Establishment and implementation of database about antiepileptic drugs among pregnant women with epilepsy in West China_Journal of Epilepsy

Authors：

 HAONanya , WUMengqian , MUJie ,  ZHOUDong

Department of Neurology, West China school of Medicine/West China Hospital, Sichuan University , Chengdu 610041, China;

Corresponding author：

ZHOUDong, Email: zhoudong66@yahoo.de

Keywords：

Women with epilepsy; Pregnancy; AED administration; Registration; Database

DOI：

10.7507/2096-0247.20160021

Video：

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Objective To establishadatabase to fully investigate current situation of antiepileptic drugs among pregnant women with epilepsy in West China. Analyzing the epidemiological characteristics and correlated influence factors of anti-epileptic drugs use among women with epilepsy in this area to promote management quality for women with epilepsy. Methods Adigital registration system was established with JAVA andastandard registration procedure was formulated. Standard registration was implemented in different levels of hospital of West China with regular follow-up. Results Registration system about antiepileptic drugs among pregnant women with epilepsy in West China was successfully established, which wasadigital registration within local area network. Information about registration centre and pregnant women with epilepsy was collected in the West China registration network. And elementary database was successfully established. Conclusion This is the first extensive and standard pregnancy register of antiepileptic drugs in China which meet the need of not only patient information management but also the development of academic subject.

Citation： HAONanya, WUMengqian, MUJie, ZHOUDong. Establishment and implementation of database about antiepileptic drugs among pregnant women with epilepsy in West China. Journal of Epilepsy, 2016, 2(2): 114-117. doi: 10.7507/2096-0247.20160021 Copy

1.	黄茂盛,洪震,曾军,等.上海市金山区农村癫痫患病率调查.中华流行病学杂志,2002, 23(5):345-346.
2.	Borthen I, Eide MG, Veiby, G, et al. Complications during pregnancy in women with epilepsy: population-based cohort study. BJOG, 2009,116(13) : 1736-1742.
3.	Vajda FJ, Graham J, Roten A,et al. Teratogenicity of the newer antiepileptic drugs-the Australian experience.J Clin Neurosci, 2012,19(1) : 57-59.
4.	Apeland T, Mansoor MA, Strandjord RE. Antiepileptic drugs as independent predictors of plasma total homocysteine levels. Epilepsy Res, 2001,,47(1-2) : 27-35.
5.	Meador KJ, Baker GA, Nancy B, et al. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study):aprospective observational study. Lancet Neurology, 2013, 12(3) : 244-252.
6.	Vajda FJ, Hollingworth S, Graham J, et al. Changing patterns of antiepileptic drug use in pregnant Australian women. Acta Neurologica Scandinavica, 2010, 121(2) : 89-93.
7.	Torbjörn T, Dina B, Erminio B, et al. EURAP: An International registry of antiepileptic drugs and pregnancy. Epilepsia, 2004, 45(11) : 1463-1464.
8.	Vajda FJE. The australian pregnancy register of anti-epileptic drugs: 10 years of progress. Journal of Clinical Neuroscience Official Journal of the Neurosurgical Society of Australasia, 2010, 17(12) : 1485-1488.
9.	Tomson T, Landmark CJ, Battino D, et al. Antiepileptic drug treatment in pregnancy: changes in drug disposition and their clinical implications. Epilepsia ,2013, 54(3) : 405-414.
10.	Hao N, Wei X, Tang Y, et al. Periconceptional folic acid supplementation among pregnant women with epilepsy inadeveloping country:aretroprospective survey in China. Epilepsy Behavior, 2015, 44(3): 27-34.
11.	方又昕, 洪震. 癫痫对女性患者健康及婚育的影响.上海医药, 2015(9) : 21-24.
12.	Hiilesmaa VK, BardyA, TeramoK. Obstetric outcome in women with epilepsy. American Journal of Obstetrics Gynecology, 1985, 152(5) : 499-504.
13.	Cantwell R, Clutton-Brock T, Cooper G, et al. Saving mothers' Lives: reviewing maternal deaths to make motherhood safer: 2006-2008. The eighth report of the confidential enquiries into maternal deaths in the united Kingdom. Bjog An International Journal of Obstetrics Gynaecology, 2011, 118 (Suppl 1) : 1.
14.	Edey S, Moran N, Nashef L. SUDEP and epilepsy-related mortality in pregnancy. Epilepsia, 2014, 55(7) : 72-74.
15.	Torbjörn T, Dina B. Teratogenic effects of antiepileptic drugs. Lancet Neurology, 2012, 11(2) : 166-171.
16.	Bjork MH, Veiby G, Reiter SC, et al. Depression and anxiety in women with epilepsy during pregnancy and after delivery:Aprospective population-based cohort study on frequency, risk factors, medication, and prognosis. Epilepsia, 2015, 56(1) : 28-39.
17.	Vajda FJE, O′Brien TJ, LanderCM, et al. The rationale for pregnancy registers for women with epilepsy. Medical Journal of Australia, 2011, 195(195) : 8-9.

