Structural abnormalities of default mode network in childhood absence epilepsy revealed by diffusion tensor imaging_Journal of Epilepsy

Authors：

QIU Wenchao ,  WANG Xiaoshan

Department of Neurology, Nanjing Brain Hospital, Nanjing 210029, China;

Corresponding author：

WANG Xiaoshan, Email: 873734205@qq.com

Keywords：

Childhood absence epilepsy; Diffusion tensor imaging; Voxel-based analysis; Default mode network

DOI：

10.7507/2096-0247.20170028

Video：

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ObjectiveChildhood absence epilepsy (CAE) is a common syndrome of idiopathic generalized epilepsy.However, little is known about the brain structural changes in this type of epilepsy, especially in the default mode network (DMN) regions.Diffusion tensor imaging (DTI) is a noninvasive techniques that can be used to quantitatively explore structural characteristics of brain.This study aims at using the DTI technique to quantify structural abnormalities of DMN nodes in CAE patients.MethodDTI data were obtained in 14 CAE patients and 13 age-and gender-matched healthy controls.The data were analyzed using voxel-based analysis (VBA) and statistically compared between patients and controls.For the regions with significant difference in group comparison, their DTI metrics were further analyzed with clinical symptoms using Pearson's correlation.ResultsPatients showed significant increase of apparent diffusion coefficient (ADC) in left medial prefrontal cortex (MPFC) (P=0.042), while fractional anisotropy (FA) value was significantly decreased in left precuneus (P=0.010).In correlation analysis, ADC value from left MPFC was positively associated with duration of epilepsy.Neither the disease duration nor the seizure frequency showed significant correlation with FA values.ConclusionThe findings indicate that structural impairments exist in DMN regions in children suffering from absence epilepsy.This may contribute to understanding the pathological mechanisms and chronic neurological deficits of this disorder.

Citation： QIU Wenchao, WANG Xiaoshan. Structural abnormalities of default mode network in childhood absence epilepsy revealed by diffusion tensor imaging. Journal of Epilepsy, 2017, 3(3): 187-192. doi: 10.7507/2096-0247.20170028 Copy

