Influencing factors of mild cognitive impairment in patients with type 2 diabetes: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

XUE Chenghao ¹ ,  GUO Haijian ² , LI Mingma ¹ , YAN Tao ¹ ,  WANG Bei ¹

1. Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210009, P. R. China;
2. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, P. R. China;

Corresponding author：

GUO Haijian, Email: guohjcdc@163.com; WANG Bei, Email: wangbeilxb@163.com

Keywords：

Type 2 diabetes; Mild cognitive impairment; Influencing factor; Meta-analysis; Systematic review

DOI：

10.7507/1672-2531.202111062

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the influencing factors of mild cognitive impairment in type 2 diabetic patients. Methods PubMed, Web of Science, EMbase, The Cochrane Library, CNKI, WanFang Data, VIP, and CBM databases were electronically searched to collect studies on the influencing factors of mild cognitive impairment in patients with type 2 diabetes from inception to December 31, 2021. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias of included studies; then, meta-analysis was performed by using RevMan 5.4 software and Stata 12.0 software. Results A total of 32 studies involving 7 519 subjects were included. The results of the meta-analysis showed that the main influencing factors of mild cognitive impairment in type 2 diabetic patients were age, duration of type 2 diabetes, educational level, cerebral infarction, hypertension, smoking, insulin resistance index, glycosylated hemoglobin, and homocysteine. Conclusion Current evidence shows that some factors such as age, duration, and educational level are the main influencing factors of mild cognitive impairment in type 2 diabetic patients. Due to the limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusions.

Citation： XUE Chenghao, GUO Haijian, LI Mingma, YAN Tao, WANG Bei. Influencing factors of mild cognitive impairment in patients with type 2 diabetes: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2022, 22(5): 568-574. doi: 10.7507/1672-2531.202111062 Copy

