Clinical studies on treatment of AIDS by traditional Chinese medicine compound preparations: an evidence map analysis_Chinese Journal of Evidence-Based Medicine

Authors：

SHA Yinyin ^1,3 ,  XU Liran ² , WANG Xueting ¹ , SHAO Cancan ¹

1. Henan University of Chinese Medicine, Zhengzhou 450000, P. R. China;
2. The First Affiliated Hospital of Henan University of TCM, Zhengzhou 450008, P. R. China;
3. Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi’an 710000, P. R. China;

Corresponding author：

XU Liran, Email: xuliran666@sina.com

Keywords：

Traditional Chinese medicine compound preparations; AIDS; Clinical research; Evidence map

DOI：

10.7507/1672-2531.202211038

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To systematically search and sort out the clinical research literature on the treatment of AIDS by traditional Chinese medicine compound preparations by using the evidence map method, and to understand the distribution of evidence in this field. Methods The CNKI, WanFang Data, VIP, CBM, PubMed and Cochrane Library databases were electronically searched to collect studies on the treatment of AIDS with traditional Chinese medicine compound preparations from inception to August 2022. The distribution characteristics of evidence were analyzed and presented in the form of charts and words. Results A total of 337 articles were included, involving 268 intervention studies, 66 observational studies and 4 systematic reviews/meta-analysis. A total of 92 kinds of traditional Chinese medicine compound preparations were obtained, and the literature quantity of different preparations was obviously stratified, with Kangaibaosheng preparation being the most frequently reported. In recent years, the number of published literature has been declining, the quality of literature is generally low, and the level of evidence is not high. As for the intervention duration, this field tends to have a longer intervention observation period. As for the outcome indicators, the evaluation criteria of some indicators are not uniform, and the characteristics of TCM advantages are not reflected. The quantity and quality of systematic reviews/meta-analyses were insufficient. No normative consensus or guidelines for the treatment of AIDS with traditional Chinese medicine compound preparations had been formed. Conclusion studies on the effectiveness and safety of traditional Chinese medicine compound preparations in treating AIDS has initially formed a certain scale of evidence group. In the future, it is necessary to further improve the quality of studies, explore outcome indicators that can reflect the advantages of TCM efficacy, and formulate relevant guidelines in a standardized manner.

Citation： SHA Yinyin, XU Liran, WANG Xueting, SHAO Cancan. Clinical studies on treatment of AIDS by traditional Chinese medicine compound preparations: an evidence map analysis. Chinese Journal of Evidence-Based Medicine, 2023, 23(5): 583-587. doi: 10.7507/1672-2531.202211038 Copy

