外科手术与药物治疗对于难治性癫痫患者发作控制外的结局指标的比较_Journal of Epilepsy

Authors：

 邹雪梅 ¹ ,  慕洁 ²

1. ;
2. ;

Corresponding author：

慕洁, Email: mujie2010@foxmail.com

Keywords：

生活质量; 认知; 社会心理功能; 死亡率; 费用; 难治性癫痫

DOI：

10.7507/2096-0247.20160014

Video：

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约有1/3的癫痫患者发展为耐药性癫痫, 控制达无发作的可能性随着添加药物而降低。经适当筛选的患者, 癫痫手术增加了其达到无发作并彻底停药的可能性。癫痫手术和药物治疗一样, 并非没有副作用。为了给病人提供明智、全面的建议, 医疗人员需要了解这两种治疗的优势和劣势。随机对照试验结果显示对于颞叶癫痫, 手术比持续药物治疗效果更好。虽然所有治疗的最终目标都是无发作, 但它只代表了各种影响患者生活质量的其中一个预后指标。了解影响预后指标的变量以及预后指标间如何相互影响是有必要的。关于比较手术治疗与药物治疗难治性癫痫的研究数据有限, 对治疗结局相关指标的数据进行了回顾。这些结局指标除无发作以外, 还包括生活质量、认知、社会心理功能、死亡率及经济成本等

Citation： 邹雪梅, 慕洁. 外科手术与药物治疗对于难治性癫痫患者发作控制外的结局指标的比较. Journal of Epilepsy, 2016, 2(1): 72-80. doi: 10.7507/2096-0247.20160014 Copy

