micro RNA调控癫痫的发生发展_Journal of Epilepsy

Authors：

江娇美 , 吴鹏程 , 王芬 ,  张明

南昌大学第二附属医院神经内科 (南昌 330006);

Corresponding author：

张明, Email: zm6861226@126.com

Keywords：

癫痫; micro RNA; 调控

DOI：

10.7507/2096-0247.20170022

Video：

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Abstract Full text Figures/Tables Video References Cited by

癫痫是神经系统第三大常见疾病，其发生发展涉及到的机制包括炎症反应、神经细胞凋亡、细胞增殖分化及突触重塑等。而近期许多研究试图从micro RNA方向找寻有关癫痫特异性生物标志及其治疗相关的潜在突破点。文章就micro RNA在癫痫的发生发展中表达水平的变化及相关可能的调控机制做一综述，为进一步的相关研究提供参考。

Citation： 江娇美, 吴鹏程, 王芬, 张明. micro RNA调控癫痫的发生发展. Journal of Epilepsy, 2017, 3(2): 145-149. doi: 10.7507/2096-0247.20170022 Copy

1.	Ngugi AK, Kariuki SM, Bottomley C, et al. Incidence of epilepsy: a systematic review and meta-analysis. Neurology, 2011, 77(10):1005-1112.
2.	常琳, 王小姗.中国癫痫流行病学调查研究进展.国际神经病学神经外科学杂志, 2012, 39(2): 161-164.
3.	Reschke CR, Henshall DC. microRNA and epilepsy. Adv Exp Med Biol, 2015, 88(8): 41-70.
4.	Roncon P, Soukupova M, Binaschi A, et al. MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy--comparison with human epileptic samples. Scientific Reports, 2015, 5(1): 14143.
5.	Wang J, Yu JT, Tan L, et al. Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy. Scientific Reports, 2015, 5 (3): 9522.
6.	Peng J, Omran A, Ashhab MU, et al. Expression patterns of miR-124, miR-134, miR-132 and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy. Journal of Molecular Neuroscience, 2013, 50 (2): 291-297.
7.	Ren L, Zhu R, Li X. Silencing miR-181a produces neuroprotection against hippocampus neuron cell apoptosis post-status epilepticus in a rat model and in children with temporal lobe epilepsy. Genetics and Molecular Research, 2016, 15(1): 15017798.
8.	Gorter JA, Iyer A, White I, et al. Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy. Neurobiology of Bisease, 2014, 62(6): 508-520.
9.	Moon J, Lee ST, Choi J, et al. Unique behavioral characteristics and microRNA signatures in a drug resistant epilepsy model. PloS ONE, 2014, 9(1): e85617.
10.	Wang J, Tan L, Tan L, et al. Circulating microRNAs are promising novel biomarkers for drug-resistant epilepsy. Scientific Reports, 2015, 5(4): 10201.
11.	Cui L, Tao H, Wang Y, et al. A functional polymorphism of the microRNA-146a gene is associated with susceptibility to drug-resistant epilepsy and seizures frequency. Seizure, 2015, 27(7): 60-65.
12.	Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Research, 2008, 18(10): 997-1006.
13.	Chang TC, Mendell JT. MicroRNAs in vertebrate physiology and human disease. Annual Review of Genomics and Human Genetics, 2007, 8(8): 215-239.
14.	Kokaia M. Seizure-induced neurogenesis in the adult brain. The European Journal of Neuroscience, 2011, 33(6): 1133-1138.
15.	Cattani AA, Allene C, Seifert V, et al. Involvement of microRNAs in epileptogenesis. Epilepsia, 2016, 57(7): 1015-1026.
16.	Kuruba R, Hattiangady B, Shetty AK. Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsy. Epilepsy & Behavior, 2009, 14(Suppl 1): 65-73.
17.	Park JH, Cho H, Kim H, et al. Repeated brief epileptic seizures by pentylenetetrazole cause neurodegeneration and promote neurogenesis in discrete brain regions of freely moving adult rats. Neuroscience, 2006, 140(2): 673-684.
18.	Cho KO, Lybrand ZR, Ito N, et al. Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. Nature Communications, 2015, 6(4): 6606.
19.	Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death and Differentiation, 2010, 17(2): 193-199.
20.	Tivnan A, Tracey L, Buckley PG, et al. MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma. BMC Cancer, 2011, 11 (7): 33.