1.	许向前, 许前磊, 金艳涛, 等. 后HAART时期中医药调节HIV/AIDS患者免疫功能研究评述. 中华中医药杂志, 2018, 33(3): 829-832.
2.	Qian Z, Zhang Y, Xie X, et al. Efficacy and safety of traditional Chinese herbal medicine combined with HAART in the treatment of HIV/AIDS: a protocol for systematic review and meta-analysis. Medicine (Baltimore), 2021, 100(52): e28287.
3.	罗伟生, 王仕衍, 黄瑞, 等. 中药复方制剂联合HAART对HIV/AIDS病人免疫重建的系统评价. 中国艾滋病性病, 2017, 23(1): 28-32.
4.	张方圆, 沈傲梅, 强万敏. AMSTAR使用过程中存在的问题及建议. 中国循证心血管医学杂志, 2018, 10(2): 138-142.
5.	熊俊, 陈日新. 系统评价/Meta分析方法学质量的评价工具AMSTAR. 中国循证医学杂志, 2011, 11(9): 1084-1089.
6.	李艳飞, 李秀霞, 李睿, 等. 证据图谱的制作与报告. 中国循证医学杂志, 2020, 20(9): 1098-1103.
7.	张情. 中西医结合治疗艾滋病对免疫功能的影响. 云南中医中药杂志, 2011, 32(10): 59-60.
8.	杨玉琪, 瞿广城, 蒲亚萍, 等. 167例转氨酶异常的老年艾滋病患者接受中西医结合治疗效果分析. 云南中医中药杂志, 2019, 40(1): 23-26.
9.	杨玉琪, 瞿广城, 陆中云, 等. 扶正抗毒丸联合HAART治疗艾滋病免疫重建不全的临床疗效分析. 中医药导报, 2020, 26(10): 66-68.
10.	孙俊, 王莉, 贺铮铮, 等. 康爱保生丸对HAART后低CD4/CD8比值的HIV/AIDS患者疗效分析. 云南中医中药杂志, 2020, 41(10): 16-19.
11.	孙俊, 汪林芬, 张祖英, 等. 人类免疫缺陷病毒/艾滋病患者接受高效抗逆转录病毒治疗联合中医药治疗后血常规结果的临床分析. 中医临床研究, 2020, 12(20): 10-13.
12.	赵竞, 王莉, 柳陈坚, 等. 1373例HIV/AIDS患者中医药治疗临床疗效分析. 云南中医学院学报, 2017, 40(5): 34-39.
13.	杨玉琪, 瞿广城, 蔡怡, 等. 中西医结合治疗对艾滋病免疫重建不全者CD4~+T淋巴细胞影响. 中国艾滋病性病, 2019, 25(7): 680-682,712.
14.	袁君, 金艳涛, 蒋自强, 等. 中医药治疗对HIV/AIDS患者CD4~+淋巴细胞计数影响的回顾性分析. 中国中西医结合杂志, 2018, 38(4): 407-409.
15.	李亮平, 徐立然, 扶伟, 等. 中医药综合干预对艾滋病病毒感染者/艾滋病患者免疫功能和机会性感染的长期影响. 中医学报, 2016, 31(1): 1-3.
16.	Wang D, Ma S, Ma Y, et al. Effect of traditional Chinese medicine therapy on the trend in CD4+ T-Cell counts among patients with HIV/AIDS treated with antiretroviral therapy: a retrospective cohort study. Evid Based Complement Alternat Med, 2021, 2021: 5576612.
17.	李静茹, 马秀兰, 张颖, 等. 中西医结合治疗1250例艾滋病前瞻性队列研究. 中国中西医结合杂志, 2022, 42(4): 425-430.
18.	吴雪. 中医药调控肠道菌群改善艾滋病免疫重建不全作用的临床观察. 北京: 中国中医科学院, 2021.
19.	Su QJ, Song C, Lu ZZ, et al. Impact of herbal preparations on outcomes of highly active antiretroviral therapy: a one-year prospective cohort study. Chin J Integr Med, 2020, 26(7): 497-501.
20.	魏叶叶, 马建萍. 太芪培元颗粒治疗HIV感染者临床疗效观察. 中国医药导刊, 2017, 19(12): 1378-1381.
21.	李佩. 中药艾可清胶囊对HIV感染者长期干预的研究. 广州: 广州中医药大学, 2010.
22.	宋夕元, 李宁, 崔伟锋, 等. 随机对照临床评价中医药干预艾滋病疗效存在的问题及对策. 中华中医药杂志, 2019, 34(12): 5774-5777.
23.	许向前, 马玉青, 许前磊, 等. 中医药联合高效联合抗反转录病毒治疗HIV/AIDS协同增效评价指标体系构建探讨. 中华中医药杂志, 2020, 35(7): 3496-3498.
24.	赵少英, 张欣欣, 许前磊, 等. 后HAART时期艾滋病合并慢性病中医药防治. 中医学报, 2022, 37(3): 524-528.
25.	许前磊, 李青雅, 金艳涛, 等. 后HAART时期中医药防治艾滋病的切入点. 中国中西医结合杂志, 2016, 36(9): 1128-1131.
26.	王莉, 和丽生, 杨玉琪, 等. 康爱保生丸联合HAART治疗404例ⅡB期艾滋病患者: 随机对照研究. 中国中西医结合杂志, 2021, 41(11): 1307-1311.
27.	Wang J, Li Y, Tang YL, et al. Effect of immune No. 2 on the immune reconstitution in patients with HIV/AIDS after highly active antiretroviral treatment:a randomized double blind placebo controlled clinical trial. Chin J Integr Med, 2013, 19(5): 340-346.
28.	咸庆飞. 从脾肾论治男男性接触(MSM)AIDS患者抗病毒治疗后免疫重建不全的研究. 北京: 中国中医科学院, 2019.
29.	张扬武, 罗伟生, 黄瑞, 等. 益气扶正法联合高效抗逆转录病毒治疗对艾滋病患者免疫重建的Meta分析. 辽宁中医杂志, 2016, 43(10): 2042-2047.
30.	王映林, 刘建忠, 肖明中, 等. 健脾补肾法治疗艾滋病患者的临床效果. 中国医药导报, 2022, 19(2): 112-116.
31.	胡智平, 曹文钦, 陈小明, 等. 益气养血、健脾祛湿方治疗无症状HIV感染期临床研究. 湖北中医杂志, 2012, 34(3): 3-5.
32.	马伯艳, 符林春, 蔡卫平, 等. 艾可清胶囊联合高效抗病毒逆转录疗法治疗艾滋病临床观察. 广州中医药大学学报, 2007, 24(6): 466-470.
33.	王阶, 林洪生, 李勇, 等. 免疫2号方对艾滋病免疫重建不全患者临床症状、体征的影响. 中医杂志, 2012, 53(11): 923-926.
34.	吴广伟, 朱克武, 李茂清, 等. 温脾补肾法联合高效抗逆转录病毒治疗对HIV/AIDS患者免疫功能影响的研究. 国际医药卫生导报, 2014, 20(13): 1874-1878.
35.	刘明, 余花, 孟伟民, 等. 抗艾扶正胶囊联合抗逆转录病毒(HAART)治疗青海地区艾滋病的临床疗效观察. 青海医药杂志, 2013, 43(9): 66-70.
36.	金艳涛, 许前磊, 蒋自强, 等. 中医药综合治疗对河南省农村地区HIV/AIDS患者生存质量的影响. 中医杂志, 2016, 57(7): 579-583.