1.	Alexandre L Jr, Walz R, Bianchin MM, et al.Seizure outcomeafter surgery for epilepsy due to focal cortical dysplastic lesions.Seizure, 2006, 15(6): 420-427.
2.	Baca CB, Vickrey BG, Vassar S, et al.Time to pediatricepilepsy surgery is related to disease severity and nonclinical factors.Neurology, 2013, 80(12):1231-1239.
3.	Baker GA, Taylor J, Aldenkamp AP. Newly diagnosed epilepsy:cognitive outcome after 12 months. Epilepsia, 2013, 52(8):1084-1091.
4.	Baxendale S, Heaney D, Thompson PJ, et al. Cognitive consequences of childhood-onset temporal lobe epilepsy across theadult lifespan.Neurology, 2010, 75(6):705-711.
5.	Begley CE, Beghi E. The economic cost of epilepsy: a review of theliterature. Epilepsia, 2002, 43(10):3-9.
6.	Begley CE, Annegers JF, Lairson DR, et al. Cost of epilepsy in the United States: a model based onincidence and prognosis. Epilepsia, 1994, 35(3):1230-1243.
7.	Begley CE, Famulair M, Annegers JF, et al. The cost of epilepsy in the United States: an estimate from population-basedclinical and survey data. Epilepsia, 2000, 41(8):342-351.
8.	Bell GS, Sinha S, de Tsi JD, et al. Premature mortality in refractory partial epilepsy: does surgical treatment make a difference?. J Neurol Neurosurg Psychiatry, 2010, 81(13):716-718.
9.	Benifla M, Rutka JT, Otsubo H, et al. Long-term seizure and social outcomes following temporal lobesurgery for intractable epilepsy during childhood. Epilepsy Res, 2008, 82(10):133-138.
10.	Berg AT, Zelko FA, Levi SR, et al.Age at onset of epilepsy, pharmacoresistance and cognitive outcomes: a prospective cohortstudy. Neurology, 2008, 79(9):1384-1391.
11.	Bernasconi N, Natsume J, Bernasconi A. Progression in temporallobe epilepsy: differential atrophy is mesial temporal structures.Neurology, 2005, 65(11):223-228.
12.	Bilginer B, Yalnizoglu D, Soylemezoglu F, et al.Surgery for epilepsy in children withdysembryoplastic neuroepithelial tumor: clinical spectrum, seizureoutcome, neuroradiology and pathology. Childs Nerv Syst, 2009, 25(7): 485-491.
13.	Chang EF, Wang DD, Barkovich AJ, et al.Predictors of seizure freedom aftersurgery for malformations of cortical development. Ann Neurol, 2011, 70(9):151-162.
14.	Chen LS, Wang N, Mei-Ing L. Seizure outcome of intractablepartial epilepsy in children. Pediatr Neurol, 2002, 26(5): 282-287.
15.	Choi H, Sell RL, Lenert L, et al. Epilepsy surgery for pharmacoresistant temporal lobeepilepsy: a decision analysis. JAMA, 2008, 300(25):2497-2505.
16.	Coan AC, Appenzeller S, Bonilha LM, et al. Seizure frequency and lateralization affect progression of atrophy in temporal lobeepilepsy. Neurology, 2009, 73(12):834-842.
17.	Cockerell OC, Johnson AL, Sander JWAS, et al. Prognosis of epilepsy: a review and further analysis of the first nine years of theBritish national general practice study of epilepsy, a prospective population-based study. Epilepsia, 1997, 38(11):31-46.
18.	Cossu M, Lo Russo G, Francione S, et al. Epilepsy surgery in children: results and predictors of outcomeon seizures. Epilepsia, 2008, 49(20):65-72.
19.	Dupont S, Tanguy ML, Clemenceau S, et al.Long-term prognosis and psychosocial outcomes after surgery for MTLE. Epilepsia, 2006, 47(12):2115-2124.
