Rasmussen脑炎的研究进展_Journal of Epilepsy

Authors：

黄亚莉 ,  任惠

昆明医科大学第一附属医院老年神经内科(昆明 650032);

Corresponding author：

任惠, Email: rh-3338@163.com

Keywords：

Rasmussen脑炎; 病因及发病机制; 临床表现; 诊断及治疗

DOI：

10.7507/2096-0247.20170036

Video：

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Rasmussen脑炎(Rasmussen’s encephalitis，RE)是一种罕见的神经系统慢性疾病，又称为Rasmussen综合征。该病多起源于儿童期，常累及一侧大脑半球，主要以药物难治性癫痫、部分性癫痫持续状态、进展性神经功能缺损(言语、运动及认知功能障碍等)为主要特点。目前神经病理学及免疫学机制尚不明确。影像学检查对其早期诊断有指导意义。该病症状重，致残率高，抗癫痫药物治疗的疗效较差，激素及免疫抑制剂等药物治疗不能从根本上阻止疾病的进展，大脑半球切除术仍是目前唯一治愈该病的方法。

Citation： 黄亚莉, 任惠. Rasmussen脑炎的研究进展. Journal of Epilepsy, 2017, 3(3): 234-237. doi: 10.7507/2096-0247.20170036 Copy

1.	陈帅, 王一松, 关宇光, 等.Rasmussen脑炎的病因及发病机制研究现状.转化医学研究电子版, 2015, 2(10):121-125.
2.	Yao Zhang, Yisong Wang, Sichang Chen, et al.Expression of human cytomegalovirus components in the brain tissues of patients with Rasmussen's encephalitis.Virologica Sinica, 2017, 10(7):250-256.
3.	Marianna Spatola, Josep Dalmau.Seizures and risk of epilepsy in autoimmune and other inflammatory encephalitis.Current Opinion in Neurology, 2017, 30(1):104-106.
4.	Tilman Schneider-Hohendorf, Hema Mohan, Christian G Bien, et al.CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing.Nature Communications, 2016, 7(1):153.
5.	朱健, 黄程, 林志国.Rasmussen综合征的发病机制和治疗策略的新进展.中国临床神经外科杂志, 2012(10):619-621.
6.	Kaitlyn K Thompson, Stella E Tsirka.The diverse roles of microglia in the neurodegenerative aspects of central nervous system (CNS) autoimmunity.International Journal of Molecular Sciences, 2017, 18(3):212-215.
7.	张璠, 郑宏.Rasmussen脑炎研究新进展.中国中西医结合儿科学杂志, 2012, 4(1):40-43.
8.	Carlos A Pardo, Rima Nabbout, Aristea S.Galanopoulou mechanisms of epileptogenesis in pediatric epileptic syndromes:Rasmussen encephalitis, Infantile spasms, and Febrile infection-related epilepsy syndrome (FIRES).Neurotherapeutics, 2014, 11(4):297-310.
9.	Sophia Varadkar, Christian G Bien, Carol A Kruse, et al.Rasmussen's encephalitis:clinical features, pathobiology, and treatment advances.Lancet Neurology, 2014, 13(2):5.
10.	Bien CG, Widman G, Urbach H, et al.The natural history of Rasmussen's encephalitis.Brain, 2002, 125(8):1751-1759.
11.	CG Bien, T Granata, C Antozzi, et al.Pathogenesis, diagnosis and treatment of rasmussen encephalitis:a european consensus statement.Brain, 2005, 128(3):54.
12.	VM Ravindra, MD Mazur, CA Mohila, et al.Rasmussen encephalitis with dual pathology in a patient without seizures:case report and literature review.Child's Nervous System, 2015, 31(11):2165-2171.
13.	Zhiliang Yang, Guilian Sun.Headache maybe the initial symptom in rasmussen's syndrome:a child case report.Epilepsy Behavior Case Reports, 2016, 6(2):75-77.
14.	F Deleo, S Matricardi, G Didato, et al. The dilemma of adult-onset rasmussen encephalitis clinical assessment:proposal for a new bedside tool to evaluate disease progression.Epilepsy Behavior, 2015, 46(7):249-251.
15.	黄光, 刘兴洲.Rasmussen综合征.中国全科医学杂志, 2009, 12(14):1298-1300.
16.	关宇光, 李天富, 栾国明.Rasmussen脑炎的研究现状.转化医学研究电子版, 2014, 7(2):24-27.
17.	R Nabbout, DM Andrade, N Bahi-Buisson, et al. Outcome of childhood-onset epilepsy from adolescence to adulthood:transition issues.Epilepsy Behavior, 2016, 54(11):451-456.
18.	CE Hoffman, A Ochi, E Widjaja, et al.Rasmussen's encephalitis:advances in management and patient outcomes.Child's Nervous System, 2016, 32(4):629-640.
19.	Christine Bulteau, Catherine Grosmaitre, Jessica Save-Pédebos, et al. Language recovery after left hemispherotomy for rasmussen encephalitis.Epilepsy Behavior, 2015, 53(7):51-57.
20.	Sophia Varadkar, Martin Tisdall.Language after hemispherotomy in rasmussen syndrome.Pediatr Neurol Briefs, 2016, 30(2):13-16.
21.	Granata T, Fusco L, Gobbi G, et al. Experience with immunomodulatory treatments in rasmussen's encephalitis.Neurology, 2003, 61(12):1807-1810.
22.	Salwa Tawila, Robin Morrisb, Nandini Mullattic, et al. Adult onset rasmussen's encephalitis associated with reflex language induced seizures responsive to rituximab therapy.Seizure European Journal of Epilepsy, 2016, 42(1):60-62.

