The prevalence of osteoarthritis in Chinese aged 40 and over: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

ZHANG Yingying ¹ ,  LI Xudong ¹ , YANG Jiajuan ² , MA Li ¹ , CHEN Yuewei ¹

1. Office of Epidemiology, Chinese Center for Disease Control and Prevention, Beijing 102206, P.R.China;
2. Yichang Center for Disease Control and Prevention, Yichang 443000, P.R.China;

Corresponding author：

LI Xudong, Email: lixd@chinacdc.cn

Keywords：

Chinese; Osteoarthritis; Mid and old aged; Prevalence; Meta-analysis; Systematic review; Cross-sectional study

DOI：

10.7507/1672-2531.202009078

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Objective To systematically review the prevalence of osteoarthritis in Chinese aged 40 and above from January 2000 to December 2019.Methods PubMed, ScienceDirect, Wiley Online Library, The Cochrane Library, CBM, VIP, CNKI and WanFang Data databases were electronically searched to collect cross-sectional studies on osteoarthritis in Chinese aged 40 and above from January 1^st, 2000 to December 31^st, 2019. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies. Meta-analysis was then performed using R 3.5.2 software.Results A total of 29 cross-sectional studies with a total sample of 60 711 cases and 19 707 patients were included. The results of meta-analysis showed that, the crude prevalence of osteoarthritis in Chinese aged 40 and over was 38.46% (95%CI 24.31% to 46.22%). Subgroup analysis results showed that the prevalence of lumbar osteoarthritis was the highest (24.79%, 95%CI 13.28% to 27.37%), followed by knee osteoarthritis prevalence (20.50%, 95%CI 14.51% to 27.23%) which increased with age. The prevalence of knee osteoarthritis in females (25.14%, 95%CI 19.54% to 31.19%) was higher than that in males (18.99%, 95%CI 13.86% to 24.71%). The prevalence of knee and lumbar osteoarthritis in rural areas was higher than that in urban areas. The prevalence of knee osteoarthritis in western China (23.59%, 95%CI 18.34% to 30.35%) was higher than that in eastern China (18.36%, 95%CI 12.43% to 27.92%) and central China (15.54%, 95%CI 11.22% to 21.53%). The prevalence of lumbar osteoarthritis in western China (31.17%, 95%CI 19.21% to 50.60%) was higher than that in eastern China (24.38%, 95%CI 16.26% to 36.54%). The incidence of cervical osteoarthritis in the eastern China (20.49%, 95%CI 13.90% to 30.21%) was higher than that in the western China (12.32% 95%CI 8.09% to 18.75%). The prevalence of hand osteoarthritis in western China (6.85%, 95%CI 2.71% to 8.13%) was higher than that in eastern China (2.7%, 95%CI 1.33% to 5.48%).Conclusions Current evidence shows that the prevalence of osteoarthritis in Chinese aged 40 and above is high, and the prevalence of lumbar osteoarthritis is the highest, and the prevalence in western China is higher than that in eastern and central China, followed by knee osteoarthritis, in which the prevalence in females, rural areas, and western China is high. Due to limited quality and quantity of the included studies, more high quality studies are required to verify above conclusion.

Citation： ZHANG Yingying, LI Xudong, YANG Jiajuan, MA Li, CHEN Yuewei. The prevalence of osteoarthritis in Chinese aged 40 and over: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2021, 21(4): 407-414. doi: 10.7507/1672-2531.202009078 Copy