20.	Elsharkawy AE, Thorbecke R, Ebner A, et al. Determinants of quality of life in patients with refractory focal epilepsy who were not eligible for surgery or who rejected surgery. Epilepsy Behav, 2012, 24(8):249-255.
21.	Engel J Jr, McDermott MP, Wiebe S, et al.Early surgical therapy for drug-resistant temporal lobe epilepsy. JAMA, 2012, 307(25):922-930.
22.	Freitag H, Tuxhorn I. Cognitive function in preschool children after epilepsy surgery: rationale for early intervention. Epilepsia, 2005, 46(12):561-567.
23.	Gilliam F. Optimizing health outcomes in active epilepsy.Neurology, 2002, 58(Suppl 1):9-20.
24.	Gilliam F. The impact of epilepsy of subjective health status. Curr Neurol Neurosci Rep, 2003, 3(7):357-362.
25.	Gilliam F, Kuzniecky R, Meador K, et al.Patient-oriented outcome assessment after temporal lobectomy for refractory epilepsy. Neurology, 2006, 53(11):687-694.
26.	Gilman J, Duchowny M, Jayakar P, et al. Medical intract ability in children evaluated for epilepsy surgery. Neurology, 1994, 44(16):1341-1343.
27.	Griffiths SY, Sherman EM, Slick DJ, et al. Postsurgical health-related quality of life (HRQOL) in children following hemispherectomy for intractable epilepsy. Epilepsia, 2007, 48(22):564-570.
28.	Guarnieri R, Walz R, Hallak JE, et al.Do psychiatric comorbidities predict postoperative seizure outcome in temporal lobe epilepsy? EpilepsyBehav, 2009, 14(8):529-534.
29.	Guilioni M, Rubboli G, Marucci G, et al.Seizure outcome of epilepsy surgery in focal epilepsiesassociated with temporomesial glioneuronal tumors: lesione ctomycompared with tailored resection. J Neurosurg, 2009, 111(24):1275-1282.
30.	Guldvog B, Loyning Y, Hauglie-Hanssen E, et al.Surgical versus medical treatment for epilepsy: outcome related tosurvival, seizures, and neurologic deficit. Epilepsia, 1991, 32(8a):375-388.
31.	Guldvog B, Loyning Y, Hauglie-Hanssen E, et al.Surgical versus medical treatment for epilepsy: outcome related tosocial areas. Epilepsia, 1991, 32(8b):477-486.
32.	Helmstaedter C, Kurthen M, Lux S, et al.Chronic epilepsy and cognition: a longitudinal study in temporal lobe epilepsy.Ann Neurol, 2003, 54(10):425-432.
33.	Hermann BP, Seidenberg M, Bell B, et al.The neurodevelopmental impact ofchildhood-onset temporal lobe epilepsy on brain structure and function.Epilepsia, 2002, 43(15):1062-1071.
34.	Hermann BP, Seidenberg M, Dow C, et al.Cognitive prognosis in chronic temporal lobe epilepsy.Ann Neurol, 2006, 60(15):80-87.
35.	Jonas R, Nguyen S, Hu B, et al.Cerebral hemispherectomy: hospital course, seizure, developmental, language and motor outcomes. Neurology, 2004, 62(17):1712-1721.
36.	Kanner AM, Byrne R, Chicarro A, et al. A life time psychiatric history predicts a worse seizure outcome followingtemporal lobectomy. Neurology, 2009, 72(16):793-799.
37.	Keene D, Ventureya ECG. Epilepsy surgery for 5-to 18-year old patients with refractory epilepsy-is it cost efficient? Childs Nerv Syst, 1999, 15(9):52-54.
38.	Kemmotsu N, Girard HM, Bernhardt BC, et al.Comparison of white matter tracts and cortical volume in RTLE vs LTLE. Epilepsia, 2001, 52(7):2257-2266.
39.	Korman B, Bernal B, Duchowny M, et al. Atpical propositional language organization in prenatal and early-acquired lesions. J Child Neurol, 2001, 25(6):985-993.
40.	Krsek P, Maton B, Jayakar P, et al. Incomplete resection of focal cortical dysplasia isthe main predictor of poor surgical outcome. Neurology, 2009, 72(30):217-223.