1. 许向前, 许前磊, 金艳涛, 等. 后HAART时期中医药调节HIV/AIDS患者免疫功能研究评述. 中华中医药杂志, 2018, 33(3): 829-832.
2. Qian Z, Zhang Y, Xie X, et al. Efficacy and safety of traditional Chinese herbal medicine combined with HAART in the treatment of HIV/AIDS: a protocol for systematic review and meta-analysis. Medicine (Baltimore), 2021, 100(52): e28287.
3. 罗伟生, 王仕衍, 黄瑞, 等. 中药复方制剂联合HAART对HIV/AIDS病人免疫重建的系统评价. 中国艾滋病性病, 2017, 23(1): 28-32.
4. 张方圆, 沈傲梅, 强万敏. AMSTAR使用过程中存在的问题及建议. 中国循证心血管医学杂志, 2018, 10(2): 138-142.
5. 熊俊, 陈日新. 系统评价/Meta分析方法学质量的评价工具AMSTAR. 中国循证医学杂志, 2011, 11(9): 1084-1089.
6. 李艳飞, 李秀霞, 李睿, 等. 证据图谱的制作与报告. 中国循证医学杂志, 2020, 20(9): 1098-1103.
7. 张情. 中西医结合治疗艾滋病对免疫功能的影响. 云南中医中药杂志, 2011, 32(10): 59-60.
8. 杨玉琪, 瞿广城, 蒲亚萍, 等. 167例转氨酶异常的老年艾滋病患者接受中西医结合治疗效果分析. 云南中医中药杂志, 2019, 40(1): 23-26.
9. 杨玉琪, 瞿广城, 陆中云, 等. 扶正抗毒丸联合HAART治疗艾滋病免疫重建不全的临床疗效分析. 中医药导报, 2020, 26(10): 66-68.
10. 孙俊, 王莉, 贺铮铮, 等. 康爱保生丸对HAART后低CD4/CD8比值的HIV/AIDS患者疗效分析. 云南中医中药杂志, 2020, 41(10): 16-19.
11. 孙俊, 汪林芬, 张祖英, 等. 人类免疫缺陷病毒/艾滋病患者接受高效抗逆转录病毒治疗联合中医药治疗后血常规结果的临床分析. 中医临床研究, 2020, 12(20): 10-13.
12. 赵竞, 王莉, 柳陈坚, 等. 1373例HIV/AIDS患者中医药治疗临床疗效分析. 云南中医学院学报, 2017, 40(5): 34-39.
13. 杨玉琪, 瞿广城, 蔡怡, 等. 中西医结合治疗对艾滋病免疫重建不全者CD4~+T淋巴细胞影响. 中国艾滋病性病, 2019, 25(7): 680-682,712.
14. 袁君, 金艳涛, 蒋自强, 等. 中医药治疗对HIV/AIDS患者CD4~+淋巴细胞计数影响的回顾性分析. 中国中西医结合杂志, 2018, 38(4): 407-409.
15. 李亮平, 徐立然, 扶伟, 等. 中医药综合干预对艾滋病病毒感染者/艾滋病患者免疫功能和机会性感染的长期影响. 中医学报, 2016, 31(1): 1-3.
16. Wang D, Ma S, Ma Y, et al. Effect of traditional Chinese medicine therapy on the trend in CD4+ T-Cell counts among patients with HIV/AIDS treated with antiretroviral therapy: a retrospective cohort study. Evid Based Complement Alternat Med, 2021, 2021: 5576612.
17. 李静茹, 马秀兰, 张颖, 等. 中西医结合治疗1250例艾滋病前瞻性队列研究. 中国中西医结合杂志, 2022, 42(4): 425-430.
18. 吴雪. 中医药调控肠道菌群改善艾滋病免疫重建不全作用的临床观察. 北京: 中国中医科学院, 2021.