1.	Ali MK, Pearson-Stuttard J, Selvin E, et al. Interpreting global trends in type 2 diabetes complications and mortality. Diabetologia, 2022, 65(1): 3-13.
2.	You Y, Liu Z, Chen Y, et al. The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis. Acta Diabetol, 2021, 58(6): 671-685.
3.	Degen C, Toro P, Schönknecht P, et al. Diabetes mellitus type Ⅱ and cognitive capacity in healthy aging, mild cognitive impairment and Alzheimer's disease. Psychiatry Res, 2016, 240: 42-46.
4.	Jongsiriyanyong S, Limpawattana P. Mild cognitive impairment in clinical practice: a review article. Am J Alzheimers Dis Other Demen, 2018, 33(8): 500-507.
5.	朱玲玲, 朱骏, 王敏, 等. 2型糖尿病合并认知功能障碍的危险因素. 实用老年医学, 2021, 35(6): 606-608.
6.	赵立华. 2型糖尿病认知功能障碍的特点及IDE, ADP和胰岛素抵抗对认知功能的影响. 天津: 天津医科大学, 2015.
7.	张冉腾, 康冬梅. 老年男性2型糖尿病患者骨代谢与认知功能障碍的关系. 慢性病学杂志, 2021, 22(5): 655-658.
8.	张玲, 陈政文, 陆晨, 等. 维吾尔族老年糖尿病患者轻度认知功能障碍的影响因素分析. 中华老年医学杂志, 2017, 36(9): 951-954.
9.	张利楠, 艾比拜·玉素甫. 血清胱抑素C水平与老年2型糖尿病患者轻度认知功能障碍的关系探讨. 饮食保健, 2019, 6(13): 8-9.
10.	谢小莉, 李燕, 霍敏, 等. 老年2型糖尿病患者轻度认知功能障碍与胰岛素抵抗、白介素-6的相关性研究. 医学信息, 2019, 32(15): 97-98,108.
11.	王颖. 2型糖尿病患者认知功能障碍与糖尿病血管并发症的相关性研究. 济南: 山东大学, 2015.
12.	王品. RAGEGly82Ser基因多态性及血清sRAGE水平与2型糖尿病相关轻度认知障碍相关性研究. 南京: 东南大学, 2015.
13.	王妮, 陈晓. 老年2型糖尿病患者轻度认知功能障碍相关危险因素研究. 现代医药卫生, 2021, 37(24): 4254-4257.
14.	汪璐璐, 刘安诺, 刘鸿雁, 等. 2型糖尿病患者自我管理行为与认知功能各维度的关系研究. 实用预防医学, 2020, 27(1): 1-4.
15.	司俊霞, 谈跃, 徐勉, 等. 胰岛素水平与轻度认知障碍关系的临床研究. 中国糖尿病杂志, 2008, 16(7): 418-420.
16.	毛秀英, 邱宏亮. 社区老年2型糖尿病患者合并轻度认知功能障碍危险因素分析. 实用老年医学, 2014, 28(7): 587-590.
17.	马丽丽. 老年2型糖尿病患者轻度认知功能障碍发生的影响因素. 中国卫生工程学, 2020, 19(3): 362-364.
18.	马彪, 杨勇, 孟宪海, 等. 2型糖尿病伴轻度认知功能减退与载脂蛋白Eε4等位基因等因素的关系. 中国慢性病预防与控制, 2014, 22(1): 81-83.
19.	李敏, 张丽, 王敏哲. 老年2型糖尿病与轻度认知功能障碍的关系研究. 中国全科医学, 2011, 14(14): 1537-1539.
20.	李春花, 郭昕, 豆静, 等. 2型糖尿病患者认知功能障碍及其影响因素调查分析. 吉林大学学报(医学版), 2018, 44(2): 431-437.
21.	李琛, 梁兴伦, 周文锐, 等. 老年2型糖尿病患者轻度认知功能障碍与胰岛素抵抗的关系研究. 临床和实验医学杂志, 2014, 13(16): 1369-1371.
22.	坎丽比努尔·买米提民, 亚森江·买买提, 麦迪娜·阿不都热依木, 等. 2型糖尿病患者并发轻度认知功能障碍的危险因素分析. 医学临床研究, 2021, 38(9): 1402-1404.
23.	黄金, 胡进, 朱熊兆, 等. 社区2型糖尿病患者认知功能现状及其影响因素研究. 中国全科医学, 2016, 19(2): 135-141.
24.	郝云玲, 严励. 2型糖尿病合并轻度认知功能障碍相关因素分析. 中国医药导报, 2012, 9(35): 84-85,88.
25.	郭连雨, 刘艳, 仇海燕, 等. 2型糖尿病合并轻度认知功能障碍的危险因素分析. 天津医药, 2013, 41(8): 772-775.
26.	宫娟, 刘安诺, 郑红英, 等. 中年2型糖尿病患者认知功能损害特征及影响因素调查. 临床护理杂志, 2020, 19(4): 26-29.
27.	Cai R, Han J, Sun J, et al. Plasma clusterin and the CLU gene rs11136000 variant are associated with mild cognitive impairment in type 2 diabetic patients. Front Aging Neurosci, 2016, 8: 179.
28.	Zheng M, Zhang M, Yang J, et al. Relationship between blood levels of methyl donor and folate and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study. J Clin Biochem Nutr, 2014, 54(2): 122-128.
29.	Damanik J, Mayza A, Rachman A, et al. Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients. PLoS One, 2019, 14(11): e0224611.
30.	Guo D, Yuan Y, Huang R, et al. Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study. BMC Endocr Disord, 2019, 19(1): 108.
31.	Gorska-Ciebiada M, Saryusz-Wolska M, Borkowska A, et al. Adiponectin, leptin and IL-1 β in elderly diabetic patients with mild cognitive impairment. Metab Brain Dis, 2016, 31(2): 257-266.
32.	Gorska-Ciebiada M, Saryusz-Wolska M, Borkowska A, et al. C-reactive protein, advanced glycation end products, and their receptor in type 2 diabetic, elderly patients with mild cognitive impairment. Front Aging Neurosci, 2015, 7: 209.
33.	Gao Y, Xiao Y, Miao R, et al. The prevalence of mild cognitive impairment with type 2 diabetes mellitus among elderly people in China: a cross-sectional study. Arch Gerontol Geriatr, 2016, 62: 138-142.
34.	Cai R, Huang R, Han J, et al. Lipoprotein-associated phospholipase A2 is associated with risk of mild cognitive impairment in Chinese patients with type 2 diabetes. Sci Rep, 2017, 7(1): 12311.