41.	Kwan P, Brodie MJ. Early identification of refractory epilepsy. NEngl J Med, 2000, 342(5):314-319.
42.	Langfitt JT, Holloway RG, McDermott MP, et al.Health care costs decline after successful epilepsy surgery.Neurology, 2007, 68(7a):1290-1298.
43.	Langfitt JT, Westerveld M, Hamberger MJ, et al.Worsening of quality of life after epilepsy surgery: effect of seizures and memory decline. Neurology, 2007, 68(7b):1988-1994.
44.	Lettori D, Battaglia D, Sacco A, et al. Early hemispherectomy in catastrophic epilepsy: a cognitive and epileptic long-term follow-up. Seizure, 2008, 17(3):49-63.
45.	Luciano AL, Shorvon SD. Results of treatment changes in patientswith apparently drug-resistant chronic epilepsy. Ann Neurol, 2007, 62(15):375-381.
46.	Macrodimitris S, Sherman EMS, Forde S, et al. Psychiatric outcomes of epilepsy surgery: a systemic review. Epilepsia, 2011, 52(10):880-890.
47.	Malmgren K, Olsson I, Engman E, et al.Seizure outcome after resective surgery in patients with low IQ. Brain, 2008, 131(29):535-542.
48.	McClelland S, Guo H, Okuyemi KS. Population-based analysis of morbidity and mortality following surgery for intractable temporal lobe epilepsy in the United States. Arch Neurol, 2011, 68(20):725-729.
49.	Mikati MA, Ataya N, Ferzil J, et al.Quality of life after surgery for intractable partial epilepsy in children: a cohort study with controls.Epilepsy Res, 2010, 90(32):207-213.
50.	Murray MI, Halpern MT, Leppik IE. Cost of refractory epilepsy inadults in the USA. Epilepsy Res, 1996, 23(5):139-148.
51.	Neligan A, Bell GS, Sander JW, et al. How refractory is refractory epilepsy? Patterns of relapse and remission in people with refractory epilepsy. Epilepsy Res, 2011, 96(30):225-230.
52.	Nickels KC, Grossardt BR, Wirrell EC. Epilepsy-related mortalityis low in children: a 30-year population-based study in Olmsted County, MN. Epilepsia, 2012, 53(17):2164-2171.
53.	Nilsson L, Tomson T, Farahmand BY, et al.Cause-specific mortality in epilepsy: a cohort study of more than 9000 patients once hospitalized for epilepsy. Epilepsia, 1997, 38(8):1062-1068.
54.	Paolicchi JM, Jayakar J, Dean P, et al.Predictors of outcome in pediatric epilepsy surgery. Neurology, 2000, 54(7):642-647.
55.	Perrine K, Hermann BP, Meador KJ, et al.The relationship of neuropsychological functioning to quality of life in epilepsy. Arch Neurol, 1995, 52(16):997-1003.
56.	Perry MS, Dunoyer C, Dean P, et al. Predictors of seizure freedom after incomplete resection in children. Neurology, 2010, 75(23):1448-1453.
57.	Platt M, Sperling MR. A comparison of surgical and medical costsfor refractory epilepsy. Epilepsia, 2002, 43(14):25-31.
58.	Rowland NC, Englot DJ, Cage TA, et al. A meta-analysis of predictors of seizure freedom in the surgical management of focal cortical dysplasia. J Neurosurg, 2012, 116(45):1035-1041.
59.	Sabaz M, Lawson JL, Cairns DR, et al.The impact of epilepsy surgery on quality of life in children. Neurology, 2006, 66(20):557-561.
60.	Schmidt D, Stavem K.Long-term seizure outcome of surgery versus no surgery for drug-resistant partial epilepsy: a review of controlled studies. Epilepsia, 2009, 50(15):1301-1309.
61.	Seiam AHR, Dhaliwal H, Wiebe S. Determinants of quality of life after epilepsy surgery: systematic review and evidence summary.Epilepsy Behav, 2011, 21(9):441-445.