19. Su QJ, Song C, Lu ZZ, et al. Impact of herbal preparations on outcomes of highly active antiretroviral therapy: a one-year prospective cohort study. Chin J Integr Med, 2020, 26(7): 497-501.
20. 魏叶叶, 马建萍. 太芪培元颗粒治疗HIV感染者临床疗效观察. 中国医药导刊, 2017, 19(12): 1378-1381.
21. 李佩. 中药艾可清胶囊对HIV感染者长期干预的研究. 广州: 广州中医药大学, 2010.
22. 宋夕元, 李宁, 崔伟锋, 等. 随机对照临床评价中医药干预艾滋病疗效存在的问题及对策. 中华中医药杂志, 2019, 34(12): 5774-5777.
23. 许向前, 马玉青, 许前磊, 等. 中医药联合高效联合抗反转录病毒治疗HIV/AIDS协同增效评价指标体系构建探讨. 中华中医药杂志, 2020, 35(7): 3496-3498.
24. 赵少英, 张欣欣, 许前磊, 等. 后HAART时期艾滋病合并慢性病中医药防治. 中医学报, 2022, 37(3): 524-528.
25. 许前磊, 李青雅, 金艳涛, 等. 后HAART时期中医药防治艾滋病的切入点. 中国中西医结合杂志, 2016, 36(9): 1128-1131.
26. 王莉, 和丽生, 杨玉琪, 等. 康爱保生丸联合HAART治疗404例ⅡB期艾滋病患者: 随机对照研究. 中国中西医结合杂志, 2021, 41(11): 1307-1311.
27. Wang J, Li Y, Tang YL, et al. Effect of immune No. 2 on the immune reconstitution in patients with HIV/AIDS after highly active antiretroviral treatment:a randomized double blind placebo controlled clinical trial. Chin J Integr Med, 2013, 19(5): 340-346.
28. 咸庆飞. 从脾肾论治男男性接触(MSM)AIDS患者抗病毒治疗后免疫重建不全的研究. 北京: 中国中医科学院, 2019.
29. 张扬武, 罗伟生, 黄瑞, 等. 益气扶正法联合高效抗逆转录病毒治疗对艾滋病患者免疫重建的Meta分析. 辽宁中医杂志, 2016, 43(10): 2042-2047.
30. 王映林, 刘建忠, 肖明中, 等. 健脾补肾法治疗艾滋病患者的临床效果. 中国医药导报, 2022, 19(2): 112-116.
31. 胡智平, 曹文钦, 陈小明, 等. 益气养血、健脾祛湿方治疗无症状HIV感染期临床研究. 湖北中医杂志, 2012, 34(3): 3-5.
32. 马伯艳, 符林春, 蔡卫平, 等. 艾可清胶囊联合高效抗病毒逆转录疗法治疗艾滋病临床观察. 广州中医药大学学报, 2007, 24(6): 466-470.
33. 王阶, 林洪生, 李勇, 等. 免疫2号方对艾滋病免疫重建不全患者临床症状、体征的影响. 中医杂志, 2012, 53(11): 923-926.
34. 吴广伟, 朱克武, 李茂清, 等. 温脾补肾法联合高效抗逆转录病毒治疗对HIV/AIDS患者免疫功能影响的研究. 国际医药卫生导报, 2014, 20(13): 1874-1878.
35. 刘明, 余花, 孟伟民, 等. 抗艾扶正胶囊联合抗逆转录病毒(HAART)治疗青海地区艾滋病的临床疗效观察. 青海医药杂志, 2013, 43(9): 66-70.
36. 金艳涛, 许前磊, 蒋自强, 等. 中医药综合治疗对河南省农村地区HIV/AIDS患者生存质量的影响. 中医杂志, 2016, 57(7): 579-583.

Chinese Journal of Evidence-Based Medicine

Clinical studies on treatment of AIDS by traditional Chinese medicine compound preparations: an evidence map analysis

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