35.	Blanquisco L, Abejero JE, Buno Ii B, et al. Factors associated with mild cognitive impairment among elderly filipinos with type 2 diabetes mellitus. J ASEAN Fed Endocr Soc, 2017, 32(2): 145-150.
36.	Aljohani A, Salem KA, Aljohani A, et al. Factors related to mild cognitive impairment among type 2 diabetic patients attending diabetes center in Al-Madinah, Saudi Arabia 2019-2020. Med Sci, 2020, 24(106): 4080-4090.
37.	Chen RH, Jiang XZ, Zhao XH, et al. Risk factors of mild cognitive impairment in middle aged patients with type 2 diabetes: a cross-section study. Ann Endocrinol (Paris), 2012, 73(3): 208-212.
38.	Korf ES, White LR, Scheltens P, et al. Brain aging in very old men with type 2 diabetes: the Honolulu-Asia Aging Study. Diabetes Care, 2006, 29(10): 2268-2274.
39.	邹小燕. 社区老年糖尿病患者认知功能障碍原因及危险因素调查. 实用预防医学, 2014, 21(5): 632-634.
40.	Espeland MA, Bryan RN, Goveas JS, et al. Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the women's health initiative magnetic resonance imaging studies. Diabetes Care, 2013, 36(1): 90-97.
41.	Parikh NM, Morgan RO, Kunik ME, et al. Risk factors for dementia in patients over 65 with diabetes. Int J Geriatr Psychiatry, 2011, 26(7): 749-757.
42.	Biessels GJ, Deary IJ, Ryan CM. Cognition and diabetes: a lifespan perspective. Lancet Neurol, 2008, 7(2): 184-190.
43.	刘风兰. 认知干预对轻度认知障碍患者认知功能和生活质量的影响研究. 长沙: 中南大学, 2012.
44.	Tu J, Wang LX, Wen HF, et al. The association of different types of cerebral infarction with post-stroke depression and cognitive impairment. Medicine (Baltimore), 2018, 97(23): e10919.
45.	Beauchet O, Herrmann FR, Annweiler C, et al. Association between ambulatory 24-hour blood pressure levels and cognitive performance: a cross-sectional elderly population-based study. Rejuvenation Res, 2010, 13(1): 39-46.
46.	Hassing LB, Hofer SM, Nilsson SE, et al. Comorbid type 2 diabetes mellitus and hypertension exacerbates cognitive decline: evidence from a longitudinal study. Age Ageing, 2004, 33(4): 355-361.
47.	Veglio F, Paglieri C, Rabbia F, et al. Hypertension and cerebrovascular damage. Atherosclerosis, 2009, 205(2): 331-341.
48.	Iadecola C, Davisson RL. Hypertension and cerebrovascular dysfunction. Cell Metab, 2008, 7(6): 476-484.
49.	孙芩玲, 雷曦, 曹英, 等. 吸烟对中老年人轻度认知功能障碍的影响. 湖北医药学院学报, 2017, 36(4): 330-333,337.
50.	Lee HJ, Seo HI, Cha HY, et al. Diabetes and alzheimer's disease: mechanisms and nutritional aspects. Clin Nutr Res, 2018, 7(4): 229-240.
51.	Arnold SE, Arvanitakis Z, Macauley-Rambach SL, et al. Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. Nat Rev Neurol, 2018, 14(3): 168-181.
52.	Weinstein G, Maillard P, Himali JJ, et al. Glucose indices are associated with cognitive and structural brain measures in young adults. Neurology, 2015, 84(23): 2329-2337.
53.	Robbins MA, Elias MF, Budge MM, et al. Homocysteine, type 2 diabetes mellitus, and cognitive performance: the maine-syracuse study. Clin Chem Lab Med, 2005, 43(10): 1101-1106.
54.	Sainani GS, Sainani R. Homocysteine and its role in the pathogenesis of atherosclerotic vascular disease. J Assoc Physicians India, 2002, 50(Suppl): 16-23.
55.	Li Y, Jiang C, Xu G, et al. Homocysteine upregulates resistin production from adipocytes in vivo and in vitro. Diabetes, 2008, 57(4): 817-827.
56.	Cukierman-Yaffe T, Gerstein HC, Williamson JD, et al. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial. Diabetes Care, 2009, 32(2): 221-226.
57.	Christman AL, Matsushita K, Gottesman RF, et al. Glycated haemoglobin and cognitive decline: the atherosclerosis risk in communities (ARIC) study. Diabetologia, 2011, 54(7): 1645-1652.
58.	韩梅, 苏俊平, 戈美琴, 等. 强化教育联合足病筛查对糖尿病足的预防效果及认知功能的影响. 检验医学与临床, 2017, 14(17): 2573-2575.
59.	Singh VP, Bali A, Singh N, et al. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol, 2014, 18(1): 1-14.