1. 黄茂盛,洪震,曾军,等.上海市金山区农村癫痫患病率调查.中华流行病学杂志,2002, 23(5):345-346.
2. Borthen I, Eide MG, Veiby, G, et al. Complications during pregnancy in women with epilepsy: population-based cohort study. BJOG, 2009,116(13) : 1736-1742.
3. Vajda FJ, Graham J, Roten A,et al. Teratogenicity of the newer antiepileptic drugs-the Australian experience.J Clin Neurosci, 2012,19(1) : 57-59.
4. Apeland T, Mansoor MA, Strandjord RE. Antiepileptic drugs as independent predictors of plasma total homocysteine levels. Epilepsy Res, 2001,,47(1-2) : 27-35.
5. Meador KJ, Baker GA, Nancy B, et al. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study):aprospective observational study. Lancet Neurology, 2013, 12(3) : 244-252.
6. Vajda FJ, Hollingworth S, Graham J, et al. Changing patterns of antiepileptic drug use in pregnant Australian women. Acta Neurologica Scandinavica, 2010, 121(2) : 89-93.
7. Torbjörn T, Dina B, Erminio B, et al. EURAP: An International registry of antiepileptic drugs and pregnancy. Epilepsia, 2004, 45(11) : 1463-1464.
8. Vajda FJE. The australian pregnancy register of anti-epileptic drugs: 10 years of progress. Journal of Clinical Neuroscience Official Journal of the Neurosurgical Society of Australasia, 2010, 17(12) : 1485-1488.
9. Tomson T, Landmark CJ, Battino D, et al. Antiepileptic drug treatment in pregnancy: changes in drug disposition and their clinical implications. Epilepsia ,2013, 54(3) : 405-414.
10. Hao N, Wei X, Tang Y, et al. Periconceptional folic acid supplementation among pregnant women with epilepsy inadeveloping country:aretroprospective survey in China. Epilepsy Behavior, 2015, 44(3): 27-34.
11. 方又昕, 洪震. 癫痫对女性患者健康及婚育的影响.上海医药, 2015(9) : 21-24.
12. Hiilesmaa VK, BardyA, TeramoK. Obstetric outcome in women with epilepsy. American Journal of Obstetrics Gynecology, 1985, 152(5) : 499-504.
13. Cantwell R, Clutton-Brock T, Cooper G, et al. Saving mothers' Lives: reviewing maternal deaths to make motherhood safer: 2006-2008. The eighth report of the confidential enquiries into maternal deaths in the united Kingdom. Bjog An International Journal of Obstetrics Gynaecology, 2011, 118 (Suppl 1) : 1.
14. Edey S, Moran N, Nashef L. SUDEP and epilepsy-related mortality in pregnancy. Epilepsia, 2014, 55(7) : 72-74.
15. Torbjörn T, Dina B. Teratogenic effects of antiepileptic drugs. Lancet Neurology, 2012, 11(2) : 166-171.
16. Bjork MH, Veiby G, Reiter SC, et al. Depression and anxiety in women with epilepsy during pregnancy and after delivery:Aprospective population-based cohort study on frequency, risk factors, medication, and prognosis. Epilepsia, 2015, 56(1) : 28-39.
17. Vajda FJE, O′Brien TJ, LanderCM, et al. The rationale for pregnancy registers for women with epilepsy. Medical Journal of Australia, 2011, 195(195) : 8-9.

Journal of Epilepsy

Establishment and implementation of database about antiepileptic drugs among pregnant women with epilepsy in West China

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