癫痫共患偏头痛的研究进展_Journal of Epilepsy

Authors：

 陈蕾 , 邱湘苗 , 朱曦 , 何时旭 , 周东

四川大学华西医院神经内科(成都，610041);

Corresponding author：

陈蕾, Email: leilei_25@126.com

Keywords：

癫痫; 偏头痛; 痫性发作; 头痛

DOI：

10.7507/2096-0247.20160024

Video：

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癫痫和偏头痛有很多相同的临床表现，偏头痛可出现在癫痫发作间期、发作前、发作时和发作后，使癫痫和偏头痛在有时难以鉴别。部分抗癫痫药物可应用于偏头痛治疗。这些均表明癫痫和偏头痛之间的共病关系。癫痫和偏头痛的基础研究也表明皮质扩散抑制可能是两者之间共病的基础。目前关于癫痫伴偏头痛有不同的国际分类，由于偏头痛可以是癫痫的唯一症状，有学者建议设立一种新的分类，命名为发作性癫痫性头痛。现将从流行病学、发病机制、临床特征、国际分类，以及治疗等方面对癫痫共患偏头痛作一综述。

Citation： 陈蕾, 邱湘苗, 朱曦, 何时旭, 周东. 癫痫共患偏头痛的研究进展. Journal of Epilepsy, 2016, 2(2): 128-132. doi: 10.7507/2096-0247.20160024 Copy

