Efficacy of high-intensity interval training on weight loss and blood lipid metabolism with overweight or obesity: a meta-analysis_Chinese Journal of Evidence-Based Medicine

Authors：

LI Peiyuan ¹ , YANG Junchao ¹ , LU Zhihui ^1,2 ,  QIU Junqiang ^1,3

1. Exercise Science School, Beijing Sport University, Beijing 100084, P. R. China;
2. China Football College, Beijing Sport University, Beijing 100084, P. R. China;
3. Beijing Sports Nutrition Engineering Research Center, Beijing 100084, P. R. China;

Corresponding author：

QIU Junqiang, Email: qiujunqiang@bsu.edu.cn

Keywords：

High intensity interval training; Overweight; Obesity; Blood lipid metabolism; Meta-analysis

DOI：

10.7507/1672-2531.202307110

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To systematically review the intervention effects of high-intensity interval training (HIIT) on weight loss and blood lipid metabolism in overweight/obese populations. Methods The computer conducted searches in the PubMed, Embase, Cochrane Library, Web of Science, CNKI, and WanFang Data database to collect randomized controlled trials (RCTs) related to HIIT and weight loss, fat reduction, and blood lipid metabolism in overweight/obese populations. The search was conducted from the inception of the databases to March 31, 2023. Two researchers independently conducted literature screening and data extraction. After evaluating the risk of bias of the included studies, a meta-analysis was performed using RevMan 5.4 software. Results A total of 19 RCTs, involving 595 overweight/obese participants, were included. The meta-analysis results showed that compared wtih the control group, HIIT interventions effectively reduced body weight (MD=−2.63, 95%CI −4.04 to −1.23, P<0.05), BMI (MD=−1.21, 95%CI −1.95 to −0.48, P<0.05), Fat% (MD=−1.66, 95%CI −2.28 to −1.04, P<0.05), TG (MD=−0.13, 95%CI −0.25 to −0.01, P=0.04), HDL (MD=0.14, 95%CI 0.05 to 0.23, P<0.05), and LDL (MD=−0.26, 95%CI −0.39 to −0.13, P<0.05) levels but did not improve TC (MD=−0.15, 95%CI −0.36 to 0.06, P=0.15) levels. Conclusion HIIT intervention can effectively improve body weight, BMI, Fat%, TG, HDL, and LDL levels in overweight/obese populations, particularly showing a more pronounced improvement in lipid profiles among overweight/obese adolescents, but it does not reduce TC levels. This study demonstrates that HIIT may be an effective strategy to assist in weight loss and prevent cardiovascular diseases in overweight/obese populations, with potential for broader application.

Citation： LI Peiyuan, YANG Junchao, LU Zhihui, QIU Junqiang. Efficacy of high-intensity interval training on weight loss and blood lipid metabolism with overweight or obesity: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2024, 24(3): 272-279. doi: 10.7507/1672-2531.202307110 Copy

