癫痫猝死：评估公众死亡负担_Journal of Epilepsy

Authors：

 刘文钰 ,  慕洁

四川大学华西医院神经内科(成都，610041);

Corresponding author：

慕洁, Email: mujie2010@foxmail.com

Keywords：

癫痫; 猝死; 发生率; 系统评价

DOI：

10.7507/2096-0247.20160032

Video：

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有关癫痫猝死的发病率及公共健康的负担的扩展，至今没有共识。在现系统性的回顾中，希望总结癫痫猝死的发病率和年龄分布，并同时计算癫痫患者的潜在寿命损失和发生猝死的累计风险。针对癫痫猝死的流行病学做了系统回顾并评估了证据级别。选取高质量的基于人群的涵盖各个年龄段的癫痫猝死发生率研究，计算了每10万人中癫痫猝死的整体发生率以及每1 000名癫痫患者中癫痫猝死的发生率。根据标准公式，计算了癫痫猝死相关的潜在寿命损失和发生猝死的累计风险。癫痫猝死在人群中发生率为0.81/10万人年，在癫痫患者中为1.16/1 000。癫痫所致猝死与其他神经科疾病所致的潜在寿命损失比较，仅次于脑卒中，排名第二。尽管研究所分析的数据本身存在局限性，但癫痫猝死引起的公众健康负担一直被低估，需要引起临床医生、研究者和公共健康组织的重视。

Citation： 刘文钰, 慕洁. 癫痫猝死：评估公众死亡负担. Journal of Epilepsy, 2016, 2(2): 165-169. doi: 10.7507/2096-0247.20160032 Copy

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15.	Harvey AS, Nolan T, Carlin JB. Community-based study of mortality in children with epilepsy. Epilepsia, 1993, 34(8): 597-603.
16.	Holst AG, Winkel BG, Risgaard B, et al. Epilepsy and risk of death and sudden unexpected death in the young: a nationwide study. Epilepsia, 2013, 54(60): 1613-1620.
17.	Nickels KC, Grossardt BR, Wirrell EC. Epilepsy-related mortality is low in children: a 30-year population-based study in olmsted county, MN. Epilepsia, 2012, 53(10): 2164-2171.
18.	Sillanpaa M, Shinnar S. Long-term mortality in childhood-onset epilepsy. N Engl J Med, 2010, 363(11): 2522-2529.
19.	Langan Y, Nashef L, Sander JWAS. Certification of deaths attributable to epilepsy. J NeurolNeurosurg Psychiatry, 2002, 73(21): 751-752.
20.	Leestma JE, Walczak T, Hughes JR, et al. A prospective study on sudden unexpected death in epilepsy. Ann Neuro, 1989, 26(6): 195-203.
21.	Opeskin K, Harvey AS, Cordner SM, et al. Sudden unexpected death in epilepsy in victoria. J ClinNeurosci, 2000, 7(2): 34-37.
22.	Terrence CF Jr, Wisotzkey HM, Perper JA. Unexpected, unexplained death in epileptic patients. Neurology, 1975, 25(4): 594-598.
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24.	Surveillance Epidemiology and End Results Program (SEER). Standard Populations Single Ages [online]. Available at: http://seer.cancer.gov/stdpopulations/stdpop.singleages.html. Accessed March 20, 2014.
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27.	Eurostat. Your key to European Statistics [online]. Available at: http://epp.eurostat.ec.europa.eu/portal/page/portal/eurostat/home. AccessedMarch 25, 2014.
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29.	Centers for Disease Control and Prevention. Sudden UnexpectedInfant Death and Sudden Infant Death Syndrome [online]. Availableat: http://www.cdc.gov/sids/. Accessed January 27, 2014.

