癫痫合并认知功能障碍研究进展_Journal of Epilepsy

Authors：

孙立超 ¹ , 吕晓民 ² ,  林卫红 ²

1. ;
2. ;

Corresponding author：

林卫红, Email: linweihong321@126.com

Keywords：

癫痫; 认知功能; 发病机制

DOI：

10.7507/2096-0247.20170009

Video：

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认知功能障碍是癫痫常见共病, 严重影响患者生活质量。近年来日益受到重视, 其机制及影响因素复杂, 目前尚缺乏特异有效的治疗手段, 且治疗效果欠佳。因此阐明癫痫认知功能障碍的发病机制对于开发新的治疗药物具有重要意义。癫痫合并认知功能障碍的原因可能是癫痫病因、发作本身、间期放电、神经网络异常、抗癫痫药物、手术等多种因素共同作用的结果, 现将对癫痫合并认知功能障碍的机制及影响因素做一综述。

Citation： 孙立超, 吕晓民, 林卫红. 癫痫合并认知功能障碍研究进展. Journal of Epilepsy, 2017, 3(1): 56-59. doi: 10.7507/2096-0247.20170009 Copy

1.	Kanner AM. Management of psychiatric and neurological comorbidities in epilepsy. Nature Reviews Neurology, 2016, 12(2):106-116.
2.	Scheffer IE, Berkovic SF, Capovilla G, et al. The organization of theepilepsies:report of the ILAE Commission on Classifi cation andTerminology. 2014, [2014-2-5]. http://www.ilae.org/Visitors/Centre/Documents/OrganizationEpilepsy.pdf.
3.	Lenck-Santini PP, Scott RC. Mechanisms responsible for cognitive impairment in epilepsy. Cold Spring HarbPerspect Med, 2015, 5(2):a022772.
4.	Dravet C, Oguni H. Dravet syndrome (severe myoclonic epilepsy in infancy). Handb Clin Neurol, 2013, 111(8):627-633.
5.	Bender AC, Natola H, Ndong C, et al. Focal Scn1a knockdown induces cognitive impairment without seizures. Neurobiology of Disease, 2013, 54(3):297-307.
6.	Sawyer NT, Helvig AW, Makinson CD, et al. Scn1a dysfunction alters behavior but not the effect of stress on seizure response. Genes, Brain & Behavior, 2016, 15(3):335-347.
7.	Suárez LM, Cid E, Gal B, et al. Systemic injection of kainic acid differently affects LTP magnitude depending on its epileptogenic efficiency. PLoS ONE, 2012, 7(10):e48128.
8.	Chauvière L, Rafrafi N, Thinus-Blanc C, et al. Early deficits in spatial memory and theta rhythm in experimental temporal lobe epilepsy. The Journal of Neuroscience, 2009, 29(17):5402-5410.
9.	Sanabria ERG, Castaneda MT, Banuelos C, et al. Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. Neuroscience, 2006, 142(3):871-883.
10.	Hyman JM, Wyble BP, Goyal V, et al. Stimulation in hippocampal region CA1 in behaving rats yields long-term potentiation when delivered to the peak of theta and long-term depression when delivered to the trough. The Journal of Neuroscience, 2003, 23(37):11725-11731.
11.	Mc Naughton N, Ruan M, Woodnorth MA. Restoring theta-like rhythmicity in rats restores initial learning in the morris water maze. Hippocampus, 2006, 16(12):1102-1110.
12.	Salvato G, Scarpa P, Francione S, et al. Declarative long-term memory and the mesial temporal lobe:Insights from a 5-year postsurgery follow-up study on refractory temporal lobe epilepsy. Epilepsy & Behavior, 2016, 64(4):102-109.
13.	Demarest ST, Whitehead MT, Turnacioglu S, et al. Phenotypic Analysis of Epilepsy in the Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes-Associated Mitochondrial DNA A3243G Mutation. Journal of Child Neurology, 2014, 29(9):1249-1256.
14.	Guida M, Pesaresi I, Fabbri S, et al. Epilepsy and phenylketonuria:a case description and EEG-fMRI findings. Functional Neurology, 2014, 29(1):75.
15.	Ampuero E, Dagnino-Subiabre A, Sandoval R, et al. Status epilepticus induces region-specific changes in dendritic spines, dendritic length and TrkB protein content of rat brain cortex. Brain Research, 2007, 1150(3):225-238.
16.	Bell B, Lin JJ, Seidenberg M, et al. The neurobiology of cognitive disorders in temporal lobe epilepsy. Nature Reviews Neurology, 2011, 7(3):154-164.