1.	GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med, 2017, 377(1): 13-27.
2.	国家卫生健康委. 中国居民营养与慢性病状况报告(2020年). 营养学报, 2020, 42(6): 521.
3.	Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol, 2021, 9(6): 373-392.
4.	Pi-Sunyer X. The medical risks of obesity. Postgrad Med, 2009, 121(6): 21-33.
5.	Visscher TL, Seidell JC. The public health impact of obesity. Annu Rev Public Health, 2001, 22: 355-375.
6.	Westerterp KR. Exercise, energy expenditure and energy balance, as measured with doubly labelled water. Proc Nutr Soc, 2018, 77(1): 4-10.
7.	邱俊强, 路明月, 张君, 等. 运动促进健康: 个性化精准解决方案. 北京体育大学学报, 2022, 45(10): 2-18.
8.	Trapp EG, Chisholm DJ, Freund J, et al. The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes (Lond), 2008, 32(4): 684-691.
9.	Kessler HS, Sisson SB, Short KR. The potential for high-intensity interval training to reduce cardiometabolic disease risk. Sports Med, 2012, 42(6): 489-509.
10.	Tjønna AE, Stølen TO, Bye A, et al. Aerobic interval training reduces cardiovascular risk factors more than a multitreatment approach in overweight adolescents. Clin Sci (Lond), 2009, 116(4): 317-326.
11.	黎涌明. 高强度间歇训练对不同训练人群的应用效果. 体育科学, 2015, 35(8): 59-75, 96.
12.	Cochrane Library. Cochrane handbook for systematic reviews of interventions (version 6.4). 2023.
13.	Cumpston M, Li T, Page MJ, et al. Updated guidance for trusted systematic reviews: a new edition of the Cochrane handbook for systematic reviews of interventions. Cochrane Database Syst Rev, 2019, (10): ED000142.
14.	Racil G, Ben Ounis O, Hammouda O, et al. Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females. Eur J Appl Physiol, 2013, 113(10): 2531-2540.
15.	韩涵. 高强度间歇和中强度持续训练对青年肥胖女性体脂分布的影响. 石家庄: 河北师范大学, 2014.
16.	Smith-Ryan AE, Melvin MN, Wingfield HL. High-intensity interval training: modulating interval duration in overweight/obese men. Phys Sportsmed, 2015, 43(2): 107-113.
17.	Smith-Ryan AE, Trexler ET, Wingfield HL, et al. Effects of high-intensity interval training on cardiometabolic risk factors in overweight/obese women. J Sports Sci, 2016, 34(21): 2038-2046.
18.	林坚, 赵红勤, 黄雄昂, 等. 高强度间歇训练对肥胖女大学生体成分和血脂及空腹胰岛素水平的影响. 中国全科医学, 2016, 19(18): 2139-2144.
19.	王玲. 高强度间歇训练对肥胖青年女性血清FGF21及糖脂代谢的影响. 石家庄: 河北师范大学, 2017.
20.	Khammassi M, Ouerghi N, Hadj-Taieb S, et al. Impact of a 12-week high-intensity interval training without caloric restriction on body composition and lipid profile in sedentary healthy overweight/obese youth. J Exerc Rehabil, 2018, 14(1): 118-125.
21.	Sañudo B, Muñoz T, Davison GW, et al. High-intensity interval training combined with vibration and dietary restriction improves body composition and blood lipids in obese adults: a randomized trial. Dose Response, 2018, 16(3): 1559325818797015.
22.	Nazari M, Minasian V, Hovsepian S. Effects of two types of moderate- and high-intensity interval training on serum salusin-α and salusin-β levels and lipid profile in women with overweight/obesity. Diabetes Metab Syndr Obes, 2020, 13: 1385-1390.
23.	曹甍. 不同训练方案对肥胖男生身体成分和糖脂代谢的干预效果研究. 上海: 上海体育学院, 2020.
24.	陈姗. 高强度间歇训练与交叉点训练对超重成年女性血脂代谢的影响. 北京: 北京体育大学, 2020.
25.	张立萌. 高强度间歇训练对超重青年循环骨钙素及其相关指标的影响. 北京: 首都体育学院, 2020.
26.	Saeidi A, Shishvan SR, Soltani M, et al. Differential effects of exercise programs on neuregulin 4, body composition and cardiometabolic risk factors in men with obesity. Front Physiol, 2022, 12: 797574.
