• 1. Department of Critical Care Medicine, the First Hospital of Lanzhou University, Lanzhou 730000, P. R. China;
  • 2. Evidence Based Medicine Center of Lanzhou University, Key Laboratory of Evidence Based Medicine and Clinical Transformation of Gansu Province, Lanzhou 730000, P. R. China;
YUE Weigang, Email: yueweigang5963@163.com
Export PDF Favorites Scan Get Citation

Objective To evaluate the effect of airway pressure release ventilation (APRV) on the hospital mortality of patients with acute respiratory distress syndrome (ARDS) by using cumulative meta-analysis. Methods The PubMed, Web of Science, Cochrane Library, WanFang Data, CNKI, and VIP databases were electronically searched to collect randomized controlled trials (RCTs) related to the objective from inception to June 30, 2022. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. A cumulative meta-analysis was then performed by using StataSE 12.0 software. Results A total of 9 RCTs involving 533 patients were included. The results of meta-analysis showed that APRV could reduce the hospital mortality of patients with ARDS (RR=0.70, 95%CI 0.54 to 0.91, P<0.01) compared with traditional mechanical ventilation. Conclusion Current evidence shows that APRV can reduce the hospital mortality of patients with ARDS. Due to the limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusion.

Citation: YUE Weigang, JIANG Youfei, YUAN Peng, YIN Ruiyuan, FENG Xin, ZHANG Zhigang, TIAN Jinhui, LI Bin. Effect of airway pressure release ventilation on the hospital mortality of patients with acute respiratory distress syndrome: a cumulative meta-analysis. Chinese Journal of Evidence-Based Medicine, 2023, 23(5): 517-521. doi: 10.7507/1672-2531.202210021 Copy

  • Previous Article

    Effectiveness of haemocoagulase agkistrodon versus tranexamic acid and sodium chloride in the prevention and treatment of perioperative bleeding: a real-world study
  • Next Article

    Efficacy and safety of bipolar radiofrequency ablation versus hysterectomy in abnormal uterine bleeding: a network meta-analysis