21.	Li MM, Jiang T, Sun Z, et al. Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy. Scientific Reports, 2014, 4 (6): 4734.
22.	Wang XM, Jia RH, Wei D, et al. MiR-134 blockade prevents status epilepticus like-activity and is neuroprotective in cultured hippocampal neurons. Neuroscience Letters, 2014, 572(11): 20-25.
23.	Mc Kiernan RC, Jimenez-Mateos EM, Sano T, et al. Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death. Experimental Neurology, 2012, 237(2): 346-354.
24.	Liu X, Wu Y, Huang Q, et al. Grouping pentylenetetrazol-induced epileptic rats according to memory impairment and microRNA expression profiles in the hippocampus. PloS ONE, 2015, 10(5): e0126123.
25.	Dingledine R, Varvel NH, Dudek FE. When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?. Advances in Experimental Medicine and Biology, 2014, 813 (10): 109-122.
26.	陶树新, 陈阳美. MicroRNA与癫痫突触重塑.中华神经医学杂志, 2009, 8(12): 1276-1278.
27.	Huang Y, Guo J, Wang Q, et al. MicroRNA-132 silencing decreases the spontaneous recurrent seizures. International Journal of Clinical and Experimental Medicine, 2014, 7(7): 1639-1649.
28.	Jimenez-Mateos EM, Engel T, Merino-Serrais P, et al. Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nature Medicine, 2012, 18(7):1087-1094.
29.	Vo N, Klein ME, Varlamova O, et al. A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102(45): 16426-16431.
30.	Wanet A, Tacheny A, Arnould T, et al. MiR-212/132 expression and functions: within and beyond the neuronal compartment. Nucleic Acids Research, 2012, 40(11): 4742-4753.
31.	Siegel G, Obernosterer G, Fiore R, et al. A functional screen implicates microRNA-138-dependent regulation of the depalmitoyla-tion enzyme APT1 in dendritic spine morphogenesis. Nature Cell Biology, 2009, 11(6): 705-716.
32.	Wang W, Wang X, Chen L, et al. The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity. Expert Reviews in Molecular Medicine, 2016, 18(1): e4.
33.	Vezzani A, French J, Bartfai T, et al.The role of inflammation in epilepsy. Nature Reviews Neurology, 2011, 7(1): 31-40.
34.	Kan AA, van Erp S, Derijck AA, et al. Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response. Cellular and Molecular Life Sciences, 2012, 69(18): 3127-3145.
35.	Aronica E, Fluiter K, Iyer A, et al. Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy. The European Journal of Neuroscience, 2010, 31(6): 1100-1107.
36.	Iyer A, Zurolo E, Prabowo A, et al. MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response. PloS ONE, 2012, 7(9): e44789.
37.	Guo J, Wang H, Wang Q, et al. Expression of p-CREB and activity-dependent miR-132 in temporal lobe epilepsy. International Journal of Clinical and Experimental Medicine, 2014, 7(5): 1297-1306.
38.	Xiang L, Ren Y, Cai H, et al. MicroRNA-132 aggravates epileptiform discharges via suppression of BDNF/TrkB signaling in cultured hippocampal neurons. Brain Res, 2015, 1638(7): 484-495.
39.	Jimenez-Mateos EM, Arribas-Blazquez M, Sanz-Rodriguez A, et al. MicroRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus. Scientific Reports, 2015, 5(5): 17486.
40.	Danis B, van Rikxoort M, Kretschmann A, et al. Differential expression of miR-184 in temporal lobe epilepsy patients with and without hippocampal sclerosis-influence on microglial function. Scientific Reports, 2016, 6(3): 33943.
41.	Xiang L, Ren Y, Li X, et al. MicroRNA-204 suppresses epileptiform discharges through regulating TrkB-ERK1/2-CREB signaling in cultured hippocampal neurons. Brain Res, 2016, 1639(8): 99-107.

