FANG Jiamin 1 , LIANG Hao 2 , ZHONG Jintao 1 , CHEN Muxin 1 , YANG Xiaomin 1 , ZHAO Yidi 3 , WEI Lin 4
  • 1. State Key Laboratory of Traditional Chinese Medicine Syndrome, the Second Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China;
  • 2. Department of Neurology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, P. R. China;
  • 3. College of Nursing, Hunan University of Traditional Chinese Medicine, Changsha 410208, P. R. China;
  • 4. State Key Laboratory of Traditional Chinese Medicine Syndrome, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, P. R. China;
WEI Lin, Email: Weilin22@gzucm.edu.cn
Cognitive frailty; Elderly; Mortality; Hospitalization; Meta-analysis
10.7507/1672-2531.202310219
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Objective To systematically review the associations of cognitive frailty with mortality and hospitalization in the elderly. Methods The VIP, PubMed, CNKI, WanFang Data, CBM, Embase, Cochrane Library and Web of Science databases were electronically searched to collect cohort studies on the association of cognitive frailty with mortality or hospitalization in the elderly from inception to May, 2023. Two reviewers independently screened the literature, extracted data and assessed risk of bias of the included studies. Meta-analysis was performed by R 4.2.2 software. Results A total of 19 cohort studies involving 63 624 elderly were included. The results of meta-analysis showed that compared with healthy elder, the elder with cognitive frailty had a higher mortality (OR=2.75, 95%CI 2.10 to 3.59, P<0.01) and hospitalization (OR=1.67, 95%CI 1.40 to 2.00, P<0.01). Subgroup analysis showed that cognitive frailty was related to the risk of death in different status of frailty and cognitive function, different assessment tools, different countries of development, different follow-up time and research sites. At the same time, different status of frailty and cognitive function and different levels of development of countries were related to the risk of hospitalization. Conclusion Current evidence shows that cognitive frailty can increase the risk of hospitalization and mortality in the elderly. It is suggested that early screening and intervention of cognitive frailty should be carried out to effectively reduce the risk of adverse consequences, so as to achieve healthy aging.

Citation： FANG Jiamin, LIANG Hao, ZHONG Jintao, CHEN Muxin, YANG Xiaomin, ZHAO Yidi, WEI Lin. Association of cognitive frailty with mortality and hospitalization in older adults: a meta-analysis. Chinese Journal of Evidence-Based Medicine, 2024, 24(6): 686-692. doi: 10.7507/1672-2531.202310219 Copy

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