17.	Korff CM, Brunklaus A, Zuberi SM. Epileptic activity is a surrogate for an underlying etiology and stopping the activity has a limited impact on developmental outcome. Epilepsia, 2015, 56(10):1477-1481.
18.	Chapman KE, Specchio N, Shinnar S, et al. Seizing control of epileptic activity can improve outcome. Epilepsia, 2015, 56(10):1482-1485.
19.	Holley AJ, Lugo JN. Effects of an acute seizure on associative learning and memory. Epilepsy & Behavior, 2016, 54(3):51-57.
20.	Nicolai J, Ebus S, Biemans DP, et al. The cognitive effects of interictal epileptiform EEG discharges and short nonconvulsive epileptic seizures. Epilepsia, 2012, 53(6):1051-1059.
21.	Kleen JK, Scott RC, Holmes GL, et al. Hippocampal interictal spikes disrupt cognition in rats. Annals of Neurology, 2010, 67(2):250-257.
22.	Kleen JK, Scott RC, Holmes GL, et al. Hippocampal interictal epileptiform activity disrupts cognition in humans. Neurology, 2013, 81(1):18-24.
23.	Liu XY, Shi T, Yin WN, et al. Interictal epileptiform discharges were associated with poorer cognitive performance in adult epileptic patients. Epilepsy Research, 2016, 128(7):1-5.
24.	Binnie CD. Cognitive impairment during epileptiform discharges:is it ever justifiable to treat the EEG. The Lancet Neurology, 2003, 2(12):725-730.
25.	Dinkelacker V, Xin X, Baulac M, et al. Interictal epileptic discharge correlates with global and frontal cognitive dysfunction in temporal lobe epilepsy. Epilepsy & Behavior, 2016, 62(5):197-203.
26.	Holmes GL. Cognitive impairment in epilepsy:the role of network abnormalities. Epileptic Disorders, 2015, 17(2):101-116.
27.	Myers CE, Bermudez-Hernandez K, Scharfman HE. The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function. PLoS ONE, 2013, 8(6):e68208.
28.	Cumbo E, Ligori LD. Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and alzheimer's disease. Epilepsy & Behavior, 2010, 17(4):461-466.
29.	Fritz N, Glogau S, Hoffmann J, et al. Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy. Epilepsy & Behavior, 2005, 6(3):373-381.
30.	Lee HW, Jung DK, Suh CK, et al. Cognitive effects of low-dose topiramate monotherapy in epilepsy patients:A 1-year follow-up. Epilepsy & Behavior, 2006, 8(4):736-741.
31.	García-Peñas JJ, Fournier-Del Castillo MC, Dominguez-Carral J. Epilepsy and cognition:the role of antiepileptic drugs. Revista De Neurologia, 2014, 58(Suppl 1):37-42.
32.	Tang Y, Yu X, Zhou B, et al. Short-term cognitive changes after surgery in patients with unilateral mesial temporal lobe epilepsy associated with hippocampal sclerosis. Journal of Clinical Neuroscience, 2014, 21(8):1413-1418.
33.	Stretton J, Sidhu MK, Winston GP, et al. Working memory network plasticity after anterior temporal lobe resection:a longitudinal functional magnetic resonance imaging study. Brain, 2014, 137(5):1439-1453.
34.	Helmstaedter C, Petzold I, Bien CG. The cognitive consequence of resecting nonlesional tissues in epilepsy surgery-results from MRI-and histopathology-negative patients with temporal lobe epilepsy. Epilepsia, 2011, 52(8):1402-1408.
35.	Marras CE, Chiesa V, De Benedictis A, et al. Vagus nerve stimulation in refractory epilepsy:new indications and outcome assessment. Epilepsy & Behavior, 2013, 28(3):374-378.
36.	Althausen A, Gleissner U, Hoppe C, et al. Long-term outcome of hemispheric surgery at different ages in 61 epilepsy patients. Neurosurgery & Psychiatry, 2013, 84(5):529-536.

