Experience and enlightenment from the design of the "All of Us" research program in the US precision medicine program_Chinese Journal of Evidence-Based Medicine

Authors：

QI Zifan ^1,2 , ZHANG Fengxu ^1,2 ,  ZHANG Ling ^1,2

1. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, P.R.China;
2. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, P.R.China;

Corresponding author：

ZHANG Ling, Email: zlilyepi@ccmu.edu.cn

Keywords：

"All of Us" research program; Precision medicine; Cohort

DOI：

10.7507/1672-2531.202104038

Video：

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The "All of Us" research program is a research project supported by the National Institutes of Health. By recruiting over 1 million volunteers residing in the United States, the project builds a strong research resource to promote the exploration of biological, clinical, social, and environmental determinants of health and disease. This paper introduced the design plan of the "All of Us" research program systematically and provided information that can be used for the construction of a million natural population cohort of precision medicine in China.

Citation： QI Zifan, ZHANG Fengxu, ZHANG Ling. Experience and enlightenment from the design of the "All of Us" research program in the US precision medicine program. Chinese Journal of Evidence-Based Medicine, 2021, 21(8): 980-985. doi: 10.7507/1672-2531.202104038 Copy

1.	李瑛. 精准医学与队列研究. 中国计划生育学杂志, 2018, 26(11): 1016-1018, 1023.
2.	Sankar PL, Parker LS. The precision medicine initiative's all of us research program: an agenda for research on its ethical, legal, and social issues. Genet Med, 2017, 19(7): 743-750.
3.	邹明明. 关于“精准医学先导队列项目”的更名. 医学与哲学, 2018, 39(1): 12-14, 70.
4.	Denny JC, Rutter JL, Goldstein DB, et al. The "all of us" research program. N Engl J Med, 2019, 381(7): 668-676.
5.	Galea S, Abdalla SM. Precision medicine approaches and the health of populations: study design concerns and considerations. Perspect Biol Med, 2018, 61(4): 527-536.
6.	Turner SP, Pompea ST, Williams KL, et al. Implementation of informatics to support the NIH all of us research program in a healthcare provider organization. AMIA Jt Summits Transl Sci Proc, 2019, 2019: 602-609.
7.	舒婷, 刘海一, 赵韡. 中美电子病历系统十年发展启示. 中国数字医学, 2019, 14(11): 10-13.
8.	Mapes BM, Foster CS, Kusnoor SV, et al. Diversity and inclusion for the all of us research program: a scoping review. PLoS One, 2020, 15(7): e0234962.
9.	Llanto K, Lim F, Ea E. Impact of the all of us research program. Nursing, 2020, 50(3): 67-68.
10.	The All Of Us Research Program. One size does not fit all. Nurse Pract, 2018, 43(8): 11.
11.	Mumba MN, Key B, Nancarrow A, et al. Engaging African-Americans in research in the era of precision medicine: an all of us research program initiative. J Natl Black Nurses Assoc, 2020, 31(2): 39-44.
12.	Baxter SL, Saseendrakumar BR, Paul P, et al. Predictive analytics for glaucoma using data from the all of us research program. Am J Ophthalmol, 2021, 227: 74-86.
13.	Coughlin SS, Chen J, Cortes JE. Health care access and utilization among adult cancer survivors: results from the national institutes of health "all of us" research program. Cancer Med, 2021, 10(11): 3646-3654.
14.	Fox K. The illusion of inclusion - the "all of us" research program and indigenous peoples' DNA. N Engl J Med, 2020, 383(5): 411-413.

1. 李瑛. 精准医学与队列研究. 中国计划生育学杂志, 2018, 26(11): 1016-1018, 1023.
2. Sankar PL, Parker LS. The precision medicine initiative's all of us research program: an agenda for research on its ethical, legal, and social issues. Genet Med, 2017, 19(7): 743-750.
3. 邹明明. 关于“精准医学先导队列项目”的更名. 医学与哲学, 2018, 39(1): 12-14, 70.
4. Denny JC, Rutter JL, Goldstein DB, et al. The "all of us" research program. N Engl J Med, 2019, 381(7): 668-676.
5. Galea S, Abdalla SM. Precision medicine approaches and the health of populations: study design concerns and considerations. Perspect Biol Med, 2018, 61(4): 527-536.
6. Turner SP, Pompea ST, Williams KL, et al. Implementation of informatics to support the NIH all of us research program in a healthcare provider organization. AMIA Jt Summits Transl Sci Proc, 2019, 2019: 602-609.
7. 舒婷, 刘海一, 赵韡. 中美电子病历系统十年发展启示. 中国数字医学, 2019, 14(11): 10-13.
8. Mapes BM, Foster CS, Kusnoor SV, et al. Diversity and inclusion for the all of us research program: a scoping review. PLoS One, 2020, 15(7): e0234962.
9. Llanto K, Lim F, Ea E. Impact of the all of us research program. Nursing, 2020, 50(3): 67-68.
10. The All Of Us Research Program. One size does not fit all. Nurse Pract, 2018, 43(8): 11.
11. Mumba MN, Key B, Nancarrow A, et al. Engaging African-Americans in research in the era of precision medicine: an all of us research program initiative. J Natl Black Nurses Assoc, 2020, 31(2): 39-44.
12. Baxter SL, Saseendrakumar BR, Paul P, et al. Predictive analytics for glaucoma using data from the all of us research program. Am J Ophthalmol, 2021, 227: 74-86.
13. Coughlin SS, Chen J, Cortes JE. Health care access and utilization among adult cancer survivors: results from the national institutes of health "all of us" research program. Cancer Med, 2021, 10(11): 3646-3654.
14. Fox K. The illusion of inclusion - the "all of us" research program and indigenous peoples' DNA. N Engl J Med, 2020, 383(5): 411-413.

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