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1. 胡浩然, 谢雪涛, 张长青, 等. 骨关节炎中软骨细胞自噬的研究进展. 中华关节外科杂志(电子版), 2018, 12(6): 68-70.
2. Mandl LA. Osteoarthritis year in review 2018: clinical. Osteoarthritis Cartilage, 2019, 27(3): 359-364.
3. Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ, 2003, 81(9): 646-656.
4. 李岩峰. 骨关节的岁月"炎"迹. 中医健康养生, 2017, (12): 62-63.
5. Wei J. High prevalence and burden of osteoarthritis in China. Lancet Rheumatol, 2020, 2(3): e127-e128.
6. Pereira D, Peleteiro B, Araújo J, et al. The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. Osteoarthritis Cartilage, 2011, 19(11): 1270-1285.
7. Long H, Zeng X, Liu Q, et al. Burden of osteoarthritis in China, 1990-2017: findings from the Global Burden of Disease Study 2017. Lancet Rheumatol, 2020, 2(3): e164-e172.
8. 梅轶芳, 张志毅. 中国骨关节炎流行病学调查研究: 任重而道远. 中华风湿病学杂志, 2019, 23(2): 73-75.
9. 曾宪涛, 刘慧, 陈曦, 等. Meta分析系列之四: 观察性研究的质量评价工具. 中国循证心血管医学杂志, 2012, 4(4): 297-299.
10. 贺倩倩, 董海原, 张军锋. 65岁以上社区居民骨关节炎患病情况及性别年龄分布调查. 中国药物与临床, 2018, 18(10): 1690-1692.
11. 何文科. 甘肃省张掖市中老年人骨关节炎流行病学调查分析. 国外医学(医学地理分册), 2017, 38(2): 129-132.
12. 韩佳旭, 张竞元. 黑龙江省哈尔滨市南岗区中老年人膝关节骨性关节炎的流行病学调查研究. 大家健康(上旬版), 2017, 11(10): 33.
13. Zhang JF, Song LH, Wei JN, et al. Prevalence of and risk factors for the occurrence of symptomatic osteoarthritis in rural regions of Shanxi Province, China. Int J Rheum Dis, 2016, 19(8): 781-789.
14. 王奕丹, 邢百芬, 朱琳, 等. 黑龙江省哈尔滨市社区中老年人骨关节炎流行病学调查. 中华疾病控制杂志, 2016, 20(6): 582-585, 594.
15. 李伟, 赵育红, 武长江, 等. 冀北地区中老年膝关节骨性关节炎发病及相关危险因素调查. 河北医学, 2015, 21(6): 1044-1046.
16. 田少奇, 王斌, 孙康, 等. 青岛地区中老年人膝骨关节炎流行病学研究. 中华关节外科杂志(电子版), 2015, 9(6): 762-766.
17. 薛庆云, 王坤正, 裴福兴, 等. 中国40岁以上人群原发性骨关节炎患病状况调查. 中华骨科杂志, 2015, 35(12): 1206-1212.
18. 曾敏川, 李康华. 湖南省郴州地区膝关节骨性关节炎流行病学调查. 实用预防医学, 2014, 21(10): 1157-1160.
19. Tian W, Lv Y, Liu Y, et al. The high prevalence of symptomatic degenerative lumbar osteoarthritis in Chinese adults: a population-based study. Spine (Phila Pa 1976), 2014, 39(16): 1301-1310.
20. 李玉飞, 刘勇, 李康华. 湖南省膝骨关节炎城乡比较研究. 湖南师范大学学报(医学版), 2015, (6): 50-52, 53.
21. 陆新建. 上海浦东泥城社区55-65岁人群症状性膝关节骨性关节炎调查分析. 医药论坛杂志, 2014, 35(4): 61-62.
22. 林培顺, 叶汉良, 刘彩婵, 等. 广州花都区新华街骨性关节炎流行现况报告. 按摩与康复医学, 2013, (12): 86-87.
23. 刘鹏, 观美华. 中老年人骨关节炎流行病学研究. 吉林医学, 2012, 33(12): 2576.
24. 曾勤, 蔡立民, 朱玉霞, 等. 东莞市社区居民症状性膝关节骨性关节炎患病情况调查. 新中医, 2011, 43(8): 70-71.
25. 胡晓琴, 杨静, 侯丰苏, 等. 四川省中老年居民骨关节炎流行现况调查. 中国慢性病预防与控制, 2011, 19(1): 20-22.
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27. 宋雄英, 李雪峰, 刘春阳, 等. 长辛店地区60岁及以上人群膝原发性骨关节炎患病率调查及影响因素分析. 中华老年医学杂志, 2011, (2): 172-174.
28. 荣杰生, 姜丽英, 陶树清, 等. 黑龙江省城市和农村地区中老年人骨关节炎患病状况调查. 中华流行病学杂志, 2010, 31(6): 655-658.
29. 苏阳. 广州地区中老年人症状性骨关节炎的流行病学调查. 广州: 南方医科大学, 2010.
30. 高靖宇, 景建刚, 赵小明, 等. 山西阳泉农村地区膝骨关节炎流行病学调查. 山西医药杂志, 2008, 37(7): 621-623.
31. 李宁华, 薛庆云, 张毅, 等. 中国6城市中老年人群X射线颈椎骨关节炎流行病学分析. 中国组织工程研究与临床康复, 2009, 13(7): 1383-1386.
32. 李宁华, 张毅, 王晓宾, 等. 中国六城市中老年人群X线膝骨关节炎流行病学分析. 实用医学杂志, 2008, 24(16): 2887-2888.
33. 王永斌, 宋志红, 阮玉琦, 等. 上海市奉贤区农村中老年人骨关节炎流行病学调查. 中国全科医学, 2008, 11(9): 785-788.
34. 王伟, 王坤正, 党小谦, 等. 中老年人人群骨关节炎的流行病学研究. 中国老年学杂志, 2007, 27(6): 566-568.
35. 杜蕙, 陈顺乐, 鲍春德, 等. 上海市黄浦区社区膝骨关节炎流行病学调查. 中华医学会风湿病学分会第十届全国风湿病学学术会议论文集, 2005.
36. 赵蓓俊, 苏励, 项珍蛹, 等. 上海浦东新区上钢社区中老年膝骨关节病影响因素流行病学调查. 中华中医药学会第十六届全国风湿病学术大会论文集, 2012: 129-133.
37. 李宁华, 张耀南, 张毅, 等. 中国六城市中老年人群X射线腰椎骨关节炎流行病学分析. 中国临床康复, 2006, 10(40): 12-14.
38. 李宁华, 薛庆云, 张毅, 等. 中国6个城市4577名中老年人手骨关节炎流行病学调查. 中国组织工程研究与临床康复, 2008, 12(33): 6546-6549.
39. 中华医学会风湿病学分会. 骨关节炎诊断及治疗指南. 中华风湿病学杂志, 2010, 14(6): 416-419.
40. Thomas S, Browne H, Mobasheri A, et al. What is the evidence for a role for diet and nutrition in osteoarthritis? Rheumatology (Oxford), 2018, 57(suppl_4): 61-74.
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Chinese Journal of Evidence-Based Medicine

The prevalence of osteoarthritis in Chinese aged 40 and over: a meta-analysis

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