青少年肌阵挛癫痫的社会心理长期结局_Journal of Epilepsy

Authors：

 MartinHoltkamp , PhilineSenf , AndreaKirschbaum , DieterJanz , 杨华俊 , 王群

Corresponding author：

MartinHoltkamp, Email: martin.holtkamp@charite.de

Keywords：

特发性全面性癫痫; 遗传性癫痫; 失神癫痫; 神经生物学改变

DOI：

10.7507/2096-0247.20160064

Video：

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青少年肌阵挛癫痫（Juvenile myoclonic epilepsy，JME）是一种定义明确的特发性全面性/遗传性癫痫综合征。它与特定的人格特征相关，并且与不利的社会结局有相关性。文章旨在分析JME患者的社会心理结局。为了从环境本身固有的神经生物学因素中描绘慢性发作性疾病的结局，对年龄和性别对照匹配的JME患者与失神癫痫（Absence epilepsy，AE）患者的社会结局进行了对比。研究纳入癫痫病程至少20年的患者。所有JME和AE患者（n=41）回答关于癫痫发作、治疗和社会心理变量的结构化问卷。除此以外，JME患者进行了癫痫生活质量量表 31（QOLIE-31）评估。在JME中，癫痫起病后46.3（20~69）年，总体社会心理长期结局是有利的（80.5%的患者从未失业超过1年，90.2%能够良好融入社会环境）。生活质量中所有询问到的方面均显示出高得分。与AE对照组相比，JME患者并未显示出更差的社会心理结局；JME患者的大学入学率和学位获得率甚至更高（70% vs 34%，P=0.001）。JME患者显示出高水平的生活质量，当前或既往精神合并症与较低的总体生活质量得分显著相关（P=0.02）。对于JME患者的长期研究显示出与以往研究不同的有利社会心理结局。这是第一个对JME和另外一个遗传决定形式的癫痫进行对比的研究。JME和AE患者的相似结局对于JME可能引起社会缺陷的特定神经生物学改变提出了质疑。在JME患者中，生活质量降低与精神合并症相关。

Citation： MartinHoltkamp, PhilineSenf, AndreaKirschbaum, DieterJanz, 杨华俊, 王群. 青少年肌阵挛癫痫的社会心理长期结局. Journal of Epilepsy, 2016, 2(4): 360-365. doi: 10.7507/2096-0247.20160064 Copy

