A systematic method for extracting survival data from Kaplan-Meier curve_Chinese Journal of Evidence-Based Medicine

Authors：

ZHAO Enhui ¹ ,  HUANG Lihong ²

1. School of Public Health, Fudan University, Shanghai 200032, P. R. China;
2. Department of Biostatistics, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China;

Corresponding author：

HUANG Lihong, Email: huang.lihong@zs-hospital.sh.cn

Keywords：

Survival analysis; Kaplan-Meier curve; Survival data; Individual patient data

DOI：

10.7507/1672-2531.202206117

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Survival data include the occurrence and duration of an event. As most survival data are distributed irregularly, the Kaplan-Meier method is often used in survival analysis; however, studies usually only report the Kaplan-Meier curve and median survival time and do not provide the original survival data, which creates issues for subsequent secondary research. This study introduced a systematic method whereby image processing software and R software were used to process and extract survival data from published Kaplan-Meier curves. It also introduced the specific steps required to obtain survival data using an example to show the accuracy and feasibility of the extraction method and provided references for the effective secondary use of survival data.

Citation： ZHAO Enhui, HUANG Lihong. A systematic method for extracting survival data from Kaplan-Meier curve. Chinese Journal of Evidence-Based Medicine, 2022, 22(11): 1358-1364. doi: 10.7507/1672-2531.202206117 Copy

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1. 魏良敏, 官锦兴, 张汝阳, 等. 生存曲线比较的方法选择及可视化. 中国卫生统计, 2020, 37(5): 768-771,775.
2. 陆守曾, 陈峰. 医学统计学. 北京: 中国统计出版社, 2016.
3. 张欣峰, 娄清涛, 陆建邦, 等. 现时生存分析方法的应用实践与评价. 中国卫生统计, 2011, 28(1): 26-28.
4. Simmonds M, Stewart G, Stewart L. A decade of individual participant data meta-analyses: a review of current practice. Contemp Clin Trials, 2015, 45(Pt A): 76-83.
5. Koopman L, van der Heijden GJ, Hoes AW, et al. Empirical comparison of subgroup effects in conventional and individual patient data meta-analyses. Int J Technol Assess Health Care, 2008, 24(3): 358-361.
6. 周支瑞, 张天嵩, 李博, 等. 生存曲线中Meta分析适宜数据的提取与转换. 中国循证心血管医学杂志, 2014, (3): 243-247.
7. Guyot P, Ades AE, Ouwens MJ, et al. Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves. BMC Med Res Methodol, 2012, 12: 9.
8. Liu N, Zhou Y, Lee JJ. IPDfromKM: reconstruct individual patient data from published Kaplan-Meier survival curves. BMC Med Res Methodol, 2021, 21(1): 111.
9. Reck M, Rodríguez-Abreu D, Robinson AG, et al. Pembrolizumab versus chemotherapy for PD-L1-positive non-Small-cell lung cancer. N Engl J Med, 2016, 375(19): 1823-1833.
10. van de Glind EM, Rhodius-Meester HF, Reitsma JB, et al. Reviews of individual patient data (IPD) are useful for geriatrics: an overview of available IPD reviews. J Am Geriatr Soc, 2014, 62(6): 1133-1138.

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