1. Ali MK, Pearson-Stuttard J, Selvin E, et al. Interpreting global trends in type 2 diabetes complications and mortality. Diabetologia, 2022, 65(1): 3-13.
2. You Y, Liu Z, Chen Y, et al. The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis. Acta Diabetol, 2021, 58(6): 671-685.
3. Degen C, Toro P, Schönknecht P, et al. Diabetes mellitus type Ⅱ and cognitive capacity in healthy aging, mild cognitive impairment and Alzheimer's disease. Psychiatry Res, 2016, 240: 42-46.
4. Jongsiriyanyong S, Limpawattana P. Mild cognitive impairment in clinical practice: a review article. Am J Alzheimers Dis Other Demen, 2018, 33(8): 500-507.
5. 朱玲玲, 朱骏, 王敏, 等. 2型糖尿病合并认知功能障碍的危险因素. 实用老年医学, 2021, 35(6): 606-608.
6. 赵立华. 2型糖尿病认知功能障碍的特点及IDE, ADP和胰岛素抵抗对认知功能的影响. 天津: 天津医科大学, 2015.
7. 张冉腾, 康冬梅. 老年男性2型糖尿病患者骨代谢与认知功能障碍的关系. 慢性病学杂志, 2021, 22(5): 655-658.
8. 张玲, 陈政文, 陆晨, 等. 维吾尔族老年糖尿病患者轻度认知功能障碍的影响因素分析. 中华老年医学杂志, 2017, 36(9): 951-954.
9. 张利楠, 艾比拜·玉素甫. 血清胱抑素C水平与老年2型糖尿病患者轻度认知功能障碍的关系探讨. 饮食保健, 2019, 6(13): 8-9.
10. 谢小莉, 李燕, 霍敏, 等. 老年2型糖尿病患者轻度认知功能障碍与胰岛素抵抗、白介素-6的相关性研究. 医学信息, 2019, 32(15): 97-98,108.
11. 王颖. 2型糖尿病患者认知功能障碍与糖尿病血管并发症的相关性研究. 济南: 山东大学, 2015.
12. 王品. RAGEGly82Ser基因多态性及血清sRAGE水平与2型糖尿病相关轻度认知障碍相关性研究. 南京: 东南大学, 2015.
13. 王妮, 陈晓. 老年2型糖尿病患者轻度认知功能障碍相关危险因素研究. 现代医药卫生, 2021, 37(24): 4254-4257.
14. 汪璐璐, 刘安诺, 刘鸿雁, 等. 2型糖尿病患者自我管理行为与认知功能各维度的关系研究. 实用预防医学, 2020, 27(1): 1-4.
15. 司俊霞, 谈跃, 徐勉, 等. 胰岛素水平与轻度认知障碍关系的临床研究. 中国糖尿病杂志, 2008, 16(7): 418-420.
16. 毛秀英, 邱宏亮. 社区老年2型糖尿病患者合并轻度认知功能障碍危险因素分析. 实用老年医学, 2014, 28(7): 587-590.
17. 马丽丽. 老年2型糖尿病患者轻度认知功能障碍发生的影响因素. 中国卫生工程学, 2020, 19(3): 362-364.
18. 马彪, 杨勇, 孟宪海, 等. 2型糖尿病伴轻度认知功能减退与载脂蛋白Eε4等位基因等因素的关系. 中国慢性病预防与控制, 2014, 22(1): 81-83.
19. 李敏, 张丽, 王敏哲. 老年2型糖尿病与轻度认知功能障碍的关系研究. 中国全科医学, 2011, 14(14): 1537-1539.
20. 李春花, 郭昕, 豆静, 等. 2型糖尿病患者认知功能障碍及其影响因素调查分析. 吉林大学学报(医学版), 2018, 44(2): 431-437.
21. 李琛, 梁兴伦, 周文锐, 等. 老年2型糖尿病患者轻度认知功能障碍与胰岛素抵抗的关系研究. 临床和实验医学杂志, 2014, 13(16): 1369-1371.
22. 坎丽比努尔·买米提民, 亚森江·买买提, 麦迪娜·阿不都热依木, 等. 2型糖尿病患者并发轻度认知功能障碍的危险因素分析. 医学临床研究, 2021, 38(9): 1402-1404.
23. 黄金, 胡进, 朱熊兆, 等. 社区2型糖尿病患者认知功能现状及其影响因素研究. 中国全科医学, 2016, 19(2): 135-141.
24. 郝云玲, 严励. 2型糖尿病合并轻度认知功能障碍相关因素分析. 中国医药导报, 2012, 9(35): 84-85,88.
25. 郭连雨, 刘艳, 仇海燕, 等. 2型糖尿病合并轻度认知功能障碍的危险因素分析. 天津医药, 2013, 41(8): 772-775.
26. 宫娟, 刘安诺, 郑红英, 等. 中年2型糖尿病患者认知功能损害特征及影响因素调查. 临床护理杂志, 2020, 19(4): 26-29.
27. Cai R, Han J, Sun J, et al. Plasma clusterin and the CLU gene rs11136000 variant are associated with mild cognitive impairment in type 2 diabetic patients. Front Aging Neurosci, 2016, 8: 179.
28. Zheng M, Zhang M, Yang J, et al. Relationship between blood levels of methyl donor and folate and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study. J Clin Biochem Nutr, 2014, 54(2): 122-128.