62.	Selwa LM, Schmidt SL, Malow BA, et al.Long-term outcome of nonsurgical candidates with medically refractory localization-related epilepsy. Epilepsia, 2003, 44(16):1568-1572.
63.	Shackleton DP, Trenite K-N, de Craen AJM, et al.Living with epilepsy: long-term prognosisand psychosocial outcomes. Neurology, 2003, 61(8):64-70.
64.	Shields D. Catastrophic epilepsy in childhood. Epilepsia, 2000, 41 (Suppl 2):s2-6.
65.	Sillanpeaea M, Shinnar S. Long-term mortality in childhood-onset epilepsy. N Engl J Med, 2010, 363(17):2522-2529.
66.	Sillanpeaea M, Jalava M, Kaleva O, et al. Long-term prognosis of seizures with onset in childhood. N Engl J Med, 1998, 338(26):1715-1722.
67.	Sillanpeaea M, Haataja L, Shinnar S. Perceived impact of childhood onset epilepsy on quality of life as an adult. Epilepsia, 2004, 45(10):971-977.
68.	Skirrow C, Cross JH, Cormack F, et al. Long-term intellectual outcome after temporallobe surgery in childhood. Neurology, 2011, 76(13):1330-1337.
69.	Smith ML, Elliott IM, Lach L. Cognitive, psychosocial, and family function one year after pediatric epilepsy surgery. Epilepsia, 2004, 45(13):650-660.
70.	Smith ML, Kelly K, Kadis DS, et al.Self-reported symptoms of psychological well-being in young adults who underwent resective epilepsy surgery in childhood.Epilepsia, 2001, 52(5):891-899.
71.	Spencer S, Huh L. Outcomes of epilepsy surgery in adults andchildren. Lancet Neurol, 2008, 7(1):525-537.
72.	Spencer SS, Berg AT, Vickrey BG, et al. Health-related quality oflife over time since respective epilepsy surgery. Ann Neurol, 2007, 62(24):327-334.
73.	Sperling M, Feldman H, Kinman J, et al.Seizure control and mortality in epilepsy. Ann Neurol, 1999, 46(10):45-50.
74.	Stavem K, Guldvog B. Long-term survival after epilepsy surgery compared with matched epilepsy controls and the general population.Epilepsy Res, 2005, 63(12):67-75.
75.	Taylor J, Baker GA. Newly diagnosed epilepsy: cognitive outcomes at 5 years. Epilepsy Behav, 2010, 18(6):387-403.
76.	Trinka E, Bauer G, Oberaigner W, et al.Cause-specific mortality among patients with epilepsy: results from a 30-year cohort study. Epilepsia, 2013, 54(8):495-501.
77.	Van Empelen R, Jennekens-Schinkel A, van Rijen PC, et al.Health-related quality of life and self perceived competence of children assessed before and up to two yearsafter epilepsy surgery. Epilepsia, 2005, 46(21):258-271.
78.	Vickrey BG, Hays RD, Rausch R, et al.Outcomes in 248 patients who had diagnostic evaluations for epilepsy surgery. Lancet, 1995, 346(53):1445-1449.
79.	Widjaja E, Li B, Schinkel CD, et al.Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy.Epilepsy Res, 2011, 94(16):61-68.
80.	Wiebe S, Blume WT, Girvin JP, et al. A randomized controlled trial of surgery for temporal lobe epilepsy. N Engl J Med, 2011, 345(54):311-318.
81.	Wilson SJ, Saling MM, Kincade P, et al. Patient expectations of temporal lobe surgery. Epilepsia, 1998, 39(12):167-174.
82.	Wyllie E, Comair YG, Kotagal P, et al.Seizure outcome after epilepsy surgery in children and adolescents. Ann Neurol, 1998, 44(10):740-748.
83.	Yang XL, Lu QC, Xu JW, et al.Predictors of outcome in the surgical treatment for epilepsy. Chin Med J, 2011, 124(81):4166-4171.