1. Ngugi AK, Kariuki SM, Bottomley C, et al. Incidence of epilepsy: a systematic review and meta-analysis. Neurology, 2011, 77(10):1005-1112.
2. 常琳, 王小姗.中国癫痫流行病学调查研究进展.国际神经病学神经外科学杂志, 2012, 39(2): 161-164.
3. Reschke CR, Henshall DC. microRNA and epilepsy. Adv Exp Med Biol, 2015, 88(8): 41-70.
4. Roncon P, Soukupova M, Binaschi A, et al. MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy--comparison with human epileptic samples. Scientific Reports, 2015, 5(1): 14143.
5. Wang J, Yu JT, Tan L, et al. Genome-wide circulating microRNA expression profiling indicates biomarkers for epilepsy. Scientific Reports, 2015, 5 (3): 9522.
6. Peng J, Omran A, Ashhab MU, et al. Expression patterns of miR-124, miR-134, miR-132 and miR-21 in an immature rat model and children with mesial temporal lobe epilepsy. Journal of Molecular Neuroscience, 2013, 50 (2): 291-297.
7. Ren L, Zhu R, Li X. Silencing miR-181a produces neuroprotection against hippocampus neuron cell apoptosis post-status epilepticus in a rat model and in children with temporal lobe epilepsy. Genetics and Molecular Research, 2016, 15(1): 15017798.
8. Gorter JA, Iyer A, White I, et al. Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy. Neurobiology of Bisease, 2014, 62(6): 508-520.
9. Moon J, Lee ST, Choi J, et al. Unique behavioral characteristics and microRNA signatures in a drug resistant epilepsy model. PloS ONE, 2014, 9(1): e85617.
10. Wang J, Tan L, Tan L, et al. Circulating microRNAs are promising novel biomarkers for drug-resistant epilepsy. Scientific Reports, 2015, 5(4): 10201.
11. Cui L, Tao H, Wang Y, et al. A functional polymorphism of the microRNA-146a gene is associated with susceptibility to drug-resistant epilepsy and seizures frequency. Seizure, 2015, 27(7): 60-65.
12. Chen X, Ba Y, Ma L, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Research, 2008, 18(10): 997-1006.
13. Chang TC, Mendell JT. MicroRNAs in vertebrate physiology and human disease. Annual Review of Genomics and Human Genetics, 2007, 8(8): 215-239.
14. Kokaia M. Seizure-induced neurogenesis in the adult brain. The European Journal of Neuroscience, 2011, 33(6): 1133-1138.
15. Cattani AA, Allene C, Seifert V, et al. Involvement of microRNAs in epileptogenesis. Epilepsia, 2016, 57(7): 1015-1026.
16. Kuruba R, Hattiangady B, Shetty AK. Hippocampal neurogenesis and neural stem cells in temporal lobe epilepsy. Epilepsy & Behavior, 2009, 14(Suppl 1): 65-73.
17. Park JH, Cho H, Kim H, et al. Repeated brief epileptic seizures by pentylenetetrazole cause neurodegeneration and promote neurogenesis in discrete brain regions of freely moving adult rats. Neuroscience, 2006, 140(2): 673-684.
18. Cho KO, Lybrand ZR, Ito N, et al. Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. Nature Communications, 2015, 6(4): 6606.
19. Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death and Differentiation, 2010, 17(2): 193-199.
20. Tivnan A, Tracey L, Buckley PG, et al. MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma. BMC Cancer, 2011, 11 (7): 33.
21. Li MM, Jiang T, Sun Z, et al. Genome-wide microRNA expression profiles in hippocampus of rats with chronic temporal lobe epilepsy. Scientific Reports, 2014, 4 (6): 4734.
22. Wang XM, Jia RH, Wei D, et al. MiR-134 blockade prevents status epilepticus like-activity and is neuroprotective in cultured hippocampal neurons. Neuroscience Letters, 2014, 572(11): 20-25.