29. Damanik J, Mayza A, Rachman A, et al. Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients. PLoS One, 2019, 14(11): e0224611.
30. Guo D, Yuan Y, Huang R, et al. Association between plasma adipsin level and mild cognitive impairment in Chinese patients with type 2 diabetes: a cross-sectional study. BMC Endocr Disord, 2019, 19(1): 108.
31. Gorska-Ciebiada M, Saryusz-Wolska M, Borkowska A, et al. Adiponectin, leptin and IL-1 β in elderly diabetic patients with mild cognitive impairment. Metab Brain Dis, 2016, 31(2): 257-266.
32. Gorska-Ciebiada M, Saryusz-Wolska M, Borkowska A, et al. C-reactive protein, advanced glycation end products, and their receptor in type 2 diabetic, elderly patients with mild cognitive impairment. Front Aging Neurosci, 2015, 7: 209.
33. Gao Y, Xiao Y, Miao R, et al. The prevalence of mild cognitive impairment with type 2 diabetes mellitus among elderly people in China: a cross-sectional study. Arch Gerontol Geriatr, 2016, 62: 138-142.
34. Cai R, Huang R, Han J, et al. Lipoprotein-associated phospholipase A2 is associated with risk of mild cognitive impairment in Chinese patients with type 2 diabetes. Sci Rep, 2017, 7(1): 12311.
35. Blanquisco L, Abejero JE, Buno Ii B, et al. Factors associated with mild cognitive impairment among elderly filipinos with type 2 diabetes mellitus. J ASEAN Fed Endocr Soc, 2017, 32(2): 145-150.
36. Aljohani A, Salem KA, Aljohani A, et al. Factors related to mild cognitive impairment among type 2 diabetic patients attending diabetes center in Al-Madinah, Saudi Arabia 2019-2020. Med Sci, 2020, 24(106): 4080-4090.
37. Chen RH, Jiang XZ, Zhao XH, et al. Risk factors of mild cognitive impairment in middle aged patients with type 2 diabetes: a cross-section study. Ann Endocrinol (Paris), 2012, 73(3): 208-212.
38. Korf ES, White LR, Scheltens P, et al. Brain aging in very old men with type 2 diabetes: the Honolulu-Asia Aging Study. Diabetes Care, 2006, 29(10): 2268-2274.
39. 邹小燕. 社区老年糖尿病患者认知功能障碍原因及危险因素调查. 实用预防医学, 2014, 21(5): 632-634.
40. Espeland MA, Bryan RN, Goveas JS, et al. Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the women's health initiative magnetic resonance imaging studies. Diabetes Care, 2013, 36(1): 90-97.
41. Parikh NM, Morgan RO, Kunik ME, et al. Risk factors for dementia in patients over 65 with diabetes. Int J Geriatr Psychiatry, 2011, 26(7): 749-757.
42. Biessels GJ, Deary IJ, Ryan CM. Cognition and diabetes: a lifespan perspective. Lancet Neurol, 2008, 7(2): 184-190.
43. 刘风兰. 认知干预对轻度认知障碍患者认知功能和生活质量的影响研究. 长沙: 中南大学, 2012.
