LI Jingwen 1,2,3 , ZHANG Na 1,2,3 , GU Qinghong 2,3 , LI Jieyun 2,3 , GUO Kangle 1,2,3 , LI Meixuan 1,2,3 , LI Yanfei 1,2,3 , ZHANG Hairong 1 , ZHANG Yunqi 1 , LIU Xingrong 1 , BAI Fei 4 , LI Xiuxia 1,2,3 , YANG Kehu 1,2,3
  • 1. Evidence-Based Social Science Research Center, Health Technology Assessment Center, School of Public Health, Lanzhou University, Lanzhou 730000, P.R.China;
  • 2. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, P.R.China;
  • 3. Evidence-Based Social Science Research Center of Lanzhou University, School of Public Health, Lanzhou University, Lanzhou 730000, P.R.China;
  • 4. Guidance Center for Medical Management Services of the National Health Commission, Beijing 100044, P.R.China;
LI Xiuxia, Email: lixiuxia@lzu.edu.cn; YANG Kehu, Email: kehuyangebm2006@126.com
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Objective To systematically review the efficacy and safety of major ozonated autohemotherapy in the treatment of ischemic stroke.Methods PubMed, EMbase, The Cochrane Library, Web of Science, CBM, WanFang Data, VIP and CNKI were electronically searched to collect randomized controlled trials (RCTs) of the efficacy and safety of major ozonated autohemotherapy in the treatment of ischemic stroke from inception to July 1st, 2020. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies. Meta-analysis was then performed by using RevMan 5.3 software.Results A total of 25 RCTs involving 3 681 patients were included. The results of meta-analysis showed that the major ozonated autohemotherapy combined with conventional therapy in the treatment of patients with ischemic stroke in terms of total effective rate (RR=1.20, 95%CI 1.15 to 1.25, P<0.001), national institutes of health stroke scale (MD=−3.15, 95%CI −4.72 to −1.59, P<0.001), total cholesterol (MD=−1.00, 95%CI −1.48 to −0.53, P<0.001), triglyceride (MD=−0.74, 95%CI −1.04 to −0.43, P<0.001), low-density lipoprotein cholesterol (MD=−0.65, 95%CI −1.22 to −0.09, P=0.02), and activity of daily living (MD=11.97, 95%CI 4.48 to 19.47, P=0.002) were superior to the conventional treatment group. There was no significant difference between the two groups in high-density lipoprotein cholesterol (MD=0.25, 95%CI −0.46 to 0.96, P=0.49) and the incidence of adverse effects (OR=3.15, 95%CI 0.93 to 10.63, P=0.06).Conclusions The major ozonated autohemotherapy can significantly improve the prognosis of patients with ischemic stroke while not affecting the adverse effects. Due to the limited quality and quantity of the included studies, more high-quality studies are needed to verify the above conclusions.

Citation: LI Jingwen, ZHANG Na, GU Qinghong, LI Jieyun, GUO Kangle, LI Meixuan, LI Yanfei, ZHANG Hairong, ZHANG Yunqi, LIU Xingrong, BAI Fei, LI Xiuxia, YANG Kehu. Efficacy and safety of major ozonated autohemotherapy in the treatment of ischemic stroke: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2021, 21(8): 889-897. doi: 10.7507/1672-2531.202011034 Copy

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