1.	鄢波, 周东. 神经系统慢性疾病的综合管理. 华西医学, 2015, 30(4): 601-603.
2.	于生元, 李舜伟, 李焰生. 中国偏头痛诊断治疗指南. 中国疼痛医学杂志, 2011, 17(2): 65-86.
3.	Nakano H, Inoue Y. Epidemiology and cause of epilepsy. Nihon rinsho Japanese Journal of Clinical Medicine, 2014, 72(5): 785-789.
4.	Yu S, Liu R, Zhao G, et al. The Prevalence and Burden of Primary Headaches in China:A Population-Based Door-to-Door Survey. Headache, 2012, 52(4): 582-591.
5.	Keezer MR, Bauer PR, Ferrari MD, et al. The comorbid relationship between migraine and epilepsy: a systematic review and meta-analysis. European Journal of Neurology, 2015, 22(7): 1038-1047.
6.	Wang XQ, Lang SY, Zhang X, et al. Comidity between headache and epilepsy in a Chinese epileptic center. Epilepsy Research, 2014, 108(3): 535-541.
7.	Grafstein B. Mechanism of spreading cortical depression. Journal of Neurophysiology, 1956, 19(2): 154-171.
8.	Herreras O. Electrical prodromals of spreading depression void Grafstein’s potassium hypothesis. Journal of Neurophysiology, 2005, 94(5): 3656; author reply 3656-3657.
9.	Bolay H, Reuter U, Dunn AK, et al. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nature Medicine, 2002, 8(2): 136-142.
10.	Ghaemi A, Sajadian A, Khodaie B, et al. The immunological and neuroimmunological response to spreading depression in Wistar rats. International Journal of Developmental Neuroscience, 2015, 47(Pt A): 6-7.
11.	Parisi P. Why is migraine rarely, and not usually, the sole ictal epileptic manifestation?. Seizure, 2009, 18(5): 309-312.
12.	Parisi P, Kasteleijn-Nolst Trenite DG, Piccioli M, et al.A case with atypical childhood occipital epilepsy “Gastaut type”: an ictal migraine manifestation with a good response to intravenous diazepam. Epilepsia, 2007, 48(11): 2181-2186.
13.	Parisi P, Piccioli M, de Sneeuw S, et al. Redefining headache diagnostic criteria as epileptic manifestation? Cephalalgia, 2008, 28(4): 408-409; author reply 409.
14.	Parisi P, Piccioli M, Villa MP, et al. Hypothesis on neurophysiopathological mechanisms linking epilepsy and headache. Medical Hypotheses, 2008, 70(6): 1150-1154.
15.	Pedersen M, Curwood EK, Vaughan DN, et al. Abnormal brain areas common to the focal epilepsies: Multivariate pattern analysis of fMRI. Brain Connectivity, 2015, Epub ahead of print.
16.	Zhao L, Liu J, Dong X, et al. Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration. The Journal of Headache and Pain, 2013, 14(2): 85.
17.	Haglund MM, Schwartzkroin PA. Role of Na-K pump potassium regulation and IPSPs in seizures and spreading depression in immature rabbit hippocampal slices. Journal of Neurophysiology, 1990, 63(2): 225-239.
18.	Silberstein SD, Dodick DW. Migraine genetics: Part II. Headache, 2013, 53(8): 1218-1229.
19.	Vanmolkot KR, Kors EE, Hottenga JJ, et al. Novel mutations in the Na⁺, K⁺-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions. Annals of Neurology, 2003, 54(3): 360-366.
20.	Costa C, Prontera P, Sarchielli P, et al.A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. Cephalalgia, 2014, 34(1): 68-72.
21.	Cestele S, Labate A, Rusconi R, et al. Divergent effects of the T1174S SCN1A mutation associated with seizures and hemiplegic migraine. Epilepsia, 2013, 54(5): 927-935.
22.	Winawer MR, Connors R, Investigators E. Evidence for a shared genetic susceptibility to migraine and epilepsy. Epilepsia, 2013, 54(2): 288-295.
23.	Raggi A, Leonardi M, D’Amico D, et al.A Step Forward on Similarities Between Migraine and Epilepsy: Psychosocial Difficulties. Headache, 2015, 55(9): 1272-1273.
24.	Hughes J, Devinsky O, Feldmann E, et al. Premonitory symptoms in epilepsy. Seizure, 1993, 2(3): 201-203.
25.	Giffin NJ, Ruggiero L, Lipton RB, et al. Premonitory symptoms in migraine: an electronic diary study. Neurology, 2003, 60(6): 935-940.
26.	Crompton DE, Berkovic SF. The borderland of epilepsy: clinical and molecular features of phenomena that mimic epileptic seizures. The Lancet Neurology, 2009, 8(4): 370-381.
27.	Wild E. Deja vu in neurology. Journal of Neurology, 2005, 252(1): 1-7.
28.	Russell MB, Olesen J.A nosographic analysis of the migraine aura in a general population. Brain, 1996, 119 ( Pt 2): 355-361.
29.	Mainieri G, Cevoli S, Giannini G, et al. Headache in epilepsy: prevalence and clinical features. The Journal of Headache and Pain, 2015, 16(10): 556.
30.	Haut SR, Bigal ME, Lipton RB. Chronic disorders with episodic manifestations: focus on epilepsy and migraine. The Lancet Neurology, 2006, 5(2): 148-157.
