• Research Center of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China;
LI Jing, Email: lijing68@Hotmail.com
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Mendelian randomization is a special type of instrumental variable analysis. Its application in the medical field increases in popularity because of its obvious advantages and the rapid development of genomics. This article aimed to introduce the basic concepts, principles, common methods, and limitations of Mendelian randomization. It is expected to provide guidance for researchers to conduct Mendelian randomization studies.

Citation: YU Tianqi, XU Wentao, SU Yana, LI Jing. Mendelian randomization: the basic principles, methods and limitations. Chinese Journal of Evidence-Based Medicine, 2021, 21(10): 1227-1234. doi: 10.7507/1672-2531.202107008 Copy

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