Clinical features of post-stroke epilepsy_Journal of Epilepsy

Authors：

 CHUFengna , HELing , LINWeihong ,  CUILi

Department of Neurology, First Hospital of Jilin University, Chuangchun 130021, China;

Corresponding author：

CUILi, Email: chuili1967@126.com

Keywords：

Stroke; Epilepsy; Clinical features; Treatment; Prognosis

DOI：

10.7507/2096-0247.20160019

Video：

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Objective To observe the clinical characteristics and influencing factors of post-stroke epilepsy. Methods Our research wasaretrospective study, the data came from the information of patients diagnosed with post-stroke epilepsy from our hospital on October 2000 to December 2014 withatotal of 160 cases. With the general collection of clinical data, including gender, past history, clinical manifestations, laboratory examinations and treatment informations. Results The shortest time of post-stroke seizures were occur immediately, the longest was 15 years after the stroke. Peak onset is as early as onset of stroke immediately, late-onset seizures after stroke peaks between 6 months to 1.5 years. 59 patients occurred early epileptic seizures, partial seizures were the most common, accounting for 47.46%; 101 patients occurred late epilepsy, generalized tonic-clonic seizures were the most common, accounting for 56.44%. 25% of patients wereasingle-site lesions, the most common site was temporal lobe; 75% of patients were multifocal lesions. Most were located in the temporal lobe, frontal lobe and the basal ganglia. 42 cases of patients performed EEG, 30 patients (71.43%) of the EEG abnormalities, including 22 cases (73.33%) recurrent epileptic seizures; 12 cases (28.57%) patients with an edge or normal EEG, including 3 cases (25%) relapsed. 54.38% patients with drug therapy to single-agent therapy, two patients with refractory epilepsy to be combination therapy. Conclusions This group of post stroke epilepsy patients were more common as late-onset epilepsy, early onset of stroke peaks is the first day, and delayed the onset of the peak after stroke is within 6 months to 18 months. Lesions in the cortex:alarge area and multiple lesions were risk factors for post-stroke epilepsy, cortical damage to the temporal lobe is most prevalent. 71.43% of patients may have abnormal EEG, EEG abnormalities have higher relapse rate in patients with epilepsy.

Citation： CHUFengna, HELing, LINWeihong, CUILi. Clinical features of post-stroke epilepsy. Journal of Epilepsy, 2016, 2(2): 106-108. doi: 10.7507/2096-0247.20160019 Copy

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1. Serafini A, Gigli GL, Gregoraci G, et al. Are Early Seizures Predictive of Epilepsy afteraStroke? Results ofaPopulation-Based Study. Neuroepidemiology, 2015, 45(1): 50-58.
2. Huang CW, Saposnik G, Fang J, et al. Influence of seizures on stroke outcomes:alarge multicenter study. Neurology, 2014, 82(9): 768-776.
3. Jungehulsing GJ, Heuschmann PU, Holtkamp M, et al. Incidence and predictors of post-stroke epilepsy. Acta Neurol Scand, 2013, 127(6): 427-430.
4. Forsgren L, Bucht G, Eriksson S, et al. Incidence and clinical characterization of unprovoked seizures in adults:aprospective population-based study. Epilepsia, 1996, 37(3): 224-229.
5. Loiseau J, Loiseau P, Duche B, et al.Asurvey of epileptic disorders in southwest France: seizures in elderly patients. Ann Neurol, 1990, 27(3): 232-237.
6. Hauser WA, Annegers JF, Kurland LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia,1993, 34(3): 453-468.
7. Procaccianti G, Zaniboni A, Rondelli F, et al. Seizures in acute stroke: incidence, risk factors and prognosis. Neuroepidemiology, 2012, 39(1): 45-50.
8. Menon B, Shorvon SD. Ischaemic stroke in adults and epilepsy. Epilepsy research, 2009, 87(1): 1-11.
9. Lamy C, Domigo V, Semah F, et al. Early and late seizures after cryptogenic ischemic stroke in young adults. Neurology, 2003, 60(3): 400-404.
10. 杨明华. 50例中风后继发癫痫的临床分析. 脑与神经疾病杂志, 2002, 10(7): 56.
11. 祝茗. 高血糖与老年人梗塞后癫痫之间的关系. 上海医学, 1998, 21(12): 738-739.
12. Luhdorf K, Jensen LK, Plesner AM. Etiology of seizures in the elderly. Epilepsia, 1986, 27(4): 458-463.

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Clinical features of post-stroke epilepsy

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