型病毒性肝炎重叠戊肝病毒感染致肝功能衰竭1例. 医学信息, 2019, 32(21): 187, 189.
10.	Denner J, Pischke S, Steinmann E, et al. Why all blood donations should be tested for hepatitis E virus (HEV). BMC Infect Dis, 2019, 19(1): 541.
11.	Purcell RH, Emerson SU. Hepatitis E: an emerging awareness of an old disease. J Hepatol, 2008, 48(3): 494-503.
12.	Khuroo MS, Khuroo MS. Hepatitis E: an emerging global disease - from discovery towards control and cure. J Viral Hepat, 2016, 23(2): 68-79.
13.	Fenaux H, Chassaing M, Berger S, et al. Transmission of hepatitis E virus by water: An issue still pending in industrialized countries. Water Res, 2019, 151: 144-157.
14.	Rein DB, Stevens GA, Theaker J, et al. The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology, 2012, 55(4): 988-997.
15.	Capai L, Charrel R, Falchi A. Hepatitis E in high-income countries: what do we know? And what are the knowledge gaps? Viruses, 2018, 10(6): E285.
16.	Yue N, Wang Q, Zheng M, et al. Prevalence of hepatitis E virus infection among people and swine in mainland China: a systematic review and meta-analysis. Zoonoses Public Health, 2019, 66(3): 265-275.
17.	黄娇凤, 林苏, 王挺, 等. 2004-2015 年我国病毒性肝炎发病及季节性趋势分析. 中国人兽共患病学报, 2017, 33(12): 1144-1148.
18.	国家卫生健康委员会. 中国卫生健康统计年鉴. 北京: 中国协和医科大学出版社, 2018.
19.	国家卫生计生委, 国家发展改革委, 教育部, 等. 中国病毒性肝炎防治规划(2017-2020 年). 中国病毒病杂志, 2018, 8(1): 1-5.
20.	万琴, 张守德, 张雪峰, 等. 2005-2015 年安陆市戊型病毒性肝炎流行病学分析. 热带医学杂志, 2017, 17(4): 533-536.
21.	Shu Y, Chen Y, Zhou S, et al. Cross-sectional seroprevalence and genotype of hepatitis E virus in humans and swine in a high-density pig-farming area in central China. Virol Sin, 2019, 34(4): 367-376.
22.	陈雅梦. 湖北地区HIV人群HEV知信行及HEV感染流行病学调查. 武汉: 武汉科技大学, 2019.
23.	沈红. 病毒性肝炎流行特征, 丙肝知晓率和戊肝感染危险因素研究. 上海: 复旦大学, 2012.
24.	Izopet J, Lhomme S, Chapuy-Regaud S, et al. HEV and transfusion-recipient risk. Transfus Clin Biol, 2017, 24(3): 176-181.
25.	卢敏芳, 常全娥. 甘肃某高校学生甲肝防治知识知晓率调查. 卫生职业教育, 2017, 35(23): 92-94.
26.	Lee GY, Poovorawan K, Intharasongkroh D, et al. Hepatitis E virus infection: Epidemiology and treatment implications. World J Virol, 2015, 4(4): 343-355.
27.	杨锟, 方大春, 秦其荣, 等. 马鞍山市常住人口乙肝相关知识知晓及疫苗接种情况调查. 现代预防医学, 2019, 46(20): 3772-3776, 3798.
28.	高日红, 姜涛. 2017 年海阳市大学新生戊型肝炎知识态度调查. 中国校医, 2018, 32(7): 495-496.
29.	王冬梅, 于旭亚, 冯国跃, 等. 烟台市 2014 年大学新生戊型肝炎病毒感染状况和认知度调查. 中国病毒病杂志, 2016, 6(5): 356-359.
30.	刘甲野, 张丽, 吕静静, 等. 山东省大学新生戊型肝炎流行及相关知识态度行为现状. 中国学校卫生, 2016, 37(11): 1739-1742.
31.	Doceul V, Bagdassarian E, Demange A, et al. Zoonotic hepatitis E virus: classification, animal reservoirs and transmission routes. Viruses, 2016, 8(10): E270.
32.	Grodzki M, Schaeffer J, Piquet JC, et al. Bioaccumulation efficiency, tissue distribution, and environmental occurrence of hepatitis E virus in bivalve shellfish from France. Appl Environ Microbiol, 2014, 80(14): 4269-4276.
33.	Crossan C, Baker PJ, Craft J, et al. Hepatitis E virus genotype 3 in shellfish, United Kingdom. Emerg Infect Dis, 2012, 18(12): 2085-2087.
34.	张雪峰, 疏义林, 周昇, 等. 湖北孝感地区戊型肝炎感染因素及其临床特征分析. 医学动物防制, 2017, 33(10): 1091-1093.

1. Jemeršić L, Prpić J, Brnić D, et al. Genetic diversity of hepatitis E virus (HEV) strains derived from humans, swine and wild boars in Croatia from 2010 to 2017. BMC Infect Dis, 2019, 19(1): 269.
2. Simanavicius M, Juskaite K, Verbickaite A, et al. Detection of rat hepatitis E virus, but not human pathogenic hepatitis E virus genotype 1-4 infections in wild rats from Lithuania. Vet Microbiol, 2018, 221: 129-133.
3. Wang L, Liu L, Wang L. An overview: Rabbit hepatitis E virus (HEV) and rabbit providing an animal model for HEV study. Rev Med Virol, 2018, 28(1): 10.