31.	Duchaczek B, Ghaeni L, Matzen J, et al. Interictal and periictal headache in patients with epilepsy. European Journal of Neurology, 2013, 20(10): 1360-1366.
32.	Vollono C, Mariotti P, Losurdo A, et al. Headache Following Occipital Brain Lesion:A Case of Migraine Triggered by Occipital Spikes?. Clinical EEG and Neuroscience, 2015, 46(4): 364-369.
33.	Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia, 2010, 51(4): 676-685.
34.	Parisi P. Who’s still afraid of the link between headache and epilepsy? Some reactions to and reflections on the article by Marte Helene Bjork and co-workers. The Journal of Headache and Pain, 2009, 10(5): 327-329.
35.	Koutroumanidis M. Panayiotopoulos syndrome: an important electroclinical example of benign childhood system epilepsy. Epilepsia, 2007, 48(6): 1044-1053.
36.	Panayiotopoulos CP. Visual phenomena and headache in occipital epilepsy: a review, a systematic study and differentiation from migraine. Epileptic Disorders, 1999, 1(4): 205-216.
37.	Sances G, Guaschino E, Perucca P, et al. Migralepsy: a call for a revision of the definition. Epilepsia, 2009, 50(11): 2487-2496.
38.	Isler H, Wieser H, Egli M. Hemicrania epileptica: synchronous ipsilateral ictal headache with migraine features// In: Andermann F, LugaresiE(eds) Migraine and epilepsy. Butterworth, Boston, 1987: 249-263.
39.	Cianchetti C, Ledda MG, Pruna D. Headache, migraine and epileptic seizures.A comment on the types of association and on terminology. Cephalalgia, 2012, 32(16): 1225-1226.
40.	Parisi P, Striano P, Negro A, et al. Ictal epileptic headache: an old story with courses and appeals. The Journal of Headache and Pain, 2012, 13(8): 607-613.
41.	Hofstra WA, Hageman G, de Weerd AW. Periictal and interictal headache including migraine in Dutch patients with epilepsy: a cross-sectional study. Epilepsy & Behavior, 2015, 44(8): 155-158.
42.	Jacob J, Goadsby PJ, Duncan JS. Use of sumatriptan in post-ictal migraine headache. Neurology, 1996, 47(4): 1104.
43.	Evans RW, Gladstein J. Postictal headache and migraine. Headache, 2006, 46(5): 810-812.
44.	Hofstra WA, Hageman G, de Weerd AW. Headache in epilepsy patients: the (un)awareness of this phenomenon among Dutch neurologists. Seizure, 2015, 25(7): 37-39.
45.	Kossoff EH, Andermann F. Migraine and epilepsy. Seminars in Pediatric Neurology, 2010, 17(2): 117-122.
46.	Piccioli M, Parisi P, Tisei P, et al. Ictal headache and visual sensitivity. Cephalalgia, 2009, 29(2): 194-203.
47.	Gronseth GS, Greenberg MK. The utility of the electroencephalogram in the evaluation of patients presenting with headache: a review of the literature. Neurology, 1995, 45(7): 1263-1267.
48.	Salazar AM, Grafman J. Post-traumatic epilepsy: clinical clues to pathogenesis and paths to prevention. Handbook of Clinical Neurology, 2015, 128(20): 525-538.
49.	Silberstein SD. Topiramate in migraine prevention: evidence-based medicine from clinical trials. Neurological Sciences, 2004, 25(Suppl 3): 244-245.
50.	Felton EA, Cervenka MC. Dietary therapy is the best option for refractory nonsurgical epilepsy. Epilepsia, 2015, 56(9): 1325-1329.
51.	Strahlman RS. Can ketosis help migraine sufferers?.A Case Report. Headache, 2006, 46(1): 182.
52.	Diener H-C, Charles A, Goadsby PJ, et al. New therapeutic approaches for the prevention and treatment of migraine. The Lancet Neurology, 2015, 14(10): 1010-1022.
53.	Bhola R, Kinsella E, Giffin N, et al. Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program. The Journal of Headache and Pain, 2015, 16(7): 535.
54.	魏强. 经颅磁刺激治疗神经系统疾病的研究进展. 国际神经病学神经外科学杂志, 2011, 38(5): 492-496.
55.	Pakalnis A, Greenberg G, Drake ME, et al. Pediatric migraine prophylaxis with divalproex. Journal of Child Neurology, 2001, 16(10): 731-734.
56.	Gaitatzis A, Sander JW. The mortality of epilepsy revisited. Epileptic Disorders, 2004, 6(1): 3-13.
57.	Velioglu SK, Boz C, Ozmenoglu M. The impact of migraine on epilepsy: a prospective prognosis study. Cephalalgia, 2005, 25(7): 528-535.
58.	Headache Classification Committee of the International Headache S. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia, 2013, 33(9): 629-808.
59.	Bianchin MM, Londero RG, Lima JE, et al. Migraine and epilepsy: a focus on overlapping clinical, pathophysiological, molecular, and therapeutic aspects. Current Pain and Headache Reports, 2010, 14(4): 276-283.