1. Alexandre L Jr, Walz R, Bianchin MM, et al.Seizure outcomeafter surgery for epilepsy due to focal cortical dysplastic lesions.Seizure, 2006, 15(6): 420-427.
2. Baca CB, Vickrey BG, Vassar S, et al.Time to pediatricepilepsy surgery is related to disease severity and nonclinical factors.Neurology, 2013, 80(12):1231-1239.
3. Baker GA, Taylor J, Aldenkamp AP. Newly diagnosed epilepsy:cognitive outcome after 12 months. Epilepsia, 2013, 52(8):1084-1091.
4. Baxendale S, Heaney D, Thompson PJ, et al. Cognitive consequences of childhood-onset temporal lobe epilepsy across theadult lifespan.Neurology, 2010, 75(6):705-711.
5. Begley CE, Beghi E. The economic cost of epilepsy: a review of theliterature. Epilepsia, 2002, 43(10):3-9.
6. Begley CE, Annegers JF, Lairson DR, et al. Cost of epilepsy in the United States: a model based onincidence and prognosis. Epilepsia, 1994, 35(3):1230-1243.
7. Begley CE, Famulair M, Annegers JF, et al. The cost of epilepsy in the United States: an estimate from population-basedclinical and survey data. Epilepsia, 2000, 41(8):342-351.
8. Bell GS, Sinha S, de Tsi JD, et al. Premature mortality in refractory partial epilepsy: does surgical treatment make a difference?. J Neurol Neurosurg Psychiatry, 2010, 81(13):716-718.
9. Benifla M, Rutka JT, Otsubo H, et al. Long-term seizure and social outcomes following temporal lobesurgery for intractable epilepsy during childhood. Epilepsy Res, 2008, 82(10):133-138.
10. Berg AT, Zelko FA, Levi SR, et al.Age at onset of epilepsy, pharmacoresistance and cognitive outcomes: a prospective cohortstudy. Neurology, 2008, 79(9):1384-1391.
11. Bernasconi N, Natsume J, Bernasconi A. Progression in temporallobe epilepsy: differential atrophy is mesial temporal structures.Neurology, 2005, 65(11):223-228.
12. Bilginer B, Yalnizoglu D, Soylemezoglu F, et al.Surgery for epilepsy in children withdysembryoplastic neuroepithelial tumor: clinical spectrum, seizureoutcome, neuroradiology and pathology. Childs Nerv Syst, 2009, 25(7): 485-491.
13. Chang EF, Wang DD, Barkovich AJ, et al.Predictors of seizure freedom aftersurgery for malformations of cortical development. Ann Neurol, 2011, 70(9):151-162.
14. Chen LS, Wang N, Mei-Ing L. Seizure outcome of intractablepartial epilepsy in children. Pediatr Neurol, 2002, 26(5): 282-287.
15. Choi H, Sell RL, Lenert L, et al. Epilepsy surgery for pharmacoresistant temporal lobeepilepsy: a decision analysis. JAMA, 2008, 300(25):2497-2505.
16. Coan AC, Appenzeller S, Bonilha LM, et al. Seizure frequency and lateralization affect progression of atrophy in temporal lobeepilepsy. Neurology, 2009, 73(12):834-842.
17. Cockerell OC, Johnson AL, Sander JWAS, et al. Prognosis of epilepsy: a review and further analysis of the first nine years of theBritish national general practice study of epilepsy, a prospective population-based study. Epilepsia, 1997, 38(11):31-46.
18. Cossu M, Lo Russo G, Francione S, et al. Epilepsy surgery in children: results and predictors of outcomeon seizures. Epilepsia, 2008, 49(20):65-72.
19. Dupont S, Tanguy ML, Clemenceau S, et al.Long-term prognosis and psychosocial outcomes after surgery for MTLE. Epilepsia, 2006, 47(12):2115-2124.
20. Elsharkawy AE, Thorbecke R, Ebner A, et al. Determinants of quality of life in patients with refractory focal epilepsy who were not eligible for surgery or who rejected surgery. Epilepsy Behav, 2012, 24(8):249-255.
21. Engel J Jr, McDermott MP, Wiebe S, et al.Early surgical therapy for drug-resistant temporal lobe epilepsy. JAMA, 2012, 307(25):922-930.
22. Freitag H, Tuxhorn I. Cognitive function in preschool children after epilepsy surgery: rationale for early intervention. Epilepsia, 2005, 46(12):561-567.
23. Gilliam F. Optimizing health outcomes in active epilepsy.Neurology, 2002, 58(Suppl 1):9-20.
24. Gilliam F. The impact of epilepsy of subjective health status. Curr Neurol Neurosci Rep, 2003, 3(7):357-362.
25. Gilliam F, Kuzniecky R, Meador K, et al.Patient-oriented outcome assessment after temporal lobectomy for refractory epilepsy. Neurology, 2006, 53(11):687-694.
26. Gilman J, Duchowny M, Jayakar P, et al. Medical intract ability in children evaluated for epilepsy surgery. Neurology, 1994, 44(16):1341-1343.
27. Griffiths SY, Sherman EM, Slick DJ, et al. Postsurgical health-related quality of life (HRQOL) in children following hemispherectomy for intractable epilepsy. Epilepsia, 2007, 48(22):564-570.