1. Kanner AM. Management of psychiatric and neurological comorbidities in epilepsy. Nature Reviews Neurology, 2016, 12(2):106-116.
2. Scheffer IE, Berkovic SF, Capovilla G, et al. The organization of theepilepsies:report of the ILAE Commission on Classifi cation andTerminology. 2014, [2014-2-5]. http://www.ilae.org/Visitors/Centre/Documents/OrganizationEpilepsy.pdf.
3. Lenck-Santini PP, Scott RC. Mechanisms responsible for cognitive impairment in epilepsy. Cold Spring HarbPerspect Med, 2015, 5(2):a022772.
4. Dravet C, Oguni H. Dravet syndrome (severe myoclonic epilepsy in infancy). Handb Clin Neurol, 2013, 111(8):627-633.
5. Bender AC, Natola H, Ndong C, et al. Focal Scn1a knockdown induces cognitive impairment without seizures. Neurobiology of Disease, 2013, 54(3):297-307.
6. Sawyer NT, Helvig AW, Makinson CD, et al. Scn1a dysfunction alters behavior but not the effect of stress on seizure response. Genes, Brain & Behavior, 2016, 15(3):335-347.
7. Suárez LM, Cid E, Gal B, et al. Systemic injection of kainic acid differently affects LTP magnitude depending on its epileptogenic efficiency. PLoS ONE, 2012, 7(10):e48128.
8. Chauvière L, Rafrafi N, Thinus-Blanc C, et al. Early deficits in spatial memory and theta rhythm in experimental temporal lobe epilepsy. The Journal of Neuroscience, 2009, 29(17):5402-5410.
9. Sanabria ERG, Castaneda MT, Banuelos C, et al. Septal GABAergic neurons are selectively vulnerable to pilocarpine-induced status epilepticus and chronic spontaneous seizures. Neuroscience, 2006, 142(3):871-883.
10. Hyman JM, Wyble BP, Goyal V, et al. Stimulation in hippocampal region CA1 in behaving rats yields long-term potentiation when delivered to the peak of theta and long-term depression when delivered to the trough. The Journal of Neuroscience, 2003, 23(37):11725-11731.
11. Mc Naughton N, Ruan M, Woodnorth MA. Restoring theta-like rhythmicity in rats restores initial learning in the morris water maze. Hippocampus, 2006, 16(12):1102-1110.
12. Salvato G, Scarpa P, Francione S, et al. Declarative long-term memory and the mesial temporal lobe:Insights from a 5-year postsurgery follow-up study on refractory temporal lobe epilepsy. Epilepsy & Behavior, 2016, 64(4):102-109.
13. Demarest ST, Whitehead MT, Turnacioglu S, et al. Phenotypic Analysis of Epilepsy in the Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes-Associated Mitochondrial DNA A3243G Mutation. Journal of Child Neurology, 2014, 29(9):1249-1256.
14. Guida M, Pesaresi I, Fabbri S, et al. Epilepsy and phenylketonuria:a case description and EEG-fMRI findings. Functional Neurology, 2014, 29(1):75.
15. Ampuero E, Dagnino-Subiabre A, Sandoval R, et al. Status epilepticus induces region-specific changes in dendritic spines, dendritic length and TrkB protein content of rat brain cortex. Brain Research, 2007, 1150(3):225-238.
16. Bell B, Lin JJ, Seidenberg M, et al. The neurobiology of cognitive disorders in temporal lobe epilepsy. Nature Reviews Neurology, 2011, 7(3):154-164.
17. Korff CM, Brunklaus A, Zuberi SM. Epileptic activity is a surrogate for an underlying etiology and stopping the activity has a limited impact on developmental outcome. Epilepsia, 2015, 56(10):1477-1481.
