Analysis of the change in disease burden of acne vulgaris in China from 1990 to 2019_Chinese Journal of Evidence-Based Medicine

Authors：

CHEN Linjiao ¹ , TU Shaozhong ¹ , ZHANG Xiaomin ¹ , BU Kailai ¹ , LIU Yongjun ¹ , WAN Xinrong ¹ , LI Donghai ² , LI Ziyi ¹ , PENG Jing ¹ ,  LIN Huaner ¹

1. Shenzhen Hospital, Beijing University of Chinese Medicine (Longgang), Shenzhen 518100, P.R.China;
2. The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, P.R.China;

Corresponding author：

LIN Huaner, Email: linhuaner4501@163.com

Keywords：

Acne vulgaris; China; Disease burden

DOI：

10.7507/1672-2531.202106198

Video：

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Objective To evaluate the disease burden of acne vulgaris in China from 1990 to 2019 and to provide references for the prevention and control of acne vulgaris in China. Methods The quantity of incidences/illnesses, age-standardized incidence/prevalence rates, disability-adjusted life years (DALYs), and DALY rate of acne vulgaris in China from 1990 to 2019 which were derived from the Global Burden of Disease (GBD) 2019 were evaluated. The epidemiological trends, age-birth-cohort trends, and the relationship between the incidence and sociodemographic index (SDI) were also analyzed. Results In 2019, the prevalence and incidence of acne vulgaris in China were higher than the global average. The quantity of patients was slightly higher in 2019 than that in 1990 (3.91%), and the prevalence, incidence, and DALY rate showed a continuous growth trend. The incidence of acne vulgaris peaked at 10 to 14 years old. Acne vulgaris mostly affected young males, and its prevalence peaked at approximately 15 to 19 years old. With these two age groups as the boundary, there was a trend of the prevalence of acne vulgaris increasing initially and then decreasing. Obvious gender differences existed for acne vulgaris diagnoses, and most of the above indicators were shown at a higher level in females than in males. The age period cohort analysis showed that the incidence rate of acne vulgaris in China from 1990 to 2019 was significantly different from the net drift, age effect, period effect and cohort effect. As the SDI value increased, the incidence of acne vulgaris showed a linear growth trend. Conclusions From 1990 to 2019, the burden of acne disease in China increases significantly.

Citation： CHEN Linjiao, TU Shaozhong, ZHANG Xiaomin, BU Kailai, LIU Yongjun, WAN Xinrong, LI Donghai, LI Ziyi, PENG Jing, LIN Huaner. Analysis of the change in disease burden of acne vulgaris in China from 1990 to 2019. Chinese Journal of Evidence-Based Medicine, 2021, 21(11): 1252-1258. doi: 10.7507/1672-2531.202106198 Copy