27.	Sanayei M, Izadi A, Hajizadeh-Sharafabad F, et al. Chlorella vulgaris in combination with high intensity interval training in overweight and obese women: a randomized double-blind clinical trial. J Diabetes Metab Disord, 2021, 20(1): 781-792.
28.	阿迪力·尤努斯. 高强度间歇训练对肥胖大学生身体成分和血脂代谢指标的影响研究. 乌鲁木齐: 新疆师范大学, 2021.
29.	袁玲玲. 高强度间歇运动对超重或肥胖男性青少年心肺适能和身体成分及血脂水平的影响. 中华物理医学与康复杂志, 2021, 43(3): 251-253.
30.	张立萌, 卜淑敏, 刘晓然. 6周高强度间歇训练对超重/肥胖男青年循环骨钙素水平的影响. 中国运动医学杂志, 2021, 40(4): 270-275.
31.	Leite N, Pizzi J, De Menezes Junior FJ, et al. Effect of mict and hiit on cardiometabolic risk and body composition in obese boys. Revista Brasileira de Medicina do Esporte, 2022, 28(4): 274-280.
32.	兰霄宇, 房国梁, 韩天雨, 等. 高强度有氧间歇运动对超重或肥胖老年人体成分、血脂及血糖的影响. 中国运动医学杂志, 2022, 41(7): 510-517.
33.	Patton GC, Coffey C, Carlin JB, et al. Overweight and obesity between adolescence and young adulthood: a 10-year prospective cohort study. J Adolesc Health, 2011, 48(3): 275-280.
34.	O'Donovan G, Blazevich AJ, Boreham C, et al. The ABC of physical activity for health: a consensus statement from the British Association of Sport and Exercise Sciences. J Sports Sci, 2010, 28(6): 573-591.
35.	Santos VOA, Browne RAV, Souza DC, et al. Effects of high-intensity interval and moderate-intensity continuous exercise on physical activity and sedentary behavior levels in inactive obese males: a crossover trial. J Sports Sci Med. 2019, 18(3): 390-398.
36.	Thompson D, Karpe F, Lafontan M, et al. Physical activity and exercise in the regulation of human adipose tissue physiology. Physiol Rev, 2012, 92(1): 157-191.
37.	Ludzki AC, Schleh MW, Krueger EM, et al. Inflammation and metabolism gene sets in subcutaneous abdominal adipose tissue are altered 1 hour after exercise in adults with obesity. J Appl Physiol (1985), 2021, 131(4): 1380-1389.
38.	Trapp EG, Chisholm DJ, Boutcher SH. Metabolic response of trained and untrained women during high-intensity intermittent cycle exercise. Am J Physiol Regul Integr Comp Physiol, 2007, 293(6): R2370-R2375.
39.	Maillard F, Pereira B, Boisseau N. Effect of high-intensity interval training on total, abdominal and visceral fat mass: a meta-analysis. Sports Med, 2018, 48(2): 269-288.
40.	Vekic J, Zeljkovic A, Stefanovic A, et al. Obesity and dyslipidemia. Metabolism, 2019, 92: 71-81.
41.	中国成人血脂异常防治指南修订联合委员会. 中国成人血脂异常防治指南(2016年修订版). 中国循环杂志, 2016, 31(10): 937-950.
42.	Chang KT, Chen CH, Chuang HH, et al. Which obesity index is the best predictor for high cardiovascular disease risk in middle-aged and elderly population. Arch Gerontol Geriatr, 2018, 78: 165-170.
43.	Buchheit M, Laursen PB. High-intensity interval training, solutions to the programming puzzle. Part II: anaerobic energy, neuromuscular load and practical applications. Sports Med, 2013, 43(10): 927-954.
44.	Laursen P. Science and application of high-intensity interval training: solutions to the programming puzzle. Human Kinetics, 2018.
45.	de Glisezinski I, Larrouy D, Bajzova M, et al. Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue. J Physiol, 2009, 587(Pt 13): 3393-3404.
46.	朱显贵, 石旅畅, 张海峰. 不同强度运动对脂解激素的影响及在减肥机制中的作用研究进展. 中国运动医学杂志, 2020, 39(7): 569-576.

