The analysis of the etiology, clinical features, treatment and prognosis of 17 partial statas epileptic cases_Journal of Epilepsy

Authors：

 HANChuntao ^1,2 , CHENYu ¹ , YUJinbei ¹ , CUILi ¹ ,  LINWeihong ¹

1. Department Of Neurology, the First Hosptial of JiLin University, Changchun 130021, JiLin, China;
2. ;

Corresponding author：

LINWeihong, Email: linweihong321@126.com

Keywords：

Status epilepticus; Partial seizure; Acute symptomatic seizure; Treatment; Prognosis

DOI：

10.7507/2096-0247.20160055

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Objective To investigate the etiology, clinical features, treatment, and prognosis of Partial status epilepticus (PSE). Methods Seventeen PSE patients were hospitalized in the Department of Neurology at the First Hospital of Jilin University from April 2013 to June 2015. Clinical data were retrospectively analyzed. Results A total of 17 patients, 8 male and 9 female, 18~91years old, at mean age (48.90±21.17) years were included. About 12 cases (70.59%) had acute symptomatic status epilepticus, the etiologies including central nervous system inflammation (5 cases), cortical infarction (3 cases), metabolic disorder (1 case), hypoxic-ischemic encephalopathy (1 case), space-occupying lesions(1 case) and degeneration (1 case); four cases (23.53%) were diagnosed with epilepsy, one case (5.88%) had no definite pathogenesis. The seizure types included complex partial status epilepticus (8 cases, 47.06%), complex part of the secondary comprehensive status epilepticus (3 cases, 17.65%), supplementary motor area (SMA) status epilepticus (4 cases, 23.53%), epilepsia partialis continua (EPC) (1case, 5.88%)and complex partial status epilepticus & aura continua (1case, 5.88%). Nine cases (52.94%) were effective after one hour treament, eight cases (47.06%) were negative. 17 cases are followed-up and 4 cases lost, the average follow-up time is (10.89±8.64) months. 8 cases are completely seizure free, and 3 cases have experience less seizures or the symptom is relived; the other 2 cases die from Creutzfeldt-Jacob desease(case No.10) and Respiratory failure(case No.12). Conclusions The inpatients of partial status epilepticus are mostly "situation related". Patients with clinical suspect should be administrated with long term video-Electroencephalogram(EEG) monitoring timely. Early diagnosis, treatment and the aggressive treatment can help to improve the prognosis. Patients of encephalitis usually progress into refractory status epilepticus, the anesthetic drugs should be used as soon as possible.

Citation： HANChuntao, CHENYu, YUJinbei, CUILi, LINWeihong. The analysis of the etiology, clinical features, treatment and prognosis of 17 partial statas epileptic cases. Journal of Epilepsy, 2016, 2(4): 312-317. doi: 10.7507/2096-0247.20160055 Copy

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1. Engel J Jr. Report of the ILAE Classification core group. Eplilepsia, 2006, 47(8):1558-1668.
2. Panayiotopoulos CP. A clinical guide to epileptic syndromes and their treatment.second edition.England:British library cataloguing in publication Data. 2007, 65-87.
3. 韩春涛, 林卫红.癫痫持续状态研究进展.癫痫杂志, 2016, 2(1):43-46.
4. Simon Shorvon. The etiologic classification of epilepsy. Epilepsia, 2006, 52(6):1052-1057.
5. Meierkord H, Holtkamp M. Non-convulsive status epilepticus in adults:clinical forms and treatment. Lancet Neurol, 2007, 6(3):329-339.
6. Cockerell OC, Rothwell J, Thompson PD, et al. Clinical and physiological features of epilepsia partial continua. Cases ascertained in the UK, 1996, 119(2):393-407.
7. Wiser HG, Chauvel P. Simple partial status epilepticus and epilepsia partial continua of Kozhvniekov. In:Engel J Jr, Pedley TA, eds. Epilepsy:A comprehensive textbook. 2006, 2:705-724.
8. Scott RC. Status epilepticus in children. In Panayiotopoulos CP, ed. Philadelphia:Lippincott Wiliams and Wilkins, 2008, 1:58-68.
9. Shigeto H, Tobimatsu S, Morioka T, et al. Jerk-locked back averaging and dipole source localization of magnetoencephalographic transients in a patient with epilepsia partialis continua. Electroencephalogr Clin Neurophysiol, 1997, 103(4):440-444.
10. Molyneux PD, Barker RA, Thom M, et al. Successful treatment of intractable epilepsia partialis continua with multiple subpial transections. J Neurol Neurosurg Psychiatry, 1998, 65(1):137-138.
11. Bien CG, Elger CE. Epilepsia partialis continua:semiology and differential diagnoses. Epileptic Disord, 2008, 10(1):3-7.
12. Obeso JA, Rothwell JC, Marsden CD. The spectrum of cortical myoclonus. From focal reflex jerks to spontaneous motor epilepsy. Brain, 1985, 108 (Pt 1):193-224.

Journal of Epilepsy

The analysis of the etiology, clinical features, treatment and prognosis of 17 partial statas epileptic cases

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