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2.	Zaenglein AL. Acne vulgaris. N Engl J Med, 2018, 379(14): 1343-1352.
3.	Shen Y, Wang T, Zhou C, et al. Prevalence of acne vulgaris in Chinese adolescents and adults: a community-based study of 17, 345 subjects in six cities. Acta Derm Venereol, 2012, 92(1): 40-44.
4.	Layton AM, Thiboutot D, Tan J. Reviewing the global burden of acne: how could we improve care to reduce the burden. Br J Dermatol, 2021, 184(2): 219-225.
5.	Mallon E, Newton JN, Klassen A, et al. The quality of life in acne: a comparison with general medical conditions using generic questionnaires. Br J Dermatol, 1999, 140(4): 672-676.
6.	Harper JC. Acne vulgaris: what's new in our 40th year. J Am Acad Dermatol, 2020, 82(2): 526-527.
7.	Rademaker M, Garioch JJ, Simpson NB. Acne in schoolchildren: no longer a concern for dermatologists. BMJ, 1989, 298(6682): 1217-1219.
8.	Law MP, Chuh AA, Lee A, et al. Acne prevalence and beyond: acne disability and its predictive factors among Chinese late adolescents in Hong Kong. Clin Exp Dermatol, 2010, 35(1): 16-21.
9.	Ayer J, Burrows N. Acne: more than skin deep. Postgrad Med J, 2006, 82(970): 500-506.
10.	Sood S, Jafferany M, Vinaya Kumar S. Depression, psychiatric comorbidities, and psychosocial implications associated with acne vulgaris. J Cosmet Dermatol, 2020, 19(12): 3177-3182.
11.	GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 2020, 396(10258): 1204-1222.
12.	Naghavi M, Makela S, Foreman K, et al. Algorithms for enhancing public health utility of national causes-of-death data. Popul Health Metr, 2010, 8: 9.
13.	屈彦, 王天一, 杨津, 等. GBD数据库的数据提取方法与流程. 中国循证心血管医学杂志, 2019, 11(9): 1043-1046.
14.	孟令昊, 胥秋艳, 李科, 等. 1990~2019年中国女性宫颈癌疾病负担变化的分析. 中国循证医学杂志, 2021, 21(6): 648-653.
15.	Rosenberg PS, Check DP, Anderson WF. A web tool for age-period-cohort analysis of cancer incidence and mortality rates. Cancer Epidemiol Biomarkers Prev, 2014, 23(11): 2296-2302.
16.	熊甜, 王雷, 魏晟, 等. 2004-2016年湖北省0~10岁人群乙肝发病变化的年龄-时期队(APC)模型. 中国卫生统计, 2018, 35(3): 388-390.
17.	Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, 380(9859): 2163-2196.
18.	Xu S, Zhu Y, Hu H, et al. The analysis of acne increasing suicide risk. Medicine (Baltimore), 2021, 100(24): e26035.
19.	Dreno B, Amici JM, Demessant-Flavigny AL, et al. The impact of acne, atopic dermatitis, skin toxicities and scars on quality of life and the importance of a holistic treatment approach. Clin Cosmet Investig Dermatol, 2021, 14: 623-632.
20.	Laughter MR, Maymone MBC, Karimkhani C, et al. The burden of skin and subcutaneous diseases in the United States from 1990 to 2017. JAMA Dermatol, 2020, 156(8): 874-881.
21.	Lynn DD, Umari T, Dunnick CA, et al. The epidemiology of acne vulgaris in late adolescence. Adolesc Health Med Ther, 2016, 7: 13-25.
22.	Purvis D, Robinson E, Watson P. Acne prevalence in secondary school students and their perceived difficulty in accessing acne treatment. N Z Med J, 2004, 117(1200): U1018.
23.	Gonçalves G, Amado JM, Matos ME, et al. The prevalence of acne among a group of Portuguese medical students. J Eur Acad Dermatol Venereol, 2012, 26(4): 514-517.
24.	Ali G, Mehtab K, Sheikh ZA, et al. Beliefs and perceptions of acne among a sample of students from Sindh Medical College, Karachi. J Pak Med Assoc, 2010, 60(1): 51-54.
25.	Peng C, Xu X, Chen W, et al. Epidemiological variations in the global burden of psoriasis, an analysis with trends from 1990 to 2017. Front Med (Lausanne), 2021, 8: 585634.
26.	GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 2020, 396(10258): 1223-1249.

