Effects of hyperuricemia on the prevalence of dyslipidemia in the elderly: an empirical study based on propensity score matching_Chinese Journal of Evidence-Based Medicine

Authors：

YUAN Kongjun ^1,2 , YU Xinglei ¹ , ZHAO Chuangyi ^1,2 , YANG Yuan ^1,2 , YAN Danhong ^1,2 ,  ZHOU Guangqing ² , WANG Wenyu ³

1. School of Health Management, Southern Medical University, Guangzhou 510080, P. R. China;
2. Health Management Center, Nanfang Hospital, Southern Medical University, Guangzhou 510080, P. R. China;
3. School of Public Health, the University of Hongkong, Hongkong 999077, P. R. China;

Corresponding author：

ZHOU Guangqing, Email: 13318898668@189.cn

Keywords：

Hyperuricemia; Dyslipidemia; Probit model; Propensity score matching; China Health and Retirement Longitudinal Study

DOI：

10.7507/1672-2531.202203006

Video：

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Objective To analyze the effects of hyperuricemia (HUA) on the prevalence of dyslipidemia in the elderly. Methods A total of 5 990 elderly people with complete and important variables from the China Health and Retirement Longitudinal Study (CHARLS) public database in 2015 were extracted. Their blood lipids, related physiological and biochemical indices, and basic demographic information were collected. The effects of HUA on the prevalence of dyslipidemia in the elderly were analyzed using the probit model, and empirical analysis was performed using the propensity score matching method (PSM). Results Among the 5 990 subjects, 13.6% of the elderly had HUA and the prevalence of dyslipidemia was 37.5%. After correcting the endogeneity among variables, the probability of dyslipidemia in elderly patients with HUA increased by 9.5%-11.7% (P<0.01), in which the probability of high triglyceridemia (TG), high total cholesterol (TC), high low-density lipoprotein cholesterol (LDL-C), and low high-density lipoprotein cholesterol (HDL-C) increased by 10.4%-11.5% (P<0.01), 2.7%-3.8% (P<0.01), 1.7%-2.3% (P<0.05), and 4.3%-4.9% (P<0.05), respectively. Conclusion HUA is associated with various types of dyslipidemia, among which its relationship with high TG and low HDL-C is strong. Targeted interventions should be taken for elderly HUA patients, aiming to reduce the rate of dyslipidemia and promote the goal of "healthy ageing" in China.

Citation： YUAN Kongjun, YU Xinglei, ZHAO Chuangyi, YANG Yuan, YAN Danhong, ZHOU Guangqing, WANG Wenyu. Effects of hyperuricemia on the prevalence of dyslipidemia in the elderly: an empirical study based on propensity score matching. Chinese Journal of Evidence-Based Medicine, 2022, 22(7): 785-790. doi: 10.7507/1672-2531.202203006 Copy

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2.	Ni W, Weng R, Yuan X, et al. Clustering of cardiovascular disease biological risk factors among older adults in Shenzhen city, China: a cross-sectional study. BMJ Open, 2019, 9(3): e024336.
3.	Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials. Lancet, 2010, 376(9753): 1670-1681.
4.	He H, Yu YQ, Li Y, et al. Dyslipidemia awareness, treatment, control and influence factors among adults in the Jilin province in China: a cross-sectional study. Lipids Health Dis, 2014, 13: 122.
5.	Joint committee for guideline revision. 2016 Chinese guidelines for the management of dyslipidemia in adults. J Geriatr Cardiol, 2018, 15(1): 1-29.
6.	Song PK, Man QQ, Li H, et al. Trends in lipids level and dyslipidemia among Chinese adults, 2002-2015. Biomed Environ Sci, 2019, 32(8): 559-570.
7.	杨珍, 谢虹. 血脂异常流行现状及其影响因素的研究进展. 护理研究, 2017, 31(27): 3364-3366.
8.	郭珺, 罗文浩, 鲜文. 高血尿酸水平与高脂血症的相关性研究. 现代医学, 2019, 47(7): 801-804.
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12.	中华医学会内分泌学分会. 高尿酸血症和痛风治疗的中国专家共识. 中华内分泌代谢杂志, 2013, 29(11): 913-920.
13.	王增武, 王文. 中国高血压防治指南(2018年修订版)解读. 中国心血管病研究, 2019, 17(3): 193-197.
14.	中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版). 中华糖尿病杂志, 2018, 10(1): 4-67.
15.	中华医学会内分泌学分会肥胖学组. 中国成人肥胖症防治专家共识. 中华内分泌代谢杂志, 2011, 27(9): 711-717.
16.	王丽敏, 陈志华, 张梅, 等. 中国老年人群慢性病患病状况和疾病负担研究. 中华流行病学杂志, 2019, 40(3): 277-283.
17.	McDonald M, Hertz RP, Unger AN, et al. Prevalence, awareness, and management of hypertension, dyslipidemia, and diabetes among United States adults aged 65 and older. J Gerontol A Biol Sci Med Sci, 2009, 64(2): 256-263.
18.	王荣, 汤哲, 孙菲, 等. 中国7城市老年人高尿酸血症患病率调查. 中华流行病学杂志, 2018, 39(3): 286-288.
19.	Wu J, Qiu L, Cheng XQ, et al. Hyperuricemia and clustering of cardiovascular risk factors in the Chinese adult population. Sci Rep, 2017, 7(1): 5456.
20.	李岩, 孙景波. 社区老年人高尿酸血症患病率及危险因素调查研究. 重庆医学, 2017, 46(12): 1666-1668.
21.	Song P, Wang H, Xia W, et al. Prevalence and correlates of hyperuricemia in the middle-aged and older adults in China. Sci Rep, 2018, 8(1): 4314.
22.	Ali N, Rahman S, Islam S, et al. The relationship between serum uric acid and lipid profile in Bangladeshi adults. BMC Cardiovasc Disord, 2019, 19(1): 42.
23.	Haukoos JS, Lewis RJ. The propensity score. JAMA, 2015, 314(15): 1637-1638.
24.	Teng F, Zhu R, Zou C, et al. Interaction between serum uric acid and triglycerides in relation to blood pressure. J Hum Hypertens, 2011, 25(11): 686-691.
25.	Peng TC, Wang CC, Kao TW, et al. Relationship between hyperuricemia and lipid profiles in US adults. Biomed Res Int, 2015, 2015: 127596.
26.	Berkowitz D. Blood lipid and uric acid interrelationships. JAMA, 1964, 190: 856-858.
27.	Kuwabara M, Borghi C, Cicero AFG, et al. Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: a five-year cohort study in Japan. Int J Cardiol, 2018, 261: 183-188.