28. Guarnieri R, Walz R, Hallak JE, et al.Do psychiatric comorbidities predict postoperative seizure outcome in temporal lobe epilepsy? EpilepsyBehav, 2009, 14(8):529-534.
29. Guilioni M, Rubboli G, Marucci G, et al.Seizure outcome of epilepsy surgery in focal epilepsiesassociated with temporomesial glioneuronal tumors: lesione ctomycompared with tailored resection. J Neurosurg, 2009, 111(24):1275-1282.
30. Guldvog B, Loyning Y, Hauglie-Hanssen E, et al.Surgical versus medical treatment for epilepsy: outcome related tosurvival, seizures, and neurologic deficit. Epilepsia, 1991, 32(8a):375-388.
31. Guldvog B, Loyning Y, Hauglie-Hanssen E, et al.Surgical versus medical treatment for epilepsy: outcome related tosocial areas. Epilepsia, 1991, 32(8b):477-486.
32. Helmstaedter C, Kurthen M, Lux S, et al.Chronic epilepsy and cognition: a longitudinal study in temporal lobe epilepsy.Ann Neurol, 2003, 54(10):425-432.
33. Hermann BP, Seidenberg M, Bell B, et al.The neurodevelopmental impact ofchildhood-onset temporal lobe epilepsy on brain structure and function.Epilepsia, 2002, 43(15):1062-1071.
34. Hermann BP, Seidenberg M, Dow C, et al.Cognitive prognosis in chronic temporal lobe epilepsy.Ann Neurol, 2006, 60(15):80-87.
35. Jonas R, Nguyen S, Hu B, et al.Cerebral hemispherectomy: hospital course, seizure, developmental, language and motor outcomes. Neurology, 2004, 62(17):1712-1721.
36. Kanner AM, Byrne R, Chicarro A, et al. A life time psychiatric history predicts a worse seizure outcome followingtemporal lobectomy. Neurology, 2009, 72(16):793-799.
37. Keene D, Ventureya ECG. Epilepsy surgery for 5-to 18-year old patients with refractory epilepsy-is it cost efficient? Childs Nerv Syst, 1999, 15(9):52-54.
38. Kemmotsu N, Girard HM, Bernhardt BC, et al.Comparison of white matter tracts and cortical volume in RTLE vs LTLE. Epilepsia, 2001, 52(7):2257-2266.
39. Korman B, Bernal B, Duchowny M, et al. Atpical propositional language organization in prenatal and early-acquired lesions. J Child Neurol, 2001, 25(6):985-993.
40. Krsek P, Maton B, Jayakar P, et al. Incomplete resection of focal cortical dysplasia isthe main predictor of poor surgical outcome. Neurology, 2009, 72(30):217-223.
41. Kwan P, Brodie MJ. Early identification of refractory epilepsy. NEngl J Med, 2000, 342(5):314-319.
42. Langfitt JT, Holloway RG, McDermott MP, et al.Health care costs decline after successful epilepsy surgery.Neurology, 2007, 68(7a):1290-1298.
43. Langfitt JT, Westerveld M, Hamberger MJ, et al.Worsening of quality of life after epilepsy surgery: effect of seizures and memory decline. Neurology, 2007, 68(7b):1988-1994.
44. Lettori D, Battaglia D, Sacco A, et al. Early hemispherectomy in catastrophic epilepsy: a cognitive and epileptic long-term follow-up. Seizure, 2008, 17(3):49-63.
45. Luciano AL, Shorvon SD. Results of treatment changes in patientswith apparently drug-resistant chronic epilepsy. Ann Neurol, 2007, 62(15):375-381.
46. Macrodimitris S, Sherman EMS, Forde S, et al. Psychiatric outcomes of epilepsy surgery: a systemic review. Epilepsia, 2011, 52(10):880-890.
47. Malmgren K, Olsson I, Engman E, et al.Seizure outcome after resective surgery in patients with low IQ. Brain, 2008, 131(29):535-542.
48. McClelland S, Guo H, Okuyemi KS. Population-based analysis of morbidity and mortality following surgery for intractable temporal lobe epilepsy in the United States. Arch Neurol, 2011, 68(20):725-729.
49. Mikati MA, Ataya N, Ferzil J, et al.Quality of life after surgery for intractable partial epilepsy in children: a cohort study with controls.Epilepsy Res, 2010, 90(32):207-213.
50. Murray MI, Halpern MT, Leppik IE. Cost of refractory epilepsy inadults in the USA. Epilepsy Res, 1996, 23(5):139-148.
51. Neligan A, Bell GS, Sander JW, et al. How refractory is refractory epilepsy? Patterns of relapse and remission in people with refractory epilepsy. Epilepsy Res, 2011, 96(30):225-230.
52. Nickels KC, Grossardt BR, Wirrell EC. Epilepsy-related mortalityis low in children: a 30-year population-based study in Olmsted County, MN. Epilepsia, 2012, 53(17):2164-2171.
53. Nilsson L, Tomson T, Farahmand BY, et al.Cause-specific mortality in epilepsy: a cohort study of more than 9000 patients once hospitalized for epilepsy. Epilepsia, 1997, 38(8):1062-1068.
54. Paolicchi JM, Jayakar J, Dean P, et al.Predictors of outcome in pediatric epilepsy surgery. Neurology, 2000, 54(7):642-647.
