特发性全面性癫痫的神经影像研究进展_Journal of Epilepsy

Authors：

 罗程 , 尧德中

电子科技大学信息医学研究中心神经信息教育部重点实验室高场磁共振脑成像四川省重点实验室, 成都, 610054;

Corresponding author：

罗程, Email: chengluo@uestc.edu.cn

Keywords：

特发性全面发作性癫痫; 神经检查; 脑电图; 磁共振; 弥散张量成像

DOI：

10.7507/2096-0247.20160011

Video：

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Abstract Full text Figures/Tables Video References Cited by

特发性全面发作性癫痫(Idiopathic generalized epilepsy, IGE)是一类没有明显病因和大脑病灶的癫痫, 主要脑电图(EEG)表现为突出背景的双侧对称的癫痫放电。现在新兴的无创的神经成像技术改变了以前对IGE的脑结构和功能网络的研究模式。当前的研究者已经迅速地采用这些新技术研究IGE的脑特征性改变, 包括EEG、功能磁共振、同步脑电和功能磁共振、结构磁共振、弥散张量成像以及结构功能脑网络技术。这些发现表明IGE中皮层-丘脑网络中存在着结构和功能指标的异常, 且越来越多的多模态神经成像结果也评估了癫痫活动对大量脑功能网络的影响。将来的研究将集中在多学科的融合和发展多模态神经成像技术, 更深入地研究IGE的脑网络机制

Citation： 罗程, 尧德中. 特发性全面性癫痫的神经影像研究进展. Journal of Epilepsy, 2016, 2(1): 55-63. doi: 10.7507/2096-0247.20160011 Copy

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20. Powell HW, Parker GJ, Alexander DC, et al. Abnormalities of language networks in temporal lobe epilepsy. Neuroimage, 2007, 36 (1): 209-221.
21. Chahboune H, Mishra AM, DeSalvo MN, et al. DTI abnormalities in anterior corpus callosum of rats with spike-wave epilepsy. NeuroImage, 2009, 47 (2): 459-466.
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23. Lui S, Ouyang L, Chen Q, et al. Differential interictal activity of the precuneus/posterior cingulate cortex revealed by resting state functional MRI at 3T in generalized vs. partial seizure. J Magn Reson Imaging, 2008, 27 (6): 1214-1220.
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27. Wang P, Luo C, Dong L, et al. Altered intrinsic brain activity in patients with familial cortical myoclonic tremor and epilepsy: an amplitude of low-frequency fluctuation study. J Neurol Sci, 2015, 351 (1-2): 133-139.
28. Zhong Y, Lu G, Zhang Z, et al. Altered regional synchronization in epileptic patients with generalized tonic-clonic seizures. Epilepsy Res, 2011, 97 (1-2): 83-91.
29. Ding J, An D, Liao W, et al. Abnormal functional connectivity density in psychogenic non-epileptic seizures. Epilepsy Res, 2014, 108 (7): 1184-1194.
30. Dong L, Luo C, Cao W, et al. Spatiotemporal consistency of local neural activities: A new imaging measure for functional MRI data. J Magn Reson Imaging, 2015, 42 (3): 729-736.
31. Ives JR, Warach S, Schmitt F, et al. Monitoring the patient's EEG during echo planar MRI. Electroencephalogr Clin Neurophysiol, 1993, 87 (6): 417-420.
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36. Lei X, Xu P, Luo C, et al. fMRI functional networks for EEG source imaging. Hum Brain Mapp, 2011, 32 (7): 1141-1160.
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40. Tyvaert L, Hawco C, Kobayashi E, et al. Different structures involved during ictal and interictal epileptic activity in malformations of cortical development: an EEG-fMRI study. Brain, 2008, 131 (Pt 8): 2042-2060.
41. Kobayashi E, Bagshaw AP, Benar CG, et al. Temporal and extratemporal BOLD responses to temporal lobe interictal spikes. Epilepsia, 2006, 47 (2): 343-354.
42. Aghakhani Y, Kobayashi E, Bagshaw AP, et al. Cortical and thalamic fMRI responses in partial epilepsy with focal and bilateral synchronous spikes. Clin Neurophysiol, 2006, 117 (1): 177-191.
43. An D, Fahoum F, Hall J, et al. Electroencephalography/functional magnetic resonance imaging responses help predict surgical outcome in focal epilepsy. Epilepsia, 2013, 54 (12): 2184-2194.
44. Gotman J, Grova C, Bagshaw A, et al. Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. Proc Natl Acad Sci USA, 2005, 102 (42): 15236-15240.
45. Hamandi K, Salek-Haddadi A, Laufs H, et al. EEG-fMRI of idiopathic and secondarily generalized epilepsies. Neuroimage, 2006, 31 (4): 1700-1710.
46. Hawco CS, Bagshaw AP, Lu Y, et al. BOLD changes occur prior to epileptic spikes seen on scalp EEG. Neuroimage, 2007, 35 (4): 1450-1458.
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