Systematic review of medication adherence in children with tic disorder_Chinese Journal of Evidence-Based Medicine

Authors：

CHENG Xiao ^1,2,3 , YANG Chunsong ^2,3 , ZHANG Chuan ^2,3 ,  ZHANG Lingli ^1,2,3

1. West China School of Pharmacy, Sichuan University, Chengdu 610041, P.R.China;
2. Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu 610041, P.R.China;
3. Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu 610041, P.R.China;

Corresponding author：

ZHANG Lingli, Email: zhanglingli@scu.edu.cn

Keywords：

Tic disorder; Drug therapy; Adherence; Systematic review

DOI：

10.7507/1672-2531.202012024

Video：

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Objective To systematically review the medication adherence in children with tic disorder to assist in the selection of clinical treatment options and enhance the efficacy of medications for tic disorder.Methods Databases including Medline (Ovid), EMbase (Ovid), The Cochrane Library, PsycINFO (EBSCOhost), CINAHL Plus (EBSCOhost), CNKI, WanFang Data and VIP were searched from inception to August 2020, and original studies on medication adherence in children with tic disorder were included. Two researchers independently screened literature, extracted data on the definition of compliance, compliance rate, and factors affecting compliance, and evaluated risk bias of included studies. Systematic review was performed to analyze the status of medication adherence in children with tic disorder.Results A total of 12 studies were included, involving seven randomized controlled trials, two case series studies, and three cross-sectional studies. Most studies failed to specify the definition of compliance. The results of cross-sectional studies showed that the proportion of children with good medication compliance was 29.3% to 47.1%. The first-line treatment drugs, tiapride, risperidone, aripiprazole, and clonidine, had relatively good adherence. Medication adherence was affected by drug factors, patient and family factors, and environmental factors.Conclusions The adherence rate of medications for tic disorder varies between studies. Few studies have analyzed the factors that affect medication adherence for tic disorder, and some influencing factors are controversial. The first-line treatment drugs, tiapride, risperidone, aripiprazole, and clonidine, have high medication adherence and are recommended for clinical use.

Citation： CHENG Xiao, YANG Chunsong, ZHANG Chuan, ZHANG Lingli. Systematic review of medication adherence in children with tic disorder. Chinese Journal of Evidence-Based Medicine, 2021, 21(5): 586-592. doi: 10.7507/1672-2531.202012024 Copy

1.	中华医学会儿科学分会神经学组. 儿童抽动障碍诊断与治疗专家共识(2017 实用版). 中华实用儿科临床杂志, 2017, 32(15): 1137-1140.
2.	Sharma N, Mishra R, Mishra D. The fifth edition of diagnostic and statistical manual of mental disorders (DSM-5): what is new for the pediatrician? Indian Pediatr, 2015, 52(2): 141-143.
3.	Yang C, Zhang L, Zhu P, et al. The prevalence of tic disorders for children in China: a systematic review and meta-analysis. Medicine (Baltimore), 2016, 95(30): 4354.
4.	Robertson MM. A personal 35 year perspective on Gilles de la Tourette syndrome: prevalence, phenomenology, comorbidities, and coexistent psychopathologies. Lancet Psychiat, 2015, 2(1): 68-87.
5.	Robertson MM. A personal 35 year perspective on Gilles de la Tourette syndrome: assessment, investigations, and management. Lancet Psychiat, 2015, 2(1): 88-104.
6.	Pringsheim T, Doja A, Gorman D, et al. Canadian guidelines for the evidence-based treatment of tic disorders: pharmacotherapy. Can J Psychiatry, 2012, 57(3): 133-143.
7.	Hamamoto Y, Fujio M, Nonaka M, et al. Expert consensus on pharmacotherapy for tic disorders in Japan. Brain Dev, 2019, 41(6): 501-506.
8.	张冉, 田庆秀, 余丽君. 支气管哮喘患者吸入糖皮质激素治疗依从性的研究. 中华护理杂志, 2015, 50(1): 42-47.
9.	亓小燕, 戴俊明, 尉敏琦, 等. 高血压患者社会支持, 药物治疗依从性与血压控制的关系. 中华高血压杂志, 2014, 22(1): 36-41.
10.	van Driel ML, Morledge MD, Ulep R, et al. Interventions to improve adherence to lipid-lowering medication. Cochrane Database Syst Rev, 2016, (12): CD004371.
11.	郑亚兵, 宋雄. 泰必利和氟哌啶醇治疗多发性抽动症依从性比较. 广西中医学院学报, 2002, 5(2): 22-23.
12.	李耀东, 罗有年, 吴海珊, 等. 利培酮与氟哌啶醇治疗儿童抽动障碍对照研究. 中国康复理论与实践, 2006, 12(10): 844-845.
13.	刘艳艳, 陈燕惠, 陈辉, 等. 阿立哌唑与硫必利治疗儿童抽动障碍的对照研究. 中国当代儿科杂志, 2010, 12(6): 421-424.
14.	秦劼. 阿立哌唑用于抽动障碍中对疗效及患儿依从性的影响. 医药前沿, 2014, (27): 128-129.
15.	徐欣欣. 阿立哌唑用于抽动障碍中对疗效和患儿依从性的影响. 世界最新医学信息文摘(连续型电子期刊), 2015, (30): 77-78.
16.	陈颖萍, 陈燕惠. 系统化行为干预对抽动障碍患儿的疗效. 中国儿童保健杂志, 2017, 25(5): 448-451.
17.	Gilbert DL, Murphy TK, Jankovic J, et al. Ecopipam, a D1 receptor antagonist, for treatment of tourette syndrome in children: A randomized, placebo-controlled crossover study. Mov Disord, 2018, 33(8): 1272-1280.
18.	Leckman JF, Detlor J, Harcherik DF, et al. Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective. Neurology, 1985, 35(3): 343-351.
19.	Silva RR, Muñoz DM, Daniel W, et al. Causes of haloperidol discontinuation in patients with Tourette's disorder: management and alternatives. J Clin Psychiatry, 1996, 57(3): 129-135.
20.	吴红波, 吕魏峰, 郭伟. 抽动障碍儿童就医行为及药物治疗影响因素. 中华高血压杂志社, 2015, 23(3): 636-637.
21.	杨春松, 俞丹, 许群芬, 等. 某院抽动障碍患儿用药依从性及影响因素分析. 儿科药学杂志, 2019, 25(3): 36-39.
22.	Yang C, Qin W, Yu D, et al. Medication adherence and associated factors for children with Tic disorders in western China: a cross-sectional survey. Front Neurol, 2019, 10: 1156.
23.	Yang C, Hao Z, Yu D, et al. The prevalence rates of medication adherence and factors influencing adherence to antiepileptic drugs in children with epilepsy: a systematic review and meta-analysis. Epilepsy Res, 2018, 142: 88-99.