1. GBD 2015 Obesity Collaborators. Health effects of overweight and obesity in 195 countries over 25 years. N Engl J Med, 2017, 377(1): 13-27.
2. 国家卫生健康委. 中国居民营养与慢性病状况报告(2020年). 营养学报, 2020, 42(6): 521.
3. Pan XF, Wang L, Pan A. Epidemiology and determinants of obesity in China. Lancet Diabetes Endocrinol, 2021, 9(6): 373-392.
4. Pi-Sunyer X. The medical risks of obesity. Postgrad Med, 2009, 121(6): 21-33.
5. Visscher TL, Seidell JC. The public health impact of obesity. Annu Rev Public Health, 2001, 22: 355-375.
6. Westerterp KR. Exercise, energy expenditure and energy balance, as measured with doubly labelled water. Proc Nutr Soc, 2018, 77(1): 4-10.
7. 邱俊强, 路明月, 张君, 等. 运动促进健康: 个性化精准解决方案. 北京体育大学学报, 2022, 45(10): 2-18.
8. Trapp EG, Chisholm DJ, Freund J, et al. The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes (Lond), 2008, 32(4): 684-691.
9. Kessler HS, Sisson SB, Short KR. The potential for high-intensity interval training to reduce cardiometabolic disease risk. Sports Med, 2012, 42(6): 489-509.
10. Tjønna AE, Stølen TO, Bye A, et al. Aerobic interval training reduces cardiovascular risk factors more than a multitreatment approach in overweight adolescents. Clin Sci (Lond), 2009, 116(4): 317-326.
11. 黎涌明. 高强度间歇训练对不同训练人群的应用效果. 体育科学, 2015, 35(8): 59-75, 96.
12. Cochrane Library. Cochrane handbook for systematic reviews of interventions (version 6.4). 2023.
13. Cumpston M, Li T, Page MJ, et al. Updated guidance for trusted systematic reviews: a new edition of the Cochrane handbook for systematic reviews of interventions. Cochrane Database Syst Rev, 2019, (10): ED000142.
14. Racil G, Ben Ounis O, Hammouda O, et al. Effects of high vs. moderate exercise intensity during interval training on lipids and adiponectin levels in obese young females. Eur J Appl Physiol, 2013, 113(10): 2531-2540.
15. 韩涵. 高强度间歇和中强度持续训练对青年肥胖女性体脂分布的影响. 石家庄: 河北师范大学, 2014.
16. Smith-Ryan AE, Melvin MN, Wingfield HL. High-intensity interval training: modulating interval duration in overweight/obese men. Phys Sportsmed, 2015, 43(2): 107-113.
17. Smith-Ryan AE, Trexler ET, Wingfield HL, et al. Effects of high-intensity interval training on cardiometabolic risk factors in overweight/obese women. J Sports Sci, 2016, 34(21): 2038-2046.
18. 林坚, 赵红勤, 黄雄昂, 等. 高强度间歇训练对肥胖女大学生体成分和血脂及空腹胰岛素水平的影响. 中国全科医学, 2016, 19(18): 2139-2144.
19. 王玲. 高强度间歇训练对肥胖青年女性血清FGF21及糖脂代谢的影响. 石家庄: 河北师范大学, 2017.
20. Khammassi M, Ouerghi N, Hadj-Taieb S, et al. Impact of a 12-week high-intensity interval training without caloric restriction on body composition and lipid profile in sedentary healthy overweight/obese youth. J Exerc Rehabil, 2018, 14(1): 118-125.
21. Sañudo B, Muñoz T, Davison GW, et al. High-intensity interval training combined with vibration and dietary restriction improves body composition and blood lipids in obese adults: a randomized trial. Dose Response, 2018, 16(3): 1559325818797015.
22. Nazari M, Minasian V, Hovsepian S. Effects of two types of moderate- and high-intensity interval training on serum salusin-α and salusin-β levels and lipid profile in women with overweight/obesity. Diabetes Metab Syndr Obes, 2020, 13: 1385-1390.
23. 曹甍. 不同训练方案对肥胖男生身体成分和糖脂代谢的干预效果研究. 上海: 上海体育学院, 2020.
24. 陈姗. 高强度间歇训练与交叉点训练对超重成年女性血脂代谢的影响. 北京: 北京体育大学, 2020.
25. 张立萌. 高强度间歇训练对超重青年循环骨钙素及其相关指标的影响. 北京: 首都体育学院, 2020.
26. Saeidi A, Shishvan SR, Soltani M, et al. Differential effects of exercise programs on neuregulin 4, body composition and cardiometabolic risk factors in men with obesity. Front Physiol, 2022, 12: 797574.
27. Sanayei M, Izadi A, Hajizadeh-Sharafabad F, et al. Chlorella vulgaris in combination with high intensity interval training in overweight and obese women: a randomized double-blind clinical trial. J Diabetes Metab Disord, 2021, 20(1): 781-792.
28. 阿迪力·尤努斯. 高强度间歇训练对肥胖大学生身体成分和血脂代谢指标的影响研究. 乌鲁木齐: 新疆师范大学, 2021.
29. 袁玲玲. 高强度间歇运动对超重或肥胖男性青少年心肺适能和身体成分及血脂水平的影响. 中华物理医学与康复杂志, 2021, 43(3): 251-253.
30. 张立萌, 卜淑敏, 刘晓然. 6周高强度间歇训练对超重/肥胖男青年循环骨钙素水平的影响. 中国运动医学杂志, 2021, 40(4): 270-275.
31. Leite N, Pizzi J, De Menezes Junior FJ, et al. Effect of mict and hiit on cardiometabolic risk and body composition in obese boys. Revista Brasileira de Medicina do Esporte, 2022, 28(4): 274-280.
32. 兰霄宇, 房国梁, 韩天雨, 等. 高强度有氧间歇运动对超重或肥胖老年人体成分、血脂及血糖的影响. 中国运动医学杂志, 2022, 41(7): 510-517.
33. Patton GC, Coffey C, Carlin JB, et al. Overweight and obesity between adolescence and young adulthood: a 10-year prospective cohort study. J Adolesc Health, 2011, 48(3): 275-280.
34. O'Donovan G, Blazevich AJ, Boreham C, et al. The ABC of physical activity for health: a consensus statement from the British Association of Sport and Exercise Sciences. J Sports Sci, 2010, 28(6): 573-591.
35. Santos VOA, Browne RAV, Souza DC, et al. Effects of high-intensity interval and moderate-intensity continuous exercise on physical activity and sedentary behavior levels in inactive obese males: a crossover trial. J Sports Sci Med. 2019, 18(3): 390-398.
36. Thompson D, Karpe F, Lafontan M, et al. Physical activity and exercise in the regulation of human adipose tissue physiology. Physiol Rev, 2012, 92(1): 157-191.
37. Ludzki AC, Schleh MW, Krueger EM, et al. Inflammation and metabolism gene sets in subcutaneous abdominal adipose tissue are altered 1 hour after exercise in adults with obesity. J Appl Physiol (1985), 2021, 131(4): 1380-1389.
38. Trapp EG, Chisholm DJ, Boutcher SH. Metabolic response of trained and untrained women during high-intensity intermittent cycle exercise. Am J Physiol Regul Integr Comp Physiol, 2007, 293(6): R2370-R2375.
39. Maillard F, Pereira B, Boisseau N. Effect of high-intensity interval training on total, abdominal and visceral fat mass: a meta-analysis. Sports Med, 2018, 48(2): 269-288.
40. Vekic J, Zeljkovic A, Stefanovic A, et al. Obesity and dyslipidemia. Metabolism, 2019, 92: 71-81.
41. 中国成人血脂异常防治指南修订联合委员会. 中国成人血脂异常防治指南(2016年修订版). 中国循环杂志, 2016, 31(10): 937-950.
42. Chang KT, Chen CH, Chuang HH, et al. Which obesity index is the best predictor for high cardiovascular disease risk in middle-aged and elderly population. Arch Gerontol Geriatr, 2018, 78: 165-170.
43. Buchheit M, Laursen PB. High-intensity interval training, solutions to the programming puzzle. Part II: anaerobic energy, neuromuscular load and practical applications. Sports Med, 2013, 43(10): 927-954.
44. Laursen P. Science and application of high-intensity interval training: solutions to the programming puzzle. Human Kinetics, 2018.
45. de Glisezinski I, Larrouy D, Bajzova M, et al. Adrenaline but not noradrenaline is a determinant of exercise-induced lipid mobilization in human subcutaneous adipose tissue. J Physiol, 2009, 587(Pt 13): 3393-3404.
46. 朱显贵, 石旅畅, 张海峰. 不同强度运动对脂解激素的影响及在减肥机制中的作用研究进展. 中国运动医学杂志, 2020, 39(7): 569-576.

Chinese Journal of Evidence-Based Medicine

Efficacy of high-intensity interval training on weight loss and blood lipid metabolism with overweight or obesity: a meta-analysis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content