18. Chapman KE, Specchio N, Shinnar S, et al. Seizing control of epileptic activity can improve outcome. Epilepsia, 2015, 56(10):1482-1485.
19. Holley AJ, Lugo JN. Effects of an acute seizure on associative learning and memory. Epilepsy & Behavior, 2016, 54(3):51-57.
20. Nicolai J, Ebus S, Biemans DP, et al. The cognitive effects of interictal epileptiform EEG discharges and short nonconvulsive epileptic seizures. Epilepsia, 2012, 53(6):1051-1059.
21. Kleen JK, Scott RC, Holmes GL, et al. Hippocampal interictal spikes disrupt cognition in rats. Annals of Neurology, 2010, 67(2):250-257.
22. Kleen JK, Scott RC, Holmes GL, et al. Hippocampal interictal epileptiform activity disrupts cognition in humans. Neurology, 2013, 81(1):18-24.
23. Liu XY, Shi T, Yin WN, et al. Interictal epileptiform discharges were associated with poorer cognitive performance in adult epileptic patients. Epilepsy Research, 2016, 128(7):1-5.
24. Binnie CD. Cognitive impairment during epileptiform discharges:is it ever justifiable to treat the EEG. The Lancet Neurology, 2003, 2(12):725-730.
25. Dinkelacker V, Xin X, Baulac M, et al. Interictal epileptic discharge correlates with global and frontal cognitive dysfunction in temporal lobe epilepsy. Epilepsy & Behavior, 2016, 62(5):197-203.
26. Holmes GL. Cognitive impairment in epilepsy:the role of network abnormalities. Epileptic Disorders, 2015, 17(2):101-116.
27. Myers CE, Bermudez-Hernandez K, Scharfman HE. The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function. PLoS ONE, 2013, 8(6):e68208.
28. Cumbo E, Ligori LD. Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and alzheimer's disease. Epilepsy & Behavior, 2010, 17(4):461-466.
29. Fritz N, Glogau S, Hoffmann J, et al. Efficacy and cognitive side effects of tiagabine and topiramate in patients with epilepsy. Epilepsy & Behavior, 2005, 6(3):373-381.
30. Lee HW, Jung DK, Suh CK, et al. Cognitive effects of low-dose topiramate monotherapy in epilepsy patients:A 1-year follow-up. Epilepsy & Behavior, 2006, 8(4):736-741.
31. García-Peñas JJ, Fournier-Del Castillo MC, Dominguez-Carral J. Epilepsy and cognition:the role of antiepileptic drugs. Revista De Neurologia, 2014, 58(Suppl 1):37-42.
32. Tang Y, Yu X, Zhou B, et al. Short-term cognitive changes after surgery in patients with unilateral mesial temporal lobe epilepsy associated with hippocampal sclerosis. Journal of Clinical Neuroscience, 2014, 21(8):1413-1418.
33. Stretton J, Sidhu MK, Winston GP, et al. Working memory network plasticity after anterior temporal lobe resection:a longitudinal functional magnetic resonance imaging study. Brain, 2014, 137(5):1439-1453.
34. Helmstaedter C, Petzold I, Bien CG. The cognitive consequence of resecting nonlesional tissues in epilepsy surgery-results from MRI-and histopathology-negative patients with temporal lobe epilepsy. Epilepsia, 2011, 52(8):1402-1408.
35. Marras CE, Chiesa V, De Benedictis A, et al. Vagus nerve stimulation in refractory epilepsy:new indications and outcome assessment. Epilepsy & Behavior, 2013, 28(3):374-378.
36. Althausen A, Gleissner U, Hoppe C, et al. Long-term outcome of hemispheric surgery at different ages in 61 epilepsy patients. Neurosurgery & Psychiatry, 2013, 84(5):529-536.

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