1. 鄢波, 周东. 神经系统慢性疾病的综合管理. 华西医学, 2015, 30(4): 601-603.
2. 于生元, 李舜伟, 李焰生. 中国偏头痛诊断治疗指南. 中国疼痛医学杂志, 2011, 17(2): 65-86.
3. Nakano H, Inoue Y. Epidemiology and cause of epilepsy. Nihon rinsho Japanese Journal of Clinical Medicine, 2014, 72(5): 785-789.
4. Yu S, Liu R, Zhao G, et al. The Prevalence and Burden of Primary Headaches in China:A Population-Based Door-to-Door Survey. Headache, 2012, 52(4): 582-591.
5. Keezer MR, Bauer PR, Ferrari MD, et al. The comorbid relationship between migraine and epilepsy: a systematic review and meta-analysis. European Journal of Neurology, 2015, 22(7): 1038-1047.
6. Wang XQ, Lang SY, Zhang X, et al. Comidity between headache and epilepsy in a Chinese epileptic center. Epilepsy Research, 2014, 108(3): 535-541.
7. Grafstein B. Mechanism of spreading cortical depression. Journal of Neurophysiology, 1956, 19(2): 154-171.
8. Herreras O. Electrical prodromals of spreading depression void Grafstein’s potassium hypothesis. Journal of Neurophysiology, 2005, 94(5): 3656; author reply 3656-3657.
9. Bolay H, Reuter U, Dunn AK, et al. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nature Medicine, 2002, 8(2): 136-142.
10. Ghaemi A, Sajadian A, Khodaie B, et al. The immunological and neuroimmunological response to spreading depression in Wistar rats. International Journal of Developmental Neuroscience, 2015, 47(Pt A): 6-7.
11. Parisi P. Why is migraine rarely, and not usually, the sole ictal epileptic manifestation?. Seizure, 2009, 18(5): 309-312.
12. Parisi P, Kasteleijn-Nolst Trenite DG, Piccioli M, et al.A case with atypical childhood occipital epilepsy “Gastaut type”: an ictal migraine manifestation with a good response to intravenous diazepam. Epilepsia, 2007, 48(11): 2181-2186.
13. Parisi P, Piccioli M, de Sneeuw S, et al. Redefining headache diagnostic criteria as epileptic manifestation? Cephalalgia, 2008, 28(4): 408-409; author reply 409.
14. Parisi P, Piccioli M, Villa MP, et al. Hypothesis on neurophysiopathological mechanisms linking epilepsy and headache. Medical Hypotheses, 2008, 70(6): 1150-1154.
15. Pedersen M, Curwood EK, Vaughan DN, et al. Abnormal brain areas common to the focal epilepsies: Multivariate pattern analysis of fMRI. Brain Connectivity, 2015, Epub ahead of print.
16. Zhao L, Liu J, Dong X, et al. Alterations in regional homogeneity assessed by fMRI in patients with migraine without aura stratified by disease duration. The Journal of Headache and Pain, 2013, 14(2): 85.
17. Haglund MM, Schwartzkroin PA. Role of Na-K pump potassium regulation and IPSPs in seizures and spreading depression in immature rabbit hippocampal slices. Journal of Neurophysiology, 1990, 63(2): 225-239.
18. Silberstein SD, Dodick DW. Migraine genetics: Part II. Headache, 2013, 53(8): 1218-1229.
19. Vanmolkot KR, Kors EE, Hottenga JJ, et al. Novel mutations in the Na⁺, K⁺-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions. Annals of Neurology, 2003, 54(3): 360-366.
20. Costa C, Prontera P, Sarchielli P, et al.A novel ATP1A2 gene mutation in familial hemiplegic migraine and epilepsy. Cephalalgia, 2014, 34(1): 68-72.
21. Cestele S, Labate A, Rusconi R, et al. Divergent effects of the T1174S SCN1A mutation associated with seizures and hemiplegic migraine. Epilepsia, 2013, 54(5): 927-935.
22. Winawer MR, Connors R, Investigators E. Evidence for a shared genetic susceptibility to migraine and epilepsy. Epilepsia, 2013, 54(2): 288-295.
23. Raggi A, Leonardi M, D’Amico D, et al.A Step Forward on Similarities Between Migraine and Epilepsy: Psychosocial Difficulties. Headache, 2015, 55(9): 1272-1273.
24. Hughes J, Devinsky O, Feldmann E, et al. Premonitory symptoms in epilepsy. Seizure, 1993, 2(3): 201-203.
25. Giffin NJ, Ruggiero L, Lipton RB, et al. Premonitory symptoms in migraine: an electronic diary study. Neurology, 2003, 60(6): 935-940.
26. Crompton DE, Berkovic SF. The borderland of epilepsy: clinical and molecular features of phenomena that mimic epileptic seizures. The Lancet Neurology, 2009, 8(4): 370-381.
27. Wild E. Deja vu in neurology. Journal of Neurology, 2005, 252(1): 1-7.
28. Russell MB, Olesen J.A nosographic analysis of the migraine aura in a general population. Brain, 1996, 119 ( Pt 2): 355-361.
29. Mainieri G, Cevoli S, Giannini G, et al. Headache in epilepsy: prevalence and clinical features. The Journal of Headache and Pain, 2015, 16(10): 556.
30. Haut SR, Bigal ME, Lipton RB. Chronic disorders with episodic manifestations: focus on epilepsy and migraine. The Lancet Neurology, 2006, 5(2): 148-157.