44. Tu J, Wang LX, Wen HF, et al. The association of different types of cerebral infarction with post-stroke depression and cognitive impairment. Medicine (Baltimore), 2018, 97(23): e10919.
45. Beauchet O, Herrmann FR, Annweiler C, et al. Association between ambulatory 24-hour blood pressure levels and cognitive performance: a cross-sectional elderly population-based study. Rejuvenation Res, 2010, 13(1): 39-46.
46. Hassing LB, Hofer SM, Nilsson SE, et al. Comorbid type 2 diabetes mellitus and hypertension exacerbates cognitive decline: evidence from a longitudinal study. Age Ageing, 2004, 33(4): 355-361.
47. Veglio F, Paglieri C, Rabbia F, et al. Hypertension and cerebrovascular damage. Atherosclerosis, 2009, 205(2): 331-341.
48. Iadecola C, Davisson RL. Hypertension and cerebrovascular dysfunction. Cell Metab, 2008, 7(6): 476-484.
49. 孙芩玲, 雷曦, 曹英, 等. 吸烟对中老年人轻度认知功能障碍的影响. 湖北医药学院学报, 2017, 36(4): 330-333,337.
50. Lee HJ, Seo HI, Cha HY, et al. Diabetes and alzheimer's disease: mechanisms and nutritional aspects. Clin Nutr Res, 2018, 7(4): 229-240.
51. Arnold SE, Arvanitakis Z, Macauley-Rambach SL, et al. Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. Nat Rev Neurol, 2018, 14(3): 168-181.
52. Weinstein G, Maillard P, Himali JJ, et al. Glucose indices are associated with cognitive and structural brain measures in young adults. Neurology, 2015, 84(23): 2329-2337.
53. Robbins MA, Elias MF, Budge MM, et al. Homocysteine, type 2 diabetes mellitus, and cognitive performance: the maine-syracuse study. Clin Chem Lab Med, 2005, 43(10): 1101-1106.
54. Sainani GS, Sainani R. Homocysteine and its role in the pathogenesis of atherosclerotic vascular disease. J Assoc Physicians India, 2002, 50(Suppl): 16-23.
55. Li Y, Jiang C, Xu G, et al. Homocysteine upregulates resistin production from adipocytes in vivo and in vitro. Diabetes, 2008, 57(4): 817-827.
56. Cukierman-Yaffe T, Gerstein HC, Williamson JD, et al. Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular risk factors: the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial. Diabetes Care, 2009, 32(2): 221-226.
57. Christman AL, Matsushita K, Gottesman RF, et al. Glycated haemoglobin and cognitive decline: the atherosclerosis risk in communities (ARIC) study. Diabetologia, 2011, 54(7): 1645-1652.
58. 韩梅, 苏俊平, 戈美琴, 等. 强化教育联合足病筛查对糖尿病足的预防效果及认知功能的影响. 检验医学与临床, 2017, 14(17): 2573-2575.
59. Singh VP, Bali A, Singh N, et al. Advanced glycation end products and diabetic complications. Korean J Physiol Pharmacol, 2014, 18(1): 1-14.

Chinese Journal of Evidence-Based Medicine

Influencing factors of mild cognitive impairment in patients with type 2 diabetes: a meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content