1. 陈帅, 王一松, 关宇光, 等.Rasmussen脑炎的病因及发病机制研究现状.转化医学研究电子版, 2015, 2(10):121-125.
2. Yao Zhang, Yisong Wang, Sichang Chen, et al.Expression of human cytomegalovirus components in the brain tissues of patients with Rasmussen's encephalitis.Virologica Sinica, 2017, 10(7):250-256.
3. Marianna Spatola, Josep Dalmau.Seizures and risk of epilepsy in autoimmune and other inflammatory encephalitis.Current Opinion in Neurology, 2017, 30(1):104-106.
4. Tilman Schneider-Hohendorf, Hema Mohan, Christian G Bien, et al.CD8+ T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing.Nature Communications, 2016, 7(1):153.
5. 朱健, 黄程, 林志国.Rasmussen综合征的发病机制和治疗策略的新进展.中国临床神经外科杂志, 2012(10):619-621.
6. Kaitlyn K Thompson, Stella E Tsirka.The diverse roles of microglia in the neurodegenerative aspects of central nervous system (CNS) autoimmunity.International Journal of Molecular Sciences, 2017, 18(3):212-215.
7. 张璠, 郑宏.Rasmussen脑炎研究新进展.中国中西医结合儿科学杂志, 2012, 4(1):40-43.
8. Carlos A Pardo, Rima Nabbout, Aristea S.Galanopoulou mechanisms of epileptogenesis in pediatric epileptic syndromes:Rasmussen encephalitis, Infantile spasms, and Febrile infection-related epilepsy syndrome (FIRES).Neurotherapeutics, 2014, 11(4):297-310.
9. Sophia Varadkar, Christian G Bien, Carol A Kruse, et al.Rasmussen's encephalitis:clinical features, pathobiology, and treatment advances.Lancet Neurology, 2014, 13(2):5.
10. Bien CG, Widman G, Urbach H, et al.The natural history of Rasmussen's encephalitis.Brain, 2002, 125(8):1751-1759.
11. CG Bien, T Granata, C Antozzi, et al.Pathogenesis, diagnosis and treatment of rasmussen encephalitis:a european consensus statement.Brain, 2005, 128(3):54.
12. VM Ravindra, MD Mazur, CA Mohila, et al.Rasmussen encephalitis with dual pathology in a patient without seizures:case report and literature review.Child's Nervous System, 2015, 31(11):2165-2171.
13. Zhiliang Yang, Guilian Sun.Headache maybe the initial symptom in rasmussen's syndrome:a child case report.Epilepsy Behavior Case Reports, 2016, 6(2):75-77.
14. F Deleo, S Matricardi, G Didato, et al. The dilemma of adult-onset rasmussen encephalitis clinical assessment:proposal for a new bedside tool to evaluate disease progression.Epilepsy Behavior, 2015, 46(7):249-251.
15. 黄光, 刘兴洲.Rasmussen综合征.中国全科医学杂志, 2009, 12(14):1298-1300.
16. 关宇光, 李天富, 栾国明.Rasmussen脑炎的研究现状.转化医学研究电子版, 2014, 7(2):24-27.
17. R Nabbout, DM Andrade, N Bahi-Buisson, et al. Outcome of childhood-onset epilepsy from adolescence to adulthood:transition issues.Epilepsy Behavior, 2016, 54(11):451-456.
18. CE Hoffman, A Ochi, E Widjaja, et al.Rasmussen's encephalitis:advances in management and patient outcomes.Child's Nervous System, 2016, 32(4):629-640.
19. Christine Bulteau, Catherine Grosmaitre, Jessica Save-Pédebos, et al. Language recovery after left hemispherotomy for rasmussen encephalitis.Epilepsy Behavior, 2015, 53(7):51-57.
20. Sophia Varadkar, Martin Tisdall.Language after hemispherotomy in rasmussen syndrome.Pediatr Neurol Briefs, 2016, 30(2):13-16.
21. Granata T, Fusco L, Gobbi G, et al. Experience with immunomodulatory treatments in rasmussen's encephalitis.Neurology, 2003, 61(12):1807-1810.
22. Salwa Tawila, Robin Morrisb, Nandini Mullattic, et al. Adult onset rasmussen's encephalitis associated with reflex language induced seizures responsive to rituximab therapy.Seizure European Journal of Epilepsy, 2016, 42(1):60-62.

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