1.	Delgado-Escueta AV, Enrile-Bacsal F. Juvenile myoclonic epilepsy of Janz. Neurology, 1984, 34(1): 285-294.
2.	Panayiotopoulos CP, Obeid T, Tahan AR. JME: a 5-year prospective study. Epilepsia, 1994, 35(6): 285-296.
3.	Janz D, Christian W. Impulsiv-Petit mal. Dtsch Z Nervenheilkd, 1957, 176(12): 346-386.
4.	Genton P. Impulsive Petit mal. In Malafosse A, Genton P, Hirsch E, Marescaux C, Broglin D, Bernasconi R (Eds). Idiopathic generalized epilepsies: clinical, experimental and genetic aspects. London: John Libbey & Company, 1994: 229-251.
5.	Janz D. Juvenile myoclonic epilepsy: epilepsy with impulsive petit mal. Cleve Clin J Med, 1989, 56(Suppl. 1): 23-33.
6.	Janz D, Durner M. Juvenile myoclonic epilepsy. In Engel J, Pedley TA (Eds) Epilepsy: a comprehensive textbook. Philadelphia, PA: Lippincott-Raven, 1997: 2389-2399.
7.	Ritaccio AL, Devinsky O. Personality disorders in epilepsy. In Ettinger AB, Kanner AM (Eds) Psychiatric issues in epilepsy: a practical guide to diagnosis and treatment. Philadelphia, PA: Lippincott Williams & Wilkins, 2001: 147-161.
8.	Hommet C, Sauerwein HC, De Toffol B, et al. Idiopathic epileptic syndrome and cognition. Neurosci Biobehav Rev, 2006, 30(8): 85-96.
9.	Karachristianou S, Katsarou Z, Postantjopoulou S, et al. Personality profile in patients with juvenile myoclonic epilepsy. Epilepsy Behav, 2008, 13(2): 654-657.
10.	Piazinni A, Turner K, Vignoli A, et al. Frontal cognitive dysfunction in juvenile myoclonic epilepsy. Epilepsia, 2008, 49(5): 657-662.
11.	Camfield CS, Camfield PR. Juvenile myoclonic epilepsy 25 years after seizure onset: a population-based study. Neurologya, 2009, 73(7): 1041-1045.
12.	Schneider-von Podewils S, Gasse C, Geithner J, et al. Clinical predictors of the long-term social outcome and quality of life in juvenile myoclonic epilepsy: 20-65 years of follow-up. Epilepsia, 2014, 55(10): 322-330.
13.	Commission on classification and terminology of the International League Against Epilepsy (ILAE). Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia, 1989, 30(3): 389-399.
14.	Senf P, Schmitz B, Holtkamp M, et al. Juvenile myoclonic epilepsy 45 years after onset: seizure outcome and predictors. Neurology, 2013, 81(8): 2128-2133.
15.	Cramer JA, Perrine K, Devinsky O, et al. Development and crosscultural translation of a 31-item quality of life questionnaire (QOLIE-31). Epilepsia, 1998, 39(11): 81-88.
16.	Devinsky O, Vickrey BG, Cramer J, et al. Development of the quality of life in epilepsy inventory. Epilepsia, 1995, 36(8): 1089-1104.
17.	Vickrey BG. A procedure for developing a quality-of-life measure for epilepsy surgery patients. Epilepsia, 1993, 34(Suppl. 4): 22-27.
18.	Pauli C, de Oliveira Thais ME, Claudino LS, et al. Predictors of quality of life in patients with refractoral mesial temporal lobe epilepsy. Epilepsy Behav, 2012, 25(10): 208-213.
19.	Moschetta S, Valtente KF. Impulsivity and seizure frequency, but not cognitive deficits, impact social adjustment in patients with juvenile myoclonic epilepsy. Epilepsia, 2013, 54(12): 866-870.
20.	Wandschneider B, Thompson PJ, Vollmar C, et al. Frontal lobe function and structure in juvenile myoclonic epilepsy: a comprehensive review of neuropsychological and imaging data. Epilepsia, 2012, 53(4): 2091-2098.
21.	Loughman A, Bowden SC, D'Souza C. Cognitive functioning in idiopathic generalized epilepsies: a systematic review and meta analysis. Neurosci Biobehav Rev, 2014, 4(1): 20-34.
22.	Trinka E, Kienpointner G, Unterberger I, et al. Psychiatric comorbidity in juvenile myoclonic epilepsy. Epilepsia, 2006, 47(5): 2086-2091.
23.	G_elisse P, Thomas P, Samuelian JC, et al. Psychiatric disorders in juvenile myoclonic epilepsy. Epilepsia, 2007, 48(9): 1032-1033.
24.	Filho GM, Mazetto L, da Silva JM, et al. Psychiatric comorbidity in patients with two prototypes of focal versus generalized epilepsy syndromes. Seizure, 2011, 20(6): 383-386.

