• 1. Neurosurgery Department, First Affiliated Hospital of PLA General Hospital, Beijing, 100048, China;
  • 2. ;
  • 3. ;
LIANGShuli, Email: liangsl304@hotmail.com
Export PDF Favorites Scan Get Citation

Objectives To study surgical outcomes and safety of unilateral anterior temporal lobectomy (ATL) in patients with intractable bilateral temporal lobe epilepsy (TLE) and dominant seizure-onset in unilateral temporal lobe. Methods Twenty three carefully selected patients with bilaterial TLE and dominant seizure-onset in unilateral temporal lobe were enrolled and divided into surgery and medicine groups according to the treatment.Seizure control were recorded for 2 to 5 years.Changes of full scale of intelligence quotient(IQ),and overall quality of life (QOL),percentage of therapeutic satisfaction,and surgical complications were analyzed 2 years after enrolling. Results Favor seizure control (Engel Class I and Class Ⅱ) reached 66.7% (10/15),60% (9/15),and 50% (5/10) at 1,2 and 5 years follow-up after unilateral ATL respectively,the percentages in medicine group is 12.5%,0% and 0% accordingly,and there were significant differences in seizures controls between patients with unilateral ATL and cases with medicine.Significantly differences were also found in changes of patients'QOL and full scale IQ at 2 years follow-up between surgery and medicine groups,and average score of overall QOL improved 5.27±6.45 in surgery group,and declined 1.40±3.58 in medicine group.In ATL group,patients with short preoperative history of seizure presented more favor seizure control than those with long preoperative history,and patients with favor seizure control and short preoperative history of seizure had more chance to improve QOL and IQ after ATL. Conclusion Intracranial EEG is vital in diagnosis of bilateral TLE.Unilateral ATL presents favor seizure control and did not render serious memory and IQ injury in carefully selected patients with true bilateral TLE and dominant seizure-onset in unilateral temporal lobe.

Citation: ZHANGShaohui, ZHANGJunchen, HUXiaohong, YUXiaoman, KONGHaibo, GAOChao, LIANGShuli. Unilateral anterior temporal lobectomy in patients with bilateral temporal lobe epilepsy and dominant seizure-onset in unilateral temporal lobe. Journal of Epilepsy, 2015, 1(1): 43-47. doi: 10.7507/2096-0247.20150007 Copy

  • Previous Article

    Clinical analysis of lamotrigine-related embryo damage and abortion
  • Next Article

    Neuroprotective effects and mechanisms of selective histone deacetylases inhibitor MS-275 on lithium-pilocarpine induced seizures in rats