Implementation of meta-analysis using incidence rate ratio as effect size in R Studio software_Chinese Journal of Evidence-Based Medicine

Authors：

WANG Huilin ¹ , BAI Yang ² , HUANG Danqi ¹ , WANG Quan ³ , YANG Min ⁴ , GE Long ^5,6 ,  ZHAI Jingbo ⁷ ,  LI Jiang ¹ ,  TIAN Jinhui ^8,9

1. Office for Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P. R. China;
2. College of Clinical Medicine, Capital Medical University, Beijing 100069, P. R. China;
3. Ambulatory Surgery Center of Xijing Hospital, Fourth Military Medical University, Xi’an 710068, P. R. China;
4. Comprehensive Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P. R. China;
5. Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou 730000, P. R. China;
6. Department of Social Science and Health Management, School of Public Health, Lanzhou University, Lanzhou 730000, P. R. China;
7. School of Public Health, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P. R. China;
8. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, P. R. China;
9. Key Laboratory of Evidence-Based Medicine and Knowledge Translation of Gansu Province, Lanzhou University, Lanzhou 730000, P. R. China;

Corresponding author：

ZHAI Jingbo, Email: zhaijingbo@foxmail.com; LI Jiang, Email: lij@cicams.ac.cn; TIAN Jinhui, Email: tianjh@lzu.edu.cn

Keywords：

Incidence rate ratio; Meta-analysis; Meta package; R Studio software

DOI：

10.7507/1672-2531.202304083

Video：

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Abstract Full text Figures/Tables Video References Cited by

Incidence rate is a common effect measure. The incidence rate ratio refers to the ratio of two different incidence rates. It is used to compare the difference in the number of cases per unit person-time between two groups. RevMan software can not perform a meta-analysis with the incidence rate ratio as the effect size at present. A set of simulation data was used to demonstrate a meta-analysis process with the incidence rate ratio as the effect size by using the meta package of R Studio software in this article.

Citation： WANG Huilin, BAI Yang, HUANG Danqi, WANG Quan, YANG Min, GE Long, ZHAI Jingbo, LI Jiang, TIAN Jinhui. Implementation of meta-analysis using incidence rate ratio as effect size in R Studio software. Chinese Journal of Evidence-Based Medicine, 2024, 24(1): 98-104. doi: 10.7507/1672-2531.202304083 Copy

1.	Dicker R , Coronado F , Koo D, et al. Principles of epidemiology in public health practice. U. S. Department of Health and Human Services Centers for Disease Control and Prevention (CDC). 2012.
2.	董圣杰, 曾宪涛, 郭毅. R软件Metafor程序包在Meta分析中的应用. 中国循证医学杂志, 2012, 12(9): 1141-1147.
3.	李多多, 俞兴, 韩晟, 等. 多元线性回归分析数据可视化的RStudio软件实践. 中国循证医学杂志, 2021, 21(4): 482-490.
4.	Sterne JA, Sutton AJ, Ioannidis JP, et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ, 2011, 343: d4002.
5.	Lai SW, Liao KF, Lin CL, et al. The incidence rate of herpes zoster in inflammatory bowel disease: a meta-analysis of cohort studies. Medicine (Baltimore), 2021, 100(33): e26863.
6.	Chu DK, Wood RA, French S, et al. Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety. Lancet, 2019, 393(10187): 2222-2232.
7.	Al Attar WSA, Khaledi EH, Bakhsh JM, et al. Injury prevention programs that include balance training exercises reduce ankle injury rates among soccer players: a systematic review. J Physiother, 2022, 68(3): 165-173.
8.	Galling B, Roldán A, Nielsen RE, et al. Type 2 diabetes mellitus in youth exposed to antipsychotics: a systematic review and meta-analysis. JAMA Psychiatry, 2016, 73(3): 247-259.
9.	Richter B, Hemmingsen B, Metzendorf MI, et al. Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia. Cochrane Database Syst Rev, 2018, (10): CD012661.
10.	Rubio JM, Schoretsanitis G, John M, et al. Psychosis relapse during treatment with long-acting injectable antipsychotics in individuals with schizophrenia-spectrum disorders: an individual participant data meta-analysis. Lancet Psychiatry, 2020, 7(9): 749-761.
11.	Andrews JR, Noubary F, Walensky RP, et al. Risk of progression to active tuberculosis following reinfection with Mycobacterium tuberculosis. Clin Infect Dis, 2012, 54(6): 784-791.
12.	Ilic D, Djulbegovic M, Jung JH, et al. Prostate cancer screening with prostate-specific antigen (PSA) test: a systematic review and meta-analysis. BMJ, 2018, 362: k3519.
13.	Crossley KM, Patterson BE, Culvenor AG, et al. Making football safer for women: a systematic review and meta-analysis of injury prevention programmes in 11 773 female football (soccer) players. Br J Sports Med, 2020, 54(18): 1089-1098.
14.	Sijbrandij M, Kleiboer A, Bisson JI, et al. Pharmacological prevention of post-traumatic stress disorder and acute stress disorder: a systematic review and meta-analysis. Lancet Psychiatry, 2015, 2(5): 413-421.
15.	Huang ZG, Feng YH, Li YH, et al. Systematic review and meta-analysis: Tai Chi for preventing falls in older adults. BMJ Open, 2017, 7(2): e013661.
16.	Emery CA, Roy TO, Whittaker JL, et al. Neuromuscular training injury prevention strategies in youth sport: a systematic review and meta-analysis. Br J Sports Med, 2015, 49(13): 865-870.
17.	Marilly E, Cottin J, Cabrera N, et al. SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits. Diabetologia, 2022, 65(12): 2000-2010.
18.	Zhang J, Yu KF. What's the relative risk. A method of correcting the odds ratio in cohort studies of common outcomes. JAMA, 1998, 280(19): 1690-1691.
19.	Trkulja V, Hrabač P. Hazard ratio. Croat Med J, 2019, 60(3): 293-296.
20.	Kenton W, Anderson S. Incidence rate: definition, calculation, and examples. 2022.
21.	黄桥, 赵明娟, 罗丽莎, 等. 前瞻性研究中效应指标危险比(RR)和风险比(HR)的辨析与转换. 中国循证医学杂志, 2020, 20(10): 1221-1225.
22.	Al Attar WSA, Soomro N, Sinclair PJ, et al. Effect of injury prevention programs that include the nordic hamstring exercise on hamstring injury rates in soccer players: a systematic review and meta-analysis. Sports Med, 2017, 47(5): 907-916.

