国际抗癫痫联盟治疗方法委员会手术治疗协作组报告——海绵状血管瘤所致癫痫治疗的回顾及推荐_Journal of Epilepsy

Authors：

 郭佳南 ,  慕洁

四川大学华西医院神经内科(成都, 610041);

Corresponding author：

慕洁, Email: mujie2010@foxmail.com

Keywords：

海绵状血管瘤; 癫痫手术; 病因; 危险因素; 疗效

DOI：

10.7507/2096-0247.20150043

Video：

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Abstract Full text Figures/Tables Video References Cited by

颅内海绵状血管瘤(Cerebral cavernous malformations, CCMs)是一种已被明确的, 最常见的单发病变, 约占人群的0.4%～0.9%。癫痫发作是CCMs患者最常见的症状, 并严重影响患者的社会功能和生活质量。然而在接受手术切除治疗的CCMs所致癫痫(CCMs related epilepsy, CRE)患者中仅有75%达到无癫痫发作。这是由于对致痫灶区域评估的不充分所致。国际抗癫痫联盟(ILAE)治疗方法委员会手术治疗协作组及受邀专家回顾了与CRE相关的文献资料, 提出以下观点:根据诊断评估及针对病因的特殊处理不同, 推荐使用"确定的CRE"与"可能的CRE"来描述诊断。未来需要前瞻性的临床研究来明确CRE的最佳手术时机及手术方案, 以及含铁血黄素沉积边缘与致痫灶之间的关系。

Citation： 郭佳南, 慕洁. 国际抗癫痫联盟治疗方法委员会手术治疗协作组报告——海绵状血管瘤所致癫痫治疗的回顾及推荐. Journal of Epilepsy, 2015, 1(3): 251-260. doi: 10.7507/2096-0247.20150043 Copy

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17. Cohen DS, Zubay GP, Goodman RR. Seizure outcome after lesionectomy for cavernous malformations. J Neurosurg, 1995, 83(4):237-242.
18. Dammann P, Barth M, Zhu Y, et al. Susceptibility weighted magnetic resonance imaging of cerebral cavernous malformations:prospects, drawbacks, and first experience at ultra-high field strength (7-Tesla) magnetic resonance imaging. Neurosurg Focus, 2010, 29(8):5.
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20. Di Gennaro G, Quarato PP, Sebastiano F, et al. Postoperative EEG and seizure outcome in temporal lobe epilepsy surgery. Clin Neurophysiol, 2004, 115(1):1212-1219.
21. Ding L, Worrell GA, Lagerlund TD, et al. 3D source localization of interictal spikes in epilepsy patients with MRI lesions. Phys Med Biol, 2006, 51(7):4047-4062.
22. Englot DJ, Han SJ, Lawton MT, et al. Predictors of seizure freedom in the surgical treatment of supratentorial cavernous malformations clinical article. J Neurosurg, 2010, 115(9):1169-1174.
23. Fedele DE, Gouder N, Guttinger M, et al. Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation. Brain, 2005, 128(3):2383-2395.
24. Felbor U, Sure U, Grimm T, et al. Genetics of cerebral cavernous angioma. Zentralbl Neurochir, 2006, 67(12):110-116.
25. Ferrer I, Kaste M, Kalimo H. Vascular diseases//Love S, Louis DN, Ellison DW, ed. Greenfield's neuropathology. Edward Arnold, London, 2010:121-240.
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30. Hammen T, Romstock J, Dorfler A, et al. Prediction of postoperative outcome with special respect to removal of hemosiderin fringe:a study in patients with cavernous haemangiomas associated with symptomatic epilepsy. Seizure, 2007, 35(8):360-363.
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34. Josephson C, Leach J, Duncan R, et al. Seizure risk from cavernous or arteriovenous malformations prospective population-based study. Neurology, 2011, 76(5):1548-1554.
35. Karlsson B, Kihlstrom L, Lindquist C, et al. Radiosurgery for cavernous malformations. J Neurosurg, 1998, 88(12):293-297.
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42. Liquori CL, Berg MJ, Siegel AM, et al. Mutations in a gene encoding a novel protein containing a phosphotyrosine-binding domain cause type 2 cerebral cavernous malformations. Am J Hum Genet, 2003, 73(5):1459-1464.
43. Lunsford L, Khan AA, NiranjanA, et al. Stereotactic radiosurgery for symptomatic solitary cerebral cavernous malformations considered high risk for resection. J Neurosurg, 2010, 113(6):23-29.
44. Maciunas JA, Syed TU, Cohen ML, et al. Triple pathology in epilepsy:coexistence of cavernous angiomas and cortical dysplasias with other lesions. Epilepsy Res, 2010, 91(9):106-110.
45. Maraire JN, Awad IA. Intracranial cavernous malformations:lesion behavior and management strategies. Neurosurgery, 1995, 37(8):591-605.
46. McCormick WF, Boulter TR. Vascular malformations ("angiomas") of the dura mater. J Neurosurg, 1966, 25(10):309-311.
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