1. 宁吉喆. 第七次全国人口普查主要数据情况. 中国统计, 2021, (5): 4-5.
2. Ni W, Weng R, Yuan X, et al. Clustering of cardiovascular disease biological risk factors among older adults in Shenzhen city, China: a cross-sectional study. BMJ Open, 2019, 9(3): e024336.
3. Baigent C, Blackwell L, Emberson J, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials. Lancet, 2010, 376(9753): 1670-1681.
4. He H, Yu YQ, Li Y, et al. Dyslipidemia awareness, treatment, control and influence factors among adults in the Jilin province in China: a cross-sectional study. Lipids Health Dis, 2014, 13: 122.
5. Joint committee for guideline revision. 2016 Chinese guidelines for the management of dyslipidemia in adults. J Geriatr Cardiol, 2018, 15(1): 1-29.
6. Song PK, Man QQ, Li H, et al. Trends in lipids level and dyslipidemia among Chinese adults, 2002-2015. Biomed Environ Sci, 2019, 32(8): 559-570.
7. 杨珍, 谢虹. 血脂异常流行现状及其影响因素的研究进展. 护理研究, 2017, 31(27): 3364-3366.
8. 郭珺, 罗文浩, 鲜文. 高血尿酸水平与高脂血症的相关性研究. 现代医学, 2019, 47(7): 801-804.
9. 曲建昌, 窦京涛, 王安平, 等. 社区老年人群尿酸与代谢综合征关系的研究. 中华老年心脑血管病杂志, 2020, 22(9): 900-903.
10. 杨媛, 周光清, 李宛霖, 等. 不同肥胖指标在高尿酸血症风险预测中的应用价值比较研究. 中国全科医学, 2022, 25(4): 453-460.
11. Zhao Y, Hu Y, Smith JP, et al. Cohort profile: the China Health and Retirement Longitudinal Study (CHARLS). Int J Epidemiol, 2014, 43(1): 61-68.
12. 中华医学会内分泌学分会. 高尿酸血症和痛风治疗的中国专家共识. 中华内分泌代谢杂志, 2013, 29(11): 913-920.
13. 王增武, 王文. 中国高血压防治指南(2018年修订版)解读. 中国心血管病研究, 2019, 17(3): 193-197.
14. 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2017年版). 中华糖尿病杂志, 2018, 10(1): 4-67.
15. 中华医学会内分泌学分会肥胖学组. 中国成人肥胖症防治专家共识. 中华内分泌代谢杂志, 2011, 27(9): 711-717.
16. 王丽敏, 陈志华, 张梅, 等. 中国老年人群慢性病患病状况和疾病负担研究. 中华流行病学杂志, 2019, 40(3): 277-283.
17. McDonald M, Hertz RP, Unger AN, et al. Prevalence, awareness, and management of hypertension, dyslipidemia, and diabetes among United States adults aged 65 and older. J Gerontol A Biol Sci Med Sci, 2009, 64(2): 256-263.
18. 王荣, 汤哲, 孙菲, 等. 中国7城市老年人高尿酸血症患病率调查. 中华流行病学杂志, 2018, 39(3): 286-288.
19. Wu J, Qiu L, Cheng XQ, et al. Hyperuricemia and clustering of cardiovascular risk factors in the Chinese adult population. Sci Rep, 2017, 7(1): 5456.
20. 李岩, 孙景波. 社区老年人高尿酸血症患病率及危险因素调查研究. 重庆医学, 2017, 46(12): 1666-1668.
21. Song P, Wang H, Xia W, et al. Prevalence and correlates of hyperuricemia in the middle-aged and older adults in China. Sci Rep, 2018, 8(1): 4314.
22. Ali N, Rahman S, Islam S, et al. The relationship between serum uric acid and lipid profile in Bangladeshi adults. BMC Cardiovasc Disord, 2019, 19(1): 42.
23. Haukoos JS, Lewis RJ. The propensity score. JAMA, 2015, 314(15): 1637-1638.
24. Teng F, Zhu R, Zou C, et al. Interaction between serum uric acid and triglycerides in relation to blood pressure. J Hum Hypertens, 2011, 25(11): 686-691.
25. Peng TC, Wang CC, Kao TW, et al. Relationship between hyperuricemia and lipid profiles in US adults. Biomed Res Int, 2015, 2015: 127596.
26. Berkowitz D. Blood lipid and uric acid interrelationships. JAMA, 1964, 190: 856-858.
27. Kuwabara M, Borghi C, Cicero AFG, et al. Elevated serum uric acid increases risks for developing high LDL cholesterol and hypertriglyceridemia: a five-year cohort study in Japan. Int J Cardiol, 2018, 261: 183-188.

Chinese Journal of Evidence-Based Medicine

Effects of hyperuricemia on the prevalence of dyslipidemia in the elderly: an empirical study based on propensity score matching

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