1. 中华医学会儿科学分会神经学组. 儿童抽动障碍诊断与治疗专家共识(2017 实用版). 中华实用儿科临床杂志, 2017, 32(15): 1137-1140.
2. Sharma N, Mishra R, Mishra D. The fifth edition of diagnostic and statistical manual of mental disorders (DSM-5): what is new for the pediatrician? Indian Pediatr, 2015, 52(2): 141-143.
3. Yang C, Zhang L, Zhu P, et al. The prevalence of tic disorders for children in China: a systematic review and meta-analysis. Medicine (Baltimore), 2016, 95(30): 4354.
4. Robertson MM. A personal 35 year perspective on Gilles de la Tourette syndrome: prevalence, phenomenology, comorbidities, and coexistent psychopathologies. Lancet Psychiat, 2015, 2(1): 68-87.
5. Robertson MM. A personal 35 year perspective on Gilles de la Tourette syndrome: assessment, investigations, and management. Lancet Psychiat, 2015, 2(1): 88-104.
6. Pringsheim T, Doja A, Gorman D, et al. Canadian guidelines for the evidence-based treatment of tic disorders: pharmacotherapy. Can J Psychiatry, 2012, 57(3): 133-143.
7. Hamamoto Y, Fujio M, Nonaka M, et al. Expert consensus on pharmacotherapy for tic disorders in Japan. Brain Dev, 2019, 41(6): 501-506.
8. 张冉, 田庆秀, 余丽君. 支气管哮喘患者吸入糖皮质激素治疗依从性的研究. 中华护理杂志, 2015, 50(1): 42-47.
9. 亓小燕, 戴俊明, 尉敏琦, 等. 高血压患者社会支持, 药物治疗依从性与血压控制的关系. 中华高血压杂志, 2014, 22(1): 36-41.
10. van Driel ML, Morledge MD, Ulep R, et al. Interventions to improve adherence to lipid-lowering medication. Cochrane Database Syst Rev, 2016, (12): CD004371.
11. 郑亚兵, 宋雄. 泰必利和氟哌啶醇治疗多发性抽动症依从性比较. 广西中医学院学报, 2002, 5(2): 22-23.
12. 李耀东, 罗有年, 吴海珊, 等. 利培酮与氟哌啶醇治疗儿童抽动障碍对照研究. 中国康复理论与实践, 2006, 12(10): 844-845.
13. 刘艳艳, 陈燕惠, 陈辉, 等. 阿立哌唑与硫必利治疗儿童抽动障碍的对照研究. 中国当代儿科杂志, 2010, 12(6): 421-424.
14. 秦劼. 阿立哌唑用于抽动障碍中对疗效及患儿依从性的影响. 医药前沿, 2014, (27): 128-129.
15. 徐欣欣. 阿立哌唑用于抽动障碍中对疗效和患儿依从性的影响. 世界最新医学信息文摘(连续型电子期刊), 2015, (30): 77-78.
16. 陈颖萍, 陈燕惠. 系统化行为干预对抽动障碍患儿的疗效. 中国儿童保健杂志, 2017, 25(5): 448-451.
17. Gilbert DL, Murphy TK, Jankovic J, et al. Ecopipam, a D1 receptor antagonist, for treatment of tourette syndrome in children: A randomized, placebo-controlled crossover study. Mov Disord, 2018, 33(8): 1272-1280.
18. Leckman JF, Detlor J, Harcherik DF, et al. Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective. Neurology, 1985, 35(3): 343-351.
19. Silva RR, Muñoz DM, Daniel W, et al. Causes of haloperidol discontinuation in patients with Tourette's disorder: management and alternatives. J Clin Psychiatry, 1996, 57(3): 129-135.
20. 吴红波, 吕魏峰, 郭伟. 抽动障碍儿童就医行为及药物治疗影响因素. 中华高血压杂志社, 2015, 23(3): 636-637.
21. 杨春松, 俞丹, 许群芬, 等. 某院抽动障碍患儿用药依从性及影响因素分析. 儿科药学杂志, 2019, 25(3): 36-39.
22. Yang C, Qin W, Yu D, et al. Medication adherence and associated factors for children with Tic disorders in western China: a cross-sectional survey. Front Neurol, 2019, 10: 1156.
23. Yang C, Hao Z, Yu D, et al. The prevalence rates of medication adherence and factors influencing adherence to antiepileptic drugs in children with epilepsy: a systematic review and meta-analysis. Epilepsy Res, 2018, 142: 88-99.

Chinese Journal of Evidence-Based Medicine

Systematic review of medication adherence in children with tic disorder

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