1. Delgado-Escueta AV, Enrile-Bacsal F. Juvenile myoclonic epilepsy of Janz. Neurology, 1984, 34(1): 285-294.
2. Panayiotopoulos CP, Obeid T, Tahan AR. JME: a 5-year prospective study. Epilepsia, 1994, 35(6): 285-296.
3. Janz D, Christian W. Impulsiv-Petit mal. Dtsch Z Nervenheilkd, 1957, 176(12): 346-386.
4. Genton P. Impulsive Petit mal. In Malafosse A, Genton P, Hirsch E, Marescaux C, Broglin D, Bernasconi R (Eds). Idiopathic generalized epilepsies: clinical, experimental and genetic aspects. London: John Libbey & Company, 1994: 229-251.
5. Janz D. Juvenile myoclonic epilepsy: epilepsy with impulsive petit mal. Cleve Clin J Med, 1989, 56(Suppl. 1): 23-33.
6. Janz D, Durner M. Juvenile myoclonic epilepsy. In Engel J, Pedley TA (Eds) Epilepsy: a comprehensive textbook. Philadelphia, PA: Lippincott-Raven, 1997: 2389-2399.
7. Ritaccio AL, Devinsky O. Personality disorders in epilepsy. In Ettinger AB, Kanner AM (Eds) Psychiatric issues in epilepsy: a practical guide to diagnosis and treatment. Philadelphia, PA: Lippincott Williams & Wilkins, 2001: 147-161.
8. Hommet C, Sauerwein HC, De Toffol B, et al. Idiopathic epileptic syndrome and cognition. Neurosci Biobehav Rev, 2006, 30(8): 85-96.
9. Karachristianou S, Katsarou Z, Postantjopoulou S, et al. Personality profile in patients with juvenile myoclonic epilepsy. Epilepsy Behav, 2008, 13(2): 654-657.
10. Piazinni A, Turner K, Vignoli A, et al. Frontal cognitive dysfunction in juvenile myoclonic epilepsy. Epilepsia, 2008, 49(5): 657-662.
11. Camfield CS, Camfield PR. Juvenile myoclonic epilepsy 25 years after seizure onset: a population-based study. Neurologya, 2009, 73(7): 1041-1045.
12. Schneider-von Podewils S, Gasse C, Geithner J, et al. Clinical predictors of the long-term social outcome and quality of life in juvenile myoclonic epilepsy: 20-65 years of follow-up. Epilepsia, 2014, 55(10): 322-330.
13. Commission on classification and terminology of the International League Against Epilepsy (ILAE). Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia, 1989, 30(3): 389-399.
14. Senf P, Schmitz B, Holtkamp M, et al. Juvenile myoclonic epilepsy 45 years after onset: seizure outcome and predictors. Neurology, 2013, 81(8): 2128-2133.
15. Cramer JA, Perrine K, Devinsky O, et al. Development and crosscultural translation of a 31-item quality of life questionnaire (QOLIE-31). Epilepsia, 1998, 39(11): 81-88.
16. Devinsky O, Vickrey BG, Cramer J, et al. Development of the quality of life in epilepsy inventory. Epilepsia, 1995, 36(8): 1089-1104.
17. Vickrey BG. A procedure for developing a quality-of-life measure for epilepsy surgery patients. Epilepsia, 1993, 34(Suppl. 4): 22-27.
18. Pauli C, de Oliveira Thais ME, Claudino LS, et al. Predictors of quality of life in patients with refractoral mesial temporal lobe epilepsy. Epilepsy Behav, 2012, 25(10): 208-213.
19. Moschetta S, Valtente KF. Impulsivity and seizure frequency, but not cognitive deficits, impact social adjustment in patients with juvenile myoclonic epilepsy. Epilepsia, 2013, 54(12): 866-870.
20. Wandschneider B, Thompson PJ, Vollmar C, et al. Frontal lobe function and structure in juvenile myoclonic epilepsy: a comprehensive review of neuropsychological and imaging data. Epilepsia, 2012, 53(4): 2091-2098.
21. Loughman A, Bowden SC, D'Souza C. Cognitive functioning in idiopathic generalized epilepsies: a systematic review and meta analysis. Neurosci Biobehav Rev, 2014, 4(1): 20-34.
22. Trinka E, Kienpointner G, Unterberger I, et al. Psychiatric comorbidity in juvenile myoclonic epilepsy. Epilepsia, 2006, 47(5): 2086-2091.
23. G_elisse P, Thomas P, Samuelian JC, et al. Psychiatric disorders in juvenile myoclonic epilepsy. Epilepsia, 2007, 48(9): 1032-1033.
24. Filho GM, Mazetto L, da Silva JM, et al. Psychiatric comorbidity in patients with two prototypes of focal versus generalized epilepsy syndromes. Seizure, 2011, 20(6): 383-386.

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