23. Mc Kiernan RC, Jimenez-Mateos EM, Sano T, et al. Expression profiling the microRNA response to epileptic preconditioning identifies miR-184 as a modulator of seizure-induced neuronal death. Experimental Neurology, 2012, 237(2): 346-354.
24. Liu X, Wu Y, Huang Q, et al. Grouping pentylenetetrazol-induced epileptic rats according to memory impairment and microRNA expression profiles in the hippocampus. PloS ONE, 2015, 10(5): e0126123.
25. Dingledine R, Varvel NH, Dudek FE. When and how do seizures kill neurons, and is cell death relevant to epileptogenesis?. Advances in Experimental Medicine and Biology, 2014, 813 (10): 109-122.
26. 陶树新, 陈阳美. MicroRNA与癫痫突触重塑.中华神经医学杂志, 2009, 8(12): 1276-1278.
27. Huang Y, Guo J, Wang Q, et al. MicroRNA-132 silencing decreases the spontaneous recurrent seizures. International Journal of Clinical and Experimental Medicine, 2014, 7(7): 1639-1649.
28. Jimenez-Mateos EM, Engel T, Merino-Serrais P, et al. Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nature Medicine, 2012, 18(7):1087-1094.
29. Vo N, Klein ME, Varlamova O, et al. A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102(45): 16426-16431.
30. Wanet A, Tacheny A, Arnould T, et al. MiR-212/132 expression and functions: within and beyond the neuronal compartment. Nucleic Acids Research, 2012, 40(11): 4742-4753.
31. Siegel G, Obernosterer G, Fiore R, et al. A functional screen implicates microRNA-138-dependent regulation of the depalmitoyla-tion enzyme APT1 in dendritic spine morphogenesis. Nature Cell Biology, 2009, 11(6): 705-716.
32. Wang W, Wang X, Chen L, et al. The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity. Expert Reviews in Molecular Medicine, 2016, 18(1): e4.
33. Vezzani A, French J, Bartfai T, et al.The role of inflammation in epilepsy. Nature Reviews Neurology, 2011, 7(1): 31-40.
34. Kan AA, van Erp S, Derijck AA, et al. Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response. Cellular and Molecular Life Sciences, 2012, 69(18): 3127-3145.
35. Aronica E, Fluiter K, Iyer A, et al. Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy. The European Journal of Neuroscience, 2010, 31(6): 1100-1107.
36. Iyer A, Zurolo E, Prabowo A, et al. MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response. PloS ONE, 2012, 7(9): e44789.
37. Guo J, Wang H, Wang Q, et al. Expression of p-CREB and activity-dependent miR-132 in temporal lobe epilepsy. International Journal of Clinical and Experimental Medicine, 2014, 7(5): 1297-1306.
38. Xiang L, Ren Y, Cai H, et al. MicroRNA-132 aggravates epileptiform discharges via suppression of BDNF/TrkB signaling in cultured hippocampal neurons. Brain Res, 2015, 1638(7): 484-495.
39. Jimenez-Mateos EM, Arribas-Blazquez M, Sanz-Rodriguez A, et al. MicroRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus. Scientific Reports, 2015, 5(5): 17486.
40. Danis B, van Rikxoort M, Kretschmann A, et al. Differential expression of miR-184 in temporal lobe epilepsy patients with and without hippocampal sclerosis-influence on microglial function. Scientific Reports, 2016, 6(3): 33943.
41. Xiang L, Ren Y, Li X, et al. MicroRNA-204 suppresses epileptiform discharges through regulating TrkB-ERK1/2-CREB signaling in cultured hippocampal neurons. Brain Res, 2016, 1639(8): 99-107.

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micro RNA调控癫痫的发生发展

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