1. Tomson T, Beghi E, Sundqvist A, et al. Medical risks in epilepsy: a review with focus on physical injuries, mortality, traffic accidents and their prevention. Epilepsy Res, 2004, 60(12): 1-16.
2. Institute of Medicine (U.S.). Committee on the Public Health Dimensions of the Epilepsies. Epilepsy across the spectrum: promoting health and understanding. Washington, DC: The National Academies Press; 2012.
3. Tellez-Zenteno JF, Ronquillo LH, Wiebe S. Sudden unexpected death in epilepsy: evidence-based analysis of incidence and risk factors. Epilepsy Res, 2005, 65(9): 101-115.
4. Tomson T, Nashef L, Ryvlin P. Sudden unexpected death in epilepsy: current knowledge and future directions. Lancet Neurol, 2008, 7(1): 1021-1031.
5. Langan Y, Nolan N, Hutchinson M. The incidence of sudden unexpected death in epilepsy (SUDEP) in South Dublin and Wicklow. Seizure, 1998, 7(4): 355-358.
6. Leestma JE, Kalelkar MB, Teas SS, et al. Sudden unexpected death associated with seizures: analysis of 66 cases. Epilepsia, 1984, 25(9): 84- 88.
7. Opeskin K, Berkovic SF. Risk factors for sudden unexpected death in epilepsy: a controlled prospective study based on coroners cases. Seizure, 2003, 12(5): 456-464.
8. Zhuo L, Zhang Y, Zielke HR, et al. Sudden unexpected death in epilepsy: evaluation of forensic autopsy cases. Forensic SciInt, 2012, 223(11): 171-175.
9. Fleiss JL, Levin BA, Paik MC. Statistical methods for rates and proportions. 3rd ed. New York, NY: John Wiley and Sons; 2003.
10. Hirtz D, Thurman DJ, Gwinn-Hardy K, et al. How common are the “common” neurologic disorders?. Neurology, 2007, 68(7): 326-337.
11. Centersfor Disease Control and Prevention National Center for Health Statistics. CDC Wonder: About Underlying Cause of Death, 1999-2010 [online]. Available at: http://wonder.cdc.gov/ucd-icd10.html. Accessed January 20, 2014.
12. Sasieni PD, Adams J. Standardized lifetime risk. Am J Epidemiol, 1999, 149(10): 869-875.
13. Hauser WA, Annegers JF, Kurland LT. Prevalence of epilepsy in rochester, Minnesota: 1940-1980. Epilepsia, 1991, 32(8): 429-445.
14. Donner EJ, Smith CR, Snead OC. Sudden unexplained death in children with epilepsy. Neurology, 2001, 57(11): 430-434.
15. Harvey AS, Nolan T, Carlin JB. Community-based study of mortality in children with epilepsy. Epilepsia, 1993, 34(8): 597-603.
16. Holst AG, Winkel BG, Risgaard B, et al. Epilepsy and risk of death and sudden unexpected death in the young: a nationwide study. Epilepsia, 2013, 54(60): 1613-1620.
17. Nickels KC, Grossardt BR, Wirrell EC. Epilepsy-related mortality is low in children: a 30-year population-based study in olmsted county, MN. Epilepsia, 2012, 53(10): 2164-2171.
18. Sillanpaa M, Shinnar S. Long-term mortality in childhood-onset epilepsy. N Engl J Med, 2010, 363(11): 2522-2529.
19. Langan Y, Nashef L, Sander JWAS. Certification of deaths attributable to epilepsy. J NeurolNeurosurg Psychiatry, 2002, 73(21): 751-752.
20. Leestma JE, Walczak T, Hughes JR, et al. A prospective study on sudden unexpected death in epilepsy. Ann Neuro, 1989, 26(6): 195-203.
21. Opeskin K, Harvey AS, Cordner SM, et al. Sudden unexpected death in epilepsy in victoria. J ClinNeurosci, 2000, 7(2): 34-37.
22. Terrence CF Jr, Wisotzkey HM, Perper JA. Unexpected, unexplained death in epileptic patients. Neurology, 1975, 25(4): 594-598.
23. Lear-KaulKC,CoughlinL,DobersenMJ. Sudden unexpected death in epilepsy: a retrospective study. Am J Forensic Med Pathol, 2005, 26(7): 11-17.
24. Surveillance Epidemiology and End Results Program (SEER). Standard Populations Single Ages [online]. Available at: http://seer.cancer.gov/stdpopulations/stdpop.singleages.html. Accessed March 20, 2014.
25. Pace M, Giampaolo L, Glickman M, et al. Revision of the European standard population: report of Eurostat′s task force. Luxembourg: Eurostat, European Union; 2013.
26. Centers for Disease Control and Prevention National Center for Health Statistics. CDC Wonder: United States Census Projections [online]. Available at: http://wonder.cdc.gov/population.html. Accessed January 20, 2014.
27. Eurostat. Your key to European Statistics [online]. Available at: http://epp.eurostat.ec.europa.eu/portal/page/portal/eurostat/home. AccessedMarch 25, 2014.
28. Schraeder PL, Delin K, McClelland RL, et al. A nationwide survey ofthe extent of autopsy in sudden unexplained death in epilepsy. Am JForensic Med Pathol, 2009, 30(6): 123-126.
29. Centers for Disease Control and Prevention. Sudden UnexpectedInfant Death and Sudden Infant Death Syndrome [online]. Availableat: http://www.cdc.gov/sids/. Accessed January 27, 2014.

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