55. Perrine K, Hermann BP, Meador KJ, et al.The relationship of neuropsychological functioning to quality of life in epilepsy. Arch Neurol, 1995, 52(16):997-1003.
56. Perry MS, Dunoyer C, Dean P, et al. Predictors of seizure freedom after incomplete resection in children. Neurology, 2010, 75(23):1448-1453.
57. Platt M, Sperling MR. A comparison of surgical and medical costsfor refractory epilepsy. Epilepsia, 2002, 43(14):25-31.
58. Rowland NC, Englot DJ, Cage TA, et al. A meta-analysis of predictors of seizure freedom in the surgical management of focal cortical dysplasia. J Neurosurg, 2012, 116(45):1035-1041.
59. Sabaz M, Lawson JL, Cairns DR, et al.The impact of epilepsy surgery on quality of life in children. Neurology, 2006, 66(20):557-561.
60. Schmidt D, Stavem K.Long-term seizure outcome of surgery versus no surgery for drug-resistant partial epilepsy: a review of controlled studies. Epilepsia, 2009, 50(15):1301-1309.
61. Seiam AHR, Dhaliwal H, Wiebe S. Determinants of quality of life after epilepsy surgery: systematic review and evidence summary.Epilepsy Behav, 2011, 21(9):441-445.
62. Selwa LM, Schmidt SL, Malow BA, et al.Long-term outcome of nonsurgical candidates with medically refractory localization-related epilepsy. Epilepsia, 2003, 44(16):1568-1572.
63. Shackleton DP, Trenite K-N, de Craen AJM, et al.Living with epilepsy: long-term prognosisand psychosocial outcomes. Neurology, 2003, 61(8):64-70.
64. Shields D. Catastrophic epilepsy in childhood. Epilepsia, 2000, 41 (Suppl 2):s2-6.
65. Sillanpeaea M, Shinnar S. Long-term mortality in childhood-onset epilepsy. N Engl J Med, 2010, 363(17):2522-2529.
66. Sillanpeaea M, Jalava M, Kaleva O, et al. Long-term prognosis of seizures with onset in childhood. N Engl J Med, 1998, 338(26):1715-1722.
67. Sillanpeaea M, Haataja L, Shinnar S. Perceived impact of childhood onset epilepsy on quality of life as an adult. Epilepsia, 2004, 45(10):971-977.
68. Skirrow C, Cross JH, Cormack F, et al. Long-term intellectual outcome after temporallobe surgery in childhood. Neurology, 2011, 76(13):1330-1337.
69. Smith ML, Elliott IM, Lach L. Cognitive, psychosocial, and family function one year after pediatric epilepsy surgery. Epilepsia, 2004, 45(13):650-660.
70. Smith ML, Kelly K, Kadis DS, et al.Self-reported symptoms of psychological well-being in young adults who underwent resective epilepsy surgery in childhood.Epilepsia, 2001, 52(5):891-899.
71. Spencer S, Huh L. Outcomes of epilepsy surgery in adults andchildren. Lancet Neurol, 2008, 7(1):525-537.
72. Spencer SS, Berg AT, Vickrey BG, et al. Health-related quality oflife over time since respective epilepsy surgery. Ann Neurol, 2007, 62(24):327-334.
73. Sperling M, Feldman H, Kinman J, et al.Seizure control and mortality in epilepsy. Ann Neurol, 1999, 46(10):45-50.
74. Stavem K, Guldvog B. Long-term survival after epilepsy surgery compared with matched epilepsy controls and the general population.Epilepsy Res, 2005, 63(12):67-75.
75. Taylor J, Baker GA. Newly diagnosed epilepsy: cognitive outcomes at 5 years. Epilepsy Behav, 2010, 18(6):387-403.
76. Trinka E, Bauer G, Oberaigner W, et al.Cause-specific mortality among patients with epilepsy: results from a 30-year cohort study. Epilepsia, 2013, 54(8):495-501.
77. Van Empelen R, Jennekens-Schinkel A, van Rijen PC, et al.Health-related quality of life and self perceived competence of children assessed before and up to two yearsafter epilepsy surgery. Epilepsia, 2005, 46(21):258-271.
78. Vickrey BG, Hays RD, Rausch R, et al.Outcomes in 248 patients who had diagnostic evaluations for epilepsy surgery. Lancet, 1995, 346(53):1445-1449.
79. Widjaja E, Li B, Schinkel CD, et al.Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy.Epilepsy Res, 2011, 94(16):61-68.
80. Wiebe S, Blume WT, Girvin JP, et al. A randomized controlled trial of surgery for temporal lobe epilepsy. N Engl J Med, 2011, 345(54):311-318.
81. Wilson SJ, Saling MM, Kincade P, et al. Patient expectations of temporal lobe surgery. Epilepsia, 1998, 39(12):167-174.
82. Wyllie E, Comair YG, Kotagal P, et al.Seizure outcome after epilepsy surgery in children and adolescents. Ann Neurol, 1998, 44(10):740-748.
83. Yang XL, Lu QC, Xu JW, et al.Predictors of outcome in the surgical treatment for epilepsy. Chin Med J, 2011, 124(81):4166-4171.

Journal of Epilepsy

外科手术与药物治疗对于难治性癫痫患者发作控制外的结局指标的比较

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