31. Duchaczek B, Ghaeni L, Matzen J, et al. Interictal and periictal headache in patients with epilepsy. European Journal of Neurology, 2013, 20(10): 1360-1366.
32. Vollono C, Mariotti P, Losurdo A, et al. Headache Following Occipital Brain Lesion:A Case of Migraine Triggered by Occipital Spikes?. Clinical EEG and Neuroscience, 2015, 46(4): 364-369.
33. Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia, 2010, 51(4): 676-685.
34. Parisi P. Who’s still afraid of the link between headache and epilepsy? Some reactions to and reflections on the article by Marte Helene Bjork and co-workers. The Journal of Headache and Pain, 2009, 10(5): 327-329.
35. Koutroumanidis M. Panayiotopoulos syndrome: an important electroclinical example of benign childhood system epilepsy. Epilepsia, 2007, 48(6): 1044-1053.
36. Panayiotopoulos CP. Visual phenomena and headache in occipital epilepsy: a review, a systematic study and differentiation from migraine. Epileptic Disorders, 1999, 1(4): 205-216.
37. Sances G, Guaschino E, Perucca P, et al. Migralepsy: a call for a revision of the definition. Epilepsia, 2009, 50(11): 2487-2496.
38. Isler H, Wieser H, Egli M. Hemicrania epileptica: synchronous ipsilateral ictal headache with migraine features// In: Andermann F, LugaresiE(eds) Migraine and epilepsy. Butterworth, Boston, 1987: 249-263.
39. Cianchetti C, Ledda MG, Pruna D. Headache, migraine and epileptic seizures.A comment on the types of association and on terminology. Cephalalgia, 2012, 32(16): 1225-1226.
40. Parisi P, Striano P, Negro A, et al. Ictal epileptic headache: an old story with courses and appeals. The Journal of Headache and Pain, 2012, 13(8): 607-613.
41. Hofstra WA, Hageman G, de Weerd AW. Periictal and interictal headache including migraine in Dutch patients with epilepsy: a cross-sectional study. Epilepsy & Behavior, 2015, 44(8): 155-158.
42. Jacob J, Goadsby PJ, Duncan JS. Use of sumatriptan in post-ictal migraine headache. Neurology, 1996, 47(4): 1104.
43. Evans RW, Gladstein J. Postictal headache and migraine. Headache, 2006, 46(5): 810-812.
44. Hofstra WA, Hageman G, de Weerd AW. Headache in epilepsy patients: the (un)awareness of this phenomenon among Dutch neurologists. Seizure, 2015, 25(7): 37-39.
45. Kossoff EH, Andermann F. Migraine and epilepsy. Seminars in Pediatric Neurology, 2010, 17(2): 117-122.
46. Piccioli M, Parisi P, Tisei P, et al. Ictal headache and visual sensitivity. Cephalalgia, 2009, 29(2): 194-203.
47. Gronseth GS, Greenberg MK. The utility of the electroencephalogram in the evaluation of patients presenting with headache: a review of the literature. Neurology, 1995, 45(7): 1263-1267.
48. Salazar AM, Grafman J. Post-traumatic epilepsy: clinical clues to pathogenesis and paths to prevention. Handbook of Clinical Neurology, 2015, 128(20): 525-538.
49. Silberstein SD. Topiramate in migraine prevention: evidence-based medicine from clinical trials. Neurological Sciences, 2004, 25(Suppl 3): 244-245.
50. Felton EA, Cervenka MC. Dietary therapy is the best option for refractory nonsurgical epilepsy. Epilepsia, 2015, 56(9): 1325-1329.
51. Strahlman RS. Can ketosis help migraine sufferers?.A Case Report. Headache, 2006, 46(1): 182.
52. Diener H-C, Charles A, Goadsby PJ, et al. New therapeutic approaches for the prevention and treatment of migraine. The Lancet Neurology, 2015, 14(10): 1010-1022.
53. Bhola R, Kinsella E, Giffin N, et al. Single-pulse transcranial magnetic stimulation (sTMS) for the acute treatment of migraine: evaluation of outcome data for the UK post market pilot program. The Journal of Headache and Pain, 2015, 16(7): 535.
54. 魏强. 经颅磁刺激治疗神经系统疾病的研究进展. 国际神经病学神经外科学杂志, 2011, 38(5): 492-496.
55. Pakalnis A, Greenberg G, Drake ME, et al. Pediatric migraine prophylaxis with divalproex. Journal of Child Neurology, 2001, 16(10): 731-734.
56. Gaitatzis A, Sander JW. The mortality of epilepsy revisited. Epileptic Disorders, 2004, 6(1): 3-13.
57. Velioglu SK, Boz C, Ozmenoglu M. The impact of migraine on epilepsy: a prospective prognosis study. Cephalalgia, 2005, 25(7): 528-535.
58. Headache Classification Committee of the International Headache S. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia, 2013, 33(9): 629-808.
59. Bianchin MM, Londero RG, Lima JE, et al. Migraine and epilepsy: a focus on overlapping clinical, pathophysiological, molecular, and therapeutic aspects. Current Pain and Headache Reports, 2010, 14(4): 276-283.

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