1. Moradi Tuchayi S, Makrantonaki E, Ganceviciene R, et al. Acne vulgaris. Nat Rev Dis Primers, 2015, 1: 15029.
2. Zaenglein AL. Acne vulgaris. N Engl J Med, 2018, 379(14): 1343-1352.
3. Shen Y, Wang T, Zhou C, et al. Prevalence of acne vulgaris in Chinese adolescents and adults: a community-based study of 17, 345 subjects in six cities. Acta Derm Venereol, 2012, 92(1): 40-44.
4. Layton AM, Thiboutot D, Tan J. Reviewing the global burden of acne: how could we improve care to reduce the burden. Br J Dermatol, 2021, 184(2): 219-225.
5. Mallon E, Newton JN, Klassen A, et al. The quality of life in acne: a comparison with general medical conditions using generic questionnaires. Br J Dermatol, 1999, 140(4): 672-676.
6. Harper JC. Acne vulgaris: what's new in our 40th year. J Am Acad Dermatol, 2020, 82(2): 526-527.
7. Rademaker M, Garioch JJ, Simpson NB. Acne in schoolchildren: no longer a concern for dermatologists. BMJ, 1989, 298(6682): 1217-1219.
8. Law MP, Chuh AA, Lee A, et al. Acne prevalence and beyond: acne disability and its predictive factors among Chinese late adolescents in Hong Kong. Clin Exp Dermatol, 2010, 35(1): 16-21.
9. Ayer J, Burrows N. Acne: more than skin deep. Postgrad Med J, 2006, 82(970): 500-506.
10. Sood S, Jafferany M, Vinaya Kumar S. Depression, psychiatric comorbidities, and psychosocial implications associated with acne vulgaris. J Cosmet Dermatol, 2020, 19(12): 3177-3182.
11. GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 2020, 396(10258): 1204-1222.
12. Naghavi M, Makela S, Foreman K, et al. Algorithms for enhancing public health utility of national causes-of-death data. Popul Health Metr, 2010, 8: 9.
13. 屈彦, 王天一, 杨津, 等. GBD数据库的数据提取方法与流程. 中国循证心血管医学杂志, 2019, 11(9): 1043-1046.
14. 孟令昊, 胥秋艳, 李科, 等. 1990~2019年中国女性宫颈癌疾病负担变化的分析. 中国循证医学杂志, 2021, 21(6): 648-653.
15. Rosenberg PS, Check DP, Anderson WF. A web tool for age-period-cohort analysis of cancer incidence and mortality rates. Cancer Epidemiol Biomarkers Prev, 2014, 23(11): 2296-2302.
16. 熊甜, 王雷, 魏晟, 等. 2004-2016年湖北省0~10岁人群乙肝发病变化的年龄-时期队(APC)模型. 中国卫生统计, 2018, 35(3): 388-390.
17. Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, 380(9859): 2163-2196.
18. Xu S, Zhu Y, Hu H, et al. The analysis of acne increasing suicide risk. Medicine (Baltimore), 2021, 100(24): e26035.
19. Dreno B, Amici JM, Demessant-Flavigny AL, et al. The impact of acne, atopic dermatitis, skin toxicities and scars on quality of life and the importance of a holistic treatment approach. Clin Cosmet Investig Dermatol, 2021, 14: 623-632.
20. Laughter MR, Maymone MBC, Karimkhani C, et al. The burden of skin and subcutaneous diseases in the United States from 1990 to 2017. JAMA Dermatol, 2020, 156(8): 874-881.
21. Lynn DD, Umari T, Dunnick CA, et al. The epidemiology of acne vulgaris in late adolescence. Adolesc Health Med Ther, 2016, 7: 13-25.
22. Purvis D, Robinson E, Watson P. Acne prevalence in secondary school students and their perceived difficulty in accessing acne treatment. N Z Med J, 2004, 117(1200): U1018.
23. Gonçalves G, Amado JM, Matos ME, et al. The prevalence of acne among a group of Portuguese medical students. J Eur Acad Dermatol Venereol, 2012, 26(4): 514-517.
24. Ali G, Mehtab K, Sheikh ZA, et al. Beliefs and perceptions of acne among a sample of students from Sindh Medical College, Karachi. J Pak Med Assoc, 2010, 60(1): 51-54.
25. Peng C, Xu X, Chen W, et al. Epidemiological variations in the global burden of psoriasis, an analysis with trends from 1990 to 2017. Front Med (Lausanne), 2021, 8: 585634.
26. GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 2020, 396(10258): 1223-1249.

Chinese Journal of Evidence-Based Medicine

Analysis of the change in disease burden of acne vulgaris in China from 1990 to 2019

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