1. Dicker R , Coronado F , Koo D, et al. Principles of epidemiology in public health practice. U. S. Department of Health and Human Services Centers for Disease Control and Prevention (CDC). 2012.
2. 董圣杰, 曾宪涛, 郭毅. R软件Metafor程序包在Meta分析中的应用. 中国循证医学杂志, 2012, 12(9): 1141-1147.
3. 李多多, 俞兴, 韩晟, 等. 多元线性回归分析数据可视化的RStudio软件实践. 中国循证医学杂志, 2021, 21(4): 482-490.
4. Sterne JA, Sutton AJ, Ioannidis JP, et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ, 2011, 343: d4002.
5. Lai SW, Liao KF, Lin CL, et al. The incidence rate of herpes zoster in inflammatory bowel disease: a meta-analysis of cohort studies. Medicine (Baltimore), 2021, 100(33): e26863.
6. Chu DK, Wood RA, French S, et al. Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety. Lancet, 2019, 393(10187): 2222-2232.
7. Al Attar WSA, Khaledi EH, Bakhsh JM, et al. Injury prevention programs that include balance training exercises reduce ankle injury rates among soccer players: a systematic review. J Physiother, 2022, 68(3): 165-173.
8. Galling B, Roldán A, Nielsen RE, et al. Type 2 diabetes mellitus in youth exposed to antipsychotics: a systematic review and meta-analysis. JAMA Psychiatry, 2016, 73(3): 247-259.
9. Richter B, Hemmingsen B, Metzendorf MI, et al. Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia. Cochrane Database Syst Rev, 2018, (10): CD012661.
10. Rubio JM, Schoretsanitis G, John M, et al. Psychosis relapse during treatment with long-acting injectable antipsychotics in individuals with schizophrenia-spectrum disorders: an individual participant data meta-analysis. Lancet Psychiatry, 2020, 7(9): 749-761.
11. Andrews JR, Noubary F, Walensky RP, et al. Risk of progression to active tuberculosis following reinfection with Mycobacterium tuberculosis. Clin Infect Dis, 2012, 54(6): 784-791.
12. Ilic D, Djulbegovic M, Jung JH, et al. Prostate cancer screening with prostate-specific antigen (PSA) test: a systematic review and meta-analysis. BMJ, 2018, 362: k3519.
13. Crossley KM, Patterson BE, Culvenor AG, et al. Making football safer for women: a systematic review and meta-analysis of injury prevention programmes in 11 773 female football (soccer) players. Br J Sports Med, 2020, 54(18): 1089-1098.
14. Sijbrandij M, Kleiboer A, Bisson JI, et al. Pharmacological prevention of post-traumatic stress disorder and acute stress disorder: a systematic review and meta-analysis. Lancet Psychiatry, 2015, 2(5): 413-421.
15. Huang ZG, Feng YH, Li YH, et al. Systematic review and meta-analysis: Tai Chi for preventing falls in older adults. BMJ Open, 2017, 7(2): e013661.
16. Emery CA, Roy TO, Whittaker JL, et al. Neuromuscular training injury prevention strategies in youth sport: a systematic review and meta-analysis. Br J Sports Med, 2015, 49(13): 865-870.
17. Marilly E, Cottin J, Cabrera N, et al. SGLT2 inhibitors in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials balancing their risks and benefits. Diabetologia, 2022, 65(12): 2000-2010.
18. Zhang J, Yu KF. What's the relative risk. A method of correcting the odds ratio in cohort studies of common outcomes. JAMA, 1998, 280(19): 1690-1691.
19. Trkulja V, Hrabač P. Hazard ratio. Croat Med J, 2019, 60(3): 293-296.
20. Kenton W, Anderson S. Incidence rate: definition, calculation, and examples. 2022.
21. 黄桥, 赵明娟, 罗丽莎, 等. 前瞻性研究中效应指标危险比(RR)和风险比(HR)的辨析与转换. 中国循证医学杂志, 2020, 20(10): 1221-1225.
22. Al Attar WSA, Soomro N, Sinclair PJ, et al. Effect of injury prevention programs that include the nordic hamstring exercise on hamstring injury rates in soccer players: a systematic review and meta-analysis. Sports Med, 2017, 47(5): 907-916.

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