4. Gerber PF, Hossain MF, Reynolds P, et al. Propagation of an avirulent turkey hemorrhagic enteritis virus isolate in chickens. Avian Dis, 2018, 62(1): 6-13.
5. World Health Organization. Hepatitis E. Available from: https://www.who.int/news-room/fact-sheets/detail/hepatitis-e.
6. 黄晓丽. 被忽视的肝炎—戊型肝炎. 肝博士, 2019, (3): 43-44.
7. Dagnew M, Belachew A, Tiruneh M, et al. Hepatitis E virus infection among pregnant women in Africa: systematic review and meta-analysis. BMC Infect Dis, 2019, 19(1): 519.
8. Nimgaonkar I, Ding Q, Schwartz RE, et al. Hepatitis E virus: advances and challenges. Nat Rev Gastroenterol Hepatol, 2018, 15(2): 96-110.
9. 陈雪飞. 慢性乙型病毒性肝炎重叠戊肝病毒感染致肝功能衰竭1例. 医学信息, 2019, 32(21): 187, 189.
10. Denner J, Pischke S, Steinmann E, et al. Why all blood donations should be tested for hepatitis E virus (HEV). BMC Infect Dis, 2019, 19(1): 541.
11. Purcell RH, Emerson SU. Hepatitis E: an emerging awareness of an old disease. J Hepatol, 2008, 48(3): 494-503.
12. Khuroo MS, Khuroo MS. Hepatitis E: an emerging global disease - from discovery towards control and cure. J Viral Hepat, 2016, 23(2): 68-79.
13. Fenaux H, Chassaing M, Berger S, et al. Transmission of hepatitis E virus by water: An issue still pending in industrialized countries. Water Res, 2019, 151: 144-157.
14. Rein DB, Stevens GA, Theaker J, et al. The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology, 2012, 55(4): 988-997.
15. Capai L, Charrel R, Falchi A. Hepatitis E in high-income countries: what do we know? And what are the knowledge gaps? Viruses, 2018, 10(6): E285.
16. Yue N, Wang Q, Zheng M, et al. Prevalence of hepatitis E virus infection among people and swine in mainland China: a systematic review and meta-analysis. Zoonoses Public Health, 2019, 66(3): 265-275.
17. 黄娇凤, 林苏, 王挺, 等. 2004-2015 年我国病毒性肝炎发病及季节性趋势分析. 中国人兽共患病学报, 2017, 33(12): 1144-1148.
18. 国家卫生健康委员会. 中国卫生健康统计年鉴. 北京: 中国协和医科大学出版社, 2018.
19. 国家卫生计生委, 国家发展改革委, 教育部, 等. 中国病毒性肝炎防治规划(2017-2020 年). 中国病毒病杂志, 2018, 8(1): 1-5.
20. 万琴, 张守德, 张雪峰, 等. 2005-2015 年安陆市戊型病毒性肝炎流行病学分析. 热带医学杂志, 2017, 17(4): 533-536.
21. Shu Y, Chen Y, Zhou S, et al. Cross-sectional seroprevalence and genotype of hepatitis E virus in humans and swine in a high-density pig-farming area in central China. Virol Sin, 2019, 34(4): 367-376.
22. 陈雅梦. 湖北地区HIV人群HEV知信行及HEV感染流行病学调查. 武汉: 武汉科技大学, 2019.
23. 沈红. 病毒性肝炎流行特征, 丙肝知晓率和戊肝感染危险因素研究. 上海: 复旦大学, 2012.
24. Izopet J, Lhomme S, Chapuy-Regaud S, et al. HEV and transfusion-recipient risk. Transfus Clin Biol, 2017, 24(3): 176-181.
25. 卢敏芳, 常全娥. 甘肃某高校学生甲肝防治知识知晓率调查. 卫生职业教育, 2017, 35(23): 92-94.
26. Lee GY, Poovorawan K, Intharasongkroh D, et al. Hepatitis E virus infection: Epidemiology and treatment implications. World J Virol, 2015, 4(4): 343-355.
27. 杨锟, 方大春, 秦其荣, 等. 马鞍山市常住人口乙肝相关知识知晓及疫苗接种情况调查. 现代预防医学, 2019, 46(20): 3772-3776, 3798.
28. 高日红, 姜涛. 2017 年海阳市大学新生戊型肝炎知识态度调查. 中国校医, 2018, 32(7): 495-496.
29. 王冬梅, 于旭亚, 冯国跃, 等. 烟台市 2014 年大学新生戊型肝炎病毒感染状况和认知度调查. 中国病毒病杂志, 2016, 6(5): 356-359.
30. 刘甲野, 张丽, 吕静静, 等. 山东省大学新生戊型肝炎流行及相关知识态度行为现状. 中国学校卫生, 2016, 37(11): 1739-1742.
31. Doceul V, Bagdassarian E, Demange A, et al. Zoonotic hepatitis E virus: classification, animal reservoirs and transmission routes. Viruses, 2016, 8(10): E270.
32. Grodzki M, Schaeffer J, Piquet JC, et al. Bioaccumulation efficiency, tissue distribution, and environmental occurrence of hepatitis E virus in bivalve shellfish from France. Appl Environ Microbiol, 2014, 80(14): 4269-4276.
33. Crossan C, Baker PJ, Craft J, et al. Hepatitis E virus genotype 3 in shellfish, United Kingdom. Emerg Infect Dis, 2012, 18(12): 2085-2087.
34. 张雪峰, 疏义林, 周昇, 等. 湖北孝感地区戊型肝炎感染因素及其临床特征分析. 医学动物防制, 2017, 33(10): 1091-1093.

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