Clinical and EEG features associated with refractoriness in benign childhood epilepsy with centrotemporal spikes_Journal of Epilepsy

Authors：

 XIAOFenglai , ANDongmei , CHENSihan ,  ZHOUDong

Department of Neurology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China;

Corresponding author：

ZHOUDong, Email: zhoudong66@yahoo.de

Keywords：

Benign childhood epilepsy with centrotemporal spikes; Antiepileptic drugs; Clinical and electroencephalographic features; Refractoriness; Risk factor

DOI：

10.7507/2096-0247.20150018

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Objective The aim of this study is to identify clinical and electroencephalographic features associated with refractoriness to the initial antiepileptic drug in typical benign childhood epilepsy with centrotemporal spikes (BECTS). Methods A total of 87 children with typical BECTS were retrospectively reviewed in the analyses.The patients were subdivided into two groups:patients whose seizures were controlled with monotherapy, and those requiring two medications. 63 childrenachieved seizure-freedom with monotherapy, while 24 received two medications for seizure control. Results Diffusing foci at the follow-up EEG and delayed treatment (duration > 1 year) are two main risk factors associated with more refractory cases (P < 0.001). Delayed diagnosis (37.1%) and non-adherence to treatment (57.2%) contributed to delayed treatment. Conclusions Our findings suggested that diffusing foci on EEG and delayed treatment are associated with more frequent seizures and refractoriness in BECTS. Diagnostic delays and non-adherence hindered timely care, which may represent opportunities for improved intervention.

Citation： XIAOFenglai, ANDongmei, CHENSihan, ZHOUDong. Clinical and EEG features associated with refractoriness in benign childhood epilepsy with centrotemporal spikes. Journal of Epilepsy, 2015, 1(2): 123-126. doi: 10.7507/2096-0247.20150018 Copy

1.	Wirrell EC. Benign epilepsy of childhood with centrotemporal spikes.Epilepsia, 2007, 39(S4):32-41.
2.	Loiseau P, Duché B, Cordova S, et al. Prognosis of benign childhood epilepsy with centrotemporal spikes:a follow-up study of 168 patients. Epilepsia, 1988, 29(3):229-235.
3.	Hughes JR. Benign epilepsy of childhood with centrotemporal spikes (BECTS):To treat or not to treat, that is the question. EpilepsyBehav, 2010, 19(3):197-203.
4.	ILAE. Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy.Epilepsia, 1989, 30(4):389-399.
5.	You SJ, Kim DS, Ko TS. Benign childhood epilepsy with centro-temporal spikes (BCECTS):early onset of seizures is associated with poorer response to initial treatment. Epileptic Disord, 2006, 8(4):285-288.
6.	Zhao X, Chi Z, Chi L, et al. Clinical and EEG characteristics of benign rolandic epilepsy in Chinese patients. Brain dev, 2007, 29(1):13-18.
7.	Incecik F, Altunbasak S, Herguner OM, et al. Prognostic significance of failure of the initial antiepileptic drug in children with benign childhood epilepsy with centrotemporal spikes. Brain Dev, 2015, 37(1):66-70.
8.	Kellaway P. The electroencephalographic features of benign centrotemporal (rolandic) epilepsy of childhood.Epilepsia, 2000, 41(8):1053-1056.
9.	Fejerman N, Caraballo R, Tenembaum SN. Atypical evolutions of benign localization-related epilepsies in children:are they predictable? Epilepsia, 2000, 41(4):380-390.
10.	Donald Shields W, Carter Snead O. Benign epilepsy with centrotemporal spikes.Epilepsia, 2009, 50(12):10-15.
11.	Modi AC. Patterns ofNonadherence to Antiepileptic drug therapy in children with newly diagnosed epilepsy. JAMA, 2011, 305(16):1669.
12.	Modi AC, Rausch JR, Glauser TA. Early pediatric antiepileptic drug nonadherence is related to lower long-term seizure freedom. Neurology, 2014, 82(8):671-673.

1. Wirrell EC. Benign epilepsy of childhood with centrotemporal spikes.Epilepsia, 2007, 39(S4):32-41.
2. Loiseau P, Duché B, Cordova S, et al. Prognosis of benign childhood epilepsy with centrotemporal spikes:a follow-up study of 168 patients. Epilepsia, 1988, 29(3):229-235.
3. Hughes JR. Benign epilepsy of childhood with centrotemporal spikes (BECTS):To treat or not to treat, that is the question. EpilepsyBehav, 2010, 19(3):197-203.
4. ILAE. Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy.Epilepsia, 1989, 30(4):389-399.
5. You SJ, Kim DS, Ko TS. Benign childhood epilepsy with centro-temporal spikes (BCECTS):early onset of seizures is associated with poorer response to initial treatment. Epileptic Disord, 2006, 8(4):285-288.
6. Zhao X, Chi Z, Chi L, et al. Clinical and EEG characteristics of benign rolandic epilepsy in Chinese patients. Brain dev, 2007, 29(1):13-18.
7. Incecik F, Altunbasak S, Herguner OM, et al. Prognostic significance of failure of the initial antiepileptic drug in children with benign childhood epilepsy with centrotemporal spikes. Brain Dev, 2015, 37(1):66-70.
8. Kellaway P. The electroencephalographic features of benign centrotemporal (rolandic) epilepsy of childhood.Epilepsia, 2000, 41(8):1053-1056.
9. Fejerman N, Caraballo R, Tenembaum SN. Atypical evolutions of benign localization-related epilepsies in children:are they predictable? Epilepsia, 2000, 41(4):380-390.
10. Donald Shields W, Carter Snead O. Benign epilepsy with centrotemporal spikes.Epilepsia, 2009, 50(12):10-15.
11. Modi AC. Patterns ofNonadherence to Antiepileptic drug therapy in children with newly diagnosed epilepsy. JAMA, 2011, 305(16):1669.
12. Modi AC, Rausch JR, Glauser TA. Early pediatric antiepileptic drug nonadherence is related to lower long-term seizure freedom. Neurology, 2014, 82(8):671-673.

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