1.	Engel J Jr.A proposed diagnostic scheme for people with epileptic seizures and with epilepsy:report of the ILAE Task Force on Classification and Terminology.Epilepsia, 2001, 42(3):796-803.
2.	Tenney JR, Glauser TA.The current state of absence epilepsy:can we have your attention.Epilepsy Curr, 2013, 13(7):135-140.
3.	Caplan R, Siddarth P, Stahl L, et al.Childhood absence epilepsy:behavioral, cognitive, and linguistic comorbidities.Epilepsia, 2008, 49(10):1838-1846.
4.	Berman R, Negishi M, Vestal M, et al.Simultaneous EEG, fMRI, and behavior in typical childhood absence seizures.Epilepsia, 2010, 51(7):2011-2022.
5.	Bai X, Vestal M, Berman R, et al.Dynamic time course of typical childhood absence seizures:EEG, behavior, and functional magnetic resonance imaging.J Neurosci, 2010, 30(4):5884-5893.
6.	Li Q, Cao W, Liao X, et al.Altered resting state functional network connectivity in children absence epilepsy.J Neurol Sci, 2015, 354(2):79-85.
7.	Miao A, Tang L, Xiang J, et al.Dynamic magnetic source imaging of absence seizure initialization and propagation:a magnetoencephalography study.Epilepsy Res, 2014, 108(1):468-480.
8.	Le Bihan D.Looking into the functional architecture of the brain with diffusion MRI.Nature Reviews Neuroscience, 2003, 4(2):469-480.
9.	Pierpaoli C, Basser PJ.Toward a quantitative assessment of diffusion anisotropy.Magn Reson Med, 1996, 36(5):893-906.
10.	Snook L, Paulson LA, Roy D.Diffusion tensor imaging of neurodevelopment in children and young adults.Neuroimage, 2005, 26(3):1164-1173.
11.	Rugg-Gunn FJ, Eriksson SH, Symms MR.Diffusion tensor imaging of cryptogenic and acquired partial epilepsies.Brain, 2001, 124(8):627-636.
12.	Di Paola M, Di Iulio F, Cherubini A, et al.When, where, and how the corpus callosum changes in MCI and AD:a multimodal MRI study.Neurology, 2010, 74(1):1136-1142.
13.	Schulte T, Sullivan EV, Muller-Oehring EM.Corpus callosal microstructural integrity influences interhemispheric processing:a diffusion tensor imaging study.Cereb Cortex, 2005, 15(3):1384-1392.
14.	Sykova E.Extrasynaptic volume transmission and diffusion parameters of the extracellular space.Neuroscience, 2004, 129(7):861-876.
15.	Luat AF, Chugani HT.Molecular and diffusion tensor imaging of epileptic networks.Epilepsia, 2008, 49(Suppl 3):15-22.
16.	Grant PE.Imaging the developing epileptic brain.Epilepsia, 2005, 46(Suppl 7):7-14.
17.	Rugg-Gunn FJ, Eriksson SH, Symms MR, et al.Diffusion tensor imaging in refractory epilepsy.Lancet, 20002, 359(6):1748-1751.
18.	吕粟.弥散张量成像揭示部分及全面发作癫痫患者的丘脑改变.首都医科大学学报, 2007, 28(6):713-716.
19.	Hutchinson E, Pulsipher D, Dabbs K, et al.Children with new-onset epilepsy exhibit diffusion abnormalities in cerebral white matter in the absence of volumetric differences.Epilepsy Res, 2010, 88(4):208-214.
20.	Yang T, Guo Z, Luo C, et al.White matter impairment in the basal ganglia-thalamocortical circuit of drug-naive childhood absence epilepsy.Epilepsy Res, 2012, 99(6):267-273.
21.	Li Q, Luo C, Yang T, et al.EEG-fMRI study on the interictal and ictal generalized spike-wave discharges in patients with childhood absence epilepsy.Epilepsy Res, 2009, 87(3):160-168.
22.	Carney PW, Jackson GD.Insights into the Mechanisms of Absence Seizure Generation Provided by EEG with Functional MRI.Frontiers in Neurology, 2014, 5(4):162.
23.	Lopes R, Moeller F, Besson P, et al.Study on the relationships between Intrinsic functional connectivity of the default mode network and transient epileptic activity.Frontiers in Neurology, 2014, 5(1):201.
24.	Buckner RL, Andrews-Hanna JR, Schacter DL.The brain's default network:anatomy, function, and relevance to disease.Ann N Y Acad Sci, 2008, 1124(12):31-38.
25.	Nolan MA, Redoblado MA, Lah S, et al.Memory function in childhood epilepsy syndromes.J Paediatr Child Health, 2004, 40(4):20-27.
26.	Thomason ME, Thompson PM.Diffusion imaging, white matter, and psychopathology.Annu Rev Clin Psychol, 2011, 7(4):83-85.
27.	Njiokiktjien C.Differences in vulnerability between the hemispheres in early childhood and adulthood.Fiziol Cheloveka, 2006, 32(5):45-50.
28.	Holmes MD, Dodrill CB, Kutsy RL.Is the left cerebral hemisphere more prone to epileptogenesis than the right.Epileptic Disord, 2011, 3(4):137-141.
29.	Vinogradova LV.Interhemispheric difference in susceptibility to epileptogenesis:evidence from the audiogenic kindling model in wistar rats.Brain Res, 2010, 1329(11):175-181.
30.	Vinogradova LV, Shatskova AB.Lateral asymmetry of early seizure manifestations in experimental generalized epilepsy.Neuroscience, 2012, 213(3):133-143.
31.	Keller SS, Ahrens T, Mohammadi S, et al.Microstructural and volumetric abnormalities of the putamen in juvenile myoclonic epilepsy.Epilepsia, 2011, 52(7):1715-1724.
32.	Keller SS, Schoene-Bake JC, Gerdes JS.Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy:cross-sectional evidence for progressive neurologic injury.PLoS One, 2012, 36(7):e46791.

1. Engel J Jr.A proposed diagnostic scheme for people with epileptic seizures and with epilepsy:report of the ILAE Task Force on Classification and Terminology.Epilepsia, 2001, 42(3):796-803.
2. Tenney JR, Glauser TA.The current state of absence epilepsy:can we have your attention.Epilepsy Curr, 2013, 13(7):135-140.
3. Caplan R, Siddarth P, Stahl L, et al.Childhood absence epilepsy:behavioral, cognitive, and linguistic comorbidities.Epilepsia, 2008, 49(10):1838-1846.
4. Berman R, Negishi M, Vestal M, et al.Simultaneous EEG, fMRI, and behavior in typical childhood absence seizures.Epilepsia, 2010, 51(7):2011-2022.
5. Bai X, Vestal M, Berman R, et al.Dynamic time course of typical childhood absence seizures:EEG, behavior, and functional magnetic resonance imaging.J Neurosci, 2010, 30(4):5884-5893.
6. Li Q, Cao W, Liao X, et al.Altered resting state functional network connectivity in children absence epilepsy.J Neurol Sci, 2015, 354(2):79-85.
7. Miao A, Tang L, Xiang J, et al.Dynamic magnetic source imaging of absence seizure initialization and propagation:a magnetoencephalography study.Epilepsy Res, 2014, 108(1):468-480.
8. Le Bihan D.Looking into the functional architecture of the brain with diffusion MRI.Nature Reviews Neuroscience, 2003, 4(2):469-480.
9. Pierpaoli C, Basser PJ.Toward a quantitative assessment of diffusion anisotropy.Magn Reson Med, 1996, 36(5):893-906.
10. Snook L, Paulson LA, Roy D.Diffusion tensor imaging of neurodevelopment in children and young adults.Neuroimage, 2005, 26(3):1164-1173.
11. Rugg-Gunn FJ, Eriksson SH, Symms MR.Diffusion tensor imaging of cryptogenic and acquired partial epilepsies.Brain, 2001, 124(8):627-636.
12. Di Paola M, Di Iulio F, Cherubini A, et al.When, where, and how the corpus callosum changes in MCI and AD:a multimodal MRI study.Neurology, 2010, 74(1):1136-1142.
13. Schulte T, Sullivan EV, Muller-Oehring EM.Corpus callosal microstructural integrity influences interhemispheric processing:a diffusion tensor imaging study.Cereb Cortex, 2005, 15(3):1384-1392.
14. Sykova E.Extrasynaptic volume transmission and diffusion parameters of the extracellular space.Neuroscience, 2004, 129(7):861-876.
15. Luat AF, Chugani HT.Molecular and diffusion tensor imaging of epileptic networks.Epilepsia, 2008, 49(Suppl 3):15-22.
16. Grant PE.Imaging the developing epileptic brain.Epilepsia, 2005, 46(Suppl 7):7-14.
17. Rugg-Gunn FJ, Eriksson SH, Symms MR, et al.Diffusion tensor imaging in refractory epilepsy.Lancet, 20002, 359(6):1748-1751.
18. 吕粟.弥散张量成像揭示部分及全面发作癫痫患者的丘脑改变.首都医科大学学报, 2007, 28(6):713-716.
19. Hutchinson E, Pulsipher D, Dabbs K, et al.Children with new-onset epilepsy exhibit diffusion abnormalities in cerebral white matter in the absence of volumetric differences.Epilepsy Res, 2010, 88(4):208-214.
20. Yang T, Guo Z, Luo C, et al.White matter impairment in the basal ganglia-thalamocortical circuit of drug-naive childhood absence epilepsy.Epilepsy Res, 2012, 99(6):267-273.
21. Li Q, Luo C, Yang T, et al.EEG-fMRI study on the interictal and ictal generalized spike-wave discharges in patients with childhood absence epilepsy.Epilepsy Res, 2009, 87(3):160-168.
22. Carney PW, Jackson GD.Insights into the Mechanisms of Absence Seizure Generation Provided by EEG with Functional MRI.Frontiers in Neurology, 2014, 5(4):162.
23. Lopes R, Moeller F, Besson P, et al.Study on the relationships between Intrinsic functional connectivity of the default mode network and transient epileptic activity.Frontiers in Neurology, 2014, 5(1):201.
24. Buckner RL, Andrews-Hanna JR, Schacter DL.The brain's default network:anatomy, function, and relevance to disease.Ann N Y Acad Sci, 2008, 1124(12):31-38.
25. Nolan MA, Redoblado MA, Lah S, et al.Memory function in childhood epilepsy syndromes.J Paediatr Child Health, 2004, 40(4):20-27.
26. Thomason ME, Thompson PM.Diffusion imaging, white matter, and psychopathology.Annu Rev Clin Psychol, 2011, 7(4):83-85.
27. Njiokiktjien C.Differences in vulnerability between the hemispheres in early childhood and adulthood.Fiziol Cheloveka, 2006, 32(5):45-50.
28. Holmes MD, Dodrill CB, Kutsy RL.Is the left cerebral hemisphere more prone to epileptogenesis than the right.Epileptic Disord, 2011, 3(4):137-141.
29. Vinogradova LV.Interhemispheric difference in susceptibility to epileptogenesis:evidence from the audiogenic kindling model in wistar rats.Brain Res, 2010, 1329(11):175-181.
30. Vinogradova LV, Shatskova AB.Lateral asymmetry of early seizure manifestations in experimental generalized epilepsy.Neuroscience, 2012, 213(3):133-143.
31. Keller SS, Ahrens T, Mohammadi S, et al.Microstructural and volumetric abnormalities of the putamen in juvenile myoclonic epilepsy.Epilepsia, 2011, 52(7):1715-1724.
32. Keller SS, Schoene-Bake JC, Gerdes JS.Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy:cross-sectional evidence for progressive neurologic injury.PLoS One, 2012, 36(7):e46791.

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