感染在儿童癫痫形成中的作用_Journal of Epilepsy

Authors：

 刘敏 , 陈旭勤 ,  李岩

苏州大学附属儿童医院神经内科(江苏苏州, 215000);

Corresponding author：

李岩, Email: yan62bh@126.com

Keywords：

DOI：

10.7507/2096-0247.20150022

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Citation： 刘敏, 陈旭勤, 李岩. 感染在儿童癫痫形成中的作用. Journal of Epilepsy, 2015, 1(2): 143-148. doi: 10.7507/2096-0247.20150022 Copy

1.	Natalie Neu, Jennifer Duchon, Philip Zachariah. TORCH Infections. Clin Perinatol, 2015, 42(1): 77-103.
2.	Libbey JE, Fujinami RS. Neurotropic viral infections leading to epilepsy:focus on Theiler's murine encephalomyelitis virus.Future Virol, 2011, 6(11):1339-1350.
3.	Wilson JC, Toovey S, Jick SS, et al. Previously diagnosed influenza infections and the risk of developing epilepsy. Epidemiol Infect, 2015, 143(11): 2408-2415.
4.	姜兰兰, 姚茎.人疱疹病毒6型基因编码蛋白研究进展.微生物与感染, 2009, 4(3):165-169.
5.	Ward KN, Ohrling A, Bryant NJ, et al. Herpes simplex serious neurological disease in young children:incidence and long-term outcome. Arch Dis Child, 2012, 97(2): 162-165.
6.	Theodore WH, Epstein L, Gaillard WD, et al. Human Herpes Virus 6B:A possible Role in Epilepsy? Epilepsia, 2008, 49(11): 1828-1837.
7.	Uesugi H, Shimizu H, Maehara T, et al. Presence of human herpesvirus 6 and herpessimplex virus detected by polymerase chain reaction in surgical tissue from temporal lobe epilepsypatients. Psychiatry Clin Neurosci, 2000, 54(5):589-593.
8.	Esposito L, Drexler JF, Braganza O, et al. Large-scale analysis of viral nucleic acid spectrum in temporal lobe epilepsy biopsies. Epilepsia, 2015, 56(2): 234-243.
9.	Karatas H, Gurer G, Pinar A, et al. Investigation of HSV-1, HSV-2, CMV, HHV-6 and HHV-8 DNA by real-time PCR in surgical resection materials of epilepsy patients with mesial temporal lobe sclerosis. J Neurol Sci, 2008, 264(1-2): 151-156.
10.	中华医学会儿科学分会感染学组, 全国儿科临床病毒感染协作组, 《中华儿科杂志》编辑委员会.儿童巨细胞病毒性疾病诊断和防治的建议.中华儿科杂志, 2012, 50(4):290-292.
11.	夏宇, 张波.人巨细胞病毒实验室诊断进展.国际检验医学杂志, 2013, 8(4):1673.
12.	Cannon MJ. Congenital cytomegalovirus epidemiology and awareness. J Clin Virol, 2009, 46(Suppl 4):6-10.
13.	Bale JF. Fatal infections and brain development. Clin Perinatol, 2009, 36(3):639-653.
14.	Dunin-Wasowicz D, Kasprzyk-Obara J, Jurkiewicz E, et al. Infantile spasms and cytomegalovirus infection:antiviral and antiepileptic treatment. Dev Med Child Neurol, 2007, 49(9):684-692.
15.	Wang X, Huong SM, Chiu ML, et al. Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus. Nature, 2003, 424(6947):456-461.
16.	罗开军, 罗敏华.先天性人巨细胞病毒感染致中枢神经系统发育异常的机制.现代医药卫生, 2004, 20(2):1009.
17.	Suzuki Y, Toribe Y, Mogami Y, et al. Epilepsy in patients with congenital cytomegalovirus infection. Brain Dev, 2008, 30(6):420-424.
18.	Smithers-Sheedy H, Raynes-Greenow C, Badawi N, et al. Neuroimaging findings in a series of children with cerebral palsy and congenital cytomegalovirus infection. Infect Disord Drug Targets, 2014, 14(3):185-190.
19.	Chen J, Tsai V, Crino PB, et al. Detection of human papillomavirus in human focal cortical dysplasia typeⅡB. Ann Neurol, 2012, 72(6):881-892.
20.	Wong M. Is Focal Cortical Dysplasia an Infectious Disease? Epilepsy Curr, 2013, 13(5):226-228.
21.	彭燕, 王新.人微小病毒B19及其研究新进展.现代医药卫生, 2013, 33(7): 1009-1021.
22.	Pistorius LR, Smal J, de Haan TR, et al. Disturbance of Cerebral Neuronal Migration following Congenital Parvovirus B19 Infection. Fetal Diagn Ther, 2008, 24(4): 491-494.
23.	Nagel HT, de Haan TR, Vandenbussche FP, et al. Long-term outcome after fetal transfusion for hydrops associated with parvovirus B19 infection. Obstet Gynecol, 2007, 109(1): 42-47.
24.	Skaff PT, Labiner DM. Status epilepticus due to human parvovirus B19 encephalitis in an immunocompetent adult. Neurology, 2001, 57(7): 1336-1337.
25.	Yeo LL, Paliwal PR, Tambyah PA, et al. Complex partial status epilepticus associated with adult H1N1 infection. J Clin Neurosci, 2012, 19(12):1728-1730.
26.	Ekstrand JJ, Herbener A, Rawlings J, et al. Heightened neurologic complications in children with pandemic H1N1 influenza. Ann Neurol, 2010, 68(5):762-766.
27.	Jurgens HA, Amancherla K, Johnson RW. Influenza infection induces neuroinflammation, alters hippocampal neuron morphology, and impairs cognition in adult mice. J Neurosci, 2012, 32(12):3958-3968.
28.	Banatvala JE, Brown DW. Rubella. Lancet, 2004, 363(9415):1127-1137.
29.	Ben Achour N, Benrhouma H, Rouissi A, et al. Epidemic of rubella encephalitis. Arch Pediatr, 2013, 20(8):858-862.
30.	Fujita Y, Imai Y, Ishii W, et al. Improvement of intractable childhood epilepsy following acute viral infection. Brain Dev, 2011, 33(1):62-68.
31.	胡亚美, 江载芳, 诸福棠.实用儿科学.第7版.北京:人民卫生出版社, 2003:912.
32.	高静, 钟建民.化脓性脑膜炎病原菌及流行病学研究进展.江西医药, 2011, 46(10):960-962.
33.	Baraff LJ, Lee SI, Schriger DL. Outcomes of bacterial meningitis in children:a meta-analysis. Pediatr Infect Dis J, 1993, 12(5):389-394.
34.	Chang CJ, Chang HW, Chang WN, et al. Seizures complicating infantile and childhood bacterial meningitis. Pediatr Neurol, 2004, 31(3):165-171.
35.	O'Brien TJ, Moses H, Cambier D. Age of meningitis or encephalitis is independently predictive of outcome from anterior temporal lobectomy. Neurology, 2002, 58(1):104-109.
36.	Sultana NK, Saha SK, Al-Emran HM, et al. Impact of introduction of the Haemophilus influenzae type b conjugate vaccine into childhood immunization onmeningitis in Bangladeshi infants. J Pediatr, 2013, 163(1 Suppl):73-78.
37.	Naito S, Tanaka J, Nagashima K, et al. The impact of heptavalent pneumococcal conjugate vaccine on the incidence of childhood community-acquiredpneumonia and bacteriologically confirmed pneumococcal pneumonia in Japan. Epidemiol Infect, 2015, 7(30):1-13.
38.	Marshall H, Wang B, Wesselingh S, et al. Control of invasive meningococcal disease:is it achievable? Int J Evid Based Healthc, 2015, 7(29):24.
39.	Ngoungou EB, Bhalla D, Nzoghe A, et al. Toxoplasmosis and Epilepsy-Systematic Review and Meta Analysis. PLos Negl Trop Dis, 2015, 9(2):e0003525.
40.	Akyol A, Bicerol B, Ertug S, et al. Epilepsy and seropositivity rates of Toxocaracanis and Toxoplasma gondii. Seizure, 2007, 16(3):233-237.
41.	Hawk MW, Shahlaie K, Kim DK, et al. Neurocysticercosis:a review. Surg Neurol, 2005, 63(2):123-132.
42.	Sotello J, Del Brutto OH. Review of neurocysticercosis. Neurosurg Focus, 2002, 12(6):e1.
43.	Garcia HH, Del Brutto OH, Neurocysticercosis:updated concepts about an old disease. Lancet Neurol, 2005, 4(10):653-661.
44.	Takayanagui OM, Odashima NS. Clinical aspects of neurocysticercosis. Parasitol Int, 2006, 55(23):S111-115.
45.	Patel R, Jha S, Yadav RK. Pleomorphism of the clinical manifestations of neurocysticercosis. Trans Soc Trop Med Hyg, 2006, 100(2):134-141.
46.	Shandera WX, Kass JS. Neurocysticercosis:current knowledge and advances. Curr Neurol Neurosci Rep, 2006, 6(6):453-459.
47.	Bern C, Garcia HH, Evans C, et al. Magnitude of the disease burden from neurocysticercosis in a developing country. Clin Infect Dis, 1999, 29(5):1203-1209.
48.	de Souza A, Nalini A, Kovoor JM, et al. Perilesional gliosis around solitary cerebral parenchymal cysticerci and long-term seizure outcome:a prospective study using serial magnetization transfer imaging. Epilepsia, 2011, 52(10):1918-1927.
49.	Carabin H, Ndimubanzi PC, Budke CM, et al. Clinical manifestations associated with neurocysticercosis:a systematic review. Plos Negl Trop Dis, 2011, 5(5):e1152.
50.	Bianchin MM, Velasco TR, Santos AC, et al. On the relationship between neurocysticercosis and mesial temporal lobe epilepsy associated with hippocampal sclerosis:coincidence or a pathogenic relationship? Pathog Glob Health, 2012, 106(5):280-285.
51.	Bitnun A, Ford-Jones E, Blaser S, et al. Mycoplasma pneumonia encephalitis. Semin Pediatr Infect Dis, 2003, 14(2):96-107.
52.	Lin JJ, Hsia SH, Wu CT, et al. Mycoplasma pneumoniae-related postencephalitic epilepsy in children. Epilepsia, 2011, 52(11):1979-1985.
53.	Ances BM, Shellhaus R, Brown MJ, et al. Neurosyphilis and status epilepticus:case report and literature review. Epilepsy Res, 2004, 59(1):67-70.
54.	葛华, 朱仁敬, 彭忠伟.类似病毒性脑炎的神经梅毒临床分析.中国综合临床, 2012, 28(12):1291-1292.
55.	Kumari S, Hayton T, Jumaa P, et al. The great imitator:Neurosyphilis and new onset refractory status epilepticus (NORSE) syndrome. Epilepsy Behav Case Rep, 2015, 6(3):33-35.
56.	Zhu LP, Wu JQ, Xu B, et al. Cryptococcal meningitis in non-HIV-infected patients in a Chinese tertiary care hospital, 1997-2007. Med Mycol, 2010, 48(4):570-579.
57.	Tiamkao S, Sawanyawisuth K, Chotmongkol V. Seizure in non-HIV cryptococcal meningitis. J Med Assoc Thai, 2007, 7(90):1298-1302.
58.	Boulware DR, Meya DB, Bergemann TL, et al. Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis:a prospective cohort study. PLo S Med, 2010, 7(12):e1000384.
59.	Seboxa T, Alemu S, Assefa A, et al. Cryptococcal meningitis in patients with acquired immuno-deficiency syndrome in pre-HAART era at Gondar College of Medical Sciences Hospital north-west Ethiopia. Ethiop Med J, 2010, 48(3):237-241.
60.	Hung CW, Chang WN, Kung CT, et al. Predictors and long-term outcome of seizures in human immuno-deficiency virus (HIV)-negative cryptococcal meningitis. BMC Neurol, 2014, 13(14):208.
61.	Dorko E, Pilipcinec E, Tkáciková L. Candida species isolated from cerebrospinal fluid. Folia Microbiol(Praha), 2002, 47(2):179-181.
62.	Hoever G, Vogel JU, Lukashenko P, et al. Impact of persistent cytomegalovirus infection onhuman neuroblastoma cell gene expression. Biochem Biophys Res Commun, 2005, 326(2):395-401.
63.	Amour D, Bartle LM, Skaletskaya A, et al. Cytomegalovirus cell death suppressor vMIA blocks Bax-but Bax-mediated apoptosis by binding and sequestering Bax at mitochondria. Proc Natl Acad Sci USA, 2004, 101(21):7988-7993.
64.	傅鹰, 陈利云, 罗敏华.先天性CMV感染致中枢神经系统畸形发育机制.生命科学, 2006, 18(1):45-50.
65.	Marin-Valencia I, Guerrini R, Gleeson JG. Pathogenetic mechanisms of focal cortical dysplasia. Epilepsia, 2014, 55(7):970-978.

1. Natalie Neu, Jennifer Duchon, Philip Zachariah. TORCH Infections. Clin Perinatol, 2015, 42(1): 77-103.
2. Libbey JE, Fujinami RS. Neurotropic viral infections leading to epilepsy:focus on Theiler's murine encephalomyelitis virus.Future Virol, 2011, 6(11):1339-1350.
3. Wilson JC, Toovey S, Jick SS, et al. Previously diagnosed influenza infections and the risk of developing epilepsy. Epidemiol Infect, 2015, 143(11): 2408-2415.
4. 姜兰兰, 姚茎.人疱疹病毒6型基因编码蛋白研究进展.微生物与感染, 2009, 4(3):165-169.
5. Ward KN, Ohrling A, Bryant NJ, et al. Herpes simplex serious neurological disease in young children:incidence and long-term outcome. Arch Dis Child, 2012, 97(2): 162-165.
6. Theodore WH, Epstein L, Gaillard WD, et al. Human Herpes Virus 6B:A possible Role in Epilepsy? Epilepsia, 2008, 49(11): 1828-1837.
7. Uesugi H, Shimizu H, Maehara T, et al. Presence of human herpesvirus 6 and herpessimplex virus detected by polymerase chain reaction in surgical tissue from temporal lobe epilepsypatients. Psychiatry Clin Neurosci, 2000, 54(5):589-593.
8. Esposito L, Drexler JF, Braganza O, et al. Large-scale analysis of viral nucleic acid spectrum in temporal lobe epilepsy biopsies. Epilepsia, 2015, 56(2): 234-243.
9. Karatas H, Gurer G, Pinar A, et al. Investigation of HSV-1, HSV-2, CMV, HHV-6 and HHV-8 DNA by real-time PCR in surgical resection materials of epilepsy patients with mesial temporal lobe sclerosis. J Neurol Sci, 2008, 264(1-2): 151-156.
10. 中华医学会儿科学分会感染学组, 全国儿科临床病毒感染协作组, 《中华儿科杂志》编辑委员会.儿童巨细胞病毒性疾病诊断和防治的建议.中华儿科杂志, 2012, 50(4):290-292.
11. 夏宇, 张波.人巨细胞病毒实验室诊断进展.国际检验医学杂志, 2013, 8(4):1673.
12. Cannon MJ. Congenital cytomegalovirus epidemiology and awareness. J Clin Virol, 2009, 46(Suppl 4):6-10.
13. Bale JF. Fatal infections and brain development. Clin Perinatol, 2009, 36(3):639-653.
14. Dunin-Wasowicz D, Kasprzyk-Obara J, Jurkiewicz E, et al. Infantile spasms and cytomegalovirus infection:antiviral and antiepileptic treatment. Dev Med Child Neurol, 2007, 49(9):684-692.
15. Wang X, Huong SM, Chiu ML, et al. Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus. Nature, 2003, 424(6947):456-461.
16. 罗开军, 罗敏华.先天性人巨细胞病毒感染致中枢神经系统发育异常的机制.现代医药卫生, 2004, 20(2):1009.
17. Suzuki Y, Toribe Y, Mogami Y, et al. Epilepsy in patients with congenital cytomegalovirus infection. Brain Dev, 2008, 30(6):420-424.
18. Smithers-Sheedy H, Raynes-Greenow C, Badawi N, et al. Neuroimaging findings in a series of children with cerebral palsy and congenital cytomegalovirus infection. Infect Disord Drug Targets, 2014, 14(3):185-190.
19. Chen J, Tsai V, Crino PB, et al. Detection of human papillomavirus in human focal cortical dysplasia typeⅡB. Ann Neurol, 2012, 72(6):881-892.
20. Wong M. Is Focal Cortical Dysplasia an Infectious Disease? Epilepsy Curr, 2013, 13(5):226-228.
21. 彭燕, 王新.人微小病毒B19及其研究新进展.现代医药卫生, 2013, 33(7): 1009-1021.
22. Pistorius LR, Smal J, de Haan TR, et al. Disturbance of Cerebral Neuronal Migration following Congenital Parvovirus B19 Infection. Fetal Diagn Ther, 2008, 24(4): 491-494.
23. Nagel HT, de Haan TR, Vandenbussche FP, et al. Long-term outcome after fetal transfusion for hydrops associated with parvovirus B19 infection. Obstet Gynecol, 2007, 109(1): 42-47.
24. Skaff PT, Labiner DM. Status epilepticus due to human parvovirus B19 encephalitis in an immunocompetent adult. Neurology, 2001, 57(7): 1336-1337.
25. Yeo LL, Paliwal PR, Tambyah PA, et al. Complex partial status epilepticus associated with adult H1N1 infection. J Clin Neurosci, 2012, 19(12):1728-1730.
26. Ekstrand JJ, Herbener A, Rawlings J, et al. Heightened neurologic complications in children with pandemic H1N1 influenza. Ann Neurol, 2010, 68(5):762-766.
27. Jurgens HA, Amancherla K, Johnson RW. Influenza infection induces neuroinflammation, alters hippocampal neuron morphology, and impairs cognition in adult mice. J Neurosci, 2012, 32(12):3958-3968.
28. Banatvala JE, Brown DW. Rubella. Lancet, 2004, 363(9415):1127-1137.
29. Ben Achour N, Benrhouma H, Rouissi A, et al. Epidemic of rubella encephalitis. Arch Pediatr, 2013, 20(8):858-862.
30. Fujita Y, Imai Y, Ishii W, et al. Improvement of intractable childhood epilepsy following acute viral infection. Brain Dev, 2011, 33(1):62-68.
31. 胡亚美, 江载芳, 诸福棠.实用儿科学.第7版.北京:人民卫生出版社, 2003:912.
32. 高静, 钟建民.化脓性脑膜炎病原菌及流行病学研究进展.江西医药, 2011, 46(10):960-962.
33. Baraff LJ, Lee SI, Schriger DL. Outcomes of bacterial meningitis in children:a meta-analysis. Pediatr Infect Dis J, 1993, 12(5):389-394.
34. Chang CJ, Chang HW, Chang WN, et al. Seizures complicating infantile and childhood bacterial meningitis. Pediatr Neurol, 2004, 31(3):165-171.
35. O'Brien TJ, Moses H, Cambier D. Age of meningitis or encephalitis is independently predictive of outcome from anterior temporal lobectomy. Neurology, 2002, 58(1):104-109.
36. Sultana NK, Saha SK, Al-Emran HM, et al. Impact of introduction of the Haemophilus influenzae type b conjugate vaccine into childhood immunization onmeningitis in Bangladeshi infants. J Pediatr, 2013, 163(1 Suppl):73-78.
37. Naito S, Tanaka J, Nagashima K, et al. The impact of heptavalent pneumococcal conjugate vaccine on the incidence of childhood community-acquiredpneumonia and bacteriologically confirmed pneumococcal pneumonia in Japan. Epidemiol Infect, 2015, 7(30):1-13.
38. Marshall H, Wang B, Wesselingh S, et al. Control of invasive meningococcal disease:is it achievable? Int J Evid Based Healthc, 2015, 7(29):24.
39. Ngoungou EB, Bhalla D, Nzoghe A, et al. Toxoplasmosis and Epilepsy-Systematic Review and Meta Analysis. PLos Negl Trop Dis, 2015, 9(2):e0003525.
40. Akyol A, Bicerol B, Ertug S, et al. Epilepsy and seropositivity rates of Toxocaracanis and Toxoplasma gondii. Seizure, 2007, 16(3):233-237.
41. Hawk MW, Shahlaie K, Kim DK, et al. Neurocysticercosis:a review. Surg Neurol, 2005, 63(2):123-132.
42. Sotello J, Del Brutto OH. Review of neurocysticercosis. Neurosurg Focus, 2002, 12(6):e1.
43. Garcia HH, Del Brutto OH, Neurocysticercosis:updated concepts about an old disease. Lancet Neurol, 2005, 4(10):653-661.
44. Takayanagui OM, Odashima NS. Clinical aspects of neurocysticercosis. Parasitol Int, 2006, 55(23):S111-115.
45. Patel R, Jha S, Yadav RK. Pleomorphism of the clinical manifestations of neurocysticercosis. Trans Soc Trop Med Hyg, 2006, 100(2):134-141.
46. Shandera WX, Kass JS. Neurocysticercosis:current knowledge and advances. Curr Neurol Neurosci Rep, 2006, 6(6):453-459.
47. Bern C, Garcia HH, Evans C, et al. Magnitude of the disease burden from neurocysticercosis in a developing country. Clin Infect Dis, 1999, 29(5):1203-1209.
48. de Souza A, Nalini A, Kovoor JM, et al. Perilesional gliosis around solitary cerebral parenchymal cysticerci and long-term seizure outcome:a prospective study using serial magnetization transfer imaging. Epilepsia, 2011, 52(10):1918-1927.
49. Carabin H, Ndimubanzi PC, Budke CM, et al. Clinical manifestations associated with neurocysticercosis:a systematic review. Plos Negl Trop Dis, 2011, 5(5):e1152.
50. Bianchin MM, Velasco TR, Santos AC, et al. On the relationship between neurocysticercosis and mesial temporal lobe epilepsy associated with hippocampal sclerosis:coincidence or a pathogenic relationship? Pathog Glob Health, 2012, 106(5):280-285.
51. Bitnun A, Ford-Jones E, Blaser S, et al. Mycoplasma pneumonia encephalitis. Semin Pediatr Infect Dis, 2003, 14(2):96-107.
52. Lin JJ, Hsia SH, Wu CT, et al. Mycoplasma pneumoniae-related postencephalitic epilepsy in children. Epilepsia, 2011, 52(11):1979-1985.
53. Ances BM, Shellhaus R, Brown MJ, et al. Neurosyphilis and status epilepticus:case report and literature review. Epilepsy Res, 2004, 59(1):67-70.
54. 葛华, 朱仁敬, 彭忠伟.类似病毒性脑炎的神经梅毒临床分析.中国综合临床, 2012, 28(12):1291-1292.
55. Kumari S, Hayton T, Jumaa P, et al. The great imitator:Neurosyphilis and new onset refractory status epilepticus (NORSE) syndrome. Epilepsy Behav Case Rep, 2015, 6(3):33-35.
56. Zhu LP, Wu JQ, Xu B, et al. Cryptococcal meningitis in non-HIV-infected patients in a Chinese tertiary care hospital, 1997-2007. Med Mycol, 2010, 48(4):570-579.
57. Tiamkao S, Sawanyawisuth K, Chotmongkol V. Seizure in non-HIV cryptococcal meningitis. J Med Assoc Thai, 2007, 7(90):1298-1302.
58. Boulware DR, Meya DB, Bergemann TL, et al. Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis:a prospective cohort study. PLo S Med, 2010, 7(12):e1000384.
59. Seboxa T, Alemu S, Assefa A, et al. Cryptococcal meningitis in patients with acquired immuno-deficiency syndrome in pre-HAART era at Gondar College of Medical Sciences Hospital north-west Ethiopia. Ethiop Med J, 2010, 48(3):237-241.
60. Hung CW, Chang WN, Kung CT, et al. Predictors and long-term outcome of seizures in human immuno-deficiency virus (HIV)-negative cryptococcal meningitis. BMC Neurol, 2014, 13(14):208.
61. Dorko E, Pilipcinec E, Tkáciková L. Candida species isolated from cerebrospinal fluid. Folia Microbiol(Praha), 2002, 47(2):179-181.
62. Hoever G, Vogel JU, Lukashenko P, et al. Impact of persistent cytomegalovirus infection onhuman neuroblastoma cell gene expression. Biochem Biophys Res Commun, 2005, 326(2):395-401.
63. Amour D, Bartle LM, Skaletskaya A, et al. Cytomegalovirus cell death suppressor vMIA blocks Bax-but Bax-mediated apoptosis by binding and sequestering Bax at mitochondria. Proc Natl Acad Sci USA, 2004, 101(21):7988-7993.
64. 傅鹰, 陈利云, 罗敏华.先天性CMV感染致中枢神经系统畸形发育机制.生命科学, 2006, 18(1):45-50.
65. Marin-Valencia I, Guerrini R, Gleeson JG. Pathogenetic mechanisms of focal cortical dysplasia. Epilepsia, 2014, 55(7):970-978.

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