Application of the subpopulation treatment effect pattern plot (STEPP) method in clinical trials_Chinese Journal of Evidence-Based Medicine

Authors：

LI Yufei ¹ , LIU Jianping ¹ , LIANG Shibing ^1,2 , CHENG Hongjie ³ , ZHANG Qiaoyan ³ ,  ZHANG Ying ¹

1. Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, P. R. China;
2. Clinical Research Center, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250013, P. R. China;
3. Fangshan Hospital Beijing University of Chinese Medicine, Beijing 102401, P. R. China;

Corresponding author：

ZHANG Ying, Email: yingzhang@bucm.edu.cn

Keywords：

Subpopulation treatment effect pattern plot method; Subgroup analyses; Interaction; R language; Randomized controlled trial

DOI：

10.7507/1672-2531.202308169

Video：

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Abstract Full text Figures/Tables Video References Cited by

Subpopulation treatment effect pattern plot (STEPP) method is a method for examining the relationship between treatment effects and continuous covariates and is characterized by dividing the study population into multiple overlapping subpopulations to be analyzed based on continuous covariate values. STEPP method has a different purpose than traditional subgroup analyses, and STEPP has a clear advantage in exploring the relationship between treatment effects and continuous covariates. In this study, the concepts, advantages, and subpopulation delineation methods of the STEPP method are introduced, and the specific operation process and result interpretation methods of STEPP method analysis using the STEPP package in R language are presented with examples.

Citation： LI Yufei, LIU Jianping, LIANG Shibing, CHENG Hongjie, ZHANG Qiaoyan, ZHANG Ying. Application of the subpopulation treatment effect pattern plot (STEPP) method in clinical trials. Chinese Journal of Evidence-Based Medicine, 2024, 24(8): 980-985. doi: 10.7507/1672-2531.202308169 Copy

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Chinese Journal of Evidence-Based Medicine

Application of the subpopulation treatment